Folding of human superoxide dismutase: Disulfide reduction prevents dimerization and produces marginally stable monomers

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 45, 2004, Pages 15893-15898

  Lindberg, Mikael J ^a   Normark, Johanna ^a   Holmgren, Arne ^b   Oliveberg, Mikael ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Disulfide bond; Protein engineering; Protein folding; Protein stability; Transition state shifts

Indexed keywords

APOPROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; DIMER; DISULFIDE; MONOMER; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CYTOSOL; DIMERIZATION; DISULFIDE BOND; NERVE INJURY; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN FOLDING; REDUCTION;

AMYOTROPHIC LATERAL SCLEROSIS; APOENZYMES; CYSTEINE; DIMERIZATION; DISULFIDES; ENZYME STABILITY; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; SUPEROXIDE DISMUTASE;

EID: 8644290067     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0403979101     Document Type: Article

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