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Volumn 9, Issue 5, 2009, Pages 353-363

Immunogenic and tolerogenic cell death

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 8; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 67349124914     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri2545     Document Type: Review
Times cited : (941)

References (124)
  • 1
    • 33745863017 scopus 로고    scopus 로고
    • Drug insight: Cancer therapy strategies based on restoration of endogenous cell death mechanisms
    • Reed, J. C. Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms. Nature Clin. Pract. Oncol. 3, 388-398 (2006).
    • (2006) Nature Clin. Pract. Oncol , vol.3 , pp. 388-398
    • Reed, J.C.1
  • 2
    • 0037066502 scopus 로고    scopus 로고
    • Decoding the patterns of self and nonself by the innate immune system
    • Medzhitov, R. & Janeway, C. A. Jr. Decoding the patterns of self and nonself by the innate immune system. Science 296, 298-300 (2002).
    • (2002) Science , vol.296 , pp. 298-300
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 3
    • 3042774310 scopus 로고    scopus 로고
    • Immune response against dying tumor cells
    • Zitvogel, L. et al. Immune response against dying tumor cells. Adv. Immunol. 84, 131-179 (2004).
    • (2004) Adv. Immunol , vol.84 , pp. 131-179
    • Zitvogel, L.1
  • 4
    • 34247590859 scopus 로고    scopus 로고
    • Clearance deficiency and systemic lupus erythematosus (SLE)
    • Gaipl, U. S. et al. Clearance deficiency and systemic lupus erythematosus (SLE). J. Autoimmun. 28, 114-121 (2007).
    • (2007) J. Autoimmun , vol.28 , pp. 114-121
    • Gaipl, U.S.1
  • 5
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger, P. The danger model: a renewed sense of self. Science 296, 301-305 (2002).
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 6
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462 (1995).
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 7
    • 29144530630 scopus 로고    scopus 로고
    • Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
    • Casares, N. et al. Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J. Exp. Med. 202, 1691-1701 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 1691-1701
    • Casares, N.1
  • 8
    • 33846057130 scopus 로고    scopus 로고
    • Calreticulin exposure dictates the immunogenicity of cancer cell death
    • This paper contains information suggesting that subtle differences in the surface characteristics of dying cells can determine how they are handled by DCs and whether an adaptive immune response will ensue
    • Obeid, M. et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nature Med. 13, 54-61 (2007). This paper contains information suggesting that subtle differences in the surface characteristics of dying cells can determine how they are handled by DCs and whether an adaptive immune response will ensue.
    • (2007) Nature Med , vol.13 , pp. 54-61
    • Obeid, M.1
  • 9
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J. F., Wyllie, A. H. & Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257 (1972).
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 10
    • 0030201014 scopus 로고    scopus 로고
    • Griffith, T. S., Yu, X., Herndon, J. M., Green, D. R. & Ferguson, T. A. CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity 5, 7-16 (1996). This is an early paper showing that apoptotic cells induce tolerance to associated antigens.
    • Griffith, T. S., Yu, X., Herndon, J. M., Green, D. R. & Ferguson, T. A. CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity 5, 7-16 (1996). This is an early paper showing that apoptotic cells induce tolerance to associated antigens.
  • 11
    • 0036604123 scopus 로고    scopus 로고
    • Uptake of apoptotic antigencoupled cells by lymphoid dendritic cells and crosspriming of CD8+ T cells produce active immune unresponsiveness
    • Ferguson, T. A. et al. Uptake of apoptotic antigencoupled cells by lymphoid dendritic cells and crosspriming of CD8+ T cells produce active immune unresponsiveness. J. Immunol. 168, 5589-5595 (2002).
    • (2002) J. Immunol , vol.168 , pp. 5589-5595
    • Ferguson, T.A.1
  • 12
    • 0037152141 scopus 로고    scopus 로고
    • The CD8α+ dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens
    • References 11 and 12 show that CD8α+ DCs cross-present antigen on MHC class I molecules to induce tolerance
    • Belz, G. T. et al. The CD8α+ dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J. Exp. Med. 196, 1099-1104 (2002). References 11 and 12 show that CD8α+ DCs cross-present antigen on MHC class I molecules to induce tolerance.
    • (2002) J. Exp. Med , vol.196 , pp. 1099-1104
    • Belz, G.T.1
  • 13
    • 0034608389 scopus 로고    scopus 로고
    • Role of antigen-presenting cells in mediating tolerance and autoimmunity
    • Garza, K. M. et al. Role of antigen-presenting cells in mediating tolerance and autoimmunity. J. Exp. Med. 191, 2021-2027 (2000).
    • (2000) J. Exp. Med , vol.191 , pp. 2021-2027
    • Garza, K.M.1
  • 14
    • 34547657835 scopus 로고    scopus 로고
    • Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens
    • Miyake, Y. et al. Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J. Clin. Invest. 117, 2268-2278 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 2268-2278
    • Miyake, Y.1
  • 15
    • 0035170432 scopus 로고    scopus 로고
    • Dendritic cell maturation is required for the crosstolerization of CD8+ T cells
    • Albert, M. L., Jegathesan, M. & Darnell, R. B. Dendritic cell maturation is required for the crosstolerization of CD8+ T cells. Nature Immunol. 2, 1010-1017 (2001).
    • (2001) Nature Immunol , vol.2 , pp. 1010-1017
    • Albert, M.L.1    Jegathesan, M.2    Darnell, R.B.3
  • 16
    • 0032543235 scopus 로고    scopus 로고
    • Cross-tolerance: A pathway for inducing tolerance to peripheral tissue antigens
    • Heath, W. R., Kurts, C., Miller, J. F. & Carbone, F. R. Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens. J. Exp. Med. 187, 1549-1553 (1998).
