-
1
-
-
0019972810
-
The cholinergic hypothesis of geriatric memory dysfunction
-
Bartus R.T., Dean R.L., Beer B., and Lippas A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 217 (1982) 408-414
-
(1982)
Science
, vol.217
, pp. 408-414
-
-
Bartus, R.T.1
Dean, R.L.2
Beer, B.3
Lippas, A.S.4
-
2
-
-
31144450053
-
Current pharmacotherapy for Alzheimer's disease
-
Lleo A., Greenberg S., and Jh G. Current pharmacotherapy for Alzheimer's disease. Annu Rev Med 57 (2006) 513-533
-
(2006)
Annu Rev Med
, vol.57
, pp. 513-533
-
-
Lleo, A.1
Greenberg, S.2
Jh, G.3
-
3
-
-
31344435588
-
A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease
-
Takeda A., Loveman E., Clegg A., Kirby J., Picot J., Payne E., et al. A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease. Int J Geriatr Psychiatry 21 (2006) 17-28
-
(2006)
Int J Geriatr Psychiatry
, vol.21
, pp. 17-28
-
-
Takeda, A.1
Loveman, E.2
Clegg, A.3
Kirby, J.4
Picot, J.5
Payne, E.6
-
4
-
-
29044448249
-
Antisense inhibition of acetylcholinesterase gene expression for treating cognition deficit in Alzheimer's disease model mice
-
Fu A.-L., Zhang X.-M., and Sun M.-J. Antisense inhibition of acetylcholinesterase gene expression for treating cognition deficit in Alzheimer's disease model mice. Brain Res 1066 (2005) 10-15
-
(2005)
Brain Res
, vol.1066
, pp. 10-15
-
-
Fu, A.-L.1
Zhang, X.-M.2
Sun, M.-J.3
-
5
-
-
0023236055
-
The nerve growth factor 35 years later
-
Levi-Montalcini R. The nerve growth factor 35 years later. Science 237 (1987) 1154-1162
-
(1987)
Science
, vol.237
, pp. 1154-1162
-
-
Levi-Montalcini, R.1
-
6
-
-
0023643241
-
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
-
Fischer W., Wictorin K., Bjorklund A., Williams L., Varon S., and Gage F. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329 (1987) 65-68
-
(1987)
Nature
, vol.329
, pp. 65-68
-
-
Fischer, W.1
Wictorin, K.2
Bjorklund, A.3
Williams, L.4
Varon, S.5
Gage, F.6
-
7
-
-
0025513602
-
Nerve growth factor infusion in primate brain reduces lesion-induced cholinergic neuronal degeneration
-
Tuszynski M.H.U.H.-S., Amaral D.G., and Gage F.H. Nerve growth factor infusion in primate brain reduces lesion-induced cholinergic neuronal degeneration. J Neurosci 10 (1990) 3604-3614
-
(1990)
J Neurosci
, vol.10
, pp. 3604-3614
-
-
Tuszynski, M.H.U.H.-S.1
Amaral, D.G.2
Gage, F.H.3
-
8
-
-
21044458854
-
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer's disease
-
Tuszynski M.H., Thal L., Pay M., Salmon D.P.U.H.-S., et al. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer's disease. Nat Med 11 (2005) 551-555
-
(2005)
Nat Med
, vol.11
, pp. 551-555
-
-
Tuszynski, M.H.1
Thal, L.2
Pay, M.3
Salmon, D.P.U.H.-S.4
-
9
-
-
0345872128
-
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial
-
Tariot P., Farlow M., Grossberg G., Graham S., Mcdonald S., and Gergel I. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA 291 (2004) 317-324
-
(2004)
JAMA
, vol.291
, pp. 317-324
-
-
Tariot, P.1
Farlow, M.2
Grossberg, G.3
Graham, S.4
Mcdonald, S.5
Gergel, I.6
-
10
-
-
0021207461
-
Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein
-
Glenner G.G., and Wong C.W. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. BBRC 122 (1984) 1131-1135
-
(1984)
BBRC
, vol.122
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
11
-
-
0021256895
-
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner G.G., and Wong C.W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. BBRC 120 (1984) 885-890
-
(1984)
BBRC
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
12
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer's Disease and Down Syndrome
-
Masters C.L., Simons G., Weinman N.A., Multhaup G., Mc Donald B.L., et al. Amyloid plaque core protein in Alzheimer's Disease and Down Syndrome. Proc Natl Acad Sci USA 82 (1985) 4245-4249
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simons, G.2
Weinman, N.A.3
Multhaup, G.4
Mc Donald, B.L.5
-
13
-
-
0023132387
-
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
-
Goldgaber D., Lerman M.I., Mcbride O.W., Saffiotti U., and Gajdusek D.C. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235 (1987) 880-887
-
(1987)
Science
, vol.235
, pp. 880-887
-
-
Goldgaber, D.1
Lerman, M.I.2
Mcbride, O.W.3
Saffiotti, U.4
Gajdusek, D.C.5
-
14
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J., Lemaire H.G., Unterbeck A., Salbaum J.M., Masters C.L., et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325 (1987) 733-736
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
-
15
-
-
0023109592
-
Amyloid b protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
-
Tanzi R.E., Gusella J.F., Watkins P.C., Bruns G.A.P., St George-Hyslop P., et al. Amyloid b protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235 (1987) 880-884
-
(1987)
Science
, vol.235
, pp. 880-884
-
-
Tanzi, R.E.1
Gusella, J.F.2
Watkins, P.C.3
Bruns, G.A.P.4
St George-Hyslop, P.5
-
17
-
-
0027422751
-
Genetic and molecular advances in Alzheimer's disease
-
Mullan M., and Crawford F. Genetic and molecular advances in Alzheimer's disease. Trends Neurosci 16 (1993) 398-403
-
(1993)
Trends Neurosci
, vol.16
, pp. 398-403
-
-
Mullan, M.1
Crawford, F.2
-
18
-
-
0029073383
-
Genetic dissection of Alzheimer disease, a heterogeneous disorder
-
Schellenberg G.D. Genetic dissection of Alzheimer disease, a heterogeneous disorder. Proc Natl Acad Sci USA 92 (1995) 8552-8559
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8552-8559
-
-
Schellenberg, G.D.1
-
19
