Analytical procedures for determination of quercetin and its glycosides in plant material

Critical Reviews in Analytical Chemistry

Volumn 39, Issue 2, 2009, Pages 95-107

  Biesaga, Magdalena ^a   Pyrzynska, Krystyna ^a  

^a UNIVERSITY OF WARSAW   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONES; ANALYTICAL PROCEDURE; ANALYTICAL STRATEGY; ANTI-INFLAMMATORIES; ANTIOXIDANT PROPERTIES; FLAVONOIDS; IN-PLANTS; PLANT KINGDOM; PLANT MATERIAL; QUANTITATIVE DATA; SAMPLE MATRIX; SEPARATION TECHNIQUES;

CAPILLARY ELECTROPHORESIS; CHROMATOGRAPHIC ANALYSIS; FATTY ACIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; PHENOLS; SEPARATION; SOLVENTS; SUGARS;

SOLVENT EXTRACTION;

ANALYTICAL METHOD; ANTIOXIDANT; ELECTROKINESIS; LIQUID CHROMATOGRAPHY;

EID: 70449555455     PISSN: 10408347     EISSN: 15476510     Source Type: Journal    
DOI: 10.1080/10408340902820718     Document Type: Article

References (111)

1. S. Fiorucci, J. Golebiowski, D. Cabrol-Bass, and S. Antonczak, DFT study of quercetin activated forms involved in antiradical, antioxidant and prooxidant biological processes. Journal of Agricultural and Food Chemistry 55 (2007):903-911.
2. M. G. L. Hertog, E. J. M. Feskens, P. C. H. Hollmann, M. B. Katan, and D. Kronthout, Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen elderly study. Lancet 342 (1993):1007-1011.
3. Y.-H. Chu, C.-L. Chang, and H.-F. Hsu, Flavonoid content of several vegetables and their antioxidant activity. Journal of the Science of Food and Agriculture 80 (2000):561-566.
4. K. Murota and J. Terao, Antioxidative flavonoid quercetin: Implication of its intestinal absorption and metabolism. Archives of Biochemistry and Biophysics 417 (2003):12-17.
5. S. A. Aherne and N. M. O'Brien, Dietary flavonols: Chemistry, food content, and metabolism. Nutrition 18 (2002):75-81.
6. A. Schieber, P. Hilt, J. Conrad, U. Beifuss, and R. Carle, Elution order of quercetin glycosides from apple pomace extracts on a new HPLC stationary phase with hydrophilic endcapping. Journal of Separation Science 25 (2002):361-364.
7. Online coupling of capillary isotachophoresis and capillary zone electrophoresis for the determination of flavonoids in methanolic extracts of Hypericum perforatum leaves or flowers. Journal of Chromatography A 958 (2002):261-271.
8. P. C. H. Hollman and I. C. W. Arts, Flavonoids, flavones and flavanols - nature, occurrence and dietary burden. Journal of the Science of Food and Agriculture 80 (2000):1081-1093.
9. K. Nemeth and M. K. Piskula, Food content, processing, absorption and metabolism of onion flavonoids. Critical Reviews in Food Science and Nutrition 47 (2007):397-409.
10. M. G. L Hertog, P. C. H. Hollman, and M. B. Katan, Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands. Journal of Agricultural and Food Chemistry 40 (1992):2379-2383.
11. H. J. Heo, J. J. Kim, D. Chung, and D. O. Kim, Antioxidant capacities of individual and combined phenolic in a model system. Food Chemistry 104 (2007):87-92.
12. M. Naczk and F. Shahidi, Extraction and analysis of phenolic in food. Journal of Chromatography A 1952 (2004):95-111.
13. W. de Rijke, P. Out, W. M. A. Niessen, F. Ariese, C. Gooijer, and U. A. Brinkman, Analytical separation and detection methods for flavonoids. Journal of Chromatography A 1112 (2006):31-63.
14. H. Chen and Y.Zuo, Identification of flavonol glycosides in American cranberry fruit. Food Chemistry 101 (2007):1357-1364.
15. L. Gennaro, C. Leonardi, F. Esposito, M. Salucci, G. Maiani, G. Quaglia, and V. Fogliano, Flavonoid and carbohydrate contents in Tropea onions: Effects of homelike peeling and storage. Journal of Agricultural and Food Chemistry 50 (2002):1904-1910.
