Diminished gene expression of ileal apical sodium bile acid transporter explains impaired absorption of bile acid in patients with hypertriglyceridemia

Journal of Lipid Research

Volumn 41, Issue 9, 2000, Pages 1384-1389

  Duane, William C ^a,b   Hartich, Linda A ^a,b   Bartman, Allen E ^a,b   Ho, Samuel B ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Atherosclerosis; Bile acids and salts; Cholelithiasis; Cholesterol; Triglycerides

Indexed keywords

BILE ACID;

ADULT; AGED; APICAL MEMBRANE; ARTICLE; BILE ACID METABOLISM; BILE SECRETION; BRUSH BORDER; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; COLONOSCOPY; FAMILIAL DISEASE; FEMALE; GENE EXPRESSION; HUMAN; HYPERTRIGLYCERIDEMIA; ILEUM MUCOSA; INTESTINE ABSORPTION; LIPID BLOOD LEVEL; MALE; PRIORITY JOURNAL; SODIUM TRANSPORT;

AGED; BILE ACIDS AND SALTS; BIOPSY; CARRIER PROTEINS; CHOLESTEROL; CHOLESTEROL, LDL; COLONOSCOPY; HUMANS; HYPERTRIGLYCERIDEMIA; ILEUM; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PROTEIN BIOSYNTHESIS; SYMPORTERS; TRANSCRIPTION, GENETIC; TRIGLYCERIDES;

EID: 0033797032     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Bile acid metabolism in hereditary forms of hypertriglyceridemia: Evidence for an increased synthesis rate in monogenic familial hypertriglyceridemia
2. Abnormal bile acid absorption in familial hypertriglyceridemia
3. Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia
4. Effects of interruption of the enterohepatic circulation of bile acids on the transport of very low density-lipoprotein triglycerides
5. Interruption of the enterohepatic circulation of bile acids in man: Comparative effects of cholestyramine and ileal exclusion on cholesterol metabolism
6. Bile acid sequestrants: Mechanisms of action on bile acid and cholesterol metabolism
7. Effects of low dose chenodeoxycholic acid feeding on biliary lipid metabolism
8. Triglyceride-lowering effect of chenodeoxycholic acid in patients with endogenous hypertriglyceridemia
9. Effects of cholestyramine and chenodeoxycholic acid on the metabolism of endogenous triglyceride in hyperlipoproteinemia
10. National Cooperative Gallstone Study: The effect of chenodeoxycholic acid on lipoproteins and apolipoproteins
11. Effect of cholic acid feeding on bile acid kinetics and neutral fecal steroid excretion in hyperlipoproteinemia (types II and IV)
12. Franco-Belgian cooperative study of ursodeoxycholic acid in the medical dissolution of gallstones: A double-blind, randomized, dose-response study and comparison with chenodeoxycholic acid
13. Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity
14. Localization of the ileal sodium-bile acid cotransporter gene (SLCl0A2) to human chromosome 13q33
15. Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)
16. Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter
17. Aberrant expression of MUC5AC and MUC6 gastric mucin genes in colorectal polyps
18. A study of mitochondrial and nuclear transcription with cloned cDNA probes
19. Rabbit small intestinal brush border membrane preparation and lipid composition
20. Bile acids suppress the secretion of very-low-density lipoprotein by human hepatocytes in primary culture
21. Bile adds inhibit secretion of very low density lipoprotein by rat hepatocytes
22. Coordinate regulation of bile acid biosynthetic and recovery pathways
23. Downregulation of taurocholate transport by ileal BBM and liver BLM in biliary-diverted rats
24. Neither intestinal sequestration of bile acids nor common bile duct ligation modulate the expression and function of the rat ileal bile acid transporter
25. Negative feedback regulation of the ileal bile acid transport system in rodents
26. Induction of sodium-dependent bile acid transporter messenger RNA, protein and activity in rat ileum by cholic acid