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Volumn 11, Issue 1, 2010, Pages 28-35

Influence of microbial environment on autoimmunity

Author keywords

[No Author keywords available]

Indexed keywords

PATTERN RECOGNITION RECEPTOR; IMMUNOGLOBULIN RECEPTOR;

EID: 74049161267     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1801     Document Type: Review
Times cited : (125)

References (139)
  • 2
    • 0016724949 scopus 로고
    • Studies of twins with systemic lupus erythematosus. A review of the literature and presentation of 12 additional sets
    • Block, S.R., winfield, J.B., Lockshin, M.D., D'Angelo, W.A. & Christian, C.L. Studies of twins with systemic lupus erythematosus. A review of the literature and presentation of 12 additional sets. Am. J. Med. 59, 533-552 (1975).
    • (1975) Am. J. Med. , vol.59 , pp. 533-552
    • Block, S.R.1    Winfield, J.B.2    Lockshin, M.D.3    D'Angelo, W.A.4    Christian, C.L.5
  • 3
    • 0037136537 scopus 로고    scopus 로고
    • The Effect of infections on susceptibILity to autoImmune and allergic diseases
    • Bach, J.F. The Effect of infections on susceptibILity to autoImmune and allergic diseases. N. Engl. J. Med. 347, 911-920 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 4
    • 0032981311 scopus 로고    scopus 로고
    • New insights into the Epidemiology of type 1 diabetes in Mediterranean countries
    • Muntoni, S. New insights into the Epidemiology of type 1 diabetes in Mediterranean countries. Diabetes Metab. res. Rev. 15, 133-140 (1999).
    • (1999) Diabetes Metab. Res. Rev. , vol.15 , pp. 133-140
    • Muntoni, S.1
  • 5
    • 10844295809 scopus 로고    scopus 로고
    • TLR activation synergizes with KILham rat virus infection to induce diabetes in BBDR rats
    • Zipris, D. et al. TLR activation synergizes with KILham rat virus infection to induce diabetes in BBDR rats. J. Immunol. 174, 131-142 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 131-142
    • Zipris, D.1
  • 6
    • 33846190681 scopus 로고    scopus 로고
    • TLR9-signaling pathways are involved in KILham rat virus-induced autoImmune diabetes in the biobreeding diabetes-resistant rat
    • Zipris, D. et al. TLR9-signaling pathways are involved in KILham rat virus-induced autoImmune diabetes in the biobreeding diabetes-resistant rat. J. Immunol. 178, 693-701 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 693-701
    • Zipris, D.1
  • 7
    • 0032795286 scopus 로고    scopus 로고
    • Tolerance and autoimmunity in TCR transgenic mice specific for myelin basic protein
    • Goverman, J. Tolerance and autoimmunity in TCR transgenic mice specific for myelin basic protein. Immunol. Rev. 169, 147-159 (1999).
    • (1999) Immunol. Rev. , vol.169 , pp. 147-159
    • Goverman, J.1
  • 8
    • 0027166934 scopus 로고
    • NOD mouse colonies around the world-recent facts and figures
    • PozzILli, P., Signore, A., WILliams, A.J. & Beales, P.E. NOD mouse colonies around the world-recent facts and figures. Immunol. Today 14, 193-196 (1993).
    • (1993) Immunol. Today , vol.14 , pp. 193-196
    • Pozzilli, P.1    Signore, A.2    Williams, A.J.3    Beales, P.E.4
  • 9
    • 17644361955 scopus 로고    scopus 로고
    • The NOD mouse: A model of Immune dysregulation
    • Anderson, M.S. & Bluestone, J.A. The NOD mouse: a model of Immune dysregulation. Annu. Rev. Immunol. 23, 447-485 (2005).
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 447-485
    • Anderson, M.S.1    Bluestone, J.A.2
  • 10
    • 0033801632 scopus 로고    scopus 로고
    • T-cell-dependent antibody response to the dominant epitope of streptococcal polysaccharide, N-acetyl-glucosamine, is cross-reactive with cardiac myosin
    • Malkiel, S., Liao, L., Cunningham, M.W. & Diamond, B. T-cell-dependent antibody response to the dominant epitope of streptococcal polysaccharide, N-acetyl-glucosamine, is cross-reactive with cardiac myosin. Infect. Immun. 68, 5803-5808 (2000).
    • (2000) Infect. Immun. , vol.68 , pp. 5803-5808
    • Malkiel, S.1    Liao, L.2    Cunningham, M.W.3    Diamond, B.4
  • 11
    • 0031664697 scopus 로고    scopus 로고
    • Molecular mimicry and Immune-mediated diseases
    • Oldstone, M.B. Molecular mimicry and Immune-mediated diseases. FaSeB J. 12, 1255-1265 (1998).
    • (1998) FaSeB J. , vol.12 , pp. 1255-1265
    • Oldstone, M.B.1
  • 12
    • 0035554950 scopus 로고    scopus 로고
    • Autoimmunity provoked by infection: How good is the case for T cell epitope mimicry?
    • Benoist, C. & Mathis, D. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? Nat. Immunol. 2, 797-801 (2001).
    • (2001) Nat Immunol. , vol.2 , pp. 797-801
    • Benoist, C.1    Mathis, D.2
  • 13
    • 63149158618 scopus 로고    scopus 로고
    • Antiviral Immune responses: Triggers of or triggered by autoimmunity?
    • Munz, C., Lunemann, J.D., Getts, M.T. & MILler, S.D. Antiviral Immune responses: triggers of or triggered by autoimmunity? Nat. Rev. Immunol. 9, 246-258 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 246-258
    • Munz, C.1    Lunemann, J.D.2    Getts, M.T.3    Miller, S.D.4
  • 14
    • 0030796646 scopus 로고    scopus 로고
    • Persistent infection with TheILer's virus leads to CNS autoimmunity via epitope spreading
    • MILler, S.D. et al. Persistent infection with TheILer's virus leads to CNS autoimmunity via epitope spreading. Nat. Med. 3, 1133-1136 (1997).
