-
1
-
-
0030174981
-
The gene defects responsible for familial Alzheimer's disease
-
Tanzi, R. E., Kovacs, D. M., Kim, T.-W., Moir, R. D., Guenette, S. Y., and Wasco, W. (1996) The gene defects responsible for familial Alzheimer's disease. Neurobiol. Dis. 3, 159-168.
-
(1996)
Neurobiol. Dis.
, vol.3
, pp. 159-168
-
-
Tanzi, R.E.1
Kovacs, D.M.2
Kim, T.-W.3
Moir, R.D.4
Guenette, S.Y.5
Wasco, W.6
-
2
-
-
0029073383
-
Genetic dissection of Alzheimer's disease, a heterogeneous disorder
-
Schellenberg, G. D. (1995) Genetic dissection of Alzheimer's disease, a heterogeneous disorder. Proc. Natl. Acad. Sci. U.S.A. 92, 8552-8559.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 8552-8559
-
-
Schellenberg, G.D.1
-
3
-
-
0029379605
-
Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease
-
Checler, F. (1995) Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 65, 1431-1444.
-
(1995)
J. Neurochem.
, vol.65
, pp. 1431-1444
-
-
Checler, F.1
-
4
-
-
0028267440
-
Normal and abnormal biology of the beta-amyloid precursor protein
-
Selkoe, D. J. (1994) Normal and abnormal biology of the beta-amyloid precursor protein. Annu. Rev. Neurosci. 17, 489-517.
-
(1994)
Annu. Rev. Neurosci.
, vol.17
, pp. 489-517
-
-
Selkoe, D.J.1
-
5
-
-
0033616590
-
Unusual phenotypic alteration of β-amyloid precursor protein (βAPP) maturation by a new Val → Met βAPP-770 mutation responsible for probable early-onset Alzheimer's disease
-
Ancolio, K., Dumanchin, C., Barelli, H., Warter, J. M., Brice, A., Campion, D., Frébourg, T., and Checler, F. (1999) Unusual phenotypic alteration of β-amyloid precursor protein (βAPP) maturation by a new Val → Met βAPP-770 mutation responsible for probable early-onset Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 96, 4119-4124.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 4119-4124
-
-
Ancolio, K.1
Dumanchin, C.2
Barelli, H.3
Warter, J.M.4
Brice, A.5
Campion, D.6
Frébourg, T.7
Checler, F.8
-
6
-
-
0026595567
-
Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs
-
Burdick, D., Soreghan, B., Kwon, M., Kosmoski, J., Knauer, M., Henschen, A., Yates, J., Cotman, C., and Glabe, C. (1992) Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs. J. Biol. Chem. 267, 546-554.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 546-554
-
-
Burdick, D.1
Soreghan, B.2
Kwon, M.3
Kosmoski, J.4
Knauer, M.5
Henschen, A.6
Yates, J.7
Cotman, C.8
Glabe, C.9
-
7
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J. F., Bruni, A. C., Montesi, M. P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinski, R. J., Wasco, W., Da Silva, H. A. R., Haines, J. L., Pericak-Vance, M. A., Tanzi, R. E., Roses, A. D., Fraser, P. E., Rommens, J. M., and St. George-Hyslop, P. H. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
Tsuda, T.11
Mar, L.12
Foncin, J.F.13
Bruni, A.C.14
Montesi, M.P.15
Sorbi, S.16
Rainero, I.17
Pinessi, L.18
Nee, L.19
Chumakov, I.20
Pollen, D.21
Brookes, A.22
Sanseau, P.23
Polinski, R.J.24
Wasco, W.25
Da Silva, H.A.R.26
Haines, J.L.27
Pericak-Vance, M.A.28
Tanzi, R.E.29
Roses, A.D.30
Fraser, P.E.31
Rommens, J.M.32
St. George-Hyslop, P.H.33
more..
-
8
-
-
0029087026
-
Candidate gene for the chromosome I familial Alzheimer's disease locus
-
Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C., Jondro, P. D., Schmidt, S. D., Wang, K., Crowley, A. C., Fu, Y. H., Guenette, S. Y., Galas, D., Nemens, E., Wisjman, E. M., Bird, T. D., Schellenberg, G. D., and Tanzi, R. (1995) Candidate gene for the chromosome I familial Alzheimer's disease locus. Science 269, 973-977.