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E., Wasco W., Poorkaj P., Romano D.M., Oshima J., et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269 (1995) 973-977
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
-
20
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev E.I., Sherrington R., Rogaeva E.A., Levesque G., Ikeda M., et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376 (1995) 775-778
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
-
21
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375 (1995) 754-760
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
-
22
-
-
0029115555
-
The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
-
Alzheimer's disease collaborative group. The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nat Genet 11 (1996) 219-222
-
(1996)
Nat Genet
, vol.11
, pp. 219-222
-
-
Alzheimer's disease collaborative, group.1
-
23
-
-
0029379605
-
Processing of the b-amyloid precursor protein and its regulation in Alzheimer's disease
-
Checler F. Processing of the b-amyloid precursor protein and its regulation in Alzheimer's disease. J Neurochem 65 (1995) 1431-1444
-
(1995)
J Neurochem
, vol.65
, pp. 1431-1444
-
-
Checler, F.1
-
24
-
-
0031030053
-
Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, Ab1-42, in differentiated PC12
-
Burdick D., Kosmoski J., Knauer M.F., and Glabe C.G. Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, Ab1-42, in differentiated PC12. Brain Res 746 (1997) 275-284
-
(1997)
Brain Res
, vol.746
, pp. 275-284
-
-
Burdick, D.1
Kosmoski, J.2
Knauer, M.F.3
Glabe, C.G.4
-
25
-
-
0035066332
-
Alzheimer's disease: Genes, proteins and therapy
-
Selkoe D.J. Alzheimer's disease: Genes, proteins and therapy. Physiol Rev 81 (2001) 741-766
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
26
-
-
0034488295
-
Generation of an apoptotic intracellular peptide by g-secretase cleavage of Alzheimer's amyloid b protein precursor
-
Passer B., Pellegrini L., Russo C., Siegel R.M., Lenardio M.J., et al. Generation of an apoptotic intracellular peptide by g-secretase cleavage of Alzheimer's amyloid b protein precursor. J Alzheimers Dis 2 (2000) 289-301
-
(2000)
J Alzheimers Dis
, vol.2
, pp. 289-301
-
-
Passer, B.1
Pellegrini, L.2
Russo, C.3
Siegel, R.M.4
Lenardio, M.J.5
-
27
-
-
0035929554
-
Distinct intramembrane cleavages of the b-amyloid precursor protein family resembling g-secretase-like cleavage of Notch
-
Gu Y., Misonou H., Sato T., Dohmae N., Takio K., et al. Distinct intramembrane cleavages of the b-amyloid precursor protein family resembling g-secretase-like cleavage of Notch. J Biol Chem 276 (2001) 35235-35238
-
(2001)
J Biol Chem
, vol.276
, pp. 35235-35238
-
-
Gu, Y.1
Misonou, H.2
Sato, T.3
Dohmae, N.4
Takio, K.5
-
28
-
-
0034774969
-
Presenilin dependent g-secretase processing of b-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
-
Sastre M., Steiner H., Fuchs K., Capell A., Multhaup G., et al. Presenilin dependent g-secretase processing of b-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO report 2 (2001) 835-841
-
(2001)
EMBO report
, vol.2
, pp. 835-841
-
-
Sastre, M.1
Steiner, H.2
Fuchs, K.3
Capell, A.4
Multhaup, G.5
-
29
-
-
0037176727
-
A novel e-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with the Notch processing
-
Weidemann A., Eggert S., Reinhard F.B.M., Vogel M., Paliga K., et al. A novel e-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with the Notch processing. Biochemistry 41 (2002) 2825-2835
-
(2002)
Biochemistry
, vol.41
, pp. 2825-2835
-
-
Weidemann, A.1
Eggert, S.2
Reinhard, F.B.M.3
Vogel, M.4
Paliga, K.5
-
30
-
-
0035816661
-
A transcriptively active complex of APP with Fe65 and histone acetyltransferase tip60
-
Cao X., and Südhof T.C. A transcriptively active complex of APP with Fe65 and histone acetyltransferase tip60. Science 293 (2001) 115-120
-
(2001)
Science
, vol.293
, pp. 115-120
-
-
Cao, X.1
Südhof, T.C.2
-
31
-
-
0037067655
-
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kB and b-amyloid precursor protein
-
Baek S.H., Ohgi K.A., Rose D.W., Koo E.H., Glass C.K., et al. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kB and b-amyloid precursor protein. Cell 110 (2002) 55-67
-
(2002)
Cell
, vol.110
, pp. 55-67
-
-
Baek, S.H.1
Ohgi, K.A.2
Rose, D.W.3
Koo, E.H.4
Glass, C.K.5
-
32
-
-
20444398562
-
Presenilin-dependent transcriptional control of the A ß-degrading enzyme neprilysin by intracellular domains of ßAPP and APLP
-
Pardossi-Piquard R., Petit A., Kawarai T., Sunyach C., Alves Da Costa C., et al. Presenilin-dependent transcriptional control of the A ß-degrading enzyme neprilysin by intracellular domains of ßAPP and APLP. Neuron 46 (2005) 541-554
-
(2005)
Neuron
, vol.46
, pp. 541-554
-
-
Pardossi-Piquard, R.1
Petit, A.2
Kawarai, T.3
Sunyach, C.4
Alves Da Costa, C.5
-
33
-
-
33745632662
-
Presenilin-dependent g-secretase-mediated control of p53-associated cell death in Alzheimer's disease
-
Alves Da Costa C., Sunyach C., Pardossi-Piquard R., Sevalle J., Vincent B., et al. Presenilin-dependent g-secretase-mediated control of p53-associated cell death in Alzheimer's disease. J Neurosci 26 (2006) 6377-6385
-
(2006)
J Neurosci
, vol.26
, pp. 6377-6385
-
-
Alves Da Costa, C.1
Sunyach, C.2
Pardossi-Piquard, R.3
Sevalle, J.4
Vincent, B.5
-
34
-
-
0030779677
-
Cellular actions of b-amyloid precursor protein and its soluble and fibrillogenic derivatives
-
Mattson M.P. Cellular actions of b-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 77 (1997) 1081-1132
