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Volumn 11, Issue 5, 2005, Pages 551-555

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; NERVE GROWTH FACTOR;

EID: 21044458854     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1239     Document Type: Article
Times cited : (931)

References (35)
  • 1
    • 0022486717 scopus 로고
    • Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbrial transection
    • Hefti, F. Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbrial transection. J. Neurosci. 6, 2155-2162 (1986).
    • (1986) J. Neurosci. , vol.6 , pp. 2155-2162
    • Hefti, F.1
  • 2
    • 0023643241 scopus 로고
    • Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
    • Fischer, W. et al. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329, 65-68 (1987).
    • (1987) Nature , vol.329 , pp. 65-68
    • Fischer, W.1
  • 3
    • 0025513602 scopus 로고
    • Nerve growth factor infusion in primate brain reduces lesion-induced cholinergic neuronal degeneration
    • Tuszynski, M.H., U, H.S., Amaral, D.G. & Gage, F.H. Nerve growth factor infusion in primate brain reduces lesion-induced cholinergic neuronal degeneration. J. Neurosci. 10, 3604-3614 (1990).
    • (1990) J. Neurosci. , vol.10 , pp. 3604-3614
    • Tuszynski, M.H.1    U, H.S.2    Amaral, D.G.3    Gage, F.H.4
  • 4
    • 0028130227 scopus 로고
    • Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: Rescue and sprouting of degenerating cholinergic basal forebrain neurons
    • Emerich, D.W. et al. Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: Rescue and sprouting of degenerating cholinergic basal forebrain neurons. J. Comp. Neurol. 349, 148-164 (1994).
    • (1994) J. Comp. Neurol. , vol.349 , pp. 148-164
    • Emerich, D.W.1
  • 5
    • 2942591228 scopus 로고    scopus 로고
    • Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion
    • Cooper, J.D. et al. Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc. Natl. Acad. Sci. USA 98, 10439-10444 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10439-10444
    • Cooper, J.D.1
  • 6
    • 0037125974 scopus 로고    scopus 로고
    • Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice
    • Capsoni, S., Giannotta, S. & Cattaneo, A. Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc. Natl. Acad. Sci. USA 99, 12432-12437 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12432-12437
    • Capsoni, S.1    Giannotta, S.2    Cattaneo, A.3
  • 7
    • 0037654372 scopus 로고    scopus 로고
    • Gene therapy for neurodegenerative disorders
    • Tuszynski, M.H. Gene therapy for neurodegenerative disorders. Lancet Neurol. 1, 51-57 (2002).
    • (2002) Lancet Neurol. , vol.1 , pp. 51-57
    • Tuszynski, M.H.1
  • 8
    • 0023236055 scopus 로고
    • The nerve growth factor 35 years later
    • Levi-Montalcini, R. The nerve growth factor 35 years later. Science 237, 1154-1162 (1987).
    • (1987) Science , vol.237 , pp. 1154-1162
    • Levi-Montalcini, R.1
  • 9
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus, R., Dean, R.L., Beer, C. & Lippa, A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 217, 408-417 (1982).
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.1    Dean, R.L.2    Beer, C.3    Lippa, A.S.4
  • 10
    • 0023715013 scopus 로고
    • Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase
    • Mesulam, M.M. & Geula, C. Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: observations based on the distribution of acetylcholinesterase and choline acetyltransferase. J. Comp. Neurol. 275, 216-240 (1988).
    • (1988) J. Comp. Neurol. , vol.275 , pp. 216-240
    • Mesulam, M.M.1    Geula, C.2
  • 11
    • 0032513387 scopus 로고    scopus 로고
    • Cortical map reorganization enabled by nucleus basalis activity
    • Kilgard, M.P. & Merzenich, M.M. Cortical map reorganization enabled by nucleus basalis activity. Science 279, 1714-1718 (1998).
    • (1998) Science , vol.279 , pp. 1714-1718
    • Kilgard, M.P.1    Merzenich, M.M.2
  • 12
    • 0038386024 scopus 로고    scopus 로고
    • Lesions of the basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning
    • Conner, J.M., Culberson, A., Packowski, C., Chiba, A., Tuszynski, M.H. Lesions of the basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron 38, 819-829 (2003).
    • (2003) Neuron , vol.38 , pp. 819-829
    • Conner, J.M.1    Culberson, A.2    Packowski, C.3    Chiba, A.4    Tuszynski, M.H.5
  • 13
    • 0018078940 scopus 로고
    • Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia
    • Perry, E.K. et al. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Brit. Med. J. 2, 1457-1459 (1978).
