Alteration of transcriptional and post-transcriptional expression of gamma-glutamylcysteine synthetase by diethyl maleate

Radiation Research

Volumn 147, Issue 5, 1997, Pages 592-597

  Sekhar, Konjeti R ^a   Long, Matthew ^b   Long, John ^b   Xu, Zhi Qi ^a   Summar, Marshall L ^a   Freeman, Michael L ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE CYSTEINE LIGASE; MALEIC ACID DIETHYL ESTER;

ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME SYNTHESIS; GENE EXPRESSION REGULATION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIATION EXPOSURE; STRESS; TRANSCRIPTION REGULATION;

EID: 0030973242     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579626     Document Type: Article

References (28)

1. m for radiosensitization at 0°C of thiol depletion by diethylmaleate pre-treatment: Quantitative differences found using the radiation-sensitizing agent misonidazole or oxygen. Radiat. Res. 98, 141-153 (1984).
2. 2 dependent damage in some glutathione deficient mutants of Escherichia coli. Int. J. Radiat. Biol. 59, 1237-1251 (1991).
3. I. J. Stratford, G. E. Adams, C. Hardy, S. Hoe, P. O'Neill and P. W. Sheldon, Thiol reactive nitroimidazoles: radiosensitization studies in vitro and in vivo. Int. J. Radiat. Biol. 46, 731-745 (1984).
4. K. D. Held, E. R. Epp, E. P. Clark and J. E. Biaglow, Effect of dimethyl fumarate on the radiation sensitivity of mammalian cells in vitro. Radiat. Res. 115, 495-502 (1988).
5. C. S. Huang, M. E. Anderson and A. Meister, Amino acid sequence and function of the light subunit of rat kidney γ-glutamylcysteine synthetase. J. Biol. Chem. 268, 20578-20583 (1993).
6. E. Sierra-Rivera, M. L. Summar, M. Dasouki, M. R. S. Krishnamani, J. A. Phillips, III and M. L. Freeman, Assignment of the gene (GLCLC) that encodes the heavy subunit of γ-glutamylcysteine synthetase to human chromosome 6. Cytogenet. Cell Genet. 70, 278-279 (1995).
7. K. Tsuchiya, R. T. Mulcahy, L. L. Reid, C. M. Disteche and T. J. Kavanagh, Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Genomics 30, 630-632 (1995).
8. E. Sierra-Rivera, M. Dasouki, M. L. Summar, M. R. S. Krishnamani, M. J. Meredith, P. N. Rao, J. A. Phillips, III and M. L. Freeman, Assignment of the human gene that encodes the regulatory subunit of γ-glutamylcysteine synthetase to chromosome 1p21. Cytogenet. Cell Genet. 72, 252-254 (1996).
9. J. J. Gipp, H. H. Bailey and R. T. Mulcahy, Cloning and sequencing of the cDNA for the light subunit of human liver γ-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues. Biochem. Biophys. Res. Commun. 206, 584-589 (1995).
10. R. T. Mulcahy and J. J. Gipp, Identification of a putative antioxidant response element in the 5′-flanking region of the human γ-glutamylcysteine synthetase heavy subunit gene. Biochem. Biophys. Res. Commun. 209, 227-233 (1995).
11. K. S. Yao, A. K. Godwin, S. W. Johnson, R. F. Ozols, P. J. O'Dwyer and T. C. Hamilton, Evidence for altered regulation of γ-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines. Cancer Res. 55, 4367-4374 (1995).
12. A. L. Wu and W. S. Moye-Rowley, GSH1, which encodes γ-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation. Mol. Cell. Biol. 14, 5832-5839 (1994).
13. M. M. Shi, A. Kugelman, T. Iwamoto, L. Tian and H. J. Forman, Quinone-induced oxidative stress elevates glutathione and induces γ-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. J. Biol. Chem. 269, 26512-26517 (1994).
14. H. Shen, S. Ranganathan, S. Kuzinich and K. D. Tew, Influence of ethacrynic acid on glutathione S-transferase π transcript and protein half-lives in human colon cancer cells. Biochem. Pharmacol. 50, 1233-1238 (1995).
15. T. Prestera and P. Talalay, Electrophile and antioxidant regulation of enzymes that detoxify carcinogens. Proc. Natl. Acad. Sci. USA 92, 8965-8969 (1995).
16. K. I. Borroz, T. M. Buetler and D. L. Eaton, Modulation of γ-glutamylcysteine synthetase large subunit mRNA expression by butylated hydroxyanisole. Toxicol. Appl. Pharmacol. 126, 150-155 (1994).
17. E. Sierra-Rivera, M. J. Meredith, M. L. Summar, M. D. Smith, G. J. Voorhees, C. M. Stoffel and M. L. Freeman, Genes regulating glutathione concentrations in X-ray transformed rat embryo fibroblasts: changes in γ-glutamylcysteine synthetase and γ-glutamyltranspeptidase expression. Carcinogenesis 15, 1301-1307 (1994).
18. K. Sasaki, T. P. Cripe, S. R. Koch, T. L. Andreone, D. D. Petersen, E. G. Beale and D. K. Granner, Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin. J. Biol. Chem. 259, 15242-15251 (1984).
19. G. S. McKnight and R. D. Palmiter, Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct. J. Biol. Chem. 254, 9050-9058 (1979).
20. K. I. Borroz, T. M. Buetler and D. L. Eaton, Modulation of γ-glutamylcysteine synthetase large subunit mRNA expression by butylated hydroxyanisole. Toxicol. Appl. Pharmacol. 126, 150-155 (1994).
21. P. Talalay, A. J. DeLong and H. J. Prochaska, Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. Proc. Natl. Acad. Sci. USA 85, 8261-8265 (1988).
22. J. Cai, W. M. Sun and S. C. Lu, Hormonal and cell density regulation of hepatic γ-glutamylcysteine synthetase gene expression. Mol. Pharmacol. 48, 212-218 (1995).
23. R. T. Mulcahy, S. Untawale and J. J. Gipp, Transcriptional up-regulation of γ-glutamylcysteine synthetase gene expression in melphalan-resistant human prostate carcinoma cells. Mol. Pharmacol. 46, 909-914 (1994).
24. K. S. Yao, A. K. Godwin, S. W. Johnson, R. F. Ozols, P. J. O'Dwyer and T. C. Hamilton, Evidence for altered regulation of γ-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines. Cancer Res. 55, 4367-4374 (1995).
25. S. Rogers, R. Wells and M. Rechsteiner, Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis. Science 234, 364-369 (1986).
26. M. Rechsteiner, PEST sequences are signals for rapid intracellular proteolysis. Semin. Cell Biol. 1, 433-440 (1990).
27. N. Yan and A. Meister, Amino acid sequence of rat kidney γ-glutamylcysteine synthetase. J. Biol. Chem. 265, 1588-1593 (1990).
28. J. J. Gipp, C. Chang and R. T. Mulcahy, Cloning and nucleotide sequence of a full length cDNA for human liver γ-glutamylcysteine synthetase. Biochem. Biophys. Res. Commun. 185, 29-35 (1992).