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Volumn 20, Issue 4, 2008, Pages 401-407

Antimicrobial peptides and self-DNA in autoimmune skin inflammation

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; INTERFERON; INTERLEUKIN 17; INTERLEUKIN 22; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; VIRUS DNA; VIRUS RNA;

EID: 48549088455     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2008.06.008     Document Type: Review
Times cited : (163)

References (55)
  • 1
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 2
    • 17644372733 scopus 로고    scopus 로고
    • IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • Liu Y.J. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 23 (2005) 275-306
    • (2005) Annu Rev Immunol , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 3
    • 34948862264 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    • This paper demonstrates that the endogenous antimicrobial peptide LL37 breaks innate tolerance to self-DNA and launches TLR9 activation of pDCs in psoriasis.
    • Lande R., Gregorio J., Facchinetti V., Chatterjee B., Wang Y.H., Homey B., Cao W., Wang Y.H., Su B., Nestle F.O., et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449 (2007) 564-569. This paper demonstrates that the endogenous antimicrobial peptide LL37 breaks innate tolerance to self-DNA and launches TLR9 activation of pDCs in psoriasis.
    • (2007) Nature , vol.449 , pp. 564-569
    • Lande, R.1    Gregorio, J.2    Facchinetti, V.3    Chatterjee, B.4    Wang, Y.H.5    Homey, B.6    Cao, W.7    Wang, Y.H.8    Su, B.9    Nestle, F.O.10
  • 4
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
    • Kadowaki N., Ho S., Antonenko S., Malefyt R.W., Kastelein R.A., Bazan F., and Liu Y.J. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 194 (2001) 863-869
    • (2001) J Exp Med , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3    Malefyt, R.W.4    Kastelein, R.A.5    Bazan, F.6    Liu, Y.J.7
  • 5
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold S.S., Kaisho T., Hemmi H., Akira S., and Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303 (2004) 1529-1531
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 10
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • This study first demonstrated that prolonged TLR9 activation in early endocytic compartments is required for robust type I IFN production by pDCs.
    • Honda K., Ohba Y., Yanai H., Negishi H., Mizutani T., Takaoka A., Taya C., and Taniguchi T. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434 (2005) 1035-1040. This study first demonstrated that prolonged TLR9 activation in early endocytic compartments is required for robust type I IFN production by pDCs.
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1    Ohba, Y.2    Yanai, H.3    Negishi, H.4    Mizutani, T.5    Takaoka, A.6    Taya, C.7    Taniguchi, T.8
  • 13
    • 0033081259 scopus 로고    scopus 로고
    • Type I interferons keep activated T cells alive
    • Marrack P., Kappler J., and Mitchell T. Type I interferons keep activated T cells alive. J Exp Med 189 (1999) 521-530
    • (1999) J Exp Med , vol.189 , pp. 521-530
    • Marrack, P.1    Kappler, J.2    Mitchell, T.3
  • 14
    • 0030036342 scopus 로고    scopus 로고
    • Induction of bystander T cell proliferation by viruses and type I interferon in vivo
    • Tough D.F., Borrow P., and Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272 (1996) 1947-1950
    • (1996) Science , vol.272 , pp. 1947-1950
    • Tough, D.F.1    Borrow, P.2    Sprent, J.3
  • 15
    • 11844268647 scopus 로고    scopus 로고
    • The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions
    • Gerosa F., Gobbi A., Zorzi P., Burg S., Briere F., Carra G., and Trinchieri G. The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions. J Immunol 174 (2005) 727-734
    • (2005) J Immunol , vol.174 , pp. 727-734
    • Gerosa, F.1    Gobbi, A.2    Zorzi, P.3    Burg, S.4    Briere, F.5    Carra, G.6    Trinchieri, G.7
  • 16
    • 0041429619 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    • Jego G., Palucka A.K., Blanck J.P., Chalouni C., Pascual V., and Banchereau J. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 19 (2003) 225-234
    • (2003) Immunity , vol.19 , pp. 225-234
    • Jego, G.1    Palucka, A.K.2    Blanck, J.P.3    Chalouni, C.4    Pascual, V.5    Banchereau, J.6
  • 17
    • 34249782859 scopus 로고    scopus 로고
    • The origin of extracellular DNA during the clearance of dead and dying cells
    • Pisetsky D.S., and Fairhurst A.M. The origin of extracellular DNA during the clearance of dead and dying cells. Autoimmunity 40 (2007) 281-284
    • (2007) Autoimmunity , vol.40 , pp. 281-284
    • Pisetsky, D.S.1    Fairhurst, A.M.2
  • 19
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20 (2002) 709-760
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 20
    • 40249088259 scopus 로고    scopus 로고
    • The DNA sugar backbone 2′ deoxyribose determines toll-like receptor 9 activation
    • This paper shows that TLR9 recognizes the sugar backbone of natural DNA including self-DNA.