    • (1978) Brit. Med. J. , vol.2 , pp. 1457-1459
    • Perry, E.K.1
  • 14
    • 0024263047 scopus 로고
    • Grafting genetically modified cells to the damaged brain: Restorative effects of NGF expression
    • Rosenberg, M.B. et al. Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression. Science 242, 1575-1578(1988).
    • (1988) Science , vol.242 , pp. 1575-1578
    • Rosenberg, M.B.1
  • 15
    • 0028965223 scopus 로고
    • Somatic gene transfer of NGF to the aged brain: Behavioral and morphological amelioration
    • Chen, K.S. & Gage, F.H. Somatic gene transfer of NGF to the aged brain: Behavioral and morphological amelioration. J. Neurosci. 15, 2819-2825 (1995).
    • (1995) J. Neurosci. , vol.15 , pp. 2819-2825
    • Chen, K.S.1    Gage, F.H.2
  • 16
    • 0030002982 scopus 로고    scopus 로고
    • Gene therapy in the adult primate brain: Intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration
    • Tuszynski, M.H., Roberts, J., Senut, M.C., U, H.-S. & Gage, F.H. Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Therapy 3, 305-314 (1996).
    • (1996) Gene Therapy , vol.3 , pp. 305-314
    • Tuszynski, M.H.1    Roberts, J.2    Senut, M.C.3    Gage, F.H.4
  • 17
    • 0032845156 scopus 로고    scopus 로고
    • Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy
    • Smith, D.E., Roberts, J., Gage, F.H., Tuszynski, M.H. Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc. Nat. Acad. Sci. USA 96, 10893-10898 (1999).
    • (1999) Proc. Nat. Acad. Sci. USA , vol.96 , pp. 10893-10898
    • Smith, D.E.1    Roberts, J.2    Gage, F.H.3    Tuszynski, M.H.4
  • 18
    • 0035852680 scopus 로고    scopus 로고
    • Non-tropic actions of neurotrophins: Subcortical NGP gene delivery reverses age-related degeneration of primate cortical cholinergic innervation
    • Conner, J.M., Darracq, M.A., Roberts, J., Tuszynski, M.H. Non-tropic actions of neurotrophins: Subcortical NGP gene delivery reverses age-related degeneration of primate cortical cholinergic innervation. Proc. Natl. Acad. Sci. USA 98, 1941-1946 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1941-1946
    • Conner, J.M.1    Darracq, M.A.2    Roberts, J.3    Tuszynski, M.H.4
  • 19
    • 0029013323 scopus 로고
    • Bridging grafts and transient NGP infusions promote long-term CNS neuronal rescue and partial functional recovery
    • Tuszynski, M.H. & Gage, F.H. Bridging grafts and transient NGP infusions promote long-term CNS neuronal rescue and partial functional recovery. Proc. Natl. Acad. Sci. USA 92, 4621-4625 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4621-4625
    • Tuszynski, M.H.1    Gage, F.H.2
  • 20
    • 0028262405 scopus 로고
    • A longitudinal study of Alzheimer's disease: Measurement, rate, and predictors of cognitive deterioration
    • Stern, R.G. et al. A longitudinal study of Alzheimer's disease: measurement, rate, and predictors of cognitive deterioration. Am. J. Psychiatry 151, 390-396 (1994).
    • (1994) Am. J. Psychiatry , vol.151 , pp. 390-396
    • Stern, R.G.1
  • 21
    • 0344738681 scopus 로고    scopus 로고
    • Idebenone treatment fails to slow cognitive decline in Alzheimer's disease
    • Thal, L.J. et al. Idebenone treatment fails to slow cognitive decline in Alzheimer's disease. Neurology 61, 1498-1502 (2003).
    • (2003) Neurology , vol.61 , pp. 1498-1502
    • Thal, L.J.1
  • 22
    • 0035699431 scopus 로고    scopus 로고
    • Brain metabolic and clinical effects of rivastigmine in Alzheimer's disease
    • Potkin, S.G. et al. Brain metabolic and clinical effects of rivastigmine in Alzheimer's disease. Int. J. Neuropsychopharmacol. 4, 223-230 (2001).
    • (2001) Int. J. Neuropsychopharmacol. , vol.4 , pp. 223-230
    • Potkin, S.G.1
  • 23
    • 0037030676 scopus 로고    scopus 로고
    • Neuronal plasticity of interrelated cerebellar and cortical networks
    • Molinari, M., Filippini, V. & Leggio, M.G. Neuronal plasticity of interrelated cerebellar and cortical networks. Neuroscience 111, 863-870 (2002).