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
Yu, C.7
Jondro, P.D.8
Schmidt, S.D.9
Wang, K.10
Crowley, A.C.11
Fu, Y.H.12
Guenette, S.Y.13
Galas, D.14
Nemens, E.15
Wisjman, E.M.16
Bird, T.D.17
Schellenberg, G.D.18
Tanzi, R.19
-
9
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., Mar, L., Sorbi, S., Nacmias, B., Piacentini, S., Amaducci, L., Chumakov, I., Cohen, D., Lannfelt, L., Fraser, P. E., Rommens, J. M., and St. Georges-Hyslop, P. H. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
Mar, L.11
Sorbi, S.12
Nacmias, B.13
Piacentini, S.14
Amaducci, L.15
Chumakov, I.16
Cohen, D.17
Lannfelt, L.18
Fraser, P.E.19
Rommens, J.M.20
St. Georges-Hyslop, P.H.21
more..
-
10
-
-
0029411573
-
Presenilins and Alzheimer's disease
-
Van Broeckhoven, C. (1995) Presenilins and Alzheimer's disease. Nat. Genet. 11, 230-232.
-
(1995)
Nat. Genet.
, vol.11
, pp. 230-232
-
-
Van Broeckhoven, C.1
-
11
-
-
0030922421
-
Presenilins: Genes for life and death
-
Haass, C. (1997) Presenilins: Genes for life and death. Neurons 18, 687-690.
-
(1997)
Neurons
, vol.18
, pp. 687-690
-
-
Haass, C.1
-
12
-
-
0031031120
-
Presenilins, amyloid-β and Alzheimer's disease
-
Lamb, B. T. (1997) Presenilins, amyloid-β and Alzheimer's disease. Nat. Genet. 3, 28-29.
-
(1997)
Nat. Genet.
, vol.3
, pp. 28-29
-
-
Lamb, B.T.1
-
13
-
-
0030761094
-
The presenilins and Alzheimer's disease
-
Hutton, M., and Hardy, J. (1997) The presenilins and Alzheimer's disease. Hum. Mol. Genet. 6, 1639-1646.
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 1639-1646
-
-
Hutton, M.1
Hardy, J.2
-
14
-
-
0031982670
-
Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease
-
Mattson, M. P., Guo, Q., Furukawa, K., and Pedersen, W. A. (1998) Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J. Neurochem. 70, 1-14.
-
(1998)
J. Neurochem.
, vol.70
, pp. 1-14
-
-
Mattson, M.P.1
Guo, Q.2
Furukawa, K.3
Pedersen, W.A.4
-
15
-
-
0031581057
-
Presenilin 1 binds to amyloid precursor protein directly
-
Waragai, M., Imafuku, I., Takeuchi, S., Kanazawa, I., Oyama, F., Udagawa, Y., Kawabata, M., and Okazawa, H. (1997) Presenilin 1 binds to amyloid precursor protein directly. Biochem. Biophys. Res. Commun. 239, 480-482.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.239
, pp. 480-482
-
-
Waragai, M.1
Imafuku, I.2
Takeuchi, S.3
Kanazawa, I.4
Oyama, F.5
Udagawa, Y.6
Kawabata, M.7
Okazawa, H.8
-
16
-
-
0031054505
-
Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein
-
Weidemann, A., Paliga. K., Dürrwang, U., Czech, C., Evin, G., Masters, C., and Beyreuther, K. (1997) Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein. Nat. Med. 3, 328-332.
-
(1997)
Nat. Med.
, vol.3
, pp. 328-332
-
-
Weidemann, A.1
Paliga, K.2
Dürrwang, U.3
Czech, C.4
Evin, G.5
Masters, C.6
Beyreuther, K.7
-
17
-
-
0032919039
-
Mapping the APP/presenilin (PS) binding domains: The hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction
-
Pradier, L., Carpentier, N., Delalonde, L., Clavel, N., Bock, M.-D., Buée, L., Mercken, L., Tocqué, B., and Czech, C. (1999) Mapping the APP/presenilin (PS) binding domains: The hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction. Neurobiol. Dis. 6, 43-55.
-
(1999)
Neurobiol. Dis.
