Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism

Science

Volumn 325, Issue 5940, 2009, Pages 617-620

  Slack, Emma ^a,e   Hapfelmeier, Siegfried ^a,e   Stecher, Bärbel ^b   Velykoredko, Yuliya ^a   Stoel, Maaike ^a   Lawson, Melissa A E ^a   Geuking, Markus B ^a   Beutler, Bruce ^c   Tedder, Thomas F ^d   Hardt, Wolf Dietrich ^b   Bercik, Premysl ^a   Verdu, Elena F ^a   McCoy, Kathy D ^a   Macpherson, Andrew J ^a,e  

^a MCMASTER UNIVERSITY   (Canada)

^b ETH ZURICH   (Switzerland)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; TOLL LIKE RECEPTOR;

ADAPTATION; ANTIBODY; BACTERIUM; COMMENSAL; IMMUNITY; MUTUALISM; RODENT; SERUM;

ADAPTIVE IMMUNITY; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; HOST PARASITE INTERACTION; IMMUNE DEFICIENCY; IN VIVO CULTURE; IN VIVO STUDY; INFLAMMATORY DISEASE; INNATE IMMUNITY; INTESTINE FLORA; MICROORGANISM; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SYMBIOSIS;

ANIMALS; ANTIBODIES, BACTERIAL; BACTEREMIA; BACTERIA; BACTERIAL INFECTIONS; CD4-POSITIVE T-LYMPHOCYTES; COLONY COUNT, MICROBIAL; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI K12; GERM-FREE LIFE; IMMUNITY; IMMUNITY, INNATE; INTESTINAL MUCOSA; INTESTINES; LYMPHOID TISSUE; MICE; MICE, INBRED C57BL; PERMEABILITY; RESPIRATORY BURST; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; SPLEEN; TOLL-LIKE RECEPTORS;

MAMMALIA; MUS;

EID: 68149091349     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1172747     Document Type: Article

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25. We thank J. Kirundi, J. Jury, and J. Lu for their technical support; A. G. Rolink and A. Strasser for providing reagents; and E. Denou, M. Heikenwälder, C. Reis e Sousa, D. Stetson, J. Danska, and C. Mueller for their helpful comments and editing of the manuscript. Grant support: Canadian Institutes of Health Research, Crohn's and Colitis Foundation of Canada, Genome Canada, Canada Research Chairs, Canadian Association of Gastroenterology, NIH grant numbers CA105001 and AI56363.