16. M. S. DuPont, Z. Mondin, G. Williamson, and K. R. Price, Journal of Agricultural and Food Chemistry 48 (2000):3957-3964.
17. L. M. Morgen, M. E. Olsson, and U. E. Gertsson, Quercetin content in stored onion (Allium cepa L.): Effects of storage conditions, cultivar, lifting time and nitrogen fertilizer level. Journal of the Science Food and Agriculture 87 (2007):1595- 1602.
18. C. Ewald, S. Fjelkner-Moding, K. Johansson, I. Sjo and dieholm, and B. Akesson, Effect of processing on major flavonoids in processed onions, green beans and peas. Food Chemistry 64 (1999):231- 235.
19. N. Buchner, A. Krunbein, S. Rohn, and L. W. Kroh, Effect of thermal processing on the flavonols rutin and quercetin. Rapid Communications in Mass Spectrometry 20 (2006):3229- 3235.
20. K. Lombard, E. Peffley, E. Geoffrisu, L. Thompson, and A. Herring, Quercetin in onion (Allium cepa L.) after heat-treatment simulating home preparation. Journal of Food Composition and Analysis 18 (2005):571-581.
21. M. J. C. Rhodes and K. R. Price, Analytical problems in the study of flavonoid compounds in onions. Food Chemistry 57 (1996):113-117.
22. Y. H. Yen, C. H. Shih, and C. H. Chang, Effect of adding ascorbic acid and glucose on the antioxidative properties during storage of dried carrots. Food Chemistry 107 (2008):265-272.
23. M. A. Rodriguez-Delago, S. Malovana, J. P. Perez, T. Borges, and E. J. Garcia Montelongo, Separation of phenolic compounds by high-performance liquid chromatography with absorbance and fluorimetric detection. Journal of Chromatography A 912 (2001):249.
24. Chromatographic, capillary electrophoretic and capillary electrochromatographic techniques in the analysis of flavonoids. Journal of Chromatography A 1073 (2005):201-227.
25. K. Robards, Strategies for the determination of bioactive phenols in plants, fruit and vegetables. Journal of Chromatography A 1000 (2003):657-691.
26. A. Wach, K. Pyrzynska, and M. Biesaga, Quercetin content in some food and herbal samples. Food Chemistry 100 (2007):699- 704.
27. M. Biesaga, A. Stafiej, and K. Pyrzynska, Extraction and hydrolysis parameters for determination of quercetin in Hypericum perforatum. Chromatographia 65 (2007):701-706.
28. G. A. Spanos, R. E. Wrolstand, and D. A. Heatherbell, Influence of processing and storage on the phenolic composition of apple juice. Journal of Agricultural and Food Chemistry 38 (1990):1572-1579.
29. J. Tabart, C. Kevers, A. Sipel, J. Pincemail, J. O. Defraigne, and J. Dommes, Optimisation of extraction of phenolic and antioxidants from black currant leaves and buds and of stability during storage. Food Chemistry 105 (2007):1268-1275.
30. K. Robards, P. D. Prenzler, G. Tucker, P. Swatsitang, and W. Glover, Phenolic compounds and their role in oxidative processes in fruits. Food Chemistry 66 (1999):401-436.
31. B. L. Lee and C. N. Ong, Comparative analysis of tea catechins and theaflavins by high-performance liquid chromatography and capillary electrophoresis. Journal of Chromatography A 881 (2000):439-447.
32. M. H. Zhang, J. Luypaert, J. A. Fernandez Pierna, Q. S. Xu, and D. L. Massart, Determination of total anti-oxidant capacity in green tea by near-infrared spectroscopy and multivariate calibration. Talanta 62 (2004):25-35.
33. Y. S. Lin, Y. J. Tsai, J. S. Tsay, and J. K. Lin, Factors affecting the levels of tea polyphenols and caffeine in tea leaves. Journal of Agricultural and Food Chemistry 51 (2003):1864-1873.
34. P. J. Larger, A. D. Jones, and C. Dacombe, Separation of tea polyphenols using micellar electrokinetic chromatography with diode array detection. Journal of Chromatography A 799 (1998):309-320.
35. C. Cabbrera, R. Gimnez, and M. C. Lopez, Determination of tea componentswith antioxidant activity. Journal of Agricultural and Food Chemistry 51 (2003):4427-4435.
36. M. Pinelo, L. Manzocco, M. J. Nuñez, and M. C. Nicoli, Solvent effect on quercetin antioxidant capacity. Food Chemistry 88 (2004):201-207.