, vol.6
, pp. 43-55
-
-
Pradier, L.1
Carpentier, N.2
Delalonde, L.3
Clavel, N.4
Bock, M.-D.5
Buée, L.6
Mercken, L.7
Tocqué, B.8
Czech, C.9
-
18
-
-
0030753089
-
Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer's disease
-
Xia, W., Zhang, J., Perez, R., Koo, E. H., and Selkoe, D. J. (1997)Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 94, 8208-8213.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 8208-8213
-
-
Xia, W.1
Zhang, J.2
Perez, R.3
Koo, E.H.4
Selkoe, D.J.5
-
19
-
-
0031196094
-
Lack of interactions between amyloid precursor protein and hydrophilic domains of presenilin 1 and 2 using the yeast two hybrid system
-
Kim, S.-S., Choi, Y.-M., and Suh, Y.-H. (1997) Lack of interactions between amyloid precursor protein and hydrophilic domains of presenilin 1 and 2 using the yeast two hybrid system. J. Mol. Neurosci. 9, 49-54.
-
(1997)
J. Mol. Neurosci.
, vol.9
, pp. 49-54
-
-
Kim, S.-S.1
Choi, Y.-M.2
Suh, Y.-H.3
-
20
-
-
0031920383
-
Stable association of presenilin derivatives and absence of presenilin interactions with APP
-
Thinakaran, G., Regard, J. B., Bouton, C. M. L., Harris, C. L., Price, D. L., Borchelt, D. R., and Sisodia, S. S. (1998) Stable association of presenilin derivatives and absence of presenilin interactions with APP. Neurobiol. Dis. 4, 438-453.
-
(1998)
Neurobiol. Dis.
, vol.4
, pp. 438-453
-
-
Thinakaran, G.1
Regard, J.B.2
Bouton, C.M.L.3
Harris, C.L.4
Price, D.L.5
Borchelt, D.R.6
Sisodia, S.S.7
-
21
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin
-
Yu, G., Chen, F., Levesque, G., Nishimura, M., Zhang, D.-M., Levesque, L., Rogaeva, E., Xu, D., Liang, Y., Duthie, M., St. George-Hyslop, P. H., and Fraser, P. E. (1998) The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin. J. Biol. Chem. 273, 16470-16475.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16470-16475
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
Nishimura, M.4
Zhang, D.-M.5
Levesque, L.6
Rogaeva, E.7
Xu, D.8
Liang, Y.9
Duthie, M.10
St. George-Hyslop, P.H.11
Fraser, P.E.12
-
22
-
-
0032545273
-
Abrogation of the presenilin 1/β-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation
-
Tesco, G., Kim, T.-W., Dielhmann, A., Beyreuther, K., and Tanzi, R. (1998) Abrogation of the presenilin 1/β-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. J. Biol. Chem. 273, 33909-33914.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 33909-33914
-
-
Tesco, G.1
Kim, T.-W.2
Dielhmann, A.3
Beyreuther, K.4
Tanzi, R.5
-
23
-
-
0032531793
-
Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
-
Zhang, Z., Hartmann, H., Do, V. M., Abramowski, D., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., van de Wetering, M., Clevers, H., Saftig, P., De Strooper, B., He, X., and Yankner, B. A. (1998) Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395, 698-702.
-
(1998)
Nature
, vol.395
, pp. 698-702
-
-
Zhang, Z.1
Hartmann, H.2
Do, V.M.3
Abramowski, D.4
Sturchler-Pierrat, C.5
Staufenbiel, M.6
Sommer, B.7
Van De Wetering, M.8
Clevers, H.9
Saftig, P.10
De Strooper, B.11
He, X.12
Yankner, B.A.13
-
24
-
-
0032905727
-
Presenilin mutations associated with Alzheimer's disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex
-
Nishimura, M., Yu, G., Levesque, G., Zhang, D. M., Ruel, L., Chen, F., Milman, P., Holmes, E., Liang, Y., Kawarai, T., Jo, E., Supala, A., Rogaeva, E., Xu, D.-M., Janus, C., Levesque, L., Bi, Q., Duthie, M., Rozmahel, R., Mattil, K., Lannfelt, L., Westaway, D., Mount, H. T. J., Woodgett, J., Fraser, P. E., and St. George-Hyslop, P. (1999) Presenilin mutations associated with Alzheimer's disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex. Nat. Med. 5, 164-169.
-
(1999)
Nat. Med.
