-
1
-
-
0030595339
-
The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
-
Lemaitre B, Nicolas E, Michaut L, et al. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell, 1996, 86: 973-983.
-
(1996)
Cell
, vol.86
, pp. 973-983
-
-
Lemaitre, B.1
Nicolas, E.2
Michaut, L.3
-
2
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov R, Preston-Hurlburt P, Janeway C A, et al. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature, 1997, 388: 394-397.
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway, C.A.3
-
3
-
-
0141532262
-
Toll-like receptor signaling
-
Akira S. Toll-like receptor signaling. J Biol Chem, 2003, 278: 38105-38108.
-
(2003)
J Biol Chem
, vol.278
, pp. 38105-38108
-
-
Akira, S.1
-
4
-
-
0034775153
-
Toll-like receptors control activation of adaptive immune responses
-
Schnare M, Barton G M, Holt A C, et al. Toll-like receptors control activation of adaptive immune responses. Nat Immunol, 2001, 2: 947-950.
-
(2001)
Nat Immunol
, vol.2
, pp. 947-950
-
-
Schnare, M.1
Barton, G.M.2
Holt, A.C.3
-
5
-
-
20644450804
-
Negative regulation of toll-like receptor-mediated immune responses
-
Liew F Y, Xu D, Brint E K, et al. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol, 2005, 5: 446-458.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 446-458
-
-
Liew, F.Y.1
Xu, D.2
Brint, E.K.3
-
6
-
-
0034610291
-
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
-
Ozinsky A, Underhill D M, Fontenot J D, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA, 2000, 97: 13766-13771.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 13766-13771
-
-
Ozinsky, A.1
Underhill, D.M.2
Fontenot, J.D.3
-
7
-
-
0036644042
-
Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
-
Takeuchi O, Sato S, Horiuchi T, et al. Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 2002, 169: 10-14.
-
(2002)
J Immunol
, vol.169
, pp. 10-14
-
-
Takeuchi, O.1
Sato, S.2
Horiuchi, T.3
-
8
-
-
27744456905
-
Domain exchange between human toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination
-
Omueti K O, Beyer J M, Johnson C M, et al. Domain exchange between human toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J Biol Chem, 2005, 280: 36616-36625.
-
(2005)
J Biol Chem
, vol.280
, pp. 36616-36625
-
-
Omueti, K.O.1
Beyer, J.M.2
Johnson, C.M.3
-
9
-
-
42349090335
-
Structural basis of toll-like receptor 3 signaling with double-stranded RNA
-
Liu L, Botos I, Wang Y, et al. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science, 2008, 320: 379-381.
-
(2008)
Science
, vol.320
, pp. 379-381
-
-
Liu, L.1
Botos, I.2
Wang, Y.3
-
10
-
-
67349182481
-
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
-
Park B S, Song D H, Kim H M, et al. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature, 2009, 458: 1191-1195.
-
(2009)
Nature
, vol.458
, pp. 1191-1195
-
-
Park, B.S.1
Song, D.H.2
Kim, H.M.3
-
11
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
O'Neill L A, Bowie A G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol, 2007, 7: 353-364.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 353-364
-
-
O'Neill, L.A.1
Bowie, A.G.2
-
12
-
-
10744233851
-
Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk
-
LeBouder E, Rey-Nores J E, Rushmere N K, et al. Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk. J Immunol, 2003, 171: 6680-6689.
-
(2003)
J Immunol
, vol.171
, pp. 6680-6689
-
-
Lebouder, E.1
Rey-Nores, J.E.2
Rushmere, N.K.3
-
13
-
-
0034672088
-
Cutting edge: Naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling
-
Iwami K I, Matsuguchi T, Masuda A, et al. Cutting edge: Naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling. J Immunol, 2000, 165: 6682-6686.
-
(2000)
J Immunol
, vol.165
, pp. 6682-6686
-
-
Iwami, K.I.1
Matsuguchi, T.2
Masuda, A.3
-
14
-
-
40949134086
-
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
-
Kagan JC, Su T, Horng T, et al. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol, 2008, 9: 361-368.
-
(2008)
Nat Immunol
, vol.9
, pp. 361-368
-
-
Kagan, J.C.1
Su, T.2
Horng, T.3
-
15
-
-
76649097727
-
-
Beijing: People's Medical Publishing House
-
Cao X. Forefront of progress in immunology. Beijing: People's Medical Publishing House, 2009. 136-160.