-
(1997)
Physiol Rev
, vol.77
, pp. 1081-1132
-
-
Mattson, M.P.1
-
35
-
-
0026646604
-
Amyloid b-peptide is produced by cultured cells during normal metabolism
-
Haass C., Schlossmacher M.G., Hung A.Y., Vigo-Pelfrey C., Mellon A., et al. Amyloid b-peptide is produced by cultured cells during normal metabolism. Nature 359 (1992) 322-325
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
-
36
-
-
0026760261
-
Production of the Alzheimer amyloid b protein by normal proteolytic processing
-
Shoji M., Golde T.E., Ghiso J., Cheung T.T., Estus S., et al. Production of the Alzheimer amyloid b protein by normal proteolytic processing. Science 258 (1992) 126-129
-
(1992)
Science
, vol.258
, pp. 126-129
-
-
Shoji, M.1
Golde, T.E.2
Ghiso, J.3
Cheung, T.T.4
Estus, S.5
-
37
-
-
0033382226
-
Identification of a novel aspartic protease (Asp2) as b-secretase
-
Hussain I., Powell D., Howlett D.R., Tew D.G., Meek T.D., et al. Identification of a novel aspartic protease (Asp2) as b-secretase. Mol Cell Neurosci 14 (1999) 419-427
-
(1999)
Mol Cell Neurosci
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
-
38
-
-
0033518251
-
Purification and cloning of amyloid precursor protein b-secretase from human brain
-
Sinha S., Anderson J.P., Barbour R., Basi G.S., and Caccavello R. Purification and cloning of amyloid precursor protein b-secretase from human brain. Nature 402 (1999) 537-540
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
-
39
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease b-secretase activity
-
Yan R., Bienkowski M.J., Shuck M.E., Miao H., Tory M.C., et al. Membrane-anchored aspartyl protease with Alzheimer's disease b-secretase activity. Nature 402 (1999) 533-537
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
-
40
-
-
0034652309
-
Human aspartyl protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
-
Lin X., Koelsch G., Wu S., Downs D., Dashti A., et al. Human aspartyl protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci USA 97 (2000) 1456-1460
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1456-1460
-
-
Lin, X.1
Koelsch, G.2
Wu, S.3
Downs, D.4
Dashti, A.5
-
41
-
-
0035112647
-
BACE1 is the major b-secretase for generation of Ab peptides by neurons
-
Cai H., Wang Y., Mccarthy D., Wen H., Borchelt D.R., et al. BACE1 is the major b-secretase for generation of Ab peptides by neurons. Nat Neurosci 4 (2001) 233-234
-
(2001)
Nat Neurosci
, vol.4
, pp. 233-234
-
-
Cai, H.1
Wang, Y.2
Mccarthy, D.3
Wen, H.4
Borchelt, D.R.5
-
42
-
-
0035116273
-
Mice deficient in BACE1, the Alzheimer's b-secretase, have normal phenotype and abolished b-amyloid generation
-
Luo Y., Bolon B., Kahn S., Bennett B.D., Babu-Khan S., et al. Mice deficient in BACE1, the Alzheimer's b-secretase, have normal phenotype and abolished b-amyloid generation. Nat Neurosci 4 (2001) 231-232
-
(2001)
Nat Neurosci
, vol.4
, pp. 231-232
-
-
Luo, Y.1
Bolon, B.2
Kahn, S.3
Bennett, B.D.4
Babu-Khan, S.5
-
43
-
-
17344388652
-
BACE knockout mice are healthy despite lacking the primary b-secretase activity in brain: implications for Alzheimer's disease therapeutics
-
Roberds S.L., Anderson J., Basi G., Bienkowski M.J., Branstetter D.G., et al. BACE knockout mice are healthy despite lacking the primary b-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Gen 10 (2001) 1317-1324
-
(2001)
Hum Mol Gen
, vol.10
, pp. 1317-1324
-
-
Roberds, S.L.1
Anderson, J.2
Basi, G.3
Bienkowski, M.J.4
Branstetter, D.G.5
-
44
-
-
0032693331
-
Presenilins: multifunctional proteins involved in Alzheimer's disease pathology
-
Checler F. Presenilins: multifunctional proteins involved in Alzheimer's disease pathology. IUBMB Life 48 (1999) 33-39
-
(1999)
IUBMB Life
, vol.48
, pp. 33-39
-
-
Checler, F.1
-
45
-
-
0033775709
-
Total inactivation of ß-secretase activity in presenilin-deficient embryonic stem cells
-
Herreman A., Serneels L., Annaert W., Collen D., Schoonjans L., and De Strooper B. Total inactivation of ß-secretase activity in presenilin-deficient embryonic stem cells. Nat Cell Biol 2 (2000) 461-462
-
(2000)
Nat Cell Biol
, vol.2
, pp. 461-462
-
-
Herreman, A.1
Serneels, L.2
Annaert, W.3
Collen, D.4
Schoonjans, L.5
De Strooper, B.6
-
46
-
-
0033779635
-
Presenilins are required for ß-secretase cleavage of ßAPP and transmembrane cleavage of Notch
-
Zhang Z., Nadeau P., Song W., Donoviel D., Yuan M., et al. Presenilins are required for ß-secretase cleavage of ßAPP and transmembrane cleavage of Notch. Nat Cell Biol 2 (2000) 463-465
-
(2000)
Nat Cell Biol
, vol.2
, pp. 463-465
-
-
Zhang, Z.1
Nadeau, P.2
Song, W.3
Donoviel, D.4
Yuan, M.5
-
47
-
-
0034080403
-
aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
-
Goutte C., Hepler W., Mickey K., and Priess J. aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127 (2000) 2481-2492
-
(2000)
Development
, vol.127
, pp. 2481-2492
-
-
Goutte, C.1
Hepler, W.2
Mickey, K.3
Priess, J.4
-
48
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp1 signal transduction and bAPP processing
-
Yu G., Nishimura M., Arawaka S., Levitan D., Zhang L., et al. Nicastrin modulates presenilin-mediated notch/glp1 signal transduction and bAPP processing. Nature 407 (2000) 48-54
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
-
49
-
-
18444417998
-
Aph-1 and pen2 are required for notch pathway signaling, g-secretase cleavage of bAPP and presenilin protein accumulation
-
Francis R., Mcgrath G., Zhang J., Ruddy Da, Sym M., et al. Aph-1 and pen2 are required for notch pathway signaling, g-secretase cleavage of bAPP and presenilin protein accumulation. Dev Cell 3 (2002) 85-97
