Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling

Nature Immunology

Volumn 7, Issue 2, 2006, Pages 139-147

  Wang, Yaya ^a,b   Tang, Yawei ^a,b   Teng, Lin ^a,b   Wu, Yalan ^a,b   Zhao, Xiaohui ^a,b   Pei, Gang ^a,b  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN 2; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE PREDISPOSITION; FEMALE; HUMAN; HUMAN CELL; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; SEPTIC SHOCK; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UBIQUITINATION;

ANIMALS; ARRESTINS; BINDING SITES; CELL LINE; CYTOKINES; FEMALE; HELA CELLS; HUMANS; IMMUNITY, NATURAL; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 1; TRANSCRIPTION FACTOR AP-1; UBIQUITIN;

EID: 31344463886     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1294     Document Type: Article

References (41)

1. Takeda, K., Kaisho, T. & Akira, S. Toll-like receptors. Annu. Rev. Immunol. 21, 335-376 (2003).
2. Dunne, A. & O'Neill, L.A. The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense. Sci. STKE 2003, 3-17 (2003).
3. Akira, S. & Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511 (2004).
4. Bradley, J.R. & Pober, J.S. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene 20, 6482-6491 (2001).
5. Chung, J.Y., Park, Y.C., Ye, H. & Wu, H. All TRAFs are not created equal: Common and distinct molecular mechanisms of TRAF-mediated signal transduction. J. Cell Sci. 115, 679-688 (2002).
6. Lomaga, M.A. et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13, 1015-1024 (1999).
7. Deng, L. et al. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361 (2000).
8. Wang, C. et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (2001).
9. Kovalenko, A. et al. The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination. Nature 424, 801-805 (2003).
10. Trompouki, E. et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members. Nature 424, 793-796 (2003).
11. Brummelkamp, T.R., Nijman, S.M., Dirac, A.M. & Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature 424, 797-801 (2003).
12. Boone, D.L. et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat. Immunol. 5, 1052-1060 (2004).
13. Lefkowitz, R.J. & Whalen, E.J. β-Arrestins: Traffic cops of cell signaling. Curr. Opin. Cell Biol. 16, 162-168 (2004).
14. Wilbanks, A.M. et al. β-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science 306, 2264-2267 (2004).
15. Chen, W. et al. Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2. Science 306, 2257-2260 (2004).
16. Perry, S.J. & Lefkowitz, R.J. Arresting developments in heptahelical receptor signaling and regulation. Trends Cell Biol. 12, 130-138 (2002).
17. Chen, W. β-Arrestin 2 mediates endocytosis of type III TGF-β receptor and down-regulation of its signaling. Science 301, 1394-1397 (2003).
18. Chen, W. et al. Dishevelled 2 recruits β-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science 301, 1391-1394 (2003).
19. Luttrell, L.M., Daaka, Y. & Lefkowitz, R.J. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr. Opin. Cell Biol. 11, 177-183 (1999).
20. McDonald, P.H. et al. β-Arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3. Science 290, 1574-1577 (2000).
21. Shenoy, S.K., McDonald, P.H., Kohout, T.A. & Lefkowitz, R.J. Regulation of receptor fate by ubiquitination of activated β2-adrenergic receptor and β-arrestin. Science 294, 1307-1313 (2001).
22. Wang, P. et al. β-Arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. J. Biol. Chem. 278, 6363-6370 (2003).
23. Gao, H. et al. Identification of β-arresting as a G protein-coupled receptor-stimulated regulator of NF-κB pathways. Mol. Cell 14, 303-317 (2004).
24. Sun, L., Deng, L., Ea, C.K., Xia, Z.P. & Chen, Z.J. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14, 289-301 (2004).
25. Kobayashi, T., Walsh, M.C. & Choi, Y. The role of TRAF6 in signal transduction and the immune response. Microbes Infect. 6, 1333-1338 (2004).
26. Ye, H. et al. Distinct molecular mechanism for initiating TRAF6 signalling. Nature 418, 443-447 (2002).
27. Li, X., Yang, Y. & Ashwell, J.D. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 416, 345-347 (2002).
28. Sato, S. et al. Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171, 4304-4310 (2003).
29. Jiang, Z. et al. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NF-κB and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J. Biol. Chem. 278, 16713-16719 (2003).
30. Jiang, Z., Mak, T.W., Sen, G. & Li, X. Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β. Proc. Natl. Acad. Sci. USA 101, 3533-3538 (2004).
31. Xu, L.G. et al. VISA Is an adapter protein required for virus-triggered IFN-β signaling. Mol. Cell 19, 727-740 (2005).
32. Pahl, H.L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18, 6853-6866 (1999).
33. Janeway, C.A., Jr. & Medzhitov, R. Innate immune recognition. Annu. Rev. Immunol. 20, 197-216 (2002).
34. Akira, S. Toll-like receptor signaling. J. Biol. Chem. 278, 38105-38108 (2003).
35. Barton, G.M. & Medzhitov, R. Toll-like receptor signaling pathways. Science 300, 1524-1525 (2003).
36. Liew, F.Y., Xu, D., Brint, E.K. & O'Neill, L.A. Negative regulation of toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5, 446-458 (2005).
37. Bohn, L.M., Gainetdinov, R.R., Lin, F.T., Lefkowitz, R.J. & Caron, M.G. μ-opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence. Nature 408, 720-723 (2000).
38. Bohn, L.M. et al. Enhanced morphine analgesia in mice lacking β-arrestin 2. Science 286, 2495-2498 (1999).
39. Beaulieu, J.M. et al. An Akt/β-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122, 261-273 (2005).
40. Witherow, D.S., Garrison, T.R., Miller, W.E. & Lefkowitz, R.J. β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα. Proc. Natl. Acad. Sci. USA 101, 8603-8607 (2004).
41. Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745 (2000).