, vol.5
, pp. 164-169
-
-
Nishimura, M.1
Yu, G.2
Levesque, G.3
Zhang, D.M.4
Ruel, L.5
Chen, F.6
Milman, P.7
Holmes, E.8
Liang, Y.9
Kawarai, T.10
Jo, E.11
Supala, A.12
Rogaeva, E.13
Xu, D.-M.14
Janus, C.15
Levesque, L.16
Bi, Q.17
Duthie, M.18
Rozmahel, R.19
Mattil, K.20
Lannfelt, L.21
Westaway, D.22
Mount, H.T.J.23
Woodgett, J.24
Fraser, P.E.25
St. George-Hyslop, P.26
more..
-
25
-
-
0032972547
-
Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and β-catenin
-
Levesque, G., Yu, G., Nishimura, M., Zhang, D. M., Levesque, L., Yu, H., Xu, D., Liang, Y, Rogaeva, E., Ikeda, M., Duthie, M., Murgolo, N., Wang, L., VanderVere, P., Bayne, M. L., Strader, C. D., Rommens, J. M., Fraser, P. E., and St. George-Hyslop, P. (1999) Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and β-catenin. J. Neurochem. 72, 999-1008.
-
(1999)
J. Neurochem.
, vol.72
, pp. 999-1008
-
-
Levesque, G.1
Yu, G.2
Nishimura, M.3
Zhang, D.M.4
Levesque, L.5
Yu, H.6
Xu, D.7
Liang, Y.8
Rogaeva, E.9
Ikeda, M.10
Duthie, M.11
Murgolo, N.12
Wang, L.13
Vandervere, P.14
Bayne, M.L.15
Strader, C.D.16
Rommens, J.M.17
Fraser, P.E.18
St. George-Hyslop, P.19
-
26
-
-
0032568846
-
Regulation of brain G-protein Go by Alzheimer's disease gene presenilin-1
-
Smine, A., Xu, X., Nishiyama, K., Katada, T., Gambetti, P., Yadav, S. P., Wu, X., Shi, Y.-C., Yasuhara, S., Homburger, V., and Okamoto, T. (1998) Regulation of brain G-protein Go by Alzheimer's disease gene presenilin-1. J. Biol. Chem. 273, 16281-16288.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16281-16288
-
-
Smine, A.1
Xu, X.2
Nishiyama, K.3
Katada, T.4
Gambetti, P.5
Yadav, S.P.6
Wu, X.7
Shi, Y.-C.8
Yasuhara, S.9
Homburger, V.10
Okamoto, T.11
-
27
-
-
13144265717
-
Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau
-
Takashima, A., Murayama, M., Murayama, O., Kohno, T., Honda, T., Yasutake, K., Nihonmatsu, N., Mercken, M., Yamaguchi, H., Sugihara, S., and Wolozin, B. (1998) Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau. Proc. Natl. Acad. Sci. U.S.A. 95, 9637-9641.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 9637-9641
-
-
Takashima, A.1
Murayama, M.2
Murayama, O.3
Kohno, T.4
Honda, T.5
Yasutake, K.6
Nihonmatsu, N.7
Mercken, M.8
Yamaguchi, H.9
Sugihara, S.10
Wolozin, B.11
-
28
-
-
0031721511
-
Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment
-
Buxbaum, J. D., Choi, E.-K., Luo, Y, Lilliehook, C., Crowley, A. C., Merriam, D. E., and Wasco, W. (1998) Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat. Med. 4, 1177-1181.
-
(1998)
Nat. Med.
, vol.4
, pp. 1177-1181
-
-
Buxbaum, J.D.1
Choi, E.-K.2
Luo, Y.3
Lilliehook, C.4
Crowley, A.C.5
Merriam, D.E.6
Wasco, W.7
-
29
-
-
0032787598
-
Presenilins interact with Rabl 1, a small GTPase involved in the regulation of vesicular transport
-
in press
-
Dumanchin, C., Czech, C., Campion, D., Cuif, M.-H., Poyot, T., Charbonnier, F., Goud, B., Pradier, L., and Frebourg, T. (1999) Presenilins interact with Rabl 1, a small GTPase involved in the regulation of vesicular transport. Hum. Mol. Genet. in press.
-
(1999)
Hum. Mol. Genet.