    • (1997) Nat Med. , vol.3 , pp. 1133-1136
    • Miller, S.D.1
  • 15
    • 0024955886 scopus 로고
    • Approaching the asymptote? evolution and revolution in immunology. cold Spring Harb
    • Janeway, C.A. JR. Approaching the asymptote? evolution and revolution in immunology. cold Spring Harb. Symp. Quant. Biol. 54, 1-13 (1989).
    • (1989) Symp. Quant. Biol. , vol.54 , pp. 1-13
    • Janeway, C.A.1
  • 16
    • 66949122854 scopus 로고    scopus 로고
    • Approaching the asymptote: 20 years later
    • Medzhitov, R. Approaching the asymptote: 20 years later. Immunity 30, 766-775 (2009)
    • (2009) Immunity , vol.30 , pp. 766-775
    • Medzhitov, R.1
  • 17
    • 58049220365 scopus 로고    scopus 로고
    • Pattern Recognition receptors and control of adaptive immunity
    • Palm, N.W. & Medzhitov, R. Pattern Recognition receptors and control of adaptive immunity. Immunol. Rev. 227, 221-233 (2009).
    • (2009) Immunol. Rev. , vol.227 , pp. 221-233
    • Palm, N.W.1    Medzhitov, R.2
  • 18
    • 63649108380 scopus 로고    scopus 로고
    • The roles of TLRs, RLRs and NLRs in pathogen Recognition
    • Kawai, T. & Akira, S. The roles of TLRs, RLRs and NLRs in pathogen Recognition. Int. Immunol. 21, 317-337 (2009).
    • (2009) Int. Immunol. , vol.21 , pp. 317-337
    • Kawai, T.1    Akira, S.2
  • 20
    • 33748367018 scopus 로고    scopus 로고
    • A proposed classification of the immunological diseases
    • McGonagle, D. & McDermott, M.F. A proposed classification of the immunological diseases. PloS Med. 3, e297 (2006).
    • (2006) PloS Med. , vol.3
    • McGonagle, D.1    McDermott, M.F.2
  • 21
    • 0001982584 scopus 로고
    • Diabetogenic Effects of lymphoctye transfusion on the NOD or NOD nude mouse
    • (eds. Rygaard, J., Graem, N. & Sprang-Thomsen, M.) Karger, Basel, Switzerland
    • Suzuki, T. et al. Diabetogenic Effects of lymphoctye transfusion on the NOD or NOD nude mouse. in Immune deficient animals in Biomedical research (eds. Rygaard, J., Graem, N. & Sprang-Thomsen, M.) 112-116 (Karger, Basel, Switzerland, 1987).
    • (1987) Immune Deficient Animals in Biomedical Research , pp. 112-116
    • Suzuki, T.1
  • 22
    • 54549122338 scopus 로고    scopus 로고
    • Innate immunity and intestinal microbiota in the development of Type 1 diabetes
    • Wen, L. et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455, 1109-1113 (2008).
    • (2008) Nature , vol.455 , pp. 1109-1113
    • Wen, L.1
  • 24
    • 0034610973 scopus 로고    scopus 로고
    • High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire
    • Anderson, A.C. et al. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J. Exp. Med. 191, 761-770 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 761-770
    • Anderson, A.C.1
  • 25
    • 0027947416 scopus 로고
    • Role of the bowel flora for development of immunity to hsp 65 and arthritis in three experimental models
    • Bjork, J., Kleinau, S., Midtvedt, T., Klareskog, L. & Smedegard, G. Role of the bowel flora for development of immunity to hsp 65 and arthritis in three experimental models. Scand. J. Immunol. 40, 648-652 (1994).
    • (1994) Scand. J. Immunol. , vol.40 , pp. 648-652
    • Bjork, J.1    Kleinau, S.2    Midtvedt, T.3    Klareskog, L.4    Smedegard, G.5
  • 26
    • 0342264383 scopus 로고    scopus 로고
    • Germ-free mice do not develop ankylosing enthesopathy, a spontaneous joint disease
    • Rehakova, Z. et al. Germ-free mice do not develop ankylosing enthesopathy, a spontaneous joint disease. Hum. Immunol. 61, 555-558 (2000).
    • (2000) Hum. Immunol. , vol.61 , pp. 555-558
    • Rehakova, Z.1
  • 27
    • 57649089008 scopus 로고    scopus 로고
    • Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2(k)) male mice
    • Sinkorova, Z., Capkova, J., Niederlova, J., Stepankova, R. & Sinkora, J. Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2(k)) male mice. Hum. Immunol. 69, 845-850 (2008).
    • (2008) Hum. Immunol. , vol.69 , pp. 845-850
    • Sinkorova, Z.1    Capkova, J.2    Niederlova, J.3    Stepankova, R.4    Sinkora, J.5
  • 28
    • 0033153482 scopus 로고    scopus 로고
    • The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice
    • Maldonado, M.A. et al. The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice. J. Immunol. 162, 6322-6330 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 6322-6330
    • Maldonado, M.A.1
  • 29
    • 34248577055 scopus 로고    scopus 로고
    • Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity
    • Stranges, P.B. et al. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity 26, 629-641 (2007).