-
(2002)
Dev Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
Mcgrath, G.2
Zhang, J.3
Ruddy Da4
Sym, M.5
-
50
-
-
0035089318
-
Constitutive a-secretase cleavage of the b-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the prohormone convertase 7 (PC7) and the disintegrin metalloprotease ADAM10
-
Lopez-Perez E., Zhang Y., Franck S.J., Creemers J., Seidah N., et al. Constitutive a-secretase cleavage of the b-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the prohormone convertase 7 (PC7) and the disintegrin metalloprotease ADAM10. J Neurochem 76 (2001) 1532-1539
-
(2001)
J Neurochem
, vol.76
, pp. 1532-1539
-
-
Lopez-Perez, E.1
Zhang, Y.2
Franck, S.J.3
Creemers, J.4
Seidah, N.5
-
51
-
-
14444272986
-
Evidence that tumor necrosis factor a converting enzyme is involved in regulated a-secretase cleavage of the Alzheimer amyloid protein precursor
-
Buxbaum J.D., Liu K.N., Luo Y., Slack J.L., Stocking K.L., et al. Evidence that tumor necrosis factor a converting enzyme is involved in regulated a-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem 273 (1998) 27765-27767
-
(1998)
J Biol Chem
, vol.273
, pp. 27765-27767
-
-
Buxbaum, J.D.1
Liu, K.N.2
Luo, Y.3
Slack, J.L.4
Stocking, K.L.5
-
52
-
-
85047690140
-
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer's disease mouse model
-
Postina R., Schroeder A., Dewachter I., Bohl J., Schmitt U., et al. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer's disease mouse model. J Clin Invest 113 (2004) 1456-1464
-
(2004)
J Clin Invest
, vol.113
, pp. 1456-1464
-
-
Postina, R.1
Schroeder, A.2
Dewachter, I.3
Bohl, J.4
Schmitt, U.5
-
53
-
-
0036077536
-
ß-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases
-
Carson J.A., and Turner A.J. ß-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases. J Neurochem 81 (2002) 1-8
-
(2002)
J Neurochem
, vol.81
, pp. 1-8
-
-
Carson, J.A.1
Turner, A.J.2
-
54
-
-
0037462769
-
Alzheimer's disease b-amyloid peptide (Ab) is increased in mice deficient in endothelin-converting enzyme
-
Eckman E.A., Watson M., Marlow L., Sambamurti K., and Eckman C.B. Alzheimer's disease b-amyloid peptide (Ab) is increased in mice deficient in endothelin-converting enzyme. J Biol Chem 278 (2003) 2081-2084
-
(2003)
J Biol Chem
, vol.278
, pp. 2081-2084
-
-
Eckman, E.A.1
Watson, M.2
Marlow, L.3
Sambamurti, K.4
Eckman, C.B.5
-
55
-
-
33750455150
-
Control of peripheral nerve myelination by the beta-secretase BACE1
-
Willem M., Garratt A.N., Novak B., Citron M., Kaufmann S., et al. Control of peripheral nerve myelination by the beta-secretase BACE1. Science 314 (2006) 664-666
-
(2006)
Science
, vol.314
, pp. 664-666
-
-
Willem, M.1
Garratt, A.N.2
Novak, B.3
Citron, M.4
Kaufmann, S.5
-
56
-
-
27744588007
-
Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model
-
Singer O., Marr R.A., Rockenstein E., Crews L., Coufal N.G., et al. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci 8 (2005) 1343-1349
-
(2005)
Nat Neurosci
, vol.8
, pp. 1343-1349
-
-
Singer, O.1
Marr, R.A.2
Rockenstein, E.3
Crews, L.4
Coufal, N.G.5
-
57
-
-
19644368873
-
Inhibition of amyloid precursor protein processing by (-secretase through site-directed antibodies
-
Arbel M., Yacoby I., and Solomon B. Inhibition of amyloid precursor protein processing by (-secretase through site-directed antibodies. Proc Natl Acad Sci USA 102 (2005) 7718-7723
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 7718-7723
-
-
Arbel, M.1
Yacoby, I.2
Solomon, B.3
-
58
-
-
0037431082
-
Aph-1, Pen-2, and nicastrin with presenilin generate an active ß-secretase complex
-
De Strooper B. Aph-1, Pen-2, and nicastrin with presenilin generate an active ß-secretase complex. Neuron 38 (2003) 9-12
-
(2003)
Neuron
, vol.38
, pp. 9-12
-
-
De Strooper, B.1
-
59
-
-
0034669031
-
A common enzyme connects Notch signaling and Alzheimer's disease
-
Kopan R., and Goate A. A common enzyme connects Notch signaling and Alzheimer's disease. Genes Dev 14 (2000) 2799-2806
-
(2000)
Genes Dev
, vol.14
, pp. 2799-2806
-
-
Kopan, R.1
Goate, A.2
-
60
-
-
3242803587
-
Non-steroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review
-
Szekely C.A., Thorne J.E., and Zandi P.P. Non-steroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review. Neuroepidemiology 23 (2004) 159-169
-
(2004)
Neuroepidemiology
, vol.23
, pp. 159-169
-
-
Szekely, C.A.1
Thorne, J.E.2
Zandi, P.P.3
-
61
-
-
38049115446
-
Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's disease
-
Poirier J. Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's disease. Alzheimers Dement 4 (2008) S91-S97
-
(2008)
Alzheimers Dement
, vol.4
-
-
Poirier, J.1
-
62
-
-
0038077567
-
Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study
-
Geerlings M., Launer L., De Jong F., Ruitenberg A., Stijnen T., et al. Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study. Ann Neurol 53 (2003) 607-615
-
(2003)
Ann Neurol
, vol.53
, pp. 607-615
-
-
Geerlings, M.1
Launer, L.2
De Jong, F.3
Ruitenberg, A.4
Stijnen, T.5
-
63
-
-
36749095848
-
Therapeutic treatment of Alzheimer's disease using metal complexing agents
-
Price K.A., Crouch P.J., and White A.R. Therapeutic treatment of Alzheimer's disease using metal complexing agents. Recent Patents CNS Drug Discov 2 (2007) 180-187
-
(2007)
Recent Patents CNS Drug Discov
, vol.2
, pp. 180-187
-
-
Price, K.A.1
Crouch, P.J.2
White, A.R.3
-
64
-
-
0033536163
-