37. F. F. Liu, C. Y. W. Ang, T. M. Heinze, J. D. Rankin, R. D. Beger, J. P. Freeman, and J. O. Lay Jr., Evaluation of major components in St. John'sWort dietary supplements byHPLCwith photodiode array detection and electrospray mass spectrometric confirmation. Journal of Chromatography A 888 (2000):85-92.
38. P. Avato and G. Guglielmi, Determination of major constituents in St. John'sWort under different extraction conditions. Pharmaceutical Biology 42 (2004):83-89.
39. F. B. Williams, L. C. Sander, S. A. Wise, and J. Girard, Development and evaluation of methods for determination of naphthodianthroned and flavonoids in St. John's wort. Journal of Chromatography A 1115 (2006):93-102.
40. A. Chafer, M. C. Pascual-Marti, A. Salvador, and A. Berna, Supercritical fluids extraction and HPLC determination of relevant polyphenolic compounds in grape skin. Journal of Separation Sciences 28 (2005):2050-2056.
41. B. J. Wang, Y. H. Lien, and Z. R. Yu, Supercritical fluid extraction-study of the anti-oxidant activities of propolis. Food Chemistry 86 (2004):237-243.
42. A. Smelcherovic, M. Spiteller, and S. Zuehlke, Comparison of methods for the exhaustive extraction of hyperins, flavonoids and hyperflorin from Hypericum perforatum L. Journal of Agricultural and Food Chemistry 54 (2006):2750-2753.
43. M. Vinatoru, An overviewof the ultrasonically assisted extraction of bioactive principles from herbs. Ultrasonics Sonochemistry 8 (2001):303-313.
44. C. J. Chang, K. L. Chiu, Y. L. Chen, and P. W. Yang, Effect of ethanol content on carbon dioxide extraction of polyphenols from tea. Journal of Food Composition and Analysis 14 (2001):75- 82.
45. R. Murga, R. Ruiz, S. Beltram, and J. L. Cabezas, Extraction of natural complex phenols and tannins from grape seeds by using supercritical mixtures of carbon dioxide and alcohol. Journal of Agricultural and Food Chemistry 48 (2000):3408-3412.
46. T. Tsao and Z. Deng, Separation procedures for naturally occurring anti-oxidant phytochemicals. Journal of Chromatography B 812 (2004):85-99.
47. A. F. Vinha, F. Ferreres, B. M. Silva, P. Valentão, A. Gonc ̧alves, J. A. Pereira, M. B. Oliveira, R. M. Seabra, and P. A. Andrade, Phenolic profiles of Portuguese olive fruits. Influences of cultivar and geographical origin. Food Chemistry 89 (2005):561-568.
48. E. Dadakova, E. Prochazkova, and M. Krizek, Application of micellar electrokinetic capillary chromatography for quantitative analysis of plant materials. Electrophoresis 22 (2001):1573-1578.
49. H. Chen, Y. Zao, and Y. Deng, Separation and determination of flavonoids and other phenolic compounds in cranberry juice by high-performance liquid chromatography. Journal of Chromatography A 913 (2001):387-395.
50. K. Ishii, T. Furuta, and Y. Kasuya, High-performance liquid chromatographic determination of quercetin in human plasma and urine utilizing solid-phase extraction and ultraviolet detection. Journal of Chromatography B 794 (2003):49-51.
51. L. Yao, Y. Jiang, B. D'Arcy, R. Singanusong, N. Datta, N. Caffin, and K. Raymont, Quantitative high-performance liquid chromatography analyses of flavonoids in Australian Eucalyptus honeys. Journal of Agricultural and Food Chemistry 52 (2004):210-214.
52. L. Yao, Y. Jiang, R. Singansong, N. Datta, and K. Raymont, Phenolic acids and abscisic acid in Australian Eucalyptus honeys and their potential for floral authentication. Food Chemistry 86 (2004):169-177.
53. B. Dimitrova, R. Gevrenova, and E. Anklam, Analysis of phenolic acids in honeys of differential floral origin by solid-phase extraction and high-performance liquid chromatography. Phytochemical Analysis 18 (2007):24-32.
54. A. Molinelli, R. Weiss, and B. Mizaikoff, Advanced solid phase extraction using molecularly imprinted polymers for the determination of quercetin in red wine. Journal of Agricultural and Food Chemistry 50 (2002):1804-1808.