    • (2007) Immunity , vol.26 , pp. 629-641
    • Stranges, P.B.1
  • 30
    • 36749013631 scopus 로고    scopus 로고
    • Danger-free autoImmune disease in Aire-deficient mice
    • The work revealed that APECED is independent of innate-adaptive connection, a prototypic Group II disease in our proposed classification
    • Gray, D.H., Gavanescu, I., Benoist, C. & Mathis, D. Danger-free autoImmune disease in Aire-deficient mice. Proc. Natl. Acad. Sci. USA 104, 18193-18198 (2007). The work revealed that APECED is independent of innate-adaptive connection, a prototypic Group II disease in our proposed classification.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 18193-18198
    • Gray, D.H.1    Gavanescu, I.2    Benoist, C.3    Mathis, D.4
  • 31
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395-1401 (2002).
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1
  • 33
    • 51849125587 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deficiency causes organ-specific autoImmune disease
    • Hase, K. et al. Activation-induced cytidine deaminase deficiency causes organ-specific autoImmune disease. PloS one 3, e3033 (2008).
    • (2008) PloS One , vol.3
    • Hase, K.1
  • 34
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim, J.M., Rasmussen, J.P. & Rudensky, A.Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8, 191-197 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 35
    • 38149048556 scopus 로고    scopus 로고
    • Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
    • Abdollahi-Roodsaz, S. et al. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J. Clin. Invest. 118, 205-216 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 205-216
    • Abdollahi-Roodsaz, S.1
  • 36
    • 54449088325 scopus 로고    scopus 로고
    • Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
    • Croker, B.A. et al. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc. Natl. Acad. Sci. USA 105, 15028-15033 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 15028-15033
    • Croker, B.A.1
  • 37
    • 0030062935 scopus 로고    scopus 로고
    • B and T cells are not required for the viable motheaten phenotype
    • Yu, C.C. et al. B and T cells are not required for the viable motheaten phenotype. J. Exp. Med. 183, 371-380 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 371-380
    • Yu, C.C.1
  • 38
    • 40249088259 scopus 로고    scopus 로고
    • The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation
    • Haas, T. et al. The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation. Immunity 28, 315-323 (2008).
    • (2008) Immunity , vol.28 , pp. 315-323
    • Haas, T.1
  • 39
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proin-flammatory gene expression
    • Gewirtz, A.T., Navas, T.A., Lyons, S., Godowski, P.J. & Madara, J.L. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proin-flammatory gene expression. J. Immunol. 167, 1882-1885 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3    Godowski, P.J.4    Madara, J.L.5
  • 40
    • 33751551466 scopus 로고    scopus 로고
    • Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
    • Lee, J. et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell Biol. 8, 1327-1336 (2006).
    • (2006) Nat. Cell Biol. , vol.8 , pp. 1327-1336
    • Lee, J.1
  • 41
    • 0034114882 scopus 로고    scopus 로고
    • Features of systemic lupus erythematosus in Dnase1-deficient mice
    • Napirei, M. et al. Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat. Genet. 25, 177-181 (2000).
    • (2000) Nat. Genet. , vol.25 , pp. 177-181
    • Napirei, M.1
  • 42
    • 0034939627 scopus 로고    scopus 로고
    • Mutation of dnaSe1 in people with systemic lupus erythema-tosus
    • Yasutomo, K. et al. Mutation of dnaSe1 in people with systemic lupus erythema-tosus. Nat. Genet. 28, 313-314 (2001).
    • (2001) Nat. Genet. , vol.28 , pp. 313-314
    • Yasutomo, K.1
  • 43
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson, D.B., Ko, J.S., Heidmann, T. & Medzhitov, R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134, 587-598 (2008).
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 44
    • 12344290452 scopus 로고    scopus 로고
    • Lethal anemia caused by Interferon-β produced in mouse embryos carrying undigested DNA
    • Yoshida, H., Okabe, Y., Kawane, K., Fukuyama, H. & Nagata, S. Lethal anemia caused by Interferon-β produced in mouse embryos carrying undigested DNA. Nat. Immunol. 6, 49-56 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 49-56
    • Yoshida, H.1    Okabe, Y.2    Kawane, K.3    Fukuyama, H.4    Nagata, S.5
  • 45
    • 33746522835 scopus 로고    scopus 로고
    • Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection
    • Crow, Y.J. et al. Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection. Nat. Genet. 38, 910-916 (2006).
    • (2006) Nat Genet. , vol.38 , pp. 910-916
    • Crow, Y.J.1
  • 46
    • 34247590859 scopus 로고    scopus 로고
    • Clearance deficiency and systemic lupus erythematosus (SLe)
    • Gaipl, U.S. et al. Clearance deficiency and systemic lupus erythematosus (SLe). J. autoimmun. 28, 114-121 (2007).
    • (2007) J. Autoimmun. , vol.28 , pp. 114-121
    • Gaipl, U.S.1
  • 47
    • 33745168605 scopus 로고    scopus 로고
    • Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
    • Pisitkun, P. et al. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 312, 1669-1672 (2006).
    • (2006) Science , vol.312 , pp. 1669-1672
    • Pisitkun, P.1
  • 48
    • 36048962438 scopus 로고    scopus 로고
    • Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    • Deane, J.A. et al. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 27, 801-810 (2007).
    • (2007) Immunity , vol.27 , pp. 801-810
    • Deane, J.A.1
  • 49
    • 50549086761 scopus 로고    scopus 로고
    • Yaa autoImmune phenotypes are conferred by overexpression of TLR7. Eur
    • Fairhurst, A.M. et al. Yaa autoImmune phenotypes are conferred by overexpression of TLR7. Eur. J. Immunol. 38, 1971-1978 (2008).
    • (2008) J. Immunol. , vol.38 , pp. 1971-1978
    • Fairhurst, A.M.1
  • 50
    • 13844292408 scopus 로고    scopus 로고
    • Polymorphisms in the tyrosine kinase 2 and Interferon Regulatory factor 5 genes are associated with systemic lupus erythematosus
    • Sigurdsson, S. et al. Polymorphisms in the tyrosine kinase 2 and Interferon Regulatory factor 5 genes are associated with systemic lupus erythematosus. Am. J. Hum. Genet. 76, 528-537 (2005).