Immunization with amyloid-beta attenuates alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D., Barbour R., Dunn W., Gordon G., Grajeda H., et al. Immunization with amyloid-beta attenuates alzheimer-disease-like pathology in the PDAPP mouse. Nature 400 (1999) 173-177
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
-
65
-
-
33745621613
-
Treatment of Alzheimer's disease: The beginning of a new era
-
Schenk D. Treatment of Alzheimer's disease: The beginning of a new era. Curr Alzheimer Res 3 (2006) 177
-
(2006)
Curr Alzheimer Res
, vol.3
, pp. 177
-
-
Schenk, D.1
-
66
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard F., Cannon C., Barbour R., Burke R.L., Games D., et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6 (2000) 916-919
-
(2000)
Nat Med
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
-
67
-
-
0035902619
-
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
-
DeMattos R.B., Bales K.R., Cummins D.J., Dodart J.C., Paul S.M., and Holtzman D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98 (2001) 8850-8855
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8850-8855
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Dodart, J.C.4
Paul, S.M.5
Holtzman, D.M.6
-
68
-
-
0344629707
-
Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations
-
Lombardo J.A., Stern E.A., Mclellan M.E., Kajdasz S.T., Hickey G.A., et al. Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. J Neurosci 23 (2003) 10879-10883
-
(2003)
J Neurosci
, vol.23
, pp. 10879-10883
-
-
Lombardo, J.A.1
Stern, E.A.2
Mclellan, M.E.3
Kajdasz, S.T.4
Hickey, G.A.5
-
69
-
-
0141457897
-
Amyloid-beta immunization effectively reduces amyloid deposition in Fcrgamma-/- Knock-out Mice
-
Das P., Howard V., Loosbrock N., Dickson D., Murphy M.P., and Golde T.E. Amyloid-beta immunization effectively reduces amyloid deposition in Fcrgamma-/- Knock-out Mice. J Neurosci 23 (2003) 8532-8538
-
(2003)
J Neurosci
, vol.23
, pp. 8532-8538
-
-
Das, P.1
Howard, V.2
Loosbrock, N.3
Dickson, D.4
Murphy, M.P.5
Golde, T.E.6
-
70
-
-
14844327972
-
Generation of anti-beta-amyloid antibodies via phage display technology towards Alzheimer's disease vaccination
-
Solomon B. Generation of anti-beta-amyloid antibodies via phage display technology towards Alzheimer's disease vaccination. Vaccine 23 (2005) 2327-2330
-
(2005)
Vaccine
, vol.23
, pp. 2327-2330
-
-
Solomon, B.1
-
71
-
-
0037155581
-
Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's Disease
-
Demattos R.B., Bales K.R., Cummins D.J., Paul S.M., and Holtzman D.M. Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's Disease. Science 295 (2002) 2264-2267
-
(2002)
Science
, vol.295
, pp. 2264-2267
-
-
Demattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Paul, S.M.4
Holtzman, D.M.5
-
72
-
-
33847775164
-
Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage
-
Epub 2007 Jan 30
-
Nikolic W.V., Bai Y., Obregon D., Hou H., Mori T., et al. Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage. Proc Natl Acad Sci USA 104 (2007) 2507-2512 Epub 2007 Jan 30
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 2507-2512
-
-
Nikolic, W.V.1
Bai, Y.2
Obregon, D.3
Hou, H.4
Mori, T.5
-
73
-
-
0036780877
-
Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning
-
Schenk D. Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning. Nat Rev Neurosci 3 (2002) 824-828
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 824-828
-
-
Schenk, D.1
-
74
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after abeta42 immunization
-
Orgogozo J.M., Gilman S., Dartigues J.F., Laurent B., Puel M., et al. Subacute meningoencephalitis in a subset of patients with AD after abeta42 immunization. Neurology 61 (2003) 46-54
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
Gilman, S.2
Dartigues, J.F.3
Laurent, B.4
Puel, M.5
-
75
-
-
20944448555
-
Clinical effects of abeta immunization (AN1792) in patients with AD in an interrupted trial
-
Gilman S., Koller M., Black R.S., Jenkins L., Griffith S.G., et al. Clinical effects of abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64 (2005) 1553-1562
-
(2005)
Neurology
, vol.64
, pp. 1553-1562
-
-
Gilman, S.1
Koller, M.2
Black, R.S.3
Jenkins, L.4
Griffith, S.G.5
-
76
-
-
47149112621
-
Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
-
Holmes C., Boche D., Wilkinson D., Yadegarfar G., Hopkins V., Bayer A., et al. Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372 (2008) 216-223
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
Yadegarfar, G.4
Hopkins, V.5
Bayer, A.6
-
77
-
-
0036327185
-
Human antibodies against amyloid beta peptide: A potential treatment for Alzheimer's disease
-
Dodel R., Hampel H., Depboylu C., Lin S., Gao F., et al. Human antibodies against amyloid beta peptide: A potential treatment for Alzheimer's disease. Ann Neurol 52 (2002) 253-256
-
(2002)
Ann Neurol
, vol.52
, pp. 253-256
-
-
Dodel, R.1
Hampel, H.2
Depboylu, C.3
Lin, S.4
Gao, F.5
-
78
-
-
33746419618
-
Intravenous immunoglobulin enhances the clearance of fibrillar amyloid-beta peptide
-
Istrin G., Bosis E., and Solomon B. Intravenous immunoglobulin enhances the clearance of fibrillar amyloid-beta peptide. J Neurosci Res 84 (2006) 434-443
-
(2006)
J Neurosci Res
, vol.84
, pp. 434-443
-
-
Istrin, G.1
Bosis, E.2
Solomon, B.3
-
79
-
-
70049083865
-
18-month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
-
Sous presse
-
Relkin NR, Szabo P, Adamiak B, Burgut T, Monthe C, Lent RW, et al. 18-month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol Aging. Sous presse.
