Analysis of the in vivo functions of Mrp3

Molecular Pharmacology

Volumn 68, Issue 1, 2005, Pages 160-168

  Belinsky, Martin G ^a   Dawson, Paul A ^b   Shchaveleva, Irina ^a   Bain, Lisa J ^c   Wang, Renxue ^d   Ling, Victor ^d   Chen, Zhe Sheng ^a,f   Grinberg, Alex ^e   Westphal, Heiner ^e   Klein Szanto, Andres ^a   Lerro, Anthony ^a   Kruh, Gary D ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS AT EL PASO   (United States)

^d BRITISH COLUMBIA CANCER AGENCY   (Canada)

^e EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^f ST JOHN'S UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; BILE ACID; ETOPOSIDE; GLUCURONIC ACID; MULTIDRUG RESISTANCE PROTEIN 3;

ANIMAL CELL; ARTICLE; BILE DUCT LIGATION; BILE FLOW; BILIRUBIN BLOOD LEVEL; CHOLESTASIS; CONTROLLED STUDY; DRUG TRANSPORT; EMBRYO; EMBRYO CELL; ENTEROHEPATIC CIRCULATION; HOMOZYGOSITY; IN VIVO STUDY; INTESTINE; KIDNEY CELL; LIPOPHILICITY; LIVER CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROBABILITY; PROTEIN ANALYSIS; SEQUENCE HOMOLOGY; WILD TYPE;

ANIMALS; BILE ACIDS AND SALTS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOPOSIDE; FEMALE; GENE SILENCING; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANOPHOSPHORUS COMPOUNDS; PREGNANCY;

EID: 22344446049     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.010587     Document Type: Article

References (49)