    • Haas T., Metzger J., Schmitz F., Heit A., Müller T., Latz E., and Wagner H. The DNA sugar backbone 2′ deoxyribose determines toll-like receptor 9 activation. Immunity 28 (2008) 315-323. This paper shows that TLR9 recognizes the sugar backbone of natural DNA including self-DNA.
    • (2008) Immunity , vol.28 , pp. 315-323
    • Haas, T.1    Metzger, J.2    Schmitz, F.3    Heit, A.4    Müller, T.5    Latz, E.6    Wagner, H.7
  • 23
    • 33947134377 scopus 로고    scopus 로고
    • Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    • Lee H.K., Lund J.M., Ramanathan B., Mizushima N., and Iwasaki A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315 (2007) 1398-1401
    • (2007) Science , vol.315 , pp. 1398-1401
    • Lee, H.K.1    Lund, J.M.2    Ramanathan, B.3    Mizushima, N.4    Iwasaki, A.5
  • 24
    • 29244450802 scopus 로고    scopus 로고
    • Intracellular localization of Toll-like receptor 9 prevents recognition of self-DNA but facilitates access to viral DNA
    • This paper demonstrates that the intracellular location of TLR9 represents a barrier that prevents recognition of self-DNA.
    • Barton G.M., Kagan J.C., and Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self-DNA but facilitates access to viral DNA. Nat Immunol 7 (2006) 49-56. This paper demonstrates that the intracellular location of TLR9 represents a barrier that prevents recognition of self-DNA.
    • (2006) Nat Immunol , vol.7 , pp. 49-56
    • Barton, G.M.1    Kagan, J.C.2    Medzhitov, R.3
  • 25
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat F.J., Meeker T., Gregorio J., Chan J.H., Uematsu S., Akira S., Chang B., Duramad O., and Coffman R.L. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 202 (2005) 1131-1139
    • (2005) J Exp Med , vol.202 , pp. 1131-1139
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3    Chan, J.H.4    Uematsu, S.5    Akira, S.6    Chang, B.7    Duramad, O.8    Coffman, R.L.9
  • 26
    • 18644383289 scopus 로고    scopus 로고
    • Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways
    • Yasuda K., Yu P., Kirschning C.J., Schlatter B., Schmitz F., Heit A., Bauer S., Hochrein H., and Wagner H. Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J Immunol 174 (2005) 6129-6136
    • (2005) J Immunol , vol.174 , pp. 6129-6136
    • Yasuda, K.1    Yu, P.2    Kirschning, C.J.3    Schlatter, B.4    Schmitz, F.5    Heit, A.6    Bauer, S.7    Hochrein, H.8    Wagner, H.9
  • 27
    • 10744221686 scopus 로고    scopus 로고
    • Role of natural interferon-alpha producing cells (plasmacytoid dendritic cells) in autoimmunity
    • Ronnblom L., Eloranta M.L., and Alm G.V. Role of natural interferon-alpha producing cells (plasmacytoid dendritic cells) in autoimmunity. Autoimmunity 36 (2003) 463-472
    • (2003) Autoimmunity , vol.36 , pp. 463-472
    • Ronnblom, L.1    Eloranta, M.L.2    Alm, G.V.3
  • 28
    • 85047693371 scopus 로고    scopus 로고
    • Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    • Means T.K., Latz E., Hayashi F., Murali M.R., Golenbock D.T., and Luster A.D. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Investig 115 (2005) 407-417
    • (2005) J Clin Investig , vol.115 , pp. 407-417
    • Means, T.K.1    Latz, E.2    Hayashi, F.3    Murali, M.R.4    Golenbock, D.T.5    Luster, A.D.6
  • 29
    • 0035900481 scopus 로고    scopus 로고
    • Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus
    • Blanco P., Palucka A.K., Gill M., Pascual V., and Banchereau J. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 294 (2001) 1540-1543
    • (2001) Science , vol.294 , pp. 1540-1543
    • Blanco, P.1    Palucka, A.K.2    Gill, M.3    Pascual, V.4    Banchereau, J.5
  • 30
    • 33847279025 scopus 로고    scopus 로고
    • Pathogenesis and therapy of psoriasis
    • Lowes M.A., Bowcock A.M., and Krueger J.G. Pathogenesis and therapy of psoriasis. Nature 445 (2007) 866-873
    • (2007) Nature , vol.445 , pp. 866-873
    • Lowes, M.A.1    Bowcock, A.M.2    Krueger, J.G.3
  • 31
    • 22344438901 scopus 로고    scopus 로고
    • Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production
    • This study demonstrates that pDCs in psoriatic skin initiate autoimmune skin inflammation and disease formation through the production of type I IFNs.