    • (1998) J. Exp. Med , vol.187 , pp. 1549-1553
    • Heath, W.R.1    Kurts, C.2    Miller, J.F.3    Carbone, F.R.4
  • 17
    • 0034614886 scopus 로고    scopus 로고
    • Steinman, R. M., Turley, S., Mellman, I. & Inaba, K. The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191, 411-416 (2000). This is an important early review on tolerance induction that is mediated by the uptake of apoptotic cells.
    • Steinman, R. M., Turley, S., Mellman, I. & Inaba, K. The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191, 411-416 (2000). This is an important early review on tolerance induction that is mediated by the uptake of apoptotic cells.
  • 18
    • 0014009059 scopus 로고    scopus 로고
    • Battisto, J. R. & Bloom, B. R. Dual immunological unresponsiveness induced by cell membrane coupled hapten or antigen. Nature 212, 156-157 (1966). Pre-dating most relevant studies by decades, this work shows that injected cells can cause immune tolerance.
    • Battisto, J. R. & Bloom, B. R. Dual immunological unresponsiveness induced by cell membrane coupled hapten or antigen. Nature 212, 156-157 (1966). Pre-dating most relevant studies by decades, this work shows that injected cells can cause immune tolerance.
  • 19
    • 0018955915 scopus 로고
    • The induction of tolerance to DNFB contact sensitivity by using hapten-modified lymphoid cells. III. Effects of hapten concentration on the ability of MLS-disparate cells to induce rapid unresponsiveness
    • Conlon, P. J., Miller, S. D. & Claman, H. N. The induction of tolerance to DNFB contact sensitivity by using hapten-modified lymphoid cells. III. Effects of hapten concentration on the ability of MLS-disparate cells to induce rapid unresponsiveness. J. Immunol. 125, 807-813 (1980).
    • (1980) J. Immunol , vol.125 , pp. 807-813
    • Conlon, P.J.1    Miller, S.D.2    Claman, H.N.3
  • 20
    • 0018854662 scopus 로고
    • Studies on transplantation immunity. IV. Murine natural immunity to lymphoid cells in vivo
    • Pincott, C. E. & Bainbridge, D. R. Studies on transplantation immunity. IV. Murine natural immunity to lymphoid cells in vivo. Eur. J. Immunol. 10, 250-257 (1980).
    • (1980) Eur. J. Immunol , vol.10 , pp. 250-257
    • Pincott, C.E.1    Bainbridge, D.R.2
  • 21
    • 9944228640 scopus 로고    scopus 로고
    • Allograft tolerance induced by donor apoptotic lymphocytes requires phagocytosis in the recipient
    • Sun, E. et al. Allograft tolerance induced by donor apoptotic lymphocytes requires phagocytosis in the recipient. Cell Death Differ. 11, 1258-1264 (2004).
    • (2004) Cell Death Differ , vol.11 , pp. 1258-1264
    • Sun, E.1
  • 22
    • 0026000947 scopus 로고
    • Pretransplantation blood transfusion revisited
    • van Twuyver, E. et al. Pretransplantation blood transfusion revisited. N. Engl. J. Med. 325, 1210-1213 (1991).
    • (1991) N. Engl. J. Med , vol.325 , pp. 1210-1213
    • van Twuyver, E.1
  • 23
    • 51549095216 scopus 로고    scopus 로고
    • A critical role for the proapoptotic protein Bid in ultraviolet-induced immune suppression and cutaneous apoptosis
    • Pradhan, S. et al. A critical role for the proapoptotic protein Bid in ultraviolet-induced immune suppression and cutaneous apoptosis. J. Immunol. 181, 3077-3088 (2008).
    • (2008) J. Immunol , vol.181 , pp. 3077-3088
    • Pradhan, S.1
  • 24
    • 0032080447 scopus 로고    scopus 로고
    • Ultraviolet light-induced immune tolerance is mediated via the Fas/Fas-ligand system
    • Schwarz, A. et al. Ultraviolet light-induced immune tolerance is mediated via the Fas/Fas-ligand system. J. Immunol. 160, 4262-4270 (1998).
    • (1998) J. Immunol , vol.160 , pp. 4262-4270
    • Schwarz, A.1
  • 25
    • 0035059416 scopus 로고    scopus 로고
    • Cross-presentation, dendritic cells, tolerance and immunity
    • Heath, W. R. & Carbone, F. R. Cross-presentation, dendritic cells, tolerance and immunity. Annu. Rev. Immunol. 19, 47-64 (2001).
    • (2001) Annu. Rev. Immunol , vol.19 , pp. 47-64
    • Heath, W.R.1    Carbone, F.R.2
  • 27
    • 38849151665 scopus 로고    scopus 로고
    • Epitope landscape in breast and colorectal cancer
    • Segal, N. H. et al. Epitope landscape in breast and colorectal cancer. Cancer Res. 68, 889-892 (2008).
    • (2008) Cancer Res , vol.68 , pp. 889-892
    • Segal, N.H.1
  • 28
    • 34948820602 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
    • This paper provides evidence that TLR4 expression by DCs dictates whether the immune system can mount a CTL response against antigens from dying tumour cells and suggests that one of the ligands for TLR4 released by dying cells is HMGB1
    • Apetoh, L. et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nature Med. 13, 1050-1059 (2007). This paper provides evidence that TLR4 expression by DCs dictates whether the immune system can mount a CTL response against antigens from dying tumour cells and suggests that one of the ligands for TLR4 released by dying cells is HMGB1.