55. Y. G. Xia, T. Y. Guo, M. D. Song, B. H. Zhang, and B. L. Zhang, Selective separation of quercetin by molecularly imprinting using chitosan as functional matrix. Reactive & Functional Polymers 66 (2006):1734-1740.
56. G. Thedoridis, M. Lepsakova, V. Skerikova, A. Tegou, N. Giantsiou, and P. Jandrea, Molecular imprinting of natural flavonoid anti-oxidants: Application in solid-phase extraction for the sample treatment of natural products prior to HPLC analysis. Journal of Separation Sciences 29 (2006):2310-2321.
57. S. A. Barker, Applications of matrix solid-phase dispersion in food analysis. Journal of Chromatography A 885 (2000):115-127.
58. S. A. Barker, Matrix solid dispersion (MSPD). Journal of Biochemical and Biophysical Methods 70 (2007):151-162.
59. H. B. Xiao, M. Krucker, K. Albert, and X. M. Liang, Determination and identification of isoflavonoids in Radix astragali by matrix solid-phase dispersion extraction and high-performance liquid chromatography with photodiode array and mass spectrometric detection. Journal of Chromatography A 1032 (2004):117-124.
60. Solidphase extraction versus matrix solid-phase dispersion: Application to white grapes. Talanta 74 (2007):20-31.
61. H. M. Merken and G. R. Beecher, Measurement of food flavonoids by high-performance liquid chromatography. Journal of Agricultural and Food Chemistry 48 (2000):577-599.
62. M. Careri, L. Elviri, A. Mangia, and M. Musci, Spectrometric and coulometric detection in the high-performance liquid chromatography of flavonoids and optimization of sample treatment for the determination of quercetin in orange juice. Journal of Chromatography A 881 (2000):449-460.
63. A. M. Nuutila, K. Kammiovirta, and K. M. Oksman-Caldentey, Comparison of methods for the hydrolysis of flavonoids and phenolic acids from onion and spinach for HPLC analysis. Food Chemistry 76 (2002):519-525.
64. Application of monolithic (continuous bed) chromatographic columns in phytochemical analysis. Journal of Chromatography A 1112 (2006):319-330.
65. M. Castellari, E. Sartini, A. Fabiani, G. Arfelli, and A. Amanti, Analysis of wine phenolics by high-performance liquid chromatography using a monolithic type column. Journal of Chromatography A 973 (2002):221-227.
66. M. Biesaga, U. Ochnik, and K. Pyrzynska, Analysis of phenolic acids in fruits by HPLC with monolithic column. Journal of Separation Sciences 30 (2007):2929-2934.
67. C. W. Huck, M. R. Buchmeiser, and G. K. Bonn, Fast analysis of flavonoids in plant extracts by liquid chromatography- ultraviolet absorbance detection on poly(carboxylic acid)-coated silica and electrospray ionization tandem mass spectrometric detection. Journal of Chromatography A 943 (2001):33-38.
68. Content of flavonols and selected phenolic acids in strawberries and Vaccinium species: Influence of cultivar, cultivation site and technique. Food Research International 33 (2000):517-524.
69. R. Baranowski, J. Kabut, and I. Baranowska, Analysis of mixture of catechins, flavones, flavanones, flavonols and anthocyanides by RP-HPLC. Analytical Letters 37 (2004):157-165.
70. W. Li and J. F. Fitzloff, High performance liquid chromatographic analysis of St. John'sWort with photodiode array detection. Journal of Chromatography B 765 (2001):99-105.
71. F. Sanchez-Rabaneda, Ol. Jauregui, R. M. Lamuela-Raventos, J. Bastida, F. Viladomat and C. Codina, Identification of phenolic compounds in artichoke waste by high-performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 1008 (2003):57-72.
72. A. Schieber, P. Hilt, J. Conrad, U. Beifuss, and R. Carle, Elution order of quercetin glycosides from apple pomace extracts on a new HPLC stationary phase with hydrophilic endcapping. Journal of Separation Science 25 (2002):361-364.
73. A. Schieber, W. Ullrich, and R. Carle, Characterization of polyphenols in mango puree concentrate by HPLC with diode array and mass spectrometric detection. Innovative Food Science & Emerging Technologies 1 (2000):161-166.
74. E. S. de Brito, M. C. P. de Araujo, L. Z. Lin, and J. Harnly, Determination of the flavonoid components of cashew apple by LC-DAD-ESI/MS. Food Chemistry 105 (2007):1112-1118.