-
(2009)
Forefront of Progress in Immunology
, pp. 136-160
-
-
Cao, X.1
-
16
-
-
0025290213
-
Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6
-
Lord K A, Hoffman-Liebermann B, Liebermann D A. Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6. Oncogene, 1990, 5: 1095-1097.
-
(1990)
Oncogene
, vol.5
, pp. 1095-1097
-
-
Lord, K.A.1
Hoffman-Liebermann, B.2
Liebermann, D.A.3
-
17
-
-
0030694108
-
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
-
Muzio M, Ni J, Feng P, et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997, 278: 1612-1615.
-
(1997)
Science
, vol.278
, pp. 1612-1615
-
-
Muzio, M.1
Ni, J.2
Feng, P.3
-
18
-
-
0031423761
-
MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
-
Wesche H, Henzel W J, Shillinglaw W, et al. MyD88: An adapter that recruits IRAK to the IL-1 receptor complex. Immunity, 1997, 7: 837-847.
-
(1997)
Immunity
, vol.7
, pp. 837-847
-
-
Wesche, H.1
Henzel, W.J.2
Shillinglaw, W.3
-
19
-
-
0033166472
-
Unresponsiveness of MyD88-deficient mice to endotoxin
-
Kawai T, Adachi O, Ogawa T, et al. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity, 1999, 11: 115-122.
-
(1999)
Immunity
, vol.11
, pp. 115-122
-
-
Kawai, T.1
Adachi, O.2
Ogawa, T.3
-
20
-
-
0036006290
-
Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88
-
Janssens S, Burns K, Tschopp J, et al. Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88. Curr Biol, 2002, 12: 467-471.
-
(2002)
Curr Biol
, vol.12
, pp. 467-471
-
-
Janssens, S.1
Burns, K.2
Tschopp, J.3
-
21
-
-
0037454946
-
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
-
Burns K, Janssens S, Brissoni B, et al. Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med, 2003, 197: 263-268.
-
(2003)
J Exp Med
, vol.197
, pp. 263-268
-
-
Burns, K.1
Janssens, S.2
Brissoni, B.3
-
22
-
-
0035817925
-
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
-
Fitzgerald K A, Palsson-McDermott E M, Bowie A G, et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature, 2001, 413: 78-83.
-
(2001)
Nature
, vol.413
, pp. 78-83
-
-
Fitzgerald, K.A.1
Palsson-McDermott, E.M.2
Bowie, A.G.3
-
23
-
-
0037153191
-
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
-
Yamamoto M, Sato S, Hemmi H, et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature, 2002, 420: 324-329.
-
(2002)
Nature
, vol.420
, pp. 324-329
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
-
24
-
-
0037153130
-
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
-
Horng T, Barton G M, Flavell R A, et al. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature, 2002, 420: 329-333.
-
(2002)
Nature
, vol.420
, pp. 329-333
-
-
Horng, T.1
Barton, G.M.2
Flavell, R.A.3
-
25
-
-
33646908228
-
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
-
Kagan J C, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell, 2006, 125: 943-955.
-
(2006)
Cell
, vol.125
, pp. 943-955
-
-
Kagan, J.C.1
Medzhitov, R.2
-
26
-
-
67649865588
-
Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling
-
Ohnishi H, Tochio H, Kato Z, et al. Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. Proc Natl Acad Sci USA, 2009, 106: 10260-10265.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 10260-10265
-
-
Ohnishi, H.1
Tochio, H.2
Kato, Z.3
-
27
-
-
0032526555
-
Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production
-
Kanakaraj P, Schafer P H, Cavender D E, et al. Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production. J Exp Med, 1998, 187: 2073-2079.
-
(1998)
J Exp Med
, vol.187
, pp. 2073-2079
-
-
Kanakaraj, P.1
Schafer, P.H.2
Cavender, D.E.3
-
28
-
-
0033565779
-
Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
-
Thomas J A, Allen J L, Tsen M, et al. Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol, 1999, 163: 978-984.