-
Neurobiol Aging
-
-
Relkin, N.R.1
Szabo, P.2
Adamiak, B.3
Burgut, T.4
Monthe, C.5
Lent, R.W.6
-
80
-
-
48949085739
-
Amyloid-beta immunisation for Alzheimer's disease
-
Wisniewski T., and Konietzko U. Amyloid-beta immunisation for Alzheimer's disease. Lancet Neurol. 7 (2008) 805-811
-
(2008)
Lancet Neurol.
, vol.7
, pp. 805-811
-
-
Wisniewski, T.1
Konietzko, U.2
-
81
-
-
0022257253
-
Mise en évidence immunologique de la protéine Tau au niveau des lésions de dégénérescence neurofibrillaire de la maladie d'Alzheimer
-
Brion J.P. Mise en évidence immunologique de la protéine Tau au niveau des lésions de dégénérescence neurofibrillaire de la maladie d'Alzheimer. Arch Biol (Brux) 95 (1985) 229-235
-
(1985)
Arch Biol (Brux)
, vol.95
, pp. 229-235
-
-
Brion, J.P.1
-
82
-
-
0033850407
-
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
-
Buée L., Bussiere T., Buée-Scherrer V., Delacourte A., and Hof P.R. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 33 (2000) 95-130
-
(2000)
Brain Res Brain Res Rev
, vol.33
, pp. 95-130
-
-
Buée, L.1
Bussiere, T.2
Buée-Scherrer, V.3
Delacourte, A.4
Hof, P.R.5
-
84
-
-
10944223484
-
Tau Protein as a differential biomarker of tauopathies
-
Sergeant N., Delacourte A., and Buée L. Tau Protein as a differential biomarker of tauopathies. Biochim Biophys Acta 1739 (2005) 179-197
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 179-197
-
-
Sergeant, N.1
Delacourte, A.2
Buée, L.3
-
85
-
-
54849428550
-
Tau as biomarker for neurodegenerative diseases
-
Schraen-Maschke S., Sergeant N., Dhaenens C.M., Bombois S., Deramecourt V., Caillet-Boudin M.L., et al. Tau as biomarker for neurodegenerative diseases. Biomarkers Med 2 (2008) 363-384
-
(2008)
Biomarkers Med
, vol.2
, pp. 363-384
-
-
Schraen-Maschke, S.1
Sergeant, N.2
Dhaenens, C.M.3
Bombois, S.4
Deramecourt, V.5
Caillet-Boudin, M.L.6
-
86
-
-
0037072278
-
Nonoverlapping but Synergetic Tau and APP pathologies in sporadic Alzheimer's disease
-
Delacourte A., Sergeant N., Champain D., Wattez A., Maurage C.A., et al. Nonoverlapping but Synergetic Tau and APP pathologies in sporadic Alzheimer's disease. Neurology 59 (2002) 398-407
-
(2002)
Neurology
, vol.59
, pp. 398-407
-
-
Delacourte, A.1
Sergeant, N.2
Champain, D.3
Wattez, A.4
Maurage, C.A.5
-
87
-
-
0017649032
-
Purification of Tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin
-
Cleveland D.W., Hwo S.Y., and Kirschner M.W. Purification of Tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol 116 (1977) 207-225
-
(1977)
J Mol Biol
, vol.116
, pp. 207-225
-
-
Cleveland, D.W.1
Hwo, S.Y.2
Kirschner, M.W.3
-
88
-
-
0024745894
-
Multiple isoforms of human microtubule-associated protein Tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
-
Goedert M., Spillantini M.G., Jakes R., Rutherford D., and Crowther R.A. Multiple isoforms of human microtubule-associated protein Tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 3 (1989) 519-526
-
(1989)
Neuron
, vol.3
, pp. 519-526
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Rutherford, D.4
Crowther, R.A.5
-
89
-
-
0024387161
-
Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein Tau containing four tandem repeats: Differential expression of Tau protein Mrnas in human brain
-
Goedert M., Spillantini M.G., Potier M.C., Ulrich J., and Crowther R.A. Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein Tau containing four tandem repeats: Differential expression of Tau protein Mrnas in human brain. EMBO J 8 (1989) 393-399
-
(1989)
EMBO J
, vol.8
, pp. 393-399
-
-
Goedert, M.1
Spillantini, M.G.2
Potier, M.C.3
Ulrich, J.4
Crowther, R.A.5
-
90
-
-
22144497090
-
Pharmacological approaches of neurofibrillary degeneration
-
Iqbal K., and Grundke-Iqbal I. Pharmacological approaches of neurofibrillary degeneration. Curr Alzheimer Res 2 (2005) 335-341
-
(2005)
Curr Alzheimer Res
, vol.2
, pp. 335-341
-
-
Iqbal, K.1
Grundke-Iqbal, I.2
-
91
-
-
33745819942
-
The peptidylprolyl Cis/Trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons: Implication in a pathological mechanism related to Alzheimer disease
-
Galas M.C., Dourlen P., Begard S., Ando K., Blum D., et al. The peptidylprolyl Cis/Trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons: Implication in a pathological mechanism related to Alzheimer disease. J Biol Chem 281 (2006) 19296-19304
-
(2006)
J Biol Chem
, vol.281
, pp. 19296-19304
-
-
Galas, M.C.1
Dourlen, P.2
Begard, S.3
Ando, K.4
Blum, D.5
-
92
-
-
33745095542
-
Pin1 allows for differential tau dephosphorylation in neuronal cells
-
Hamdane M., Dourlen P., Bretteville A., Sambo A.V., Ferreira S., et al. Pin1 allows for differential tau dephosphorylation in neuronal cells. Mol Cell Neurosci 32 (2006) 155-160
-
(2006)
Mol Cell Neurosci
, vol.32
, pp. 155-160
-
-
Hamdane, M.1
Dourlen, P.2
Bretteville, A.3
Sambo, A.V.4
Ferreira, S.5