75. A. Schieber, P. Keller and R. Carle, Determination of phenolic acids and flavonoids of apple and pear by high-performance liquid chromatography. Journal of Chromatography A 910 (2001):265-273.
76. P. Bonaccorsi, C. Caristi, C. Gargiulli, and U. Leuzzi, Flavonol glucoside profile of southern Italian red onion (Allium cepa L.). Journal of Agricultural and Food Chemistry 53 (2005):2733-2740.
77. Q. Zhang and H. Cai, Simultaneous determination of quercetin, kaempferol and isorhamnetin in phytopharmaceuticals of Hippophae rhamnoides L. by HPLC with chemiluminescence detection. Journal of Separation Sciences 28 (2005):1171-1178.
78. M. E. Swartz, UPLC TM:An introduction and review. Journal of Liquid Chromatography & Related Technologies 28 (2005):1253-1263.
79. K. A. Cooper, E. Campos-Gimenez, D. J. Alvarez, K. Nagy, J. L. Donovan, and G. Williamson, Rapid reverse phase ultraperformance liquid chromatography analysis of the major cocoa polyphenols and inter-relationships of their concentrations in chocolate. Journal of Agricultural and Food Chemistry 55 (2007):2841-2847.
80. E. Marchart and B. Knopp, Capillary electrophoretic separation and quantification of flavone-O- and C-glycosides in Achilles setcea W. et K. Journal of Chromatography B 792 (2003):363-368.
81. D. Caridi, V. C. Trenerry, S. Rochfort, S. Duong, D. Laugher, and R. Jones, Profiling and quantifying quercetin glucosides in onion varieties using capillary zone electrophoresis and high performance liquid chromatography. Food Chemistry 105 (2007):691-699.
82. R. Harmoudova, M. Urbanek, M. Pospisilova, and M. Polasek, Assay of phenolic compounds in redwine by on-line combination of capillary isotachophoresis with capillary zone electrophoresis. Journal of Chromatography A 1032 (2004):281-287.
83. L. Sutontornsuk, S. Kasemsook, and S. Wongyai, Quantitative analysis of aglycone quercetin in mulberry leaves by capillary zone electrophoresis. Electrophoresis 24 (2003):1238-1241.
84. Y. Sun, T. Guo, Y. Sui, and F. Li, Quantitative determination of rutin, quercetin and adenosine in Flos Carthami y capillary electrophoresis. Journal of Separation Sciences 26 (2003):1203-1206.
85. N. Volpi, Separation of flavonoids and phenolic acids from propolis by capillary zone electrophoresis. Electrophoresis 25 (2004):1872-1878.
86. T. Akiyama, T. Yamada, and T. Maitani, Analysis of enzymatically glucosylated flavonoids by capillary electrophoresis. Journal of Chromatography A 895 (2000):279-283.
87. M. Luo, H. Lu, H. Ma, L. Zhao, X. Liu, and S. Jiang, Separation and determination of flavonoids in Lamiophlomis rotata by capillary electrophoresis using borate as electrolyte. Journal of Pharmaceutical and Biomedical Analysis 44 (2007):881-886.
88. S. P. Wang and K. J. Huang, Determination of flavonoids by highperformance liquid chromatography and capillary electrophoresis. Journal of Chromatography A 1032 (2004):273-279.
89. Y. Su, N. Fang, D. D. Y. Chen and K. K. Donkor, Determination of potentially anti-carcinogenic flavonoids in wines by micellar electrokinetic chromatography. Food Chemistry 106 (2008): 415-420.
90. P. J. Lager, A. D. Jones, and C. Dacombe, Separation of tea polyphenols using micellar electrokinetic chromatography with diode array detection. Journal of Chromatography A 799 (1998):309-320.
91. M. Polasek, I. Petriska, M. Pospisilova, and L. Jahodar, Use of molybdate as novel complex-forming selector in the analysis of polyhydric phenols in capillary zone electrophoresis. Talanta 69 (2006):192-198.
92. S. F. Wang, J. Y. Zhang, X. G. Chen, and Z. D. Hu, Study of the electrophoretic behavior of flavonoids. Chromatographia 59 (2004):507-511.
93. Z. Demianova, H. Siren, R. R. Kuldvee, and M. L. Riekkola, Nonaqueous capillary electrophoretic separation of polyphenolic compounds in wine using coated capillaries at high pH in methanol. Electrophoresis 24 (2004):4264-4271.