-
(1999)
J Immunol
, vol.163
, pp. 978-984
-
-
Thomas, J.A.1
Allen, J.L.2
Tsen, M.3
-
29
-
-
0037117543
-
IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase
-
Li S, Strelow A, Fontana E J, et al. IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci USA, 2002, 99: 5567-5572.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 5567-5572
-
-
Li, S.1
Strelow, A.2
Fontana, E.J.3
-
30
-
-
0037178785
-
IRAK-M is a negative regulator of Toll-like receptor signaling
-
Kobayashi K, Hernandez L D, Galan J E, et al. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell, 2002, 110: 191-202.
-
(2002)
Cell
, vol.110
, pp. 191-202
-
-
Kobayashi, K.1
Hernandez, L.D.2
Galan, J.E.3
-
31
-
-
0037471003
-
Pyogenic bacterial infections in humans with IRAK-4 deficiency
-
Picard C, Puel A, Bonnet M, et al. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science, 2003, 299: 2076-2079.
-
(2003)
Science
, vol.299
, pp. 2076-2079
-
-
Picard, C.1
Puel, A.2
Bonnet, M.3
-
32
-
-
34249078495
-
A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity
-
Kim T W, Staschke K, Bulek K, et al. A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J Exp Med, 2007, 204: 1025-1036.
-
(2007)
J Exp Med
, vol.204
, pp. 1025-1036
-
-
Kim, T.W.1
Staschke, K.2
Bulek, K.3
-
33
-
-
44049097129
-
Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
-
Kawagoe T, Sato S, Matsushita K, et al. Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat Immunol, 2008, 9: 684-691.
-
(2008)
Nat Immunol
, vol.9
, pp. 684-691
-
-
Kawagoe, T.1
Sato, S.2
Matsushita, K.3
-
34
-
-
18444390259
-
Distinct molecular mechanism for initiating TRAF6 signalling
-
Ye H, Arron J R, Lamothe B, et al. Distinct molecular mechanism for initiating TRAF6 signalling. Nature, 2002, 418: 443-447.
-
(2002)
Nature
, vol.418
, pp. 443-447
-
-
Ye, H.1
Arron, J.R.2
Lamothe, B.3
-
35
-
-
0037097519
-
Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: Distinct alterations in IL-1 receptor-associated kinase
-
Jacinto R, Hartung T, McCall C, et al. Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: Distinct alterations in IL-1 receptor-associated kinase. J Immunol, 2002, 168: 6136-6141.
-
(2002)
J Immunol
, vol.168
, pp. 6136-6141
-
-
Jacinto, R.1
Hartung, T.2
McCall, C.3
-
36
-
-
0033002994
-
Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase
-
Li X, Commane M, Burns C, et al. Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase. Mol Cell Biol, 1999, 19: 4643-4652.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4643-4652
-
-
Li, X.1
Commane, M.2
Burns, C.3
-
37
-
-
0035800878
-
IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability
-
Jensen L E, Whitehead A S. IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. J Biol Chem, 2001, 276: 29037-29044.
-
(2001)
J Biol Chem
, vol.276
, pp. 29037-29044
-
-
Jensen, L.E.1
Whitehead, A.S.2
-
38
-
-
22544451204
-
A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling
-
Rao N, Nguyen S, Ngo K, et al. A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. Mol Cell Biol, 2005, 25: 6521-6532.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6521-6532
-
-
Rao, N.1
Nguyen, S.2
Ngo, K.3
-
39
-
-
3042686382
-
The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory
-
Hardy M P, O'Neill L A. The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory. J Biol Chem, 2004, 279: 27699-27708.
-
(2004)
J Biol Chem
, vol.279
, pp. 27699-27708
-
-
Hardy, M.P.1
O'Neill, L.A.2
-
40
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang C, Deng L, Hong M, et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature, 2001, 412: 346-351.
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
-
41
-
-
5444274514
-
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
-
Kawai T, Sato S, Ishii K J, et al. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol, 2004, 5: 1061-1068.
-
(2004)
Nat Immunol
, vol.5
, pp. 1061-1068
-
-
Kawai, T.1
Sato, S.2
Ishii, K.J.3
-
42
-
-
30544451546
-
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
-
Hacker H, Redecke V, Blagoev B, et al. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature, 2006, 439: 204-207.