    • (2005) Am. J. Hum. Genet. , vol.76 , pp. 528-537
    • Sigurdsson, S.1
  • 51
    • 37149055953 scopus 로고    scopus 로고
    • Association of an IRF5 gene functional polymorphism with Sjogren's syndrome
    • Miceli-Richard, C. et al. Association of an IRF5 gene functional polymorphism with Sjogren's syndrome. Arthritis Rheum. 56, 3989-3994 (2007).
    • (2007) Arthritis Rheum. , vol.56 , pp. 3989-3994
    • Miceli-Richard, C.1
  • 52
    • 34247566510 scopus 로고    scopus 로고
    • The famILy of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • O'NeILl, L.A. & Bowie, A.G. The famILy of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7, 353-364 (2007).
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 53
    • 40649121122 scopus 로고    scopus 로고
    • Comprehensive evaluation of the genetic variants of Interferon Regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus
    • Sigurdsson, S. et al. Comprehensive evaluation of the genetic variants of Interferon Regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus. Hum. Mol. Genet. 17, 872-881 (2008).
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 872-881
    • Sigurdsson, S.1
  • 54
    • 60549094684 scopus 로고    scopus 로고
    • TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming
    • Richez, C. et al. TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming. J. Immunol. 182, 820-828 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 820-828
    • Richez, C.1
  • 55
    • 62749123000 scopus 로고    scopus 로고
    • The role of Toll-like receptor pathways in the mechanism of type 1 diabetes
    • Lien, E. & Zipris, D. The role of Toll-like receptor pathways in the mechanism of type 1 diabetes. Curr. Mol. Med. 9; 52-68 (2009).
    • (2009) Curr. Mol. Med. , vol.9 , pp. 52-68
    • Lien, E.1    Zipris, D.2
  • 56
    • 20044385554 scopus 로고    scopus 로고
    • Toll-like receptor engagement converts T-cell autoreactivity into overt autoImmune disease
    • Lang, K.S. et al. Toll-like receptor engagement converts T-cell autoreactivity into overt autoImmune disease. Nat. Med. 11, 138-145 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 138-145
    • Lang, K.S.1
  • 57
    • 0036206669 scopus 로고    scopus 로고
    • Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity
    • Garza, K.M. et al. enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity. Eur. J. Immunol. 32, 885-894 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 885-894
    • Garza, K.M.1
  • 58
    • 0031874342 scopus 로고    scopus 로고
    • Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
    • Horwitz, M.S. et al. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat. Med. 4, 781-785 (1998).
    • (1998) Nat. Med. , vol.4 , pp. 781-785
    • Horwitz, M.S.1
  • 59
    • 0033941714 scopus 로고    scopus 로고
    • SusceptibILity to diabetes is widely distributed in normal class IIu haplotype rats
    • Ellerman, K.E. & Like, A.A. SusceptibILity to diabetes is widely distributed in normal class IIu haplotype rats. Diabetologia 43, 890-898 (2000).
    • (2000) Diabetologia , vol.43 , pp. 890-898
    • Ellerman, K.E.1    Like, A.A.2
  • 60
    • 34249026701 scopus 로고    scopus 로고
    • Syk-and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
    • LeibundGut-Landmann, S. et al. Syk-and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 8, 630-638 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 630-638
    • Leibundgut-Landmann, S.1
  • 61
    • 34249079176 scopus 로고    scopus 로고
    • Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    • Acosta-Rodriguez, E.V. et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 8; 639-646 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 639-646
    • Acosta-Rodriguez, E.V.1
  • 62
    • 64149088746 scopus 로고    scopus 로고
    • Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T Regulatory responses and inhibits autoimmunity
    • Manicassamy, S. et al. Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T Regulatory responses and inhibits autoimmunity. Nat. Med. 15, 401-409 (2009).
    • (2009) Nat Med. , vol.15 , pp. 401-409
    • Manicassamy, S.1
  • 63
    • 33745240931 scopus 로고    scopus 로고
    • A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the Interferon-induced helicase (IFIH1) region
    • Smyth, D.J. et al. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the Interferon-induced helicase (IFIH1) region. Nat. Genet. 38, 617-619 (2006).
    • (2006) Nat. Genet. , vol.38 , pp. 617-619
    • Smyth, D.J.1
  • 64
    • 65249131713 scopus 로고    scopus 로고
    • Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    • Nejentsev, S., Walker, N., Riches, D., Egholm, M. & Todd, J.A. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324, 387-389 (2009).
    • (2009) Science , vol.324 , pp. 387-389
    • Nejentsev, S.1    Walker, N.2    Riches, D.3    Egholm, M.4    Todd, J.A.5
  • 65
    • 13244277880 scopus 로고    scopus 로고
    • Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    • Maeda, S. et al. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 307, 734-738 (2005).
    • (2005) Science , vol.307 , pp. 734-738
    • Maeda, S.1
  • 66
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi, K.S. et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307, 731-734 (2005)
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1
  • 67
    • 54349095688 scopus 로고    scopus 로고
    • The molecular basis of NOD2 susceptibILity mutations in Crohn's disease
    • Strober, W., Kitani, A., Fuss, I., Asano, N. & Watanabe, T. The molecular basis of NOD2 susceptibILity mutations in Crohn's disease. Mucosal Immunol. 1 (suppl. 1), S5-S9 (2008).
    • (2008) Mucosal Immunol. , vol.1 , Issue.SUPPL. 1
    • Strober, W.1    Kitani, A.2    Fuss, I.3    Asano, N.4    Watanabe, T.5
  • 68
    • 32944470765 scopus 로고    scopus 로고
    • Cryopyrin activates the inflammasome in response to toxins and ATP
    • Mariathasan, S. et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440, 228-232 (2006).
