Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress

Nature Medicine

Volumn 14, Issue 8, 2008, Pages 828-836

  Bochkis, Irina M ^a   Rubins, Nir E ^a   White, Peter ^a   Furth, Emma E ^a   Friedman, Joshua R ^b   Kaestner, Klaus H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; BILE SALT; CHOLIC ACID; HEPATOCYTE NUCLEAR FACTOR 3BETA; WINGED HELIX TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIET; DISEASE EXACERBATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EXPERIMENTAL MOUSE; FOXA2 GENE; GENE; GENE DELETION; GENETIC TRANSCRIPTION; HOMEOSTASIS; HUMAN; HUMAN TISSUE; INTRAHEPATIC CHOLESTASIS; KNOCKOUT MOUSE; LIVER; LIVER CELL; LIVER INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE SECTION;

ANIMALS; BILE ACIDS AND SALTS; CHOLESTASIS, INTRAHEPATIC; ENDOPLASMIC RETICULUM; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUTATHIONE; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HEPATOCYTES; HOMEOSTASIS; HUMANS; LIVER; MICE;

MUS;

EID: 49149090637     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.1853     Document Type: Article

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