    • Nestle F.O., Conrad C., Tun-Kyi A., Homey B., Gombert M., Boyman O., Burg G., Liu Y.J., and Gilliet M. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med 202 (2005) 135-143. This study demonstrates that pDCs in psoriatic skin initiate autoimmune skin inflammation and disease formation through the production of type I IFNs.
    • (2005) J Exp Med , vol.202 , pp. 135-143
    • Nestle, F.O.1    Conrad, C.2    Tun-Kyi, A.3    Homey, B.4    Gombert, M.5    Boyman, O.6    Burg, G.7    Liu, Y.J.8    Gilliet, M.9
  • 33
    • 0033635304 scopus 로고    scopus 로고
    • CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling
    • Hida S., Ogasawara K., Sato K., Abe M., Takayanagi H., Yokochi T., Sato T., Hirose S., Shirai T., Taki S., et al. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling. Immunity 13 (2000) 643-655
    • (2000) Immunity , vol.13 , pp. 643-655
    • Hida, S.1    Ogasawara, K.2    Sato, K.3    Abe, M.4    Takayanagi, H.5    Yokochi, T.6    Sato, T.7    Hirose, S.8    Shirai, T.9    Taki, S.10
  • 34
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 415 (2002) 389-395
    • (2002) Nature , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 35
    • 20544442905 scopus 로고    scopus 로고
    • Alarmins: chemotactic activators of immune responses
    • Oppenheim J.J., and Yang D. Alarmins: chemotactic activators of immune responses. Curr Opin Immunol 17 (2005) 359-365
    • (2005) Curr Opin Immunol , vol.17 , pp. 359-365
    • Oppenheim, J.J.1    Yang, D.2
  • 36
    • 0842326097 scopus 로고    scopus 로고
    • Cathelicidins, multifunctional peptides of the innate immunity
    • Zanetti M. Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol 75 (2004) 39-48
    • (2004) J Leukoc Biol , vol.75 , pp. 39-48
    • Zanetti, M.1
  • 37
    • 0034596945 scopus 로고    scopus 로고
    • LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells
    • De Y., Chen Q., Schmidt A.P., Anderson G.M., Wang J.M., Wooters J., Oppenheim J.J., and Chertov O. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 192 (2000) 1069-1074
    • (2000) J Exp Med , vol.192 , pp. 1069-1074
    • De, Y.1    Chen, Q.2    Schmidt, A.P.3    Anderson, G.M.4    Wang, J.M.5    Wooters, J.6    Oppenheim, J.J.7    Chertov, O.8
  • 38
    • 1842581655 scopus 로고    scopus 로고
    • A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release
    • Elssner A., Duncan M., Gavrilin M., and Wewers M.D. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J Immunol 172 (2004) 4987-4994
    • (2004) J Immunol , vol.172 , pp. 4987-4994
    • Elssner, A.1    Duncan, M.2    Gavrilin, M.3    Wewers, M.D.4
  • 39
    • 0034852301 scopus 로고    scopus 로고
    • Specific binding and stabilization of DNA and phosphorothioate DNA by amphiphilic alpha-helical peptides
    • Kubo T., and Fujii M. Specific binding and stabilization of DNA and phosphorothioate DNA by amphiphilic alpha-helical peptides. Nucleosides Nucleotides Nucleic Acids 20 (2001) 1313-1316
    • (2001) Nucleosides Nucleotides Nucleic Acids , vol.20 , pp. 1313-1316
    • Kubo, T.1    Fujii, M.2
  • 40
    • 2342520028 scopus 로고    scopus 로고
    • The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis
    • Sandgren S., Wittrup A., Cheng F., Jonsson M., Eklund E., Busch S., and Belting M. The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis. J Biol Chem 279 (2004) 17951-17956