-
93
-
-
1642562894
-
O-GlcNac glycosylation and neurological disorders
-
Lefebvre T., Caillet-Boudin M.L., Buée L., Delacourte A., and Michalski J.C. O-GlcNac glycosylation and neurological disorders. Adv Exp Med Biol 535 (2003) 189-202
-
(2003)
Adv Exp Med Biol
, vol.535
, pp. 189-202
-
-
Lefebvre, T.1
Caillet-Boudin, M.L.2
Buée, L.3
Delacourte, A.4
Michalski, J.C.5
-
94
-
-
2942708228
-
Mechanism of neurodegenerative disease: Role of the ubiquitin proteasome system
-
Petrucelli L., and Dawson T.M. Mechanism of neurodegenerative disease: Role of the ubiquitin proteasome system. Ann Med 36 (2004) 315-320
-
(2004)
Ann Med
, vol.36
, pp. 315-320
-
-
Petrucelli, L.1
Dawson, T.M.2
-
95
-
-
0023140474
-
Ubiquitin is a component of paired helical filaments in Alzheimer's disease
-
Mori H., Kondo J., and Ihara Y. Ubiquitin is a component of paired helical filaments in Alzheimer's disease. Science 235 (1987) 1641-1644
-
(1987)
Science
, vol.235
, pp. 1641-1644
-
-
Mori, H.1
Kondo, J.2
Ihara, Y.3
-
96
-
-
11144356089
-
Chip and Hsp70 regulate Tau ubiquitination, degradation and aggregation
-
Petrucelli L., Dickson D., Kehoe K., Taylor J., Snyder H., et al. Chip and Hsp70 regulate Tau ubiquitination, degradation and aggregation. Hum Mol Genet 13 (2004) 703-714
-
(2004)
Hum Mol Genet
, vol.13
, pp. 703-714
-
-
Petrucelli, L.1
Dickson, D.2
Kehoe, K.3
Taylor, J.4
Snyder, H.5
-
97
-
-
3242749074
-
Caspase-cleavage of Tau is an early event in Alzheimer disease tangle pathology
-
Rissman R.A., Poon W.W., Blurton-Jones M., Oddo S., Torp R., et al. Caspase-cleavage of Tau is an early event in Alzheimer disease tangle pathology. J Clin Invest 114 (2004) 121-130
-
(2004)
J Clin Invest
, vol.114
, pp. 121-130
-
-
Rissman, R.A.1
Poon, W.W.2
Blurton-Jones, M.3
Oddo, S.4
Torp, R.5
-
98
-
-
33749150163
-
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
-
Braak H., Alafuzoff I., Arzberger T., Kretzschmar H., and Del Tredici K. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol (Berl) 112 (2006) 389-404
-
(2006)
Acta Neuropathol (Berl)
, vol.112
, pp. 389-404
-
-
Braak, H.1
Alafuzoff, I.2
Arzberger, T.3
Kretzschmar, H.4
Del Tredici, K.5
-
99
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l Tau transgenic mice induced by Abeta 42 fibrils
-
Gotz J., Chen F., Van Dorpe J., and Nitsch R.M. Formation of neurofibrillary tangles in P301l Tau transgenic mice induced by Abeta 42 fibrils. Science 293 (2001) 1491-1495
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
100
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant Tau and APP
-
Lewis J., Dickson D.W., Lin W.L., Chisholm L., Corral A., et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant Tau and APP. Science 293 (2001) 1487-1491
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
-
101
-
-
34248181511
-
Reducing endogenous Tau ameliorates amyloid (-induced deficits in an Alzheimer's disease mouse model
-
10.1126/science.1141736
-
Roberson E.D., Scearce-Levie K., Palop J.J., Yan F., Cheng I.H., et al. Reducing endogenous Tau ameliorates amyloid (-induced deficits in an Alzheimer's disease mouse model. Science 316 (2007) 10.1126/science.1141736
-
(2007)
Science
, vol.316
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
-
102
-
-
33746652117
-
Alzheimer's disease-like Tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated Tau transgenic mouse without any motor deficits
-
Schindowski K., Bretteville A., Leroy K., Begard S., Brion J.P., et al. Alzheimer's disease-like Tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated Tau transgenic mouse without any motor deficits. Am J Pathol 169 (2006) 599-616
-
(2006)
Am J Pathol
, vol.169
, pp. 599-616
-
-
Schindowski, K.1
Bretteville, A.2
Leroy, K.3
Begard, S.4
Brion, J.P.5
-
103
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) Tau protein
-
Lewis J., Mcgowan E., Rockwood J., Melrose H., Nacharaju P., et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) Tau protein. Nat Genet 25 (2000) 402-405
-
(2000)
Nat Genet
, vol.25
, pp. 402-405
-
-
Lewis, J.1
Mcgowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
-
104
-
-
22344438508
-
Tau suppression in a neurodegenerative mouse model improves memory function
-
Santacruz K., Lewis J., Spires T., Paulson J., Kotilinek L., et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 309 (2005) 476-481
-
(2005)
Science
, vol.309
, pp. 476-481
-
-
Santacruz, K.1
Lewis, J.2
Spires, T.3
Paulson, J.4
Kotilinek, L.5
-
105
-
-
0035808361
-
Tau filament formation in transgenic mice expressing P301l Tau
-
Gotz J., Chen F., Barmettler R., and Nitsch R.M. Tau filament formation in transgenic mice expressing P301l Tau. J Biol Chem 276 (2001) 529-534
-
(2001)
J Biol Chem
, vol.276
, pp. 529-534
-
-
Gotz, J.1
Chen, F.2
Barmettler, R.3
Nitsch, R.M.4
-
106
-
-
0036850725
-
