Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding

Journal of Biological Chemistry

Volumn 278, Issue 12, 2003, Pages 10028-10032

  Kassam, Altaf ^a   Miao, Bowman ^b   Young, Peter R ^c   Mukherjee, Ranjan ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b BRISTOL MYERS SQUIBB   (United States)

^c SUGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOASSAY; DNA; GENES; LIPIDS;

BILE ACIDS;

BIOCHEMISTRY;

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; 6 [1 (5,6,7,8 TETRAHYDRO 3,5,5,8,8 PENTAMETHYL 2 NAPHTHYL)CYCLOPROPYL]NICOTINIC ACID; BILE SALT; BILE SALT EXPORT PUMP; CELL RECEPTOR; CHENODEOXYCHOLIC ACID; FARNESOID X RECEPTOR; GENE PRODUCT; LIGAND; RETINOID X RECEPTOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCB11 PROTEIN, HUMAN; DNA; DNA BINDING PROTEIN; FARNESOID X-ACTIVATED RECEPTOR; NICOTINIC ACID DERIVATIVE; RETINOIC ACID RECEPTOR; TETRALIN DERIVATIVE; TRANSCRIPTION FACTOR;

ARTICLE; DNA BINDING; DNA RESPONSIVE ELEMENT; GENE EXPRESSION; GENE INDUCTION; HOMEOSTASIS; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR BINDING; CELL LINE; CHEMISTRY; DIMERIZATION; DRUG ANTAGONISM; GENETICS; METABOLISM; PHYSIOLOGY; PROMOTER REGION;

RODENTIA;

ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; DIMERIZATION; DNA; DNA-BINDING PROTEINS; HUMANS; NICOTINIC ACIDS; PROMOTER REGIONS (GENETICS); RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RESPONSE ELEMENTS; RETINOID X RECEPTORS; TETRAHYDRONAPHTHALENES; TRANSCRIPTION FACTORS;

EID: 0038701656     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208312200     Document Type: Article

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