    • (2006) Nature , vol.440 , pp. 228-232
    • Mariathasan, S.1
  • 69
    • 33748598700 scopus 로고    scopus 로고
    • Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
    • Gurcel, L., Abrami, L., Girardin, S., Tschopp, J. & van der Goot, F.G. Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 126, 1135-1145 (2006).
    • (2006) Cell , vol.126 , pp. 1135-1145
    • Gurcel, L.1    Abrami, L.2    Girardin, S.3    Tschopp, J.4    Van Der Goot, F.G.5
  • 70
    • 67650736238 scopus 로고    scopus 로고
    • Horror autoinflammaticus: The molecular pathophysiology of autoinflammatory disease
    • Masters, S.L., Simon, A., Aksentijevich, I. & Kastner, D.L. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease. Annu. Rev. Immunol. 27, 621-668 (2009).
    • (2009) Annu. Rev Immunol. , vol.27 , pp. 621-668
    • Masters, S.L.1    Simon, A.2    Aksentijevich, I.3    Kastner, D.L.4
  • 71
  • 72
    • 66349089266 scopus 로고    scopus 로고
    • IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
    • Ben-Sasson, S.Z. et al. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc. Natl. Acad. Sci. USA 106, 7119-7124 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 7119-7124
    • Ben-Sasson, S.Z.1
  • 73
    • 60549112774 scopus 로고    scopus 로고
    • Inflammasome Recognition of influenza virus is essential for adaptive Immune responses
    • Ichinohe, T., Lee, H.K., Ogura, Y., Flavell, R. & Iwasaki, A. Inflammasome Recognition of influenza virus is essential for adaptive Immune responses. J. Exp. Med. 206, 79-87 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 79-87
    • Ichinohe, T.1    Lee, H.K.2    Ogura, Y.3    Flavell, R.4    Iwasaki, A.5
  • 74
    • 42649106556 scopus 로고    scopus 로고
    • H17-cell-mediated autoim-munity to environmental toxins
    • H17-cell-mediated autoim-munity to environmental toxins. Nature 453, 106-109 (2008).
    • (2008) Nature , vol.453 , pp. 106-109
    • Vveldhoen, M.1
  • 75
    • 64049096013 scopus 로고    scopus 로고
    • Modulation of Th17 development and function by activation of the aryl hydrocarbon receptor-the role of endogenous ligands
    • Stockinger, B., veldhoen, M. & Hirota, K. Modulation of Th17 development and function by activation of the aryl hydrocarbon receptor-the role of endogenous ligands. Eur. J. Immunol. 39, 652-654 (2009).
    • (2009) Eur. J. Immunol. , Issue.39 , pp. 652-654
    • Stockinger, B.1    Veldhoen, M.2    Hirota, K.3
  • 76
    • 0028201732 scopus 로고
    • Tolerance danger, and the extended famILy
    • Matzinger, P. Tolerance, danger, and the extended famILy. Annu. Rev. Immunol. 12, 991-1045 (1994).
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 77
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger, P. The danger model: a renewed sense of self. Science 296, 301-305 (2002).
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 78
    • 34548608447 scopus 로고    scopus 로고
    • Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
    • Jin, M.S. et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130, 1071-1082 (2007).
    • (2007) Cell , vol.130 , pp. 1071-1082
    • Jin, M.S.1
  • 79
    • 34548222514 scopus 로고    scopus 로고
    • Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran
    • Kim, H.M. et al. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran. Cell 130, 906-917 (2007).
    • (2007) Cell , vol.130 , pp. 906-917
    • Kim, H.M.1
  • 80
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: All we need to know about danger
    • Bianchi, M.E. DAMPs, PAMPs and alarmins: all we need to know about danger. J. leukoc. Biol. 81, 1-5 (2007).
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 81
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the Immune system to danger
    • Kono, H. & Rock, K.L. How dying cells alert the Immune system to danger. Nat. Rev. Immunol. 8, 279-289 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 82
    • 0037928705 scopus 로고    scopus 로고
    • Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages
    • Gao, B. & Tsan, M.F. Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages. J. Biol. chem. 278, 22523-22529 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 22523-22529
    • Gao, B.1    Tsan, M.F.2
  • 83
    • 0037414787 scopus 로고    scopus 로고
    • Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages
    • Gao, B. & Tsan, M.F. Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages. J. Biol. chem. 278, 174-179 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 174-179
    • Gao, B.1    Tsan, M.F.2
  • 84
    • 33645711396 scopus 로고    scopus 로고
    • In vivo delivery of heat shock protein 70 accelerates wound healing by up-regulating macrophage-mediated phagocytosis
    • Kovalchin, J.T. et al. In vivo delivery of heat shock protein 70 accelerates wound healing by up-regulating macrophage-mediated phagocytosis. Wound Repair Regen. 14, 129-137 (2006).
    • (2006) Wound Repair Regen. , vol.14 , pp. 129-137
    • Kovalchin, J.T.1
  • 85
    • 33847220444 scopus 로고    scopus 로고
    • Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism
    • Schauber, J. et al. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J. Clin. Invest. 117, 803-811 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 803-811
    • Schauber, J.1
  • 86
    • 48549088455 scopus 로고    scopus 로고
    • Antimicrobial peptides and self-DNA in autoImmune skin inflammation
    • GILliet, M. & Lande, R. Antimicrobial peptides and self-DNA in autoImmune skin inflammation. Curr. opin. Immunol. 20, 401-407 (2008).
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 401-407
    • Gilliet, M.1    Lande, R.2
  • 87
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum, S., Paglino, J., Eslami-varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004).
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 88
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov, R. Origin and physiological roles of inflammation. Nature 454, 428-435 (2008).