-
-
Dumanchin, C.1
Czech, C.2
Campion, D.3
Cuif, M.-H.4
Poyot, T.5
Charbonnier, F.6
Goud, B.7
Pradier, L.8
Frebourg, T.9
-
30
-
-
0033014046
-
Evidence for a physical interaction between presenilin and Notch
-
Ray, W. J., Yao, M., Nowotny, P., Mumm, J., Zhang, W., Wu, J. Y., Kopan, R., and Goate, A. M. (1999) Evidence for a physical interaction between presenilin and Notch. Proc. Natl. Acad. Sci. U.S.A. 96, 3263-3268.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 3263-3268
-
-
Ray, W.J.1
Yao, M.2
Nowotny, P.3
Mumm, J.4
Zhang, W.5
Wu, J.Y.6
Kopan, R.7
Goate, A.M.8
-
31
-
-
0033515530
-
Direct interaction of Alzheimer's disease-related presenilin 1 with Armadillo protein p0071
-
Stahl, B., Diehlmann, A., and Südhof, T. C. (1999) Direct interaction of Alzheimer's disease-related presenilin 1 with Armadillo protein p0071. J. Biol. Chem. 274, 9141-9148.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 9141-9148
-
-
Stahl, B.1
Diehlmann, A.2
Südhof, T.C.3
-
32
-
-
0342601492
-
Lack of effect of presenilin 1, βAPP and their Alzheimer's disease-related mutated forms on xenopus oocytes membrane current
-
Dauch, P., Champigny, G., Ricci, J.-E., and Checler, F. (1997) Lack of effect of presenilin 1, βAPP and their Alzheimer's disease-related mutated forms on xenopus oocytes membrane current. Neurosci. Lett. 221, 1-4.
-
(1997)
Neurosci. Lett.
, vol.221
, pp. 1-4
-
-
Dauch, P.1
Champigny, G.2
Ricci, J.-E.3
Checler, F.4
-
33
-
-
16044365171
-
The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
-
Lemere, C. A., Lopera, F., Kosik, K. S., Lendon, C. L., Ossa, J., Saido, T. C., Yamaguchi, H., Ruiz, A., Martinez, A., Madrigal, L., Hincapie, L., Arango, L. J. C., Anthony, D. C., Koo, H., Goate, A. M., Selkoe, D. J., and Arango, V. J. C. (1996) The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology. Nat. Med. 2, 1146-1150.
-
(1996)
Nat. Med.
, vol.2
, pp. 1146-1150
-
-
Lemere, C.A.1
Lopera, F.2
Kosik, K.S.3
Lendon, C.L.4
Ossa, J.5
Saido, T.C.6
Yamaguchi, H.7
Ruiz, A.8
Martinez, A.9
Madrigal, L.10
Hincapie, L.11
Arango, L.J.C.12
Anthony, D.C.13
Koo, H.14
Goate, A.M.15
Selkoe, D.J.16
Arango, V.J.C.17
-
34
-
-
9444276544
-
Amyloid β protein (Aβ) deposition in chromosome 14-linked Alzheimer's disease: Predominance of Aβ42(43)
-
Mann, D. M. A., Iwatsubo, T., Cairns, N. J., Lantos, P. L., Nochlin, D., Sumi, S. M., Bird, T. D., Poorkaj, P., Hardy, J., Hutton, M., Prihar, G., Crook, R., Rossor, M. N., and Haltia, M. (1997) Amyloid β protein (Aβ) deposition in chromosome 14-linked Alzheimer's disease: Predominance of Aβ42(43). Ann. Neurol. 40, 149-156.
-
(1997)
Ann. Neurol.
, vol.40
, pp. 149-156
-
-
Mann, D.M.A.1
Iwatsubo, T.2
Cairns, N.J.3
Lantos, P.L.4
Nochlin, D.5
Sumi, S.M.6
Bird, T.D.7
Poorkaj, P.8
Hardy, J.9
Hutton, M.10
Prihar, G.11
Crook, R.12
Rossor, M.N.13
Haltia, M.14
-
35
-
-
0030857182
-
Increased Aβ 42(43)-plaque deposition in early-onset familial Alzheimer's disease brains with the deletion of exon 9 and the missense point mutation
-
Ishii, K., Ii, K., Hasegawa, T., Shoji, S., Doi, A., and Mori, H. (1997) Increased Aβ 42(43)-plaque deposition in early-onset familial Alzheimer's disease brains with the deletion of exon 9 and the missense point mutation. Neurosci. Lett. 228, 17-20.