-
(2006)
Nature
, vol.439
, pp. 204-207
-
-
Hacker, H.1
Redecke, V.2
Blagoev, B.3
-
43
-
-
30544447047
-
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
-
Oganesyan G, Saha S K, Guo B, et al. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature, 2006, 439: 208-211.
-
(2006)
Nature
, vol.439
, pp. 208-211
-
-
Oganesyan, G.1
Saha, S.K.2
Guo, B.3
-
44
-
-
56349164239
-
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
-
Zarnegar B J, Wang Y, Mahoney D J, et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol, 2008, 9: 1371-1378.
-
(2008)
Nat Immunol
, vol.9
, pp. 1371-1378
-
-
Zarnegar, B.J.1
Wang, Y.2
Mahoney, D.J.3
-
45
-
-
42149110830
-
Control of canonical NF-kappaB activation through the NIK-IKK complex pathway
-
Zarnegar B, Yamazaki S, He J Q, et al. Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc Natl Acad Sci USA, 2008, 105: 3503-3508.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 3503-3508
-
-
Zarnegar, B.1
Yamazaki, S.2
He, J.Q.3
-
46
-
-
27544434183
-
Essential function for the kinase TAK1 in innate and adaptive immune responses
-
Sato S, Sanjo H, Takeda K, et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol, 2005, 6: 1087-1095.
-
(2005)
Nat Immunol
, vol.6
, pp. 1087-1095
-
-
Sato, S.1
Sanjo, H.2
Takeda, K.3
-
47
-
-
0033634977
-
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
-
Takaesu G, Kishida S, Hiyama A, et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell, 2000, 5: 649-658.
-
(2000)
Mol Cell
, vol.5
, pp. 649-658
-
-
Takaesu, G.1
Kishida, S.2
Hiyama, A.3
-
48
-
-
69949093459
-
Direct activation of protein kinases by unanchored polyubiquitin chains
-
Xia Z P, Sun L, Chen X, et al. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature, 2009, 7620: 114-119.
-
(2009)
Nature
, vol.7620
, pp. 114-119
-
-
Xia, Z.P.1
Sun, L.2
Chen, X.3
-
49
-
-
58149401211
-
CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages
-
Liu X, Yao M, Li N, et al. CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages. Blood, 2008, 112: 4961-4970.
-
(2008)
Blood
, vol.112
, pp. 4961-4970
-
-
Liu, X.1
Yao, M.2
Li, N.3
-
50
-
-
0037114185
-
Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling
-
Yamamoto M, Sato S, Mori K, et al. Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol, 2002, 169: 6668-6672.
-
(2002)
J Immunol
, vol.169
, pp. 6668-6672
-
-
Yamamoto, M.1
Sato, S.2
Mori, K.3
-
51
-
-
0042679529
-
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
-
Hoebe K, Du X, Georgel P, et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature, 2003, 424: 743-748.
-
(2003)
Nature
, vol.424
, pp. 743-748
-
-
Hoebe, K.1
Du, X.2
Georgel, P.3
-
52
-
-
0043176281
-
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
-
Yamamoto M, Sato S, Hemmi H, et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science, 2003, 301: 640-643.
-
(2003)
Science
, vol.301
, pp. 640-643
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
-
53
-
-
0037320451
-
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction
-
Oshiumi H, Matsumoto M, Funami K, et al. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol, 2003, 4: 161-167.
-
(2003)
Nat Immunol
, vol.4
, pp. 161-167
-
-
Oshiumi, H.1
Matsumoto, M.2
Funami, K.3
-
54
-
-
0141923690
-
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling
-
Sato S, Sugiyama M, Yamamoto M, et al. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol, 2003, 171: 4304-4310.
-
(2003)
J Immunol
, vol.171
, pp. 4304-4310
-
-
Sato, S.1
Sugiyama, M.2
Yamamoto, M.3
-
55
-
-
1542723466
-
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta
-
Jiang Z, Mak T W, Sen G, et al. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci USA, 2004, 101: 3533-3538.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3533-3538
-
-
Jiang, Z.1
Mak, T.W.2
Sen, G.3
-
56
-
-
42449121356
-
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1
-
An H, Hou J, Zhou J, et al. Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nat Immunol, 2008, 9: 542-550.