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 90
    • 35748967851 scopus 로고    scopus 로고
    • High-mobILity group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
    • Bianchi, M.E. & Manfredi, A.A. High-mobILity group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol. Rev. 220, 35-46 (2007).
    • (2007) Immunol. Rev. , vol.220 , pp. 35-46
    • Bianchi, M.E.1    Manfredi, A.A.2
  • 91
    • 43449096032 scopus 로고    scopus 로고
    • Mycobacterial infection induces the secretion of high-mobILity group box 1 protein
    • Grover, A. et al. Mycobacterial infection induces the secretion of high-mobILity group box 1 protein. Cell. Microbiol. 10, 1390-1404 (2008).
    • (2008) Cell. Microbiol. , vol.10 , pp. 1390-1404
    • Grover, A.1
  • 92
    • 0035911959 scopus 로고    scopus 로고
    • The high mobILity group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells
    • Degryse, B. et al. The high mobILity group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. J. Cell Biol. 152, 1197-1206 (2001).
    • (2001) J. Cell Biol. , vol.152 , pp. 1197-1206
    • Degryse, B.1
  • 93
    • 43749112963 scopus 로고    scopus 로고
    • High-mobILity group box 1 protein in human and murine skin: Involvement in wound healing
    • Straino, S. et al. High-mobILity group box 1 protein in human and murine skin: involvement in wound healing. J. Invest. dermatol. 128, 1545-1553 (2008)
    • (2008) J. Invest. Dermatol. , vol.128 , pp. 1545-1553
    • Straino, S.1
  • 94
    • 70450228592 scopus 로고    scopus 로고
    • HMGb1 promotes scratch wound closure of HaCaT keratinocytes via eRK1/2 activation
    • published online, doi:10.1007/s11010-009-0192-4 (9 July 2009)
    • Ranzato, E., Patrone, M., Pedrazzi, M. & Burlando, B. HMGb1 promotes scratch wound closure of HaCaT keratinocytes via eRK1/2 activation. Mol. Cell Biochem. published online, doi:10.1007/s11010-009-0192-4 (9 July 2009).
    • Mol. Cell Biochem
    • Ranzato, E.1    Patrone, M.2    Pedrazzi, M.3    Burlando, B.4
  • 95
    • 63149171602 scopus 로고    scopus 로고
    • CD24 and Siglec-10 selectively repress tissue damage-induced Immune responses
    • Chen, G.Y., Tang, J., Zheng, P. & Liu, Y. CD24 and Siglec-10 selectively repress tissue damage-induced Immune responses. Science 323, 1722-1725 (2009).
    • (2009) Science , vol.323 , pp. 1722-1725
    • Chen, G.Y.1    Tang, J.2    Zheng, P.3    Liu, Y.4
  • 96
    • 34948862264 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    • Lande, R. et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449, 564-569 (2007).
    • (2007) Nature , vol.449 , pp. 564-569
    • Lande, R.1
  • 97
    • 34247236200 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent activation by DNA-containing Immune complexes is mediated by HMGB1 and RAGe
    • Tian, J. et al. Toll-like receptor 9-dependent activation by DNA-containing Immune complexes is mediated by HMGB1 and RAGe. Nat. Immunol. 8, 487-496 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 487-496
    • Tian, J.1
  • 98
    • 0037061453 scopus 로고    scopus 로고
    • Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    • Leadbetter, E.A. et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603-607 (2002).
    • (2002) Nature , vol.416 , pp. 603-607
    • Leadbetter, E.A.1
  • 99
    • 61849115785 scopus 로고    scopus 로고
    • Copy number variation in the human genome and its implication in autoimmunity
    • Schaschl, H., Aitman, T.J. & Vyse, T.J. Copy number variation in the human genome and its implication in autoimmunity. Clin. exp. Immunol. 156, 12-16 (2009).
    • (2009) Clin. Exp. Immunol. , vol.156 , pp. 12-16
    • Schaschl, H.1    Aitman, T.J.2    Vyse, T.J.3
  • 101
    • 34548036686 scopus 로고    scopus 로고
    • Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoImmune diabetes
    • Kim, H.S. et al. Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoImmune diabetes. Immunity 27, 321-333 (2007).
    • (2007) Immunity , vol.27 , pp. 321-333
    • Kim, H.S.1
  • 102
    • 19544366408 scopus 로고    scopus 로고
    • Commensal gut bacteria: Mechanisms of Immune modulation
    • Kelly, D., Conway, S. & Aminov, R. Commensal gut bacteria: mechanisms of Immune modulation. Trends Immunol. 26, 326-333 (2005).
    • (2005) Trends Immunol. , vol.26 , pp. 326-333
    • Kelly, D.1    Conway, S.2    Aminov, R.3
  • 103
    • 34848861840 scopus 로고    scopus 로고
    • The functional Interactions of commensal bacteria with intestinal secretory IgA
    • Macpherson, A.J. & Slack, E. The functional Interactions of commensal bacteria with intestinal secretory IgA. Curr. opin. Gastroenterol. 23, 673-678 (2007).
    • (2007) Curr. Opin. Gastroenterol. , vol.23 , pp. 673-678
    • MacPherson, A.J.1    Slack, E.2
  • 104
    • 64749106669 scopus 로고    scopus 로고
    • Do symbiotic bacteria subvert host immunity?
    • Hooper, L.V. Do symbiotic bacteria subvert host immunity? Nat. Rev. Microbiol. 7, 367-374 (2009).
    • (2009) Nat Rev. Microbiol. , vol.7 , pp. 367-374
    • Hooper, L.V.1
  • 105
    • 0035793372 scopus 로고    scopus 로고
    • Molecular analysis of commensal host-microbial relationships in the intestine
    • Hooper, L.V. et al. Molecular analysis of commensal host-microbial relationships in the intestine. Science 291, 881-884 (2001).