1. Belinsky MG, Bain LJ, Balsara BB, Testa JR, and Kruh GD (1998) Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. J Natl Cancer Inst 90:1735-1741.
2. Bohan A, Chen WS, Denson LA, Held MA, and Boyer JL (2003) Tumor necrosis factor α-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis. J Biol Chem 278:36688-36698.
3. Chen F, Ma L, Dawson PA, Sinal CJ, Sehayek E, Gonzalez FJ, Breslow J, Ananthanarayanan M, and Shneider BL (2003) Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J Biol Chem 278:19909-19916.
4. Chen Z-S, Lee K, and Kruh GD (2001) Transport of cyclic nucleotides and estradiol 17-β-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. J Biol Chem 276:33747-33754.
5. Cui Y, Konig J, Buchholz JK, Spring H, Leier I, and Keppler D (1999) Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 55:929-937.
6. Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, and Ballatori N (2005) The heteromeric organic solute transporter α-β, Ostα-Ostβ, is an ileal basolateral bile acid transporter. J Biol Chem 280:6960-6968.
7. Denk GU, Soroka CJ, Takeyama Y, Chen WS, Schuetz JD, and Boyer JL (2004) Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. J Hepatol 40:585-591.
8. Donner MG and Keppler D (2001) Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver. Hepatology 34:351-359.
9. Gerk PM and Vore M (2002) Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. J Pharmacol Exp Ther 302:407-415.
10. Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF, and Meier PJ (1998) The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 273:10046-10050.
11. Grober J, Zaghini I, Fujii H, Jones SA, Kliewer SA, Willson TM, Ono T, and Besnard P (1999) Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. J Biol Chem 274:29749-29754.
12. Hirohashi T, Suzuki H, Ito K, Ogawa K, Kume K, Shimizu T, and Sugiyama Y (1998) Hepatic expression of multidrug resistance-associated protein-like proteins maintained in Eisai hyperbilirubinemic rats. Mol Pharmacol 53:1068-1075.
13. Hirohashi T, Suzuki H, and Sugiyama Y (1999) Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3). J Biol Chem 274:15181-15185.
14. Hirohashi T, Suzuki H, Takikawa H, and Sugiyama Y (2000) ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J Biol Chem 275:2905-2910.
15. Inokuchi A, Hinoshita E, Iwamoto Y, Kohno K, Kuwano M, and Uchiumi T (2001) Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes: a transcriptional control of a plausible bile acid transporter. J Biol Chem 276:46822-46829.
16. Johnson DR, Finch RA, Lin ZP, Zeiss CJ, and Sartorelli AC (2001) The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice. Cancer Res 61:1469-1476.
17. Konig J, Rost D, Cui Y, and Keppler D (1999) Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology 29:1156-1163.
18. Kool M, van der Linden M, de Haas M, Scheffer GL, de Vree JM, Smith AJ, Jansen G, Peters GJ, Ponne N, Scheper RJ, et al. (1999) MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc Natl Acad Sci USA 96:6914-6919.
19. Kruh GD and Belinsky MG (2003) The MRP family of drug efflux pumps. Oncogene 22:7537-7552.
20. Laupeze B, Amiot L, Payen L, Drenou B, Grosset JM, Lehne G, Fauchet R, and Fardel O (2001) Multidrug resistance protein (MRP) activity in normal mature leukocytes and CD34-positive hematopoietic cells from peripheral blood. Life Sci 68:1323-1331.
21. Lee YM, Cui Y, Konig J, Risch A, Jager B, Drings P, Bartsch H, Keppler D, and Nies AT (2004) Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3). Pharmacogenetics 14:213-223.
22. Lorico A, Rappa G, Finch RA, Yang D, Flavell RA, and Sartorelli AC (1997) Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. Cancer Res 57:5238-5242.
23. Mashige F, Tanaka N, Maki A, Kamei S, and Yamanaka M (1981) Direct spectrophotometry of total bile acids in serum. Clin Chem 27:1352-1356.
24. Nies AT, Konig J, Pfannschmidt M, Klar E, Hofmann WJ, and Keppler D (2001) Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma. Int J Cancer 94:492-499.
25. Paulusma CC, Kothe MJ, Bakker CT, Bosma PJ, van Bokhoven I, van Marle J, Bolder U, Tytgat GN, and Oude Elferink RP (2000) Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver. Hepatology 31:684-693.
26. Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, and Keppler D (2003) Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology 38:374-384.
27. Rost D, Kartenbeck J, and Keppler D (1999) Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis. Hepatology 29:814-821.
28. Rost D, Mahner S, Sugiyama Y, and Stremmel W (2002) Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine. Am J Physiol 282:G720-G726.
29. Scheffer GL, Kool M, de Haas M, de Vree JM, Pijnenborg AC, Bosman DK, Elferink RP, van der Valk P, Borst P, and Scheper RJ (2002) Tissue distribution and induction of human multidrug resistant protein 3. Lab Investig 82:193-201.
30. Schultz MJ, Wijnholds J, Peppelenbosch MP, Vervoordeldonk MJ, Speelman P, van Deventer SJ, Borst P, and van der Poll T (2001) Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia. J Immunol 166:4059-5064.
31. Schwarz M, Russell DW, Dietschy JM, and Turley SD (1998) Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia. J Lipid Res 39:1833-1843.
32. Seward DJ, Koh AS, Boyer JL, and Ballatori N (2003) Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTα-OSTβ. J Biol Chem 278:27473-27482.
33. Shneider BL (2001) Intestinal bile acid transport: biology, physiology and pathophysiology. J Pediatr Gastroenterol Nutr 32:407-417.
34. Shoji T, Suzuki H, Kusuhara H, Watanabe Y, Sakamoto S, and Sugiyama Y (2004) ATP-dependent transport of organic anions into isolated basolateral membrane vesicles from rat intestine. Am J Physiol 287:G749-G756.
35. Soroka CJ, Lee JM, Azzaroli F, and Boyer JL (2001) Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology 33:783-791.
36. Steinbach D, Wittig S, Cario G, Viehmann S, Mueller A, Gruhn B, Haefer R, Zintl F, and Sauerbrey A (2003) The multidrug resistance-associated protein 3 (MRP3) is associated with a poor outcome in childhood ALL and may account for the worse prognosis in male patients and T-cell immunophenotype. Blood 102:4493-4498.
37. Stride BD, Grant CE, Loe DW, Hipfner DR, Cole SPC, and Deeley RG (1997) Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol 52:344-353.
38. Torchia EC, Labonte ED, and Agellon LB (2001) Separation and quantitation of bile acids using an isocratic solvent system for high performance liquid chromatography coupled to an evaporative light scattering detector. Anal Biochem 298:293-298.
39. Turley SD, Daggy BP, and Dietschy JM (1996) Effect of feeding psyllium and cholestyramine in combination on low density lipoprotein metabolism and fecal bile acid excretion in hamsters with dietary-induced hypercholesterolemia. J Cardiovasc Pharmacol 27:71-79.
40. Wang R, Lam P, Liu L, Forrest D, Yousef IM, Mignault D, Phillips MJ, and Ling V (2003) Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein. Hepatology 38:1489-1499.
41. Wang R, Salem M, Yousef IM, Tuchweber B, Lam P, Childs SJ, Helgason CD, Ackerley C, Phillips MJ, and Ling V (2001) Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis. Proc Natl Acad Sci USA 98:2011-2016.
42. Weinberg SL, Burckhardt G, and Wilson FA (1986) Taurocholate transport by rat intestinal basolateral membrane vesicles. Evidence for the presence of an anion exchange transport system. J Clin Investig 78:44-50.
43. Wijnholds J, Evers R, van Leusden MR, Mol CA, Zaman GJ, Mayer U, Beijnen JH, van der Valk M, Krimpenfort P, and Borst P (1997) Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med 3:1275-1279.
44. Xiong H, Yoshinari K, Brouwer KL, and Negishi M (2002) Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital. Drug Metab Dispos 30:918-923.
45. Zeng H, Bain LJ, Belinsky MG, and Kruh GD (1999) Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents. Cancer Res 59:5964-5967.
46. Zeng H, Chen Z-S, Belinsky MG, Rea PA, and Kruh GD (2001) Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res 61:7225-7232.
47. Zeng H, Liu G, Rea PA, and Kruh GD (2000) Transport of amphipathic anions by human multidrug resistance protein 3. Cancer Res 60:4779-4784.
48. Zhang J, Huang W, Qatanani M, Evans RM, and Moore DD (2004) The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem 279:49517-49522.
49. Zollner G, Fickert P, Fuchsbichler A, Silbert D, Wagner M, Arbeiter S, Gonzalez FJ, Marschall HU, Zatloukal K, Denk H, et al. (2003) Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. J Hepatol 39:480-488.