    • (2007) Nature Med , vol.13 , pp. 1050-1059
    • Apetoh, L.1
  • 30
    • 34548654130 scopus 로고    scopus 로고
    • Triggering of dendritic cell responses after exposure to activated, but not resting, apoptotic PBMCs
    • Johansson, U., Walther-Jallow, L., Smed-Sorensen, A. & Spetz, A. L. Triggering of dendritic cell responses after exposure to activated, but not resting, apoptotic PBMCs. J. Immunol. 179, 1711-1720 (2007).
    • (2007) J. Immunol , vol.179 , pp. 1711-1720
    • Johansson, U.1    Walther-Jallow, L.2    Smed-Sorensen, A.3    Spetz, A.L.4
  • 31
    • 15444378924 scopus 로고    scopus 로고
    • Peripheral deletion of antigen-specific T cells leads to long-term tolerance mediated by CD8+ cytotoxic cells
    • Herndon, J. M., Stuart, P. M. & Ferguson, T. A. Peripheral deletion of antigen-specific T cells leads to long-term tolerance mediated by CD8+ cytotoxic cells. J. Immunol. 174, 4098-4104 (2005).
    • (2005) J. Immunol , vol.174 , pp. 4098-4104
    • Herndon, J.M.1    Stuart, P.M.2    Ferguson, T.A.3
  • 32
    • 24144443517 scopus 로고    scopus 로고
    • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    • Gasser, S., Orsulic, S., Brown, E. J. & Raulet, D. H. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436, 1186-1190 (2005).
    • (2005) Nature , vol.436 , pp. 1186-1190
    • Gasser, S.1    Orsulic, S.2    Brown, E.J.3    Raulet, D.H.4
  • 33
    • 38849168162 scopus 로고    scopus 로고
    • Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
    • Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M. & Green, M. R. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132, 363-374 (2008).
    • (2008) Cell , vol.132 , pp. 363-374
    • Wajapeyee, N.1    Serra, R.W.2    Zhu, X.3    Mahalingam, M.4    Green, M.R.5
  • 34
    • 44649101304 scopus 로고    scopus 로고
    • Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
    • Kuilman, T. et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133, 1019-1031 (2008).
    • (2008) Cell , vol.133 , pp. 1019-1031
    • Kuilman, T.1
  • 35
    • 44649120132 scopus 로고    scopus 로고
    • Chemokine signaling via the CXCR2 receptor reinforces senescence
    • Acosta, J. C. et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133, 1006-1018 (2008).
    • (2008) Cell , vol.133 , pp. 1006-1018
    • Acosta, J.C.1
  • 36
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • An interesting study in which induction of cellular senescence triggers immune-mediated tumour cell clearance
    • Xue, W. et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656-660 (2007). An interesting study in which induction of cellular senescence triggers immune-mediated tumour cell clearance.
    • (2007) Nature , vol.445 , pp. 656-660
    • Xue, W.1
  • 37
    • 33644636996 scopus 로고    scopus 로고
    • Therapeutic cancer vaccines
    • Srivastava, P. K. Therapeutic cancer vaccines. Curr. Opin. Immunol. 18, 201-205 (2006).
    • (2006) Curr. Opin. Immunol , vol.18 , pp. 201-205
    • Srivastava, P.K.1
  • 38
    • 35748933181 scopus 로고    scopus 로고
    • Ecto-calreticulin in immunogenic chemotherapy
    • Obeid, M. et al. Ecto-calreticulin in immunogenic chemotherapy. Immunol. Rev. 220, 22-34 (2007).
    • (2007) Immunol. Rev , vol.220 , pp. 22-34
    • Obeid, M.1
  • 39
    • 34249650184 scopus 로고    scopus 로고
    • Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: Therapeutic implications
    • Spisek, R. et al. Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. Blood 109, 4839-4845 (2007).
    • (2007) Blood , vol.109 , pp. 4839-4845
    • Spisek, R.1
  • 40
    • 49949115791 scopus 로고    scopus 로고
    • The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death
    • Panaretakis, T. et al. The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death. Cell Death Differ. 15, 1499-1509 (2008).
    • (2008) Cell Death Differ , vol.15 , pp. 1499-1509
    • Panaretakis, T.1
  • 41
    • 0038820117 scopus 로고    scopus 로고
    • Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal
    • Lauber, K. et al. Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 113, 717-730 (2003).
    • (2003) Cell , vol.113 , pp. 717-730
    • Lauber, K.1
  • 42
    • 0035020493 scopus 로고    scopus 로고
    • Mice lacking the orphan G proteincoupled receptor G2A develop a late-onset autoimmune syndrome
    • Le, L. Q. et al. Mice lacking the orphan G proteincoupled receptor G2A develop a late-onset autoimmune syndrome. Immunity 14, 561-571 (2001).
    • (2001) Immunity , vol.14 , pp. 561-571
    • Le, L.Q.1
  • 43
    • 41949104092 scopus 로고    scopus 로고
    • Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A
    • Peter, C. et al. Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. J. Biol. Chem. 283, 5296-5305 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 5296-5305
    • Peter, C.1
  • 44
    • 34247637676 scopus 로고    scopus 로고
    • UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis
    • Koizumi, S. et al. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446, 1091-1095 (2007).
    • (2007) Nature , vol.446 , pp. 1091-1095
    • Koizumi, S.1
  • 45
    • 3042634614 scopus 로고    scopus 로고
    • Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages
    • Hanley, P. J. et al. Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages. Proc. Natl Acad. Sci. USA 101, 9479-9484 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 9479-9484
    • Hanley, P.J.1
  • 46
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241 (2006).