-
(2008)
Nat Immunol
, vol.9
, pp. 542-550
-
-
An, H.1
Hou, J.2
Zhou, J.3
-
57
-
-
0347065364
-
Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa
-
Wietek C, Miggin S M, Jefferies C A, et al. Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa. J Biol Chem, 2003, 278: 50923-50931.
-
(2003)
J Biol Chem
, vol.278
, pp. 50923-50931
-
-
Wietek, C.1
Miggin, S.M.2
Jefferies, C.A.3
-
58
-
-
67349092199
-
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway
-
Palsson-McDermott E M, Doyle S L, McGettrick A F, et al. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. Nat Immunol, 2009, 10: 579-586.
-
(2009)
Nat Immunol
, vol.10
, pp. 579-586
-
-
Palsson-McDermott, E.M.1
Doyle, S.L.2
McGettrick, A.F.3
-
59
-
-
2942721674
-
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
-
Brint E K, Xu D, Liu H, et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol, 2004, 5: 373-379.
-
(2004)
Nat Immunol
, vol.5
, pp. 373-379
-
-
Brint, E.K.1
Xu, D.2
Liu, H.3
-
60
-
-
0035336425
-
A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression
-
Sweet M J, Leung B P, Kang D, et al. A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J Immunol, 2001, 166: 6633-6639.
-
(2001)
J Immunol
, vol.166
, pp. 6633-6639
-
-
Sweet, M.J.1
Leung, B.P.2
Kang, D.3
-
61
-
-
0042733592
-
SIGIR R, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
-
Wald D, Qin J, Zhao Z, et al. SIGIR R, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol, 2003, 4: 920-927.
-
(2003)
Nat Immunol
, vol.4
, pp. 920-927
-
-
Wald, D.1
Qin, J.2
Zhao, Z.3
-
62
-
-
20644450101
-
Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105
-
Divanovic S, Trompette A, Atabani S F, et al. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat Immunol, 2005, 6: 571-578.
-
(2005)
Nat Immunol
, vol.6
, pp. 571-578
-
-
Divanovic, S.1
Trompette, A.2
Atabani, S.F.3
-
63
-
-
10344260656
-
TRAIL-R as a negative regulator of innate immune cell responses
-
Diehl G E, Yue H H, Hsieh K, et al. TRAIL-R as a negative regulator of innate immune cell responses. Immunity, 2004, 21: 877-889.
-
(2004)
Immunity
, vol.21
, pp. 877-889
-
-
Diehl, G.E.1
Yue, H.H.2
Hsieh, K.3
-
64
-
-
38849124287
-
PECAM-1 ligation negatively regulates TLR4 signaling in macrophages
-
Rui Y, Liu X, Li N, et al. PECAM-1 ligation negatively regulates TLR4 signaling in macrophages. J Immunol, 2007, 179: 7344-7351.
-
(2007)
J Immunol
, vol.179
, pp. 7344-7351
-
-
Rui, Y.1
Liu, X.2
Li, N.3
-
65
-
-
20644443886
-
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
-
Hamerman J A, Tchao N K, Lowell C A, et al. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol, 2005, 6: 579-586.
-
(2005)
Nat Immunol
, vol.6
, pp. 579-586
-
-
Hamerman, J.A.1
Tchao, N.K.2
Lowell, C.A.3
-
66
-
-
23744513114
-
DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis
-
Turnbull I R, McDunn J E, Takai T, et al. DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis. J Exp Med, 2005, 202: 363-369.
-
(2005)
J Exp Med
, vol.202
, pp. 363-369
-
-
Turnbull, I.R.1
McDunn, J.E.2
Takai, T.3
-
67
-
-
33748871187
-
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
-
Carty M, Goodbody R, Schroder M, et al. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol, 2006, 7: 1074-1081.
-
(2006)
Nat Immunol
, vol.7
, pp. 1074-1081
-
-
Carty, M.1
Goodbody, R.2
Schroder, M.3
-
68
-
-
0033776154
-
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
-
Burns K, Clatworthy J, Martin L, et al. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol, 2000, 2: 346-351.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 346-351
-
-
Burns, K.1
Clatworthy, J.2
Martin, L.3
-
69
-
-
0035879283
-
Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: Role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling
-
Bulut Y, Faure E, Thomas L, et al. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: Role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J Immunol, 2001, 167: 987-994.