    • (2002) Neuroscience , vol.111 , pp. 863-870
    • Molinari, M.1    Filippini, V.2    Leggio, M.G.3
  • 24
    • 0038721951 scopus 로고    scopus 로고
    • Does the cerebellum contribute to specific aspects of attention?
    • Gottwald, B., Mihajlovic, Z., Wilde, B. & Mehdorn, H.M. Does the cerebellum contribute to specific aspects of attention? Neuropsychologia 41, 1452-1460 (2003).
    • (2003) Neuropsychologia , vol.41 , pp. 1452-1460
    • Gottwald, B.1    Mihajlovic, Z.2    Wilde, B.3    Mehdorn, H.M.4
  • 25
    • 4143075792 scopus 로고    scopus 로고
    • Surgical and hardware complications of subthalamic stimulation: A series of 160 procedures
    • Lyons, K.E., Wilkinson, S.B., Overman, J. & Pahwa, R. Surgical and hardware complications of subthalamic stimulation: a series of 160 procedures. Neurology 63, 612-616 (2004).
    • (2004) Neurology , vol.63 , pp. 612-616
    • Lyons, K.E.1    Wilkinson, S.B.2    Overman, J.3    Pahwa, R.4
  • 26
    • 0005868926 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease
    • Eriksdotter Jonhagen, M. et al. Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 9, 246-257 (1998).
    • (1998) Dement. Geriatr. Cogn. Disord. , vol.9 , pp. 246-257
    • Eriksdotter Jonhagen, M.1
  • 27
    • 0033604631 scopus 로고    scopus 로고
    • Treatment of Alzheimer's disease
    • Mayeux, R., Sano M. Treatment of Alzheimer's disease. N. Engl. J. Med. 341, 1670-1679 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , pp. 1670-1679
    • Mayeux, R.1    Sano, M.2
  • 28
    • 0028235419 scopus 로고
    • Synaptic and neuritic alterations during the progression of Alzheimer's disease
    • Masliah, E. et al. Synaptic and neuritic alterations during the progression of Alzheimer's disease. Neurosci. Lett. 174, 67-72 (1994).
    • (1994) Neurosci. Lett. , vol.174 , pp. 67-72
    • Masliah, E.1
  • 29
    • 0842304284 scopus 로고    scopus 로고
    • The cholinergic lesion of Alzheimer's disease: Pivotal factor or side show?
    • Mesulam, M. The cholinergic lesion of Alzheimer's disease: pivotal factor or side show? Learn. Mem. 11, 43-49 (2004).
    • (2004) Learn. Mem. , vol.11 , pp. 43-49
    • Mesulam, M.1
  • 30
    • 0001181116 scopus 로고    scopus 로고
    • Alzheimer's disease: Molecular understanding predicts amyloid-based therapeutics
    • Selkoe, D.J. & Schenk, D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu. Rev. Pharmacol. Toxicol. 43, 545-584 (2003).
    • (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 545-584
    • Selkoe, D.J.1    Schenk, D.2
  • 31
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
    • Gill, S.S. et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat. Med. 9, 589-595 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 589-595
    • Gill, S.S.1
  • 32
    • 14844311296 scopus 로고    scopus 로고
    • Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
    • Slevin, J.T., Gerhardt, G.A., Smith, C.D., Gash, D.M., Kryscio, R.J. & Young, A.B. Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor. J. Neurosurg. 102, 216-222 (2005).
    • (2005) J. Neurosurg. , vol.102 , pp. 216-222
    • Slevin, J.T.1    Gerhardt, G.A.2    Smith, C.D.3    Gash, D.M.4    Kryscio, R.J.5    Young, A.B.6
  • 33
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann, G. et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944 (1984).
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1
  • 34
    • 0035976524 scopus 로고    scopus 로고
    • Regulation of cell survival by secreted proneurotrophins
    • Lee, R., Kermani, P., Teng, K.K. & Hempstead, B.L. Regulation of cell survival by secreted proneurotrophins. Science 294, 1945-1948(2001).
    • (2001) Science , vol.294 , pp. 1945-1948
    • Lee, R.1    Kermani, P.2    Teng, K.K.3    Hempstead, B.L.4
  • 35
    • 0021520020 scopus 로고
    • A new rating scale for Alzheimer's disease
    • Rosen, W.G., Mohs, R.C., et al. A new rating scale for Alzheimer's disease. Am. J. Psychiatry 141, 1356-1364 (1984).
    • (1984) Am. J. Psychiatry , vol.141 , pp. 1356-1364
    • Rosen, W.G.1    Mohs, R.C.2


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