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 48
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • This is a key study that identifies HMGB1 as a DAMP
    • Scaffidi, P., Misteli, T. & Bianchi, M. E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418, 191-195 (2002). This is a key study that identifies HMGB1 as a DAMP.
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 50
    • 34248229237 scopus 로고    scopus 로고
    • The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid
    • Jiang, W., Bell, C. W. & Pisetsky, D. S. The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid. J. Immunol. 178, 6495-6503 (2007).
    • (2007) J. Immunol , vol.178 , pp. 6495-6503
    • Jiang, W.1    Bell, C.W.2    Pisetsky, D.S.3
  • 51
    • 46749136790 scopus 로고    scopus 로고
    • Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein
    • This study 'connects the dots' from caspase activation to ROS production to modification of HMGB1 and to immune tolerance
    • Kazama, H. et al. Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity 29, 21-32 (2008). This study 'connects the dots' from caspase activation to ROS production to modification of HMGB1 and to immune tolerance.
    • (2008) Immunity , vol.29 , pp. 21-32
    • Kazama, H.1
  • 52
    • 35748967851 scopus 로고    scopus 로고
    • High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
    • Bianchi, M. E. & Manfredi, A. A. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol. Rev. 220, 35-46 (2007).
    • (2007) Immunol. Rev , vol.220 , pp. 35-46
    • Bianchi, M.E.1    Manfredi, A.A.2
  • 53
    • 33750369226 scopus 로고    scopus 로고
    • Toll-like receptors in systemic autoimmune disease
    • Marshak-Rothstein, A. Toll-like receptors in systemic autoimmune disease. Nature Rev. Immunol. 6, 823-835 (2006).
    • (2006) Nature Rev. Immunol , vol.6 , pp. 823-835
    • Marshak-Rothstein, A.1
  • 54
    • 34247236200 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    • Tian, J. et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nature Immunol. 8, 487-496 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 487-496
    • Tian, J.1
  • 55
    • 52549125928 scopus 로고    scopus 로고
    • Mincle is an ITAM-coupled activating receptor that senses damaged cells
    • Yamasaki, S. et al. Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nature Immunol. 9, 1179-1188 (2008).
    • (2008) Nature Immunol , vol.9 , pp. 1179-1188
    • Yamasaki, S.1
  • 56
    • 67249158956 scopus 로고    scopus 로고
    • Sancho, D. et al. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 15 Feb 2009 (doi:10.1038/nature07750). This paper reports the identification of a new PRR on DCs that senses the presence of an unknown intracellular ligand that becomes accessible in dead cells following permeabilization of the plasma membrane and directs antigens for cross-presentation.
    • Sancho, D. et al. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 15 Feb 2009 (doi:10.1038/nature07750). This paper reports the identification of a new PRR on DCs that senses the presence of an unknown intracellular ligand that becomes accessible in dead cells following permeabilization of the plasma membrane and directs antigens for cross-presentation.
  • 57
    • 57649149333 scopus 로고    scopus 로고
    • Classifications of cell death: Recommendations of the Nomenclature Committee on Cell Death 2009
    • Kroemer, G. et al. Classifications of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Diff. 16, 3-11 (2008).
    • (2008) Cell Death Diff , vol.16 , pp. 3-11
    • Kroemer, G.1
  • 58
    • 0036168270 scopus 로고    scopus 로고
    • Apoptosis-dependent subversion of the T-lymphocyte epitope hierarchy in lymphoma cells
    • Castiglioni, P. et al. Apoptosis-dependent subversion of the T-lymphocyte epitope hierarchy in lymphoma cells. Cancer Res. 62, 1116-1122 (2002).
    • (2002) Cancer Res , vol.62 , pp. 1116-1122
    • Castiglioni, P.1
  • 59
    • 36849094070 scopus 로고    scopus 로고
    • Cross-presentation of caspasecleaved apoptotic self antigens in HIV infection
    • Rawson, P. M. et al. Cross-presentation of caspasecleaved apoptotic self antigens in HIV infection. Nature Med. 13, 1431-1439 (2007).
    • (2007) Nature Med , vol.13 , pp. 1431-1439
    • Rawson, P.M.1
  • 60
    • 34248999834 scopus 로고    scopus 로고
    • The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism
    • Tenev, T., Ditzel, M., Zachariou, A. & Meier, P. The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism. Cell Death Differ. 14, 1191-1201 (2007).
    • (2007) Cell Death Differ , vol.14 , pp. 1191-1201
    • Tenev, T.1    Ditzel, M.2    Zachariou, A.3    Meier, P.4
  • 61
    • 34548576109 scopus 로고    scopus 로고
    • Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC lightinduced apoptosis
    • Obeid, M. et al. Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC lightinduced apoptosis. Cell Death Differ. 14, 1848-1850 (2007).
    • (2007) Cell Death Differ , vol.14 , pp. 1848-1850
    • Obeid, M.1
  • 62
    • 56749170677 scopus 로고    scopus 로고
    • Autophagic cell death: The story of a misnomer
    • Kroemer, G. & Levine, B. Autophagic cell death: the story of a misnomer. Nature Rev. Mol. Cell Biol. 9, 1004-1010 (2008).
    • (2008) Nature Rev. Mol. Cell Biol , vol.9 , pp. 1004-1010
    • Kroemer, G.1    Levine, B.2
  • 63
    • 33847400593 scopus 로고    scopus 로고
    • Metabolic catastrophe as a means to cancer cell death
    • Jin, S., DiPaola, R. S., Mathew, R. & White, E. Metabolic catastrophe as a means to cancer cell death. J. Cell Sci. 120, 379-383 (2007).