-
(2001)
J Immunol
, vol.167
, pp. 987-994
-
-
Bulut, Y.1
Faure, E.2
Thomas, L.3
-
70
-
-
0036510366
-
Negative regulation of toll-like receptor-mediated signaling by Tollip
-
Zhang G, Ghosh S. Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem, 2002, 277: 7059-7065.
-
(2002)
J Biol Chem
, vol.277
, pp. 7059-7065
-
-
Zhang, G.1
Ghosh, S.2
-
71
-
-
31344463886
-
Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
-
Wang Y, Tang Y, Teng L, et al. Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol, 2006, 7: 139-147.
-
(2006)
Nat Immunol
, vol.7
, pp. 139-147
-
-
Wang, Y.1
Tang, Y.2
Teng, L.3
-
72
-
-
69049086481
-
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis
-
Kawagoe T, Takeuchi O, Takabatake Y, et al. TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat Immunol, 2009, 10: 965-972.
-
(2009)
Nat Immunol
, vol.10
, pp. 965-972
-
-
Kawagoe, T.1
Takeuchi, O.2
Takabatake, Y.3
-
73
-
-
31344442772
-
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock
-
Zhao Q, Wang X, Nelin L D, et al. MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J Exp Med, 2006, 203: 131-140.
-
(2006)
J Exp Med
, vol.203
, pp. 131-140
-
-
Zhao, Q.1
Wang, X.2
Nelin, L.D.3
-
74
-
-
31344475056
-
Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
-
Hammer M, Mages J, Dietrich H, et al. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med, 2006, 203: 15-20.
-
(2006)
J Exp Med
, vol.203
, pp. 15-20
-
-
Hammer, M.1
Mages, J.2
Dietrich, H.3
-
75
-
-
33144460185
-
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses
-
Chi H, Barry S P, Roth R J, et al. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci USA, 2006, 103: 2274-2279.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 2274-2279
-
-
Chi, H.1
Barry, S.P.2
Roth, R.J.3
-
76
-
-
33646192473
-
Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1
-
Jeffrey K L, Brummer T, Rolph M S, et al. Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1. Nat Immunol, 2006, 7: 274-283.
-
(2006)
Nat Immunol
, vol.7
, pp. 274-283
-
-
Jeffrey, K.L.1
Brummer, T.2
Rolph, M.S.3
-
77
-
-
46749119743
-
Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages
-
Xu H, An H, Hou J, et al. Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages. Mol Immunol, 2008, 45: 3545-3552.
-
(2008)
Mol Immunol
, vol.45
, pp. 3545-3552
-
-
Xu, H.1
An, H.2
Hou, J.3
-
78
-
-
33845438110
-
SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production
-
An H, Zhao W, Hou J, et al. SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity, 2006, 25: 919-928.
-
(2006)
Immunity
, vol.25
, pp. 919-928
-
-
An, H.1
Zhao, W.2
Hou, J.3
-
79
-
-
2442643942
-
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
-
Chuang T H, Ulevitch R J. Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat Immunol, 2004, 5: 495-502.
-
(2004)
Nat Immunol
, vol.5
, pp. 495-502
-
-
Chuang, T.H.1
Ulevitch, R.J.2
-
80
-
-
34547953017
-
Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4
-
Wang Y, Chen T, Han C, et al. Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood, 2007, 110: 962-971.
-
(2007)
Blood
, vol.110
, pp. 962-971
-
-
Wang, Y.1
Chen, T.2
Han, C.3
-
81
-
-
68149132205
-
Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages
-
Yao M, Liu X, Li D, et al. Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages. J Immunol, 2009, 183: 1751-1758.
-
(2009)
J Immunol
, vol.183
, pp. 1751-1758
-
-
Yao, M.1
Liu, X.2
Li, D.3
-
82
-
-
0036850946
-
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
-
Kinjyo I, Hanada T, Inagaki-Ohara K, et al. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity, 2002, 17: 583-591.
-
(2002)
Immunity
, vol.17
, pp. 583-591
-
-
Kinjyo, I.1
Hanada, T.2
Inagaki-Ohara, K.3
-
83
-
-
18744371050
-
SOCS-1 participates in negative regulation of LPS responses
-
Nakagawa R, Naka T, Tsutsui H, et al. SOCS-1 participates in negative regulation of LPS responses. Immunity, 2002, 17: 677-687.