94. H. Schwerz, C. W. Huck, and G. K. Bonn, CEC and EKC of natural compounds. Electrophoresis 28 (2007):1645-1657.
95. F. N. Fonseca, M. F. M. Tavares, and C. Horvath, Capillary electrochromatography of selected phenolic compounds of Chamonilla recutita. Journal of Chromatography A 1154 (2007):390-399.
96. W. M. Stoggl, C. W. Huck, G. Stecher, and G. K. Bonn, Capillary electrochromatography of biologically relevant flavonoids. Electrophoresis 27 (2006):787-792.
97. P. C. H. Holiman, J. M. P. van Trijp, and N. C. P. Buysman, Fluorescence detection of flavonols in HPLC by postcolumn chelation with aluminium. Analytical Chemistry 68 (1996): 3511-3515.
98. I. Surowiec, J. Orska-Gawry, M. Biesaga, M. Trojanowicz, M. Hutta, R. Halko, and K. Urbaniak-Walczak, Identification of natural dyestuff in archeological Coptic textiles by HPLC with fluorimetric detection. Analytical Letters 36 (2003):1211-1229.
99. J. P. Cornard and J. C. Merlin, Spectroscopic and structural study of complexes of quercetin with Al(III). Journal of Inorganic Biochemistry 91 (2002): 19-27.
100. G. Le Nest, O. Caille, M. Woudstra, S. Roche, F. Guerlesquin and D. Lexa, Zn-polyphenol chelation: Complexes with quercetin, (+)-catechin and derivatives: Optical and NMR studies. Inorganica Chimica Acta 357 (2004):775-784.
101. A. Romani, M. Minunni, N. Mulinacci, P. Pinelli, and F. F. Vinecieri, Comparison among differential pulse voltammetry, amperometric biosensor and HPLC/DAD analysis for polyphenol determination. Journal of Agricultural and Food Chemistry 48 (2000):1197-1203.
102. G. Chen, H. Zhang, and J. Ye, Determination of rutin and quercetin in plants by capillary electrophoresis with electrochemical detection. Analytica Chimica Acta 423 (2000):69-76.
103. Y. Q. Guan, T. Wu, M. Lin and J.N. Ye, Determination of pharmacologically active ingredients in sweet potato (Ipomoea batatas L.) by capillary electrophoresis with electrochemical detection. Journal of Agricultural and Food Chemistry 54 (2006):24-28.
104. T. Wu, Y. Q. Guan, and J. N. Ye, Determination of flavonoids and ascorbic acid in grapefruit peel and juice by capillary electrophoresis with electrochemical detection. Food Chemistry 100 (2007):1573-1579.
105. X. Q. Lin, J. B. He, and Z. G. Zha, Simultaneous determination of quercetin and rutin ay a multiwall carbon-nanotube paste electrodes by reversing differential pulse voltammetry. Sensors and Actuators B 109 (2006):608-614.
106. J. Xu, H. Zhang, and G. Chen, Carbon nanotube/polystyrene composite electrode for microchip electrophoretic determination of rutin and quercetin in Flos Sophorae Immaturus. Talanta 73 (2007):932-937.
107. Z. Charrouf, M. Hilali, O. Jauregui, M. Saufiaoui, and D. Guillaume, Separation and characterization of phenolic compounds in argan fruit pulp using liquid chromatography-negative electrospray ionization tandem mass spectroscopy. Food Chemistry 100 (2007): 1398-1401.
108. C. S. Harris, A. J. Burt, A. Saleem, P. M. Li, L. C. Martineau, P. S. Haddad, S. A. L. Bennett, and J. T. Arnason, A single HPLCAPCI/ MS method for the quantitative comparison of phenolic compounds found in leaf, stem, root and fruit extracts of Vaccinium angustifolium. Phytochemical Analysis 18 (2007):161-169.
109. L. Wang and M. E. Morris, Liquid chromatography - tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine. Journal of Chromatography B 821 (2005):194-201.
110. M. S. Olivella, L. Lhez, N. B. Pappano, and N. B. Debattista, Effects of dimethylformamide and L-menthol permeation enhancers on Transdermal delivery of quercetin. Pharmaceutical Development and Technology 12 (2007):481-484.
111. T. Fossen, A. T. Pedersen, and Ø. M. Andersen, Flavonoids from red onion (Allium cepa). Phytochemistry 47 (1998):281-285.