Phase I to II cross-induction of xenobiotic metabolizing enzymes: A feedforward control mechanism for potential hormetic responses

Toxicology and Applied Pharmacology

Volumn 237, Issue 3, 2009, Pages 345-356

  Zhang, Qiang ^a   Pi, Jingbo ^a   Woods, Courtney G ^a,b   Andersen, Melvin E ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

Author keywords

Bioactivation; Feedback; Feedforward; Hormesis; Nrf2; Overcompensation; Reactive metabolite; Xenobiotics

Indexed keywords

CELL NUCLEUS RECEPTOR; CYTOCHROME P450; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE; TRANSCRIPTION FACTOR NRF2; XENOBIOTIC AGENT;

ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; GENE INDUCTION; HORMESIS; MATHEMATICAL MODEL; METABOLITE; NEGATIVE FEEDBACK; PHYSICAL CHEMISTRY; POSITIVE FEEDBACK; STEADY STATE; XENOBIOTIC METABOLISM;

CHEMISTRY, PHYSICAL; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDBACK, BIOCHEMICAL; HOMEOSTASIS; PHARMACEUTICAL PREPARATIONS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRESS, PHYSIOLOGICAL; XENOBIOTICS;

EID: 65749113675     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.04.005     Document Type: Article

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