A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 2,3-disubstituted-4-phenylquinolines

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 3, 2000, Pages 277-279

  Tollefson, Michael B ^a   Vernier, William F ^a   Huang, Horng Chih ^a   Chen, Fang Ping ^a   Reinhard, Emily J ^a   Beaudry, Judith ^a   Keller, Bradley T ^a   Reitz, David B ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYLQUINOLINE DERIVATIVE; COMPLEMENTARY DNA; DRUG ANALOG; QUINOLINE DERIVATIVE; SODIUM DEPENDENT BILE ACID TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; DRUG SYNTHESIS; HAMSTER; HUMAN; IN VITRO STUDY; NONHUMAN;

CARRIER PROTEINS; HYDROXYSTEROID DEHYDROGENASES; MEMBRANE GLYCOPROTEINS; MOLECULAR STRUCTURE; QUINOLINES; SODIUM;

ANIMALIA; CRICETINAE;

EID: 0034615121     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00683-6     Document Type: Article

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9. 2. After the incubation period, the plates were decanted and each well washed twice with ice-cold phosphate-buffered saline (PBS) containing 0.1% fatty-acid free BSA followed by one time with straight PBS. Each well received 200 μL Microscint-20 and a clear plastic heat seal was placed over the top of the plate. The radioactivity in each well was counted in a Packard TopCount scintillation counter.