    • (2007) J. Cell Sci , vol.120 , pp. 379-383
    • Jin, S.1    DiPaola, R.S.2    Mathew, R.3    White, E.4
  • 64
    • 33847404337 scopus 로고    scopus 로고
    • Autophagy gene-dependent clearance of apoptotic cells during embryonic development
    • Qu, X. et al. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 128, 931-946 (2007).
    • (2007) Cell , vol.128 , pp. 931-946
    • Qu, X.1
  • 65
    • 57649217868 scopus 로고    scopus 로고
    • Autophagy regulates selective HMGB1 release in tumor cells that are destined to die
    • Thorburn, J. et al. Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. Cell Death Differ. 16, 175-183 (2008).
    • (2008) Cell Death Differ , vol.16 , pp. 175-183
    • Thorburn, J.1
  • 66
    • 10344262564 scopus 로고    scopus 로고
    • Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
    • Shimizu, S. et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nature Cell Biol. 6, 1221-1228 (2004).
    • (2004) Nature Cell Biol , vol.6 , pp. 1221-1228
    • Shimizu, S.1
  • 67
    • 67549117101 scopus 로고    scopus 로고
    • Autophagic death facilitates efficient antigen cross-priming by stimulating type I IFN production by phagocytic dendritic cells
    • 20 Feb, doi:10.1038/cdd.2009.8
    • Uhl, M., Kepp, O., Jusforgues-Saklani, H., Kroemer, G. & Albert, M. L. Autophagic death facilitates efficient antigen cross-priming by stimulating type I IFN production by phagocytic dendritic cells. Cell Death Diff. 20 Feb 2009 (doi:10.1038/cdd.2009.8).
    • (2009) Cell Death Diff
    • Uhl, M.1    Kepp, O.2    Jusforgues-Saklani, H.3    Kroemer, G.4    Albert, M.L.5
  • 68
    • 3543053363 scopus 로고    scopus 로고
    • Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
    • Albert, M. L. et al. Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 188, 1359-1368 (1998).
    • (1998) J. Exp. Med , vol.188 , pp. 1359-1368
    • Albert, M.L.1
  • 69
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • Schoenberger, S. P., Toes, R. E., van der Voort, E. I., Offringa, R. & Melief, C. J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393, 480-483 (1998).
    • (1998) Nature , vol.393 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    van der Voort, E.I.3    Offringa, R.4    Melief, C.J.5
  • 70
    • 0037432776 scopus 로고    scopus 로고
    • Defective CD8 T cell memory following acute infection without CD4 T cell help
    • Sun, J. C. & Bevan, M. J. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300, 339-342 (2003).
    • (2003) Science , vol.300 , pp. 339-342
    • Sun, J.C.1    Bevan, M.J.2
  • 71
    • 14544288632 scopus 로고    scopus 로고
    • CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
    • This studied characterizes the production of TRAIL following restimulation of helpless CTLs and defines its role both in killing the CTLs and inhibiting T cell responses
    • Janssen, E. M. et al. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature 434, 88-93 (2005). This studied characterizes the production of TRAIL following restimulation of helpless CTLs and defines its role both in killing the CTLs and inhibiting T cell responses.
    • (2005) Nature , vol.434 , pp. 88-93
    • Janssen, E.M.1
  • 72
    • 0037456367 scopus 로고    scopus 로고
    • CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
    • Janssen, E. M. et al. CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 421, 852-856 (2003).
    • (2003) Nature , vol.421 , pp. 852-856
    • Janssen, E.M.1
  • 73
    • 33847407835 scopus 로고    scopus 로고
    • Apoptotic cells induce tolerance by generating helpless CD8+ T cells that produce TRAIL
    • This study shows that of the induction of tolerance by apoptotic cells involves helpless CTLs and the production of TRAIL
    • Griffith, T. S. et al. Apoptotic cells induce tolerance by generating helpless CD8+ T cells that produce TRAIL. J. Immunol. 178, 2679-2687 (2007). This study shows that of the induction of tolerance by apoptotic cells involves helpless CTLs and the production of TRAIL.
    • (2007) J. Immunol , vol.178 , pp. 2679-2687
    • Griffith, T.S.1
  • 74
    • 0019227124 scopus 로고
    • Studies on hapten specific T cell immunity and suppression
    • Greene, M. I. & Benacerraf, B. Studies on hapten specific T cell immunity and suppression. Immunol. Rev. 50, 163-186 (1980).
    • (1980) Immunol. Rev , vol.50 , pp. 163-186
    • Greene, M.I.1    Benacerraf, B.2
  • 75
    • 0020510998 scopus 로고
    • Regulation of the hapten-specific T cell response. I. Preferential induction of hyporesponsiveness to the D-end of the major histocompatibility complex in the hapten-specific cytotoxic T cell response
    • Scott, C. F. Jr, Tsurufuji, M., Benacerraf, B. & Sy, M. S. Regulation of the hapten-specific T cell response. I. Preferential induction of hyporesponsiveness to the D-end of the major histocompatibility complex in the hapten-specific cytotoxic T cell response. J. Immunol. 131, 2184-2189 (1983).
    • (1983) J. Immunol , vol.131 , pp. 2184-2189
    • Scott Jr, C.F.1    Tsurufuji, M.2    Benacerraf, B.3    Sy, M.S.4
  • 76
    • 34748882505 scopus 로고    scopus 로고
    • Molecular determinants of immunogenic cell death: Surface exposure of calreticulin makes the difference
    • Chaput, N. et al. Molecular determinants of immunogenic cell death: surface exposure of calreticulin makes the difference. J. Mol. Med. 85, 1069-1076 (2007).