-
(2002)
Immunity
, vol.17
, pp. 677-687
-
-
Nakagawa, R.1
Naka, T.2
Tsutsui, H.3
-
84
-
-
31344467156
-
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
-
Mansell A, Smith R, Doyle S L, et al. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol, 2006, 7: 148-155.
-
(2006)
Nat Immunol
, vol.7
, pp. 148-155
-
-
Mansell, A.1
Smith, R.2
Doyle, S.L.3
-
85
-
-
11144224785
-
Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling
-
Gingras S, Parganas E, de Pauw A, et al. Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J Biol Chem, 2004, 279: 54702-54707.
-
(2004)
J Biol Chem
, vol.279
, pp. 54702-54707
-
-
Gingras, S.1
Parganas, E.2
de Pauw, A.3
-
86
-
-
11144233242
-
Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells
-
Baetz A, Frey M, Heeg K, et al. Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells. J Biol Chem, 2004, 279: 54708-54715.
-
(2004)
J Biol Chem
, vol.279
, pp. 54708-54715
-
-
Baetz, A.1
Frey, M.2
Heeg, K.3
-
87
-
-
5444223519
-
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
-
Boone D L, Turer E E, Lee E G, et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol, 2004, 5: 1052-1060.
-
(2004)
Nat Immunol
, vol.5
, pp. 1052-1060
-
-
Boone, D.L.1
Turer, E.E.2
Lee, E.G.3
-
88
-
-
12444287911
-
A20 is a negative regulator of IFN regulatory factor 3 signaling
-
Saitoh T, Yamamoto M, Miyagishi M, et al. A20 is a negative regulator of IFN regulatory factor 3 signaling. J Immunol, 2005, 174: 1507-1512.
-
(2005)
J Immunol
, vol.174
, pp. 1507-1512
-
-
Saitoh, T.1
Yamamoto, M.2
Miyagishi, M.3
-
89
-
-
18844464056
-
Identification of the familial cylindromatosis tumour-suppressor gene
-
Bignell G R, Warren W, Seal S, et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet, 2000, 25: 160-165.
-
(2000)
Nat Genet
, vol.25
, pp. 160-165
-
-
Bignell, G.R.1
Warren, W.2
Seal, S.3
-
90
-
-
0041967054
-
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
-
Kovalenko A, Chable-Bessia C, Cantarella G, et al. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature, 2003, 424: 801-805.
-
(2003)
Nature
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
Chable-Bessia, C.2
Cantarella, G.3
-
91
-
-
0042467554
-
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
-
Brummelkamp T R, Nijman S M, Dirac A M, et al. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature, 2003, 424: 797-801.
-
(2003)
Nature
, vol.424
, pp. 797-801
-
-
Brummelkamp, T.R.1
Nijman, S.M.2
Dirac, A.M.3
-
92
-
-
0042467558
-
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
-
Trompouki E, Hatzivassiliou E, Tsichritzis T, et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature, 2003, 424: 793-796.
-
(2003)
Nature
, vol.424
, pp. 793-796
-
-
Trompouki, E.1
Hatzivassiliou, E.2
Tsichritzis, T.3
-
93
-
-
28844460239
-
The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7
-
Yoshida H, Jono H, Kai H, et al. The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. J Biol Chem, 2005, 280: 41111-41121.
-
(2005)
J Biol Chem
, vol.280
, pp. 41111-41121
-
-
Yoshida, H.1
Jono, H.2
Kai, H.3
-
94
-
-
67649229630
-
The E3 ubiquitin ligase Nrdp1' preferentially' promotes TLR-mediated production of type I interferon
-
Wang C, Chen T, Zhang J, et al. The E3 ubiquitin ligase Nrdp1' preferentially' promotes TLR-mediated production of type I interferon. Nat Immunol 2009, 10: 744-752.
-
(2009)
Nat Immunol
, vol.10
, pp. 744-752
-
-
Wang, C.1
Chen, T.2
Zhang, J.3
-
95
-
-
40949163764
-
TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation
-
Shi M, Deng W, Bi E, et al. TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation. Nat Immunol, 2008, 9: 369-377.
-
(2008)
Nat Immunol
, vol.9
, pp. 369-377
-
-
Shi, M.1
Deng, W.2
Bi, E.3
|