Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity

Journal of Pharmacology and Experimental Therapeutics

Volumn 291, Issue 3, 1999, Pages 1204-1209

  Kim, Richard B ^a   Leake, Brenda ^a   Cvetkovic, Mirjana ^a   Roden, Mark M ^a   Nadeau, Jessica ^a   Walubo, Andrew ^a   Wilkinson, Grant R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; CARRIER PROTEIN; CYCLOSPORIN; LIDOCAINE; MESSENGER RNA; PROGESTERONE; PROPRANOLOL; QUINIDINE; TAUROCHOLIC ACID;

ADOLESCENT; ADULT; ARTICLE; BILE FLOW; DRUG PROTEIN BINDING; DRUG UPTAKE; FEMALE; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MALE; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SCHOOL CHILD;

BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CELLS, CULTURED; HELA CELLS; HUMANS; KINETICS; LIVER; NICOTINE; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PLASMIDS; RNA, MESSENGER; SALICYLATES; SYMPORTERS; VACCINIA VIRUS; VALPROIC ACID;

EID: 0032732615     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Arias IM (1993) Cyclosporin, the biology of the bile canaliculus, and cholestasis. Gastroenterology 104:1558-1560.
2. Azer SA and Stacey NH (1993) Cyclosporine-induced interference with uptake of bile acids by human hepatocytes. Transplant Proc 26:2892-2893.
3. Blakely RD, Clark JA, Rudnick G and Amara SG (1991) Vaccinia-T7 RNA polymerase expression system: Evaluation for the expression cloning of plasma membrane transporters. Anal Biochem 194:302-308.
4. +-dependent bile acid uptake by albumin: Direct demonstration in rat basolateral liver plasma membrane vesicles. Am J Physiol 249:G34-G38.
5. +-coupled ion transport on bile acid uptake by isolated rat hepatocytes. Am J Physiol 243:G48-G53.
6. Bouscarel B, Nussbaum R, Dubner H and Fromm H (1995) The role of sodium in the uptake of ursodeoxycholic acid in isolated hamster hepatocytes. Hepatology 21: 145-154.
7. + bile acid cotransport system in COS-7 cells. Am J Physiol 268:G382-G387.
8. Cardarelli CO, Aksentijevich I, Pastan I and Gottesman MM (1995) Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters. Cancer Res 55:1086-1091.
9. de Vree JM, Jacquemin E, Sturm E, Cresteil D, Bosma PJ, Aten J, Deleuze J-F, Desrochers M, Burdelski M, Bernard O, Oude Elferinck RP and Hadchouel M (1998) Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. Proc Natl Acad Sci USA 95:282-287.
10. Fromm MF, Kim RB, Stein CM, Wilkinson GR and Roden DM (1999) Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine. Circulation 99:552-557.
11. Galle PR, Theilmann L, Raedsch R, Otto G and Stiehl A (1990) Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes. Hepatology 12:486-491.
12. +/bile acid cotransporter. J Clin Invest 93:1326-1331.
13. Hagenbuch B, Scharschmidt BF and Meier PJ (1996) Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laeuis oocytes. Biochem J 316:901-904.
14. +/bile acid cotransport system. Proc Natl Acad Sci USA 88:10629-10633.
15. Heuman DM (1993) Hepatoprotective properties of ursodeoxycholic acid. Gastroenterology 104:1865-1870.
16. Leu B-L and Huang J-D (1995) Inhibition of intestinal P-glycoprotein and effects on etoposide absorption. Cancer Chemother Pharmacol 36:432-436.
17. +-TC cotransport. Am J Physiol 268:G11-G17.
18. Moseley RH, Johnson TR and Morrissette JM (1990) Inhibition of bile acid transport by cyclosporine A in rat liver plasma membrane vesicles. J Pharmacol Exp Ther 253:974-980.
19. Ostrow JD (1993) Metabolism of bile salts in cholestasis in humans, in Hepatic Transport and Bile Secretion (Tavoloni N and Berk PD eds) pp 673-712, Raven Press, New York.
20. Poupon R and Poupon RE (1995) Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children. Pharmacol Ther 66:1-15.
21. Scharschmidt BF and Lake JR (1989) Hepatocellular bile acid transport and uraodeoxycholic acid hypercholeresis. Dig Dis Sci 34:5S-15S.
22. Stacey NH and Kotecka B (1988) Inhibition of taurocholate and ouabain transport in isolated rat hepatocytes by cyclosporin A. Gastroenterology 95:780-786.
23. Stieger B and Meier PJ (1998) Bile acid and xenobiotic transporters in liver. Curr Opin Cell Biol 10:462-467.
24. Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, Sokal E, Dahan K, Childs S, Ling V, Tanner MS, Kagalwalla AF, Németh A, Pawlowska J, Baker A, Mieli-Vergani G, Freimer NB, Gardiner RM and Thompson RJ (1998) A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat Genet 20:233-238.
25. Trauner M, Meier PJ and Boyer JL (1998) Mechanisms of disease: Molecular pathogenesis of cholestasis. N Engl J Med 339:1217-1227.
26. +-dependent taurocholate uptake in basolateral (sinusoidal) rat liver plasma membrane vesicles. J Pharmacol Exp Ther 250:301-308.