Clearance deficiency and systemic lupus erythematosus (SLE)

Journal of Autoimmunity

Volumn 28, Issue 2-3, 2007, Pages 114-121

  Gaipl, Udo S ^a,b   Munoz, Luis E ^a   Grossmayer, Gerhard ^a   Lauber, Kirsten ^c   Franz, Sandra ^a   Sarter, Kerstin ^a   Voll, Reinhard E ^b   Winkler, Thomas ^b   Kuhn, Annegret ^d   Kalden, Joachim ^a   Kern, Peter ^e   Herrmann, Martin ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e Franz von Prummer Klinik   (Germany)

Author keywords

Apoptotic cells; Chronic autoimmunity; Clearance; Cutaneous lupus erythematosus; Systemic lupus erythematosus

Indexed keywords

ALBUMIN; AUTOANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; BLOOD ANALYSIS; CELL MATURATION; CELL MIGRATION; CELL SURFACE; CLEARANCE; CONTROLLED STUDY; DNA BINDING; FOLLICULAR DENDRITIC CELL; GERMINAL CENTER; GRANULOCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE; MACROPHAGE; MONOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN LUPUS ERYTHEMATOSUS; SOMATIC MUTATION; SYSTEMIC LUPUS ERYTHEMATOSUS; ULTRAVIOLET IRRADIATION;

APOPTOSIS; B-LYMPHOCYTES; GERMINAL CENTER; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LUPUS ERYTHEMATOSUS, CUTANEOUS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MACROPHAGES; MODELS, IMMUNOLOGICAL; MONOCYTES; PHAGOCYTOSIS;

EID: 34247590859     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2007.02.005     Document Type: Article

References (53)

