Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

Nature

Volumn 423, Issue 6941, 2003, Pages 769-773

  Salmeen, Annette ^a,c   Andersen, Jannlk N ^b   Myers, Mlchael P ^b   Meng, Tzu Ching ^b   Hinks, John A ^a   Tonks, Nicholas K ^b   Barford, David ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b Simons Center for Quantitative Biology   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; CONFORMATIONS; HYDROGEN PEROXIDE; INSULIN; OXIDATION; REDOX REACTIONS; SUBSTRATES;

SIGNAL TRANSDUCTION;

ENZYMES;

HYDROGEN PEROXIDE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; SULFENAMIDE DERIVATIVE; SULFENIC ACID DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

MEDICINE;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; OXIDATION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN MODIFICATION; SECOND MESSENGER; SIGNAL TRANSDUCTION;

AMIDES; AMINO ACID SUBSTITUTION; BINDING SITES; CYSTEINE; EPIDERMAL GROWTH FACTOR; INSULIN; MODELS, MOLECULAR; OXIDATION-REDUCTION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, INSULIN; SERINE; SULFENIC ACIDS;

EID: 0038411479     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01680     Document Type: Article

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