    • (2007) J. Mol. Med , vol.85 , pp. 1069-1076
    • Chaput, N.1
  • 77
    • 34247348275 scopus 로고    scopus 로고
    • Immunogenic chemotherapy: Discovery of a critical protein through proteomic analyses of tumor cells
    • Apetoh, L. et al. Immunogenic chemotherapy: discovery of a critical protein through proteomic analyses of tumor cells. Cancer Genomics Proteomics 4, 65-70 (2007).
    • (2007) Cancer Genomics Proteomics , vol.4 , pp. 65-70
    • Apetoh, L.1
  • 78
    • 0024341652 scopus 로고
    • The immune response and the eye. III. Anterior chamberassociated immune deviation can be adoptively transferred by serum
    • Ferguson, T. A., Hayashi, J. D. & Kaplan, H. J. The immune response and the eye. III. Anterior chamberassociated immune deviation can be adoptively transferred by serum. J. Immunol. 143, 821-826 (1989).
    • (1989) J. Immunol , vol.143 , pp. 821-826
    • Ferguson, T.A.1    Hayashi, J.D.2    Kaplan, H.J.3
  • 79
    • 0034684659 scopus 로고    scopus 로고
    • CD8+ but not CD8- dendritic cells cross-prime cytotoxic T cells in vivo
    • den Haan, J. M., Lehar, S. M. & Bevan, M. J. CD8+ but not CD8- dendritic cells cross-prime cytotoxic T cells in vivo. J. Exp. Med. 192, 1685-1696 (2000).
    • (2000) J. Exp. Med , vol.192 , pp. 1685-1696
    • den Haan, J.M.1    Lehar, S.M.2    Bevan, M.J.3
  • 80
    • 33846636409 scopus 로고    scopus 로고
    • Differential antigen processing by dendritic cell subsets in vivo
    • Dudziak, D. et al. Differential antigen processing by dendritic cell subsets in vivo. Science 315, 107-111 (2007).
    • (2007) Science , vol.315 , pp. 107-111
    • Dudziak, D.1
  • 81
    • 0037141105 scopus 로고    scopus 로고
    • The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo
    • Iyoda, T. et al. The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J. Exp. Med. 195, 1289-1302 (2002).
    • (2002) J. Exp. Med , vol.195 , pp. 1289-1302
    • Iyoda, T.1
  • 82
    • 0141654300 scopus 로고    scopus 로고
    • Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells
    • Allan, R. S. et al. Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells. Science 301, 1925-1928 (2003).
    • (2003) Science , vol.301 , pp. 1925-1928
    • Allan, R.S.1
  • 83
    • 0028674991 scopus 로고
    • The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo
    • Huang, L., Soldevila, G., Leeker, M., Flavell, R. & Crispe, I. N. The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo. Immunity 1, 741-749 (1994).
    • (1994) Immunity , vol.1 , pp. 741-749
    • Huang, L.1    Soldevila, G.2    Leeker, M.3    Flavell, R.4    Crispe, I.N.5
  • 84
    • 33748741858 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of liver tolerance
    • Crispe, I. N. et al. Cellular and molecular mechanisms of liver tolerance. Immunol. Rev. 213, 101-118 (2006).
    • (2006) Immunol. Rev , vol.213 , pp. 101-118
    • Crispe, I.N.1
  • 85
    • 0034614897 scopus 로고    scopus 로고
    • Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
    • Sauter, B. et al. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 191, 423-434 (2000).
    • (2000) J. Exp. Med , vol.191 , pp. 423-434
    • Sauter, B.1
  • 86
    • 46949084717 scopus 로고    scopus 로고
    • Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus
    • Yamaguchi, H. et al. Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus. J. Leukoc. Biol. 83, 1300-1307 (2008).
    • (2008) J. Leukoc. Biol , vol.83 , pp. 1300-1307
    • Yamaguchi, H.1
  • 87
    • 33744971173 scopus 로고    scopus 로고
    • Inefficient clearance of dying cells and autoreactivity
    • Gaipl, U. S. et al. Inefficient clearance of dying cells and autoreactivity. Curr. Top. Microbiol. Immunol. 305, 161-176 (2006).
    • (2006) Curr. Top. Microbiol. Immunol , vol.305 , pp. 161-176
    • Gaipl, U.S.1
  • 88
    • 2442665179 scopus 로고    scopus 로고
    • Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    • This paper outlines the functional link between defective clearance of apoptotic cells and systemic autoimmune disease
    • Hanayama, R. et al. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 304, 1147-1150 (2004). This paper outlines the functional link between defective clearance of apoptotic cells and systemic autoimmune disease.
    • (2004) Science , vol.304 , pp. 1147-1150
    • Hanayama, R.1
  • 89
    • 36248944555 scopus 로고    scopus 로고
    • Identification of Tim4 as a phosphatidylserine receptor
    • Miyanishi, M. et al. Identification of Tim4 as a phosphatidylserine receptor. Nature 450, 435-439 (2007).
    • (2007) Nature , vol.450 , pp. 435-439
    • Miyanishi, M.1
  • 90
    • 36448961645 scopus 로고    scopus 로고
    • Engulfment of apoptotic cells: Signals for a good meal
    • Ravichandran, K. S. & Lorenz, U. Engulfment of apoptotic cells: signals for a good meal. Nature Rev. Immunol. 7, 964-974 (2007).
    • (2007) Nature Rev. Immunol , vol.7 , pp. 964-974
    • Ravichandran, K.S.1    Lorenz, U.2
  • 91
    • 33748501056 scopus 로고    scopus 로고
    • Requirements for apoptotic cell contact in regulation of macrophage responses
    • Lucas, M. et al. Requirements for apoptotic cell contact in regulation of macrophage responses. J. Immunol. 177, 4047-4054 (2006).