1. Mok C.C., and Lau C.S. Pathogenesis of systemic lupus erythematosus. J Clin Pathol 56 (2003) 481-490
2. Reichlin M., Harley J.B., and Lockshin M.D. Serologic studies of monozygotic twins with systemic lupus erythematosus. Arthritis Rheum 35 (1992) 457-464
3. Krieg A.M., Gourley M.F., and Perl A. Endogenous retroviruses: potential etiologic agents in autoimmunity. FASEB J 6 (1992) 2537-2544
4. Harel M., Aron-Maor A., Sherer Y., Blank M., and Shoenfeld Y. The infectious etiology of the antiphospholipid syndrome: links between infection and autoimmunity. Immunobiology 210 (2005) 743-747
5. Nisengard R.J., Jablonska S., Chorzelski T.P., Blaszcyk M., Jarret C., and Beutner E.H. Diagnosis of systemic lupus erythematosus. Importance of antinuclear antibody titers and peripheral staining patterns. Arch Dermatol 111 (1975) 1298-1300
6. Svensson B. Occurrence of deficient monocyte yeast cell phagocytosis in presence of rheumatic sera. Scand J Rheumatol Suppl 31 (1980) 21-27
7. Herrmann M., Voll R.E., Zoller O.M., Hagenhofer M., Ponner B.B., and Kalden J.R. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 41 (1998) 1241-1250
8. Shoshan Y., Shapira I., Toubi E., Frolkis I., Yaron M., and Mevorach D. Accelerated Fas-mediated apoptosis of monocytes and maturing macrophages from patients with systemic lupus erythematosus: relevance to in vitro impairment of interaction with iC3b-opsonized apoptotic cells. J Immunol 167 (2001) 5963-5969
9. Cairns A.P., Crockard A.D., McConnell J.R., Courtney P.A., and Bell A.L. Reduced expression of CD44 on monocytes and neutrophils in systemic lupus erythematosus: relations with apoptotic neutrophils and disease activity. Ann Rheum Dis 60 (2001) 950-955
10. Gaipl U.S., Sheriff A., Franz S., Munoz L.E., Voll R.E., Kalden J.R., et al. Inefficient clearance of dying cells and autoreactivity. Curr Top Microbiol Immunol 305 (2006) 161-176
11. Ren Y., Tang J., Mok M.Y., Chan A.W., Wu A., and Lau C.S. Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus. Arthritis Rheum 48 (2003) 2888-2897
12. Mevorach D., Mascarenhas J.O., Gershov D., and Elkon K.B. Complement-dependent clearance of apoptotic cells by human macrophages. J Exp Med 188 (1998) 2313-2320
13. Taylor P.R., Carugati A., Fadok V.A., Cook H.T., Andrews M., Carroll M.C., et al. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells In vivo [In Process Citation]. J Exp Med 192 (2000) 359-366
14. Gaipl U.S., Kuenkele S., Voll R.E., Beyer T.D., Kolowos W., Heyder P., et al. Complement binding is an early feature of necrotic and a rather late event during apoptotic cell death. Cell Death Differ 8 (2001) 327-334
15. Gaipl U.S., Beyer T.D., Heyder P., Kuenkele S., Bottcher A., Voll R.E., et al. Cooperation between C1q and DNase I in the clearance of necrotic cell-derived chromatin. Arthritis Rheum 50 (2004) 640-649
16. Quartier P., Potter P.K., Ehrenstein M.R., Walport M.J., and Botto M. Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro. Eur J Immunol 35 (2005) 252-260
17. Gorgani N.N., Smith B.A., Kono D.H., and Theofilopoulos A.N. Histidine-rich glycoprotein binds to DNA and Fc gamma RI and potentiates the ingestion of apoptotic cells by macrophages. J Immunol 169 (2002) 4745-4751
18. Jersmann H.P., Dransfield I., and Hart S.P. Fetuin/alpha2-HS glycoprotein enhances phagocytosis of apoptotic cells and macropinocytosis by human macrophages. Clin Sci (Lond) 105 (2003) 273-278
19. Gershov D., Kim S., Brot N., and Elkon K.B. C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J Exp Med 192 (2000) 1353-1364
20. Rossi A.G., McCutcheon J.C., Roy N., Chilvers E.R., Haslett C., and Dransfield I. Regulation of macrophage phagocytosis of apoptotic cells by cAMP. J Immunol 160 (1998) 3562-3568
21. Grossmayer G.E., Munoz L.E., Gaipl U.S., Franz S., Sheriff A., Voll R.E., et al. Removal of dying cells and systemic lupus erythematosus. Mod Rheumatol 15 (2005) 383-390
22. Hochberg M.C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40 (1997) 1725
23. Tan E.M., Cohen A.S., Fries J.F., Masi A.T., McShane D.J., Rothfield N.F., et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25 (1982) 1271-1277
24. Kuhn A.S.R., and Ruzicka T. Clinical manifestations of cutaneous lupus erythematosus. In: Lehmann P., Kuhn A., and Ruzicka T. (Eds). Cutaneous lupus erythematosus (2004), Springer, Heidelberg 59-93
25. Wellmann U., Letz M., Herrmann M., Angermuller S., Kalden J.R., and Winkler T.H. The evolution of human anti-double-stranded DNA autoantibodies. Proc Natl Acad Sci USA 102 (2005) 9258-9263