    • (2001) Science , vol.291 , pp. 881-884
    • Hooper, L.V.1
  • 106
    • 0035843993 scopus 로고    scopus 로고
    • Commensal host-bacterial relationships in the gut
    • Hooper, L.V. & Gordon, J.I. Commensal host-bacterial relationships in the gut. Science 292, 1115-1118 (2001).
    • (2001) Science , vol.292 , pp. 1115-1118
    • Hooper, L.V.1    Gordon, J.I.2
  • 107
    • 2942578705 scopus 로고
    • The response of the lymphatic tissue to the microbial flora. Studies on germfree mice
    • Bauer, H., Horowitz, R.E., Levenson, S.M. & Popper, H. The response of the lymphatic tissue to the microbial flora. Studies on germfree mice. Am. J. Pathol. 42, 471-483 (1963).
    • (1963) Am. J. Pathol. , vol.42 , pp. 471-483
    • Bauer, H.1    Horowitz, R.E.2    Levenson, S.M.3    Popper, H.4
  • 108
    • 0037438711 scopus 로고    scopus 로고
    • Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches
    • Yamanaka, T. et al. Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches. J. Immunol. 170, 816-822 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 816-822
    • Yamanaka, T.1
  • 109
    • 56749146467 scopus 로고    scopus 로고
    • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    • Bouskra, D. et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 456, 507-510 (2008).
    • (2008) Nature , vol.456 , pp. 507-510
    • Bouskra, D.1
  • 110
    • 0037180433 scopus 로고    scopus 로고
    • Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
    • Stappenbeck, T.S., Hooper, L.V. & Gordon, J.I. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc. Natl. Acad. Sci. USA 99, 15451-15455 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 15451-15455
    • Stappenbeck, T.S.1    Hooper, L.V.2    Gordon, J.I.3
  • 111
    • 33744804299 scopus 로고    scopus 로고
    • Metagenomic analysis of the human distal gut microbiome
    • GILl, S.R. et al. Metagenomic analysis of the human distal gut microbiome. Science 312, 1355-1359 (2006).
    • (2006) Science , vol.312 , pp. 1355-1359
    • Gill, S.R.1
  • 112
    • 35348968286 scopus 로고    scopus 로고
    • The human microbiome project
    • Turnbaugh, P.J. et al. The human microbiome project. Nature 449, 804-810 (2007).
    • (2007) Nature , vol.449 , pp. 804-810
    • Turnbaugh, P.J.1
  • 113
    • 35148888609 scopus 로고    scopus 로고
    • Microbial population structures in the deep marine biosphere
    • Huber, J.A. et al. Microbial population structures in the deep marine biosphere. Science 318, 97-100 (2007).
    • (2007) Science , vol.318 , pp. 97-100
    • Huber, J.A.1
  • 114
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley, R.E., Turnbaugh, P.J., Klein, S. & Gordon, J.I. Microbial ecology: human gut microbes associated with obesity. Nature 444; 1022-1023 (2006).
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 115
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • Turnbaugh, P.J. et al. A core gut microbiome in obese and lean twins. Nature 457, 480-484 (2009).
    • (2009) Nature , vol.457 , pp. 480-484
    • Turnbaugh, P.J.1
  • 117
    • 60549102720 scopus 로고    scopus 로고
    • Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    • Takatori, H. et al. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J. Exp. Med. 206, 35-41 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 35-41
    • Takatori, H.1
  • 118
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    • Ivanov, I.I. et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4, 337-349 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 337-349
    • Ivanov, I.I.1
  • 119
    • 23844493809 scopus 로고    scopus 로고
    • Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoImmune diabetes in the non-obese diabetic mouse
    • Calcinaro, F. et al. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoImmune diabetes in the non-obese diabetic mouse. diabetologia 48, 1565-1575 (2005).
    • (2005) Diabetologia , vol.48 , pp. 1565-1575
    • Calcinaro, F.1
  • 120
    • 68149091349 scopus 로고    scopus 로고
    • Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism
    • Slack, E. et al. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 325; 617-620 (2009).
    • (2009) Science , vol.325 , pp. 617-620
    • Slack, E.1
  • 121
    • 57749177662 scopus 로고    scopus 로고
    • The role of Toll-like receptors 3 and 9 in the development of autoImmune diabetes in NOD mice
    • Wong, F.S. et al. The role of Toll-like receptors 3 and 9 in the development of autoImmune diabetes in NOD mice. Ann. NY Acad. Sci. 1150, 146-148 (2008).
    • (2008) Ann. NY Acad Sci. , vol.1150 , pp. 146-148
    • Wong, F.S.1
  • 122
    • 42649143598 scopus 로고    scopus 로고
    • Viral infections in the pathogenesis of autoImmune diseases: Focus on type 1 diabetes
    • Richer, M.J. & Horwitz, M.S. Viral infections in the pathogenesis of autoImmune diseases: focus on type 1 diabetes. Front. BioscI. 13, 4241-4257 (2008).
    • (2008) Front. BioscI. , vol.13 , pp. 4241-4257
    • Richer, M.J.1    Horwitz, M.S.2
  • 123
    • 63249107452 scopus 로고    scopus 로고
    • Epidemiology of type 1 diabetes and what animal models teach us about the role of viruses in disease mechanisms
    • Zipris, D. Epidemiology of type 1 diabetes and what animal models teach us about the role of viruses in disease mechanisms. Clin. Immunol. 131; 11-23 (2009).
    • (2009) Clin. Immunol. , vol.131 , pp. 11-23
    • Zipris, D.1
  • 124
    • 34249005003 scopus 로고    scopus 로고
    • Herpesvirus latency confers symbiotic protection from bacterial infection
    • Barton, E.S. et al. Herpesvirus latency confers symbiotic protection from bacterial infection. Nature 447, 326-329 (2007).