    • (2006) J. Immunol , vol.177 , pp. 4047-4054
    • Lucas, M.1
  • 92
    • 2942581328 scopus 로고    scopus 로고
    • Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain
    • Ricci, J. E. et al. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell 117, 773-786 (2004).
    • (2004) Cell , vol.117 , pp. 773-786
    • Ricci, J.E.1
  • 93
    • 37049031230 scopus 로고    scopus 로고
    • Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    • This is a detailed study on the mechanistic link between phagocytosis of dying cells and the production of immunosuppressive cytokines by macrophages
    • Chung, E. Y. et al. Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity 27, 952-964 (2007). This is a detailed study on the mechanistic link between phagocytosis of dying cells and the production of immunosuppressive cytokines by macrophages.
    • (2007) Immunity , vol.27 , pp. 952-964
    • Chung, E.Y.1
  • 94
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
    • Fadok, V. A. et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF. J. Clin. Invest. 101, 890-898 (1998).
    • (1998) J. Clin. Invest , vol.101 , pp. 890-898
    • Fadok, V.A.1
  • 95
    • 0031454570 scopus 로고    scopus 로고
    • Immunosuppressive effects of apoptotic cells
    • Voll, R. E. et al. Immunosuppressive effects of apoptotic cells. Nature 390, 350-351 (1997).
    • (1997) Nature , vol.390 , pp. 350-351
    • Voll, R.E.1
  • 96
    • 30044449982 scopus 로고    scopus 로고
    • Resolution of inflammation: The beginning programs the end
    • Serhan, C. N. & Savill, J. Resolution of inflammation: the beginning programs the end. Nature Immunol. 6, 1191-1197 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 1191-1197
    • Serhan, C.N.1    Savill, J.2
  • 97
    • 0036143018 scopus 로고    scopus 로고
    • Phosphatidylserine- dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation
    • Huynh, M. L., Fadok, V. A. & Henson, P. M. Phosphatidylserine- dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation. J. Clin. Invest. 109, 41-50 (2002).
    • (2002) J. Clin. Invest , vol.109 , pp. 41-50
    • Huynh, M.L.1    Fadok, V.A.2    Henson, P.M.3
  • 98
    • 0034642522 scopus 로고    scopus 로고
    • Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages
    • Freire-de-Lima, C. G. et al. Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages. Nature 403, 199-203 (2000).
    • (2000) Nature , vol.403 , pp. 199-203
    • Freire-de-Lima, C.G.1
  • 99
    • 12444275550 scopus 로고    scopus 로고
    • Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo
    • Hoffmann, P. R. et al. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J. Immunol. 174, 1393-1404 (2005).
    • (2005) J. Immunol , vol.174 , pp. 1393-1404
    • Hoffmann, P.R.1
  • 100
    • 0032494144 scopus 로고    scopus 로고
    • Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis
    • Gao, Y., Herndon, J. M., Zhang, H., Griffith, T. S. & Ferguson, T. A. Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis. J. Exp. Med. 188, 887-896 (1998).
    • (1998) J. Exp. Med , vol.188 , pp. 887-896
    • Gao, Y.1    Herndon, J.M.2    Zhang, H.3    Griffith, T.S.4    Ferguson, T.A.5
  • 101
    • 0034960320 scopus 로고    scopus 로고
    • TGF-β released by apoptotic T cells contributes to an immunosuppressive milieu
    • Chen, W., Frank, M. E., Jin, W. & Wahl, S. M. TGF-β released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 14, 715-725 (2001).
    • (2001) Immunity , vol.14 , pp. 715-725
    • Chen, W.1    Frank, M.E.2    Jin, W.3    Wahl, S.M.4
  • 102
    • 29844432142 scopus 로고    scopus 로고
    • Intravenous apoptotic spleen cell infusion induces a TGF-β-dependent regulatory T-cell expansion
    • Kleinclauss, F. et al. Intravenous apoptotic spleen cell infusion induces a TGF-β-dependent regulatory T-cell expansion. Cell Death Differ. 13, 41-52 (2006).
    • (2006) Cell Death Differ , vol.13 , pp. 41-52
    • Kleinclauss, F.1
  • 103
    • 18644372264 scopus 로고    scopus 로고
    • Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigenspecific regulatory T cells
    • Maeda, A. et al. Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigenspecific regulatory T cells. J. Immunol. 174, 5968-5976 (2005).
    • (2005) J. Immunol , vol.174 , pp. 5968-5976
    • Maeda, A.1
  • 104
    • 61949472508 scopus 로고    scopus 로고
    • Torchinsky, M. B., Garaude, J., Martin, A. & Blander, J. M. Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation. Nature 458, 78-82 (2009). This paper shows that engulfment of apoptotic cells by DCs induces TReg or T helper 17 cells, depending on additional signals that are relevant to infection.
    • Torchinsky, M. B., Garaude, J., Martin, A. & Blander, J. M. Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation. Nature 458, 78-82 (2009). This paper shows that engulfment of apoptotic cells by DCs induces TReg or T helper 17 cells, depending on additional signals that are relevant to infection.
  • 105
    • 8444249576 scopus 로고    scopus 로고
    • The acquired immune system: A vantage from beneath
    • Hedrick, S. M. The acquired immune system: a vantage from beneath. Immunity 21, 607-615 (2004).
    • (2004) Immunity , vol.21 , pp. 607-615
    • Hedrick, S.M.1
  • 106
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • Shi, Y., Evans, J. E. & Rock, K. L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425, 516-521 (2003).