    • (2004) J Biol Chem , vol.279 , pp. 17951-17956
    • Sandgren, S.1    Wittrup, A.2    Cheng, F.3    Jonsson, M.4    Eklund, E.5    Busch, S.6    Belting, M.7
  • 46
    • 0035877995 scopus 로고    scopus 로고
    • Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3
    • Sorensen O.E., Follin P., Johnsen A.H., Calafat J., Tjabringa G.S., Hiemstra P.S., and Borregaard N. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 97 (2001) 3951-3959
    • (2001) Blood , vol.97 , pp. 3951-3959
    • Sorensen, O.E.1    Follin, P.2    Johnsen, A.H.3    Calafat, J.4    Tjabringa, G.S.5    Hiemstra, P.S.6    Borregaard, N.7
  • 48
    • 34547660319 scopus 로고    scopus 로고
    • Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea [see comment]
    • This paper shows that increased serine protease activity results in increased levels of LL37 and derivatives, which are associated with skin inflammation in acne rosacea patients.
    • Yamasaki K., Di Nardo A., Bardan A., Murakami M., Ohtake T., Coda A., Dorschner R.A., Bonnart C., Descargues P., Hovnanian A., et al. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea [see comment]. Nat Med 13 (2007) 975-980. This paper shows that increased serine protease activity results in increased levels of LL37 and derivatives, which are associated with skin inflammation in acne rosacea patients.
    • (2007) Nat Med , vol.13 , pp. 975-980
    • Yamasaki, K.1    Di Nardo, A.2    Bardan, A.3    Murakami, M.4    Ohtake, T.5    Coda, A.6    Dorschner, R.A.7    Bonnart, C.8    Descargues, P.9    Hovnanian, A.10
  • 49
    • 0037335205 scopus 로고    scopus 로고
    • The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium
    • Heilborn J.D., Nilsson M.F., Kratz G., Weber G., Sorensen O., Borregaard N., and Stahle-Backdahl M. The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium. J Investig Dermatol 120 (2003) 379-389
    • (2003) J Investig Dermatol , vol.120 , pp. 379-389
    • Heilborn, J.D.1    Nilsson, M.F.2    Kratz, G.3    Weber, G.4    Sorensen, O.5    Borregaard, N.6    Stahle-Backdahl, M.7
  • 50
    • 0030956070 scopus 로고    scopus 로고
    • The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders
    • Frohm M., Agerberth B., Ahangari G., Stahle-Backdahl M., Liden S., Wigzell H., and Gudmundsson G.H. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 272 (1997) 15258-15263
    • (1997) J Biol Chem , vol.272 , pp. 15258-15263
    • Frohm, M.1    Agerberth, B.2    Ahangari, G.3    Stahle-Backdahl, M.4    Liden, S.5    Wigzell, H.6    Gudmundsson, G.H.7
  • 52
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • Liang S.C., Tan X.Y., Luxenberg D.P., Karim R., Dunussi-Joannopoulos K., Collins M., and Fouser L.A. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203 (2006) 2271-2279
    • (2006) J Exp Med , vol.203 , pp. 2271-2279
    • Liang, S.C.1    Tan, X.Y.2    Luxenberg, D.P.3    Karim, R.4    Dunussi-Joannopoulos, K.5    Collins, M.6    Fouser, L.A.7
  • 54
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng Y., Danilenko D.M., Valdez P., Kasman I., Eastham-Anderson J., Wu J., and Ouyang W. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445 (2007) 648-651
    • (2007) Nature , vol.445 , pp. 648-651
    • Zheng, Y.1    Danilenko, D.M.2    Valdez, P.3    Kasman, I.4    Eastham-Anderson, J.5    Wu, J.6    Ouyang, W.7


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