    • (2007) Nature , vol.447 , pp. 326-329
    • Barton, E.S.1
  • 125
    • 67650395616 scopus 로고    scopus 로고
    • Murine norovirus infection has no significant Effect on adaptive immunity to vaccinia virus or influenza A virus
    • Hensley, S.E. et al. Murine norovirus infection has no significant Effect on adaptive immunity to vaccinia virus or influenza A virus. J. Virol. 83, 7357-7360 (2009).
    • (2009) J. Virol. , vol.83 , pp. 7357-7360
    • Hensley, S.E.1
  • 126
    • 37349095946 scopus 로고    scopus 로고
    • Suppression of acute anti-friend virus CD8+ T-cell responses by coinfection with lactate dehydrogenase-elevating virus
    • Robertson, S.J. et al. Suppression of acute anti-friend virus CD8+ T-cell responses by coinfection with lactate dehydrogenase-elevating virus. J. Virol. 82, 408-418 (2008).
    • (2008) J. Virol. , vol.82 , pp. 408-418
    • Robertson, S.J.1
  • 127
    • 43049146524 scopus 로고    scopus 로고
    • HapMap harvest of insights into the genetics of common disease
    • Manolio, T.A., Brooks, L.D. & Collins, F.S.A. HapMap harvest of insights into the genetics of common disease. J. Clin. Invest. 118, 1590-1605 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 1590-1605
    • Manolio, T.A.1    Brooks, L.D.2    Collins, F.S.A.3
  • 128
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell Regulatory gene CTLA4 with susceptibILity to autoImmune disease
    • Ueda, H. et al. Association of the T-cell Regulatory gene CTLA4 with susceptibILity to autoImmune disease. Nature 423, 506-511 (2003).
    • (2003) Nature , vol.423 , pp. 506-511
    • Ueda, H.1
  • 129
    • 12144291502 scopus 로고    scopus 로고
    • A functional variant of lymphoid tyrosine phosphatase is associated with type i diabetes
    • Bottini, N. et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat. Genet. 36, 337-338 (2004).
    • (2004) Nat. Genet. , vol.36 , pp. 337-338
    • Bottini, N.1
  • 130
    • 34548367511 scopus 로고    scopus 로고
    • Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    • Lowe, C.E. et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat. Genet. 39, 1074-1082 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 1074-1082
    • Lowe, C.E.1
  • 131
    • 63249115398 scopus 로고    scopus 로고
    • Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes
    • Grant, S.F. et al. Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Diabetes 58, 290-295 (2009).
    • (2009) Diabetes , vol.58 , pp. 290-295
    • Grant, S.F.1
  • 132
    • 34249293731 scopus 로고    scopus 로고
    • Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b
    • DOI 10.1016/j.smim.2007.02.004, PII S1044532307000115, Molecular Mechanisms Supporting Peripheral T cell Tolerance: Potential Therapeutic Approaches to Autoimmunity and Allograft Rejection
    • Loeser, S. & Penninger, J.M. Regulation of peripheral T cell tolerance by the e3 ubiquitin ligase Cbl-b. Semin. Immunol. 19, 206-214 (2007). (Pubitemid 46810290)
    • (2007) Seminars in Immunology , vol.19 , Issue.3 , pp. 206-214
    • Loeser, S.1    Penninger, J.M.2
  • 133
    • 67650709487 scopus 로고    scopus 로고
    • Recent advances in the genetics of autoImmune disease
    • Gregersen, P.K. & Olsson, L.M. Recent advances in the genetics of autoImmune disease. Annu. Rev. Immunol. 27, 363-391 (2009).
    • (2009) Annu. Rev Immunol. , vol.27 , pp. 363-391
    • Gregersen, P.K.1    Olsson, L.M.2
  • 134
    • 48249152671 scopus 로고    scopus 로고
    • PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes
    • Smyth, D.J. et al. PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes. Diabetes 57, 1730-1737 (2008).
    • (2008) Diabetes , vol.57 , pp. 1730-1737
    • Smyth, D.J.1
  • 135
    • 57749208427 scopus 로고    scopus 로고
    • Gene-gene Interactions in the NOD mouse model of type 1 diabetes
    • Ridgway, W.M. et al. Gene-gene Interactions in the NOD mouse model of type 1 diabetes. Adv. Immunol. 100; 151-175 (2008).
    • (2008) Adv. Immunol. , vol.100 , pp. 151-175
    • Ridgway, W.M.1
  • 136
    • 60549091762 scopus 로고    scopus 로고
    • Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors
    • Duty, J.A. et al. Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors. J. Exp. Med. 206, 139-151 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 139-151
    • Duty, J.A.1
  • 137
    • 33645734929 scopus 로고    scopus 로고
    • Toll-dependent selection of microbial antigens for presentation by dendritic cells
    • Blander, J.M. & Medzhitov, R. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440, 808-812 (2006).
    • (2006) Nature , vol.440 , pp. 808-812
    • Blander, J.M.1    Medzhitov, R.2
  • 138
    • 33748848754 scopus 로고    scopus 로고
    • On regulation of phagosome maturation and antigen presentation
    • Blander, J.M. & Medzhitov, R. On regulation of phagosome maturation and antigen presentation. Nat. Immunol. 7, 1029-1035 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 1029-1035
    • Blander, J.M.1    Medzhitov, R.2
  • 139
    • 33644502594 scopus 로고    scopus 로고
    • Dendritic cell apoptosis in the maintenance of Immune tolerance
    • Chen, M. et al. Dendritic cell apoptosis in the maintenance of Immune tolerance. Science 311, 1160-1164 (2006).
    • (2006) Science , vol.311 , pp. 1160-1164
    • Chen, M.1


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