    • (2003) Nature , vol.425 , pp. 516-521
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 107
    • 50549100499 scopus 로고    scopus 로고
    • Pattern recognition receptors in the immune response against dying cells
    • Jeannin, P., Jaillon, S. & Delneste, Y. Pattern recognition receptors in the immune response against dying cells. Curr. Opin. Immunol. 20, 530-537 (2008).
    • (2008) Curr. Opin. Immunol , vol.20 , pp. 530-537
    • Jeannin, P.1    Jaillon, S.2    Delneste, Y.3
  • 109
    • 34548444551 scopus 로고    scopus 로고
    • Di Virgilio, F. Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol. Sci. 28, 465-472 (2007).
    • Di Virgilio, F. Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol. Sci. 28, 465-472 (2007).
  • 110
    • 51149097174 scopus 로고    scopus 로고
    • The forward genetic dissection of afferent innate immunity
    • Beutler, B. & Moresco, E. M. The forward genetic dissection of afferent innate immunity. Curr. Top. Microbiol. Immunol. 321, 3-26 (2008).
    • (2008) Curr. Top. Microbiol. Immunol , vol.321 , pp. 3-26
    • Beutler, B.1    Moresco, E.M.2
  • 111
    • 34250753161 scopus 로고    scopus 로고
    • Cell death modalities: Classification and pathophysiological implications
    • Galluzzi, L. et al. Cell death modalities: classification and pathophysiological implications. Cell Death Differ. 14, 1237-1243 (2007).
    • (2007) Cell Death Differ , vol.14 , pp. 1237-1243
    • Galluzzi, L.1
  • 112
    • 33749178260 scopus 로고    scopus 로고
    • Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response
    • Festjens, N., Vanden Berghe, T. & Vandenabeele, P. Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim. Biophys. Acta 1757, 1371-1387 (2006).
    • (2006) Biochim. Biophys. Acta , vol.1757 , pp. 1371-1387
    • Festjens, N.1    Vanden Berghe, T.2    Vandenabeele, P.3
  • 113
    • 33846018602 scopus 로고    scopus 로고
    • Cell death by necrosis: Towards a molecular definition
    • Golstein, P. & Kroemer, G. Cell death by necrosis: towards a molecular definition. Trends Biochem. Sci. 32, 37-43 (2007).
    • (2007) Trends Biochem. Sci , vol.32 , pp. 37-43
    • Golstein, P.1    Kroemer, G.2
  • 115
    • 38049123476 scopus 로고    scopus 로고
    • Clearance of apoptotic cells by phagocytes
    • Erwig, L. P. & Henson, P. M. Clearance of apoptotic cells by phagocytes. Cell Death Differ. 15, 243-250 (2008).
    • (2008) Cell Death Differ , vol.15 , pp. 243-250
    • Erwig, L.P.1    Henson, P.M.2
  • 116
    • 58149398634 scopus 로고    scopus 로고
    • CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis
    • Truman, L. A. et al. CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood 112, 5026-5036 (2008).
    • (2008) Blood , vol.112 , pp. 5026-5036
    • Truman, L.A.1
  • 117
    • 36849080928 scopus 로고    scopus 로고
    • Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages
    • Miksa, M., Amin, D., Wu, R., Ravikumar, T. S. & Wang, P. Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages. Mol. Med. 13, 553-560 (2007).
    • (2007) Mol. Med , vol.13 , pp. 553-560
    • Miksa, M.1    Amin, D.2    Wu, R.3    Ravikumar, T.S.4    Wang, P.5
  • 118
    • 0037062989 scopus 로고    scopus 로고
    • Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
    • Brown, S. et al. Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment. Nature 418, 200-203 (2002).
    • (2002) Nature , vol.418 , pp. 200-203
    • Brown, S.1
  • 119
    • 26844468253 scopus 로고    scopus 로고
    • Cell-surface calreticulin initiates clearance of viable or apoptotic cells through transactivation of LRP on the phagocyte
    • Gardai, S. J. et al. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through transactivation of LRP on the phagocyte. Cell 123, 321-334 (2005).
    • (2005) Cell , vol.123 , pp. 321-334
    • Gardai, S.J.1
  • 120
    • 0028800947 scopus 로고
    • Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
    • Martin, S. J. et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182, 1545-1556 (1995).
    • (1995) J. Exp. Med , vol.182 , pp. 1545-1556
    • Martin, S.J.1
  • 121
    • 34247890161 scopus 로고    scopus 로고
    • Changing story of the receptor for phosphatidylserine-dependent clearance of apoptotic cells
    • 465-469
    • Wolf, A., Schmitz, C. & Bottger, A. Changing story of the receptor for phosphatidylserine-dependent clearance of apoptotic cells. EMBO Rep. 8, 465-469 (2007).
    • (2007) EMBO Rep , vol.8
    • Wolf, A.1    Schmitz, C.2    Bottger, A.3
  • 122
    • 0037046580 scopus 로고    scopus 로고
    • Identification of a factor that links apoptotic cells to phagocytes
    • Hanayama, R. et al. Identification of a factor that links apoptotic cells to phagocytes. Nature 417, 182-187 (2002).
    • (2002) Nature , vol.417 , pp. 182-187
    • Hanayama, R.1
  • 123
    • 0037390598 scopus 로고    scopus 로고
    • Annexin I is an endogenous ligand that mediates apoptotic cell engulfment
    • Arur, S. et al. Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Dev. Cell 4, 587-598 (2003).
    • (2003) Dev. Cell , vol.4 , pp. 587-598
    • Arur, S.1
  • 124
    • 41249092199 scopus 로고    scopus 로고
    • Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-κB transcriptional activation
    • Tibrewal, N. et al. Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-κB transcriptional activation. J. Biol. Chem. 283, 3618-3627 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 3618-3627
    • Tibrewal, N.1


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