Abundant Tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301s Tau protein
-
Allen B., Ingram E., Takao M., Smith M.J., Jakes R., et al. Abundant Tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301s Tau protein. J Neurosci 22 (2002) 9340-9351
-
(2002)
J Neurosci
, vol.22
, pp. 9340-9351
-
-
Allen, B.1
Ingram, E.2
Takao, M.3
Smith, M.J.4
Jakes, R.5
-
107
-
-
33646198145
-
Tau therapeutic strategies for the treatment of Alzheimer's disease
-
Churcher I. Tau therapeutic strategies for the treatment of Alzheimer's disease. Curr Top Med Chem 6 (2006) 579-595
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 579-595
-
-
Churcher, I.1
-
108
-
-
0345276565
-
Clogging of axons by Tau, inhibition of axonal traffic and starvation of synapses
-
Mandelkow E.M., Stamer K., Vogel R., Thies E., and Mandelkow E. Clogging of axons by Tau, inhibition of axonal traffic and starvation of synapses. Neurobiol Aging 24 (2003) 1079-1085
-
(2003)
Neurobiol Aging
, vol.24
, pp. 1079-1085
-
-
Mandelkow, E.M.1
Stamer, K.2
Vogel, R.3
Thies, E.4
Mandelkow, E.5
-
109
-
-
19944429064
-
Microtubule-binding drugs offset Tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
-
Zhang B., Maiti A., Shively S., Lakhani F., Mcdonald-Jones G., et al. Microtubule-binding drugs offset Tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proc Natl Acad Sci USA 102 (2005) 227-231
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 227-231
-
-
Zhang, B.1
Maiti, A.2
Shively, S.3
Lakhani, F.4
Mcdonald-Jones, G.5
-
110
-
-
21044449225
-
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
-
Noble W., Planel E., Zehr C., Olm V., Meyerson J., et al. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci USA 102 (2005) 6990-6995
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 6990-6995
-
-
Noble, W.1
Planel, E.2
Zehr, C.3
Olm, V.4
Meyerson, J.5
-
111
-
-
33745449875
-
An Inhibitor of Tau hyperphosphorylation prevents severe motor impairments in Tau transgenic mice
-
Le Corre S., Klafki H.W., Plesnila N., Hubinger G., Obermeier A., et al. An Inhibitor of Tau hyperphosphorylation prevents severe motor impairments in Tau transgenic mice. Proc Natl Acad Sci USA 103 (2006) 9673-9678
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9673-9678
-
-
Le Corre, S.1
Klafki, H.W.2
Plesnila, N.3
Hubinger, G.4
Obermeier, A.5
-
112
-
-
1542328910
-
Cdk5, a therapeutic target for Alzheimer's disease?
-
Tsai L.H., Lee M.S., and Cruz J. Cdk5, a therapeutic target for Alzheimer's disease?. Biochim Biophys Acta 1697 (2004) 137-142
-
(2004)
Biochim Biophys Acta
, vol.1697
, pp. 137-142
-
-
Tsai, L.H.1
Lee, M.S.2
Cruz, J.3
-
113
-
-
22744432396
-
Control of protein-protein interactions: Structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 Ww domain and phosphopeptides
-
Smet C., Duckert J.F., Wieruszeski J.M., Landrieu I., Buée L., et al. Control of protein-protein interactions: Structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 Ww domain and phosphopeptides. J Med Chem 48 (2005) 4815-4823
-
(2005)
J Med Chem
, vol.48
, pp. 4815-4823
-
-
Smet, C.1
Duckert, J.F.2
Wieruszeski, J.M.3
Landrieu, I.4
Buée, L.5
-
114
-
-
1242307774
-
The Peptidyl prolyl Cis/Trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau
-
Smet C., Sambo A.V., Wieruszeski J.M., Leroy A., Landrieu I., et al. The Peptidyl prolyl Cis/Trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau. Biochemistry 43 (2004) 2032-2040
-
(2004)
Biochemistry
, vol.43
, pp. 2032-2040
-
-
Smet, C.1
Sambo, A.V.2
Wieruszeski, J.M.3
Leroy, A.4
Landrieu, I.5
-
115
-
-
13544251748
-
Anthraquinones inhibit Tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
-
Pickhardt M., Gazova Z., Von Bergen M., Khlistunova I., Wang Y., et al. Anthraquinones inhibit Tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. J Biol Chem 280 (2005) 3628-3635
-
(2005)
J Biol Chem
, vol.280
, pp. 3628-3635
-
-
Pickhardt, M.1
Gazova, Z.2
Von Bergen, M.3
Khlistunova, I.4
Wang, Y.5
-
116
-
-
33645509903
-
Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy
-
Lippens G., Sillen A., Smet C., Wieruszeski J.M., Leroy A., et al. Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy. Protein Pept Lett 13 (2006) 235-246
-
(2006)
Protein Pept Lett
, vol.13
, pp. 235-246
-
-
Lippens, G.1
Sillen, A.2
Smet, C.3
Wieruszeski, J.M.4
Leroy, A.5
-
117
-
-
23044439880
-
Cyanine dye N744 Inhibits Tau fibrillization by blocking filament extension: Implications for the treatment of tauopathic neurodegenerative diseases
-
Necula M., Chirita C.N., and Kuret J. Cyanine dye N744 Inhibits Tau fibrillization by blocking filament extension: Implications for the treatment of tauopathic neurodegenerative diseases. Biochemistry 44 (2005) 10227-10237
-
(2005)
Biochemistry
, vol.44
, pp. 10227-10237
-
-
Necula, M.1
Chirita, C.N.2
Kuret, J.3
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