The JNK cascade as a biochemical switch in mammalian cells: Ultrasensitive and all-or-none responses

Current Biology

Volumn 13, Issue 4, 2003, Pages 315-320

  Bagowski, Christoph P ^a   Besser, Jaya ^a   Frey, Christian R ^a   Ferrell Jr , James E ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; LEUKOCYTE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE ANTIGEN;

ANIMAL; ARTICLE; CELL LINE; ENZYME ACTIVATION; METABOLISM; XENOPUS;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELL LINE; ENZYME ACTIVATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; TETRADECANOYLPHORBOL ACETATE; XENOPUS;

ANIMALIA; MAMMALIA;

EID: 0242515913     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(03)00083-6     Document Type: Article

References (26)

1. Davis, R.J. (1999). Signal transduction by the c-Jun N-terminal kinase. Biochem. Soc. Symp. 64, 1-12.
2. Weston, C.R., and Davis, R.J. (2002). The JNK signal transduction pathway. Curr. Opin. Genet. Dev. 12, 14-21.
3. Bagowski, C.P., and Ferrell, J.E. (2001). Bistability in the JNK cascade. Curr. Biol. 11, 1176-1182.
4. Ferrell, J.E., Jr. (1999). Regulatory cascades: function and properties. In Encyclopedia of Life Science (London: Nature Publishing Group). Published online August, 2002. http://www.els.net/.
5. Ferrell, J.E., Jr. (1996). Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem. Sci. 21, 460-466.
6. Ferrell, J.E., Jr. (1997). How responses get more switch-like as you move down a protein kinase cascade. Trends Biochem. Sci. 22, 288-289.
7. Goldbeter, A., and Koshland, D.E., Jr. (1982). Sensitivity amplification in biochemical systems. Q. Rev. Biophys. 15, 555-591.
8. Goldbeter, A., and Koshland, D.E., Jr. (1981). An amplified sensitivity arising from covalent modification in biological systems. Proc. Natl. Acad. Sci. USA 78, 6840-6844.
9. Chock, P.B., Rhee, S.G., and Stadtman, E.R. (1980). Interconvertible enzyme cascades in cellular regulation. Annu. Rev. Biochem. 49, 813-843.
10. Huang, C.-Y.F., and Ferrell, J.E., Jr. (1996). Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 93, 10078-10083.
11. Becskei, A., and Serrano, L. (2000). Engineering stability in gene networks by autoregulation. Nature 405, 590-593.
12. Yi, T.M., Huang, Y., Simon, M.I., and Doyle, J. (2000). Robust perfect adaptation in bacterial chemotaxis through integral feedback control. Proc. Natl. Acad. Sci. USA 97, 4649-4653.
13. Elowitz, M.B., and Leibler, S. (2000). A synthetic oscillatory network of transcriptional regulators. Nature 403, 335-338.
14. Kholodenko, B.N. (2000). Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades. Eur. J. Biochem. 267, 1583-1588.
15. Laurent, M., and Kellershohn, N. (1999). Multistability: a major means of differentiation and evolution in biological systems. Trends Biochem. Sci. 24, 418-422.
16. Gardner, T.S., Cantor, C.R., and Collins, J.J. (2000). Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339-342.
17. Becskei, A., Seraphin, B., and Serrano, L. (2001). Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion. EMBO J. 20, 2528-2535.
18. Bagowski, C.P., Xiong, W., and Ferrell, J.E., Jr. (2001). c-Jun N-terminal kinase activation in Xenopus laevis eggs and embryos: a possible non-genomic role for the JNK signaling pathway. J. Biol. Chem. 276, 1459-1465.
19. Hibi, M., Lin, A., Smeal, T., Minden, A., and Karin, M. (1993). Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7, 2135-2148.
20. Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and BenNeriah, Y. (1994). JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77, 727-736.
21. Ferrell, J.E., Jr., and Machleder, E.M. (1998). The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science 280, 895-898.
22. Tsien, R.Y. (1992). Intracellular signal transduction in four dimensions: from molecular design to physiology. Am. J. Physiol. 263, C723-C728.
23. Teruel, M.N., and Meyer, T. (2002). Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module. Science 295, 1910-1912.
24. Cross, F.R., Archambault, V., Miller, M., and Klovstad, M. (2002). Testing a mathematical model of the yeast cell cycle. Mol. Biol. Cell 13, 52-70.
25. Eto, M., Elliott, E., Prickett, T.D., and Brautigan, D.L. (2002). Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. J. Biol. Chem. 277, 44013-44020.
26. Biggar, S.R., and Crabtree, G.R. (2001). Cell signaling can direct either binary or graded transcriptional responses. EMBO J. 20, 3167-3176.