26. Lauber K., Bohn E., Krober S.M., Xiao Y.J., Blumenthal S.G., Lindemann R.K., et al. Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 113 (2003) 717-730
27. Baumann I., Kolowos W., Voll R.E., Manger B., Gaipl U., Neuhuber W.L., et al. Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum 46 (2002) 191-201
28. Janeway C.A. Immunobiology: the immune system in health and disease (1999), Current Biology Publications, New York pp. 236-92
29. Winkler T.H., Jahn S., and Kalden J.R. IgG human monoclonal anti-DNA autoantibodies from patients with systemic lupus erythematosus. Clin Exp Immunol 85 (1991) 379-385
30. Winkler T.H., Fehr H., and Kalden J.R. Analysis of immunoglobulin variable region genes from human IgG anti- DNA hybridomas. Eur J Immunol 22 (1992) 1719-1728
31. Russell A.I., Cunninghame Graham D.S., Shepherd C., Roberton C.A., Whittaker J., Meeks J., et al. Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus. Hum Mol Genet 13 (2004) 137-147
32. Chitrabamrung S., Rubin R.L., and Tan E.M. Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus. Rheumatol Int 1 (1981) 55-60
33. Walport M.J., Davies K.A., and Botto M. C1q and systemic lupus erythematosus. Immunobiology 199 (1998) 265-285
34. Botto M. Links between complement deficiency and apoptosis. Arthritis Res 3 (2001) 207-210 [Epub 2001 Mar 2026]
35. Kawane K., Ohtani M., Miwa K., Kizawa T., Kanbara Y., Yoshioka Y., et al. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 443 (2006) 998-1002
36. Kimberly R.P., Salmon J.E., Edberg J.C., and Gibofsky A. The role of Fc gamma receptors in mononuclear phagocyte system function. Clin Exp Rheumatol 3 Suppl. 7 (1989) S103-S108
37. Hoffman R.D., Kligerman M., Sundt T.M., Anderson N.D., and Shin H.S. Stereospecific chemoattraction of lymphoblastic cells by gradients of lysophosphatidylcholine. Proc Natl Acad Sci USA 79 (1982) 3285-3289
38. Fernandez-Madrid F., and Mattioli M. Antinuclear antibodies (ANA): immunologic and clinical significance. Semin Arthritis Rheum 6 (1976) 83-124
39. Gaipl U.S., Voll R.E., Sheriff A., Franz S., Kalden J.R., and Herrmann M. Impaired clearance of dying cells in systemic lupus erythematosus. Autoimmun Rev 4 (2005) 189-194
40. Ballestar E., Esteller M., and Richardson B.C. The epigenetic face of systemic lupus erythematosus. J Immunol 176 (2006) 7143-7147
41. Hall J.C., Casciola-Rosen L., and Rosen A. Altered structure of autoantigens during apoptosis. Rheum Dis Clin North Am 30 (2004) 455-471 vii
42. Gallucci S., and Matzinger P. Danger signals: SOS to the immune system. Curr Opin Immunol 13 (2001) 114-119
43. Tan J.K., and O'Neill H.C. Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity. J Leukoc Biol 78 (2005) 319-324
44. Rovere P., Vallinoto C., Bondanza A., Crosti M.C., Rescigno M., Ricciardi-Castagnoli P., et al. Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. J Immunol 161 (1998) 4467-4471
45. Murphy G., Young A.R., Wulf H.C., Kulms D., and Schwarz T. The molecular determinants of sunburn cell formation. Exp Dermatol 10 (2001) 155-160
46. Furukawa F., Kashihara-Sawami M., Lyons M.B., and Norris D.A. Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the pathogenesis of photosensitive cutaneous lupus. J Invest Dermatol 94 (1990) 77-85
47. Kuhn A., Herrmann M., Kleber S., Beckmann-Welle M., Fehsel K., Martin-Villalba A., et al. Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis Rheum 54 (2006) 939-950
48. Reefman E., de Jong M.C., Kuiper H., Jonkman M.F., Limburg P.C., Kallenberg C.G., et al. Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus?. Arthritis Res Ther 8 (2006) R156
49. Reefman E., Kuiper H., Jonkman M.F., Limburg P.C., Kallenberg C.G., and Bijl M. Skin sensitivity to UVB irradiation in systemic lupus erythematosus is not related to the level of apoptosis induction in keratinocytes. Rheumatology (Oxf) 45 (2006) 538-544
50. Kuhn A., Krammer P.H., and Kolb-Bachofen V. Pathophysiology of cutaneous lupus erythematosus - novel aspects. Rheumatology (Oxf) 45 Suppl. 3 (2006) iii14-iii16
51. Smith J.P., Burton G.F., Tew J.G., and Szakal A.K. Tingible body macrophages in regulation of germinal center reactions. Dev Immunol 6 (1998) 285-294
52. Kuenkele S., Beyer T.D., Voll R.E., Kalden J.R., and Herrmann M. Impaired clearance of apoptotic cells in systemic lupus erythematosus: challenge of T and B cell tolerance. Curr Rheumatol Rep 5 (2003) 175-177
53. Gaipl U.S., Kuhn A., Sheriff A., Munoz L.E., Franz S., Voll R.E., et al. Clearance of apoptotic cells in human SLE. Curr Dir Autoimmun 9 (2006) 173-187