-
(1997)
Neurosci. Lett.
, vol.228
, pp. 17-20
-
-
Ishii, K.1
Ii, K.2
Hasegawa, T.3
Shoji, S.4
Doi, A.5
Mori, H.6
-
36
-
-
0030614569
-
Amyloid (Aβ) deposition in chromosome 1-linked Alzheimer's disease: The Volga German family
-
Mann, D. M. A., Iwatsubo, T., Nochlin, D., Sumi, S. M., Levy-Lahad, E., and Bird, T. D. (1997) Amyloid (Aβ) deposition in chromosome 1-linked Alzheimer's disease: The Volga German family. Ann. Neurol. 41, 52-57.
-
(1997)
Ann. Neurol.
, vol.41
, pp. 52-57
-
-
Mann, D.M.A.1
Iwatsubo, T.2
Nochlin, D.3
Sumi, S.M.4
Levy-Lahad, E.5
Bird, T.D.6
-
37
-
-
0029416825
-
246) familial Alzheimer's cells
-
246) familial Alzheimer's cells. NeuroReport 7, 217-220.
-
(1995)
NeuroReport
, vol.7
, pp. 217-220
-
-
Martins, R.N.1
Turner, B.A.2
Carroll, R.T.3
Sweeney, D.4
Kim, K.S.5
Wisniewski, H.M.6
Blass, J.P.7
Gibson, G.E.8
Gandy, S.9
-
38
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., Larson, E., Levy-Lahad, E., Viitanen, M., Peskind, E., Poorkaj, P., Schellenberg, G., Tanzi, R., Wasco, W., Lannfelt, L., Selkoe, D., and Younkin, S. (1996) Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2, 864-870.
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
39
-
-
16044366039
-
Increased amyloid-β42(43) in brains expressing mutant presenilin 1
-
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Perez-Tur, J., Hutton, M., Buee, L., Harigaya, Y., Yager, D., Morgan, D., Gordon, M. N., Holcomb, L., Refolo, L., Zenk, B., Hardy, J., and Younkin, S. (1996) Increased amyloid-β42(43) in brains expressing mutant presenilin 1. Nature 383, 710-713.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.-M.5
Perez-Tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
40
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 in vitro and in vivo
-
Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., Slunt, H. H., Wang, R., Seeger, M., Levey, A. I., Gandy, S. E., Copeland, N. G., Jenkins, N. A., Price, D. L., Younkin, S. G., and Sisodia, S. S. (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 in vitro and in vivo. Neuron 17, 1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.-M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
41
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
-
Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-Wood, K., Lee, M., Seubert, P., Davis, A., Kholodenko, D., Motter, R., Sherrington, R., Perry, B., Yao, H., Strome, R., Lieberburg, I., Rommens, J., Kim, S., Schenk, D., Fraser, P., St. George-Hyslop, P., and Selkoe, D. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nat. Med. 3, 67-72.
-
(1997)
Nat. Med.
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
Kholodenko, D.11
Motter, R.12
Sherrington, R.13
Perry, B.14
Yao, H.15
Strome, R.16
Lieberburg, I.17
Rommens, J.18
Kim, S.19
Schenk, D.20
Fraser, P.21
St. George-Hyslop, P.22
Selkoe, D.23
more..
-
42
-
-
0030833055
-
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
-
Borchelt, D. R., Ratovitski, T., Van Lare, J., Lee, M. K., Gonzales, V. Jenkins, N. A., Copeland, N. G., Price, D. L., and Sisodia, S. S. (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19, 939-945.
-
(1997)
Neuron
, vol.19
, pp. 939-945
-
-
Borchelt, D.R.1
Ratovitski, T.2
Van Lare, J.3
Lee, M.K.4
Gonzales, V.5
Jenkins, N.A.6
Copeland, N.G.7
Price, D.L.8
Sisodia, S.S.9
-
43
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb, L., Gordon, M. N., McGowan, E., Yu. X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., Sanders, S., Zehr, C., O'Campo, K., Hardy, J., Prada, C.-M., Eckman, C., Younkin, S., Hsiao, K., and Duff, K. (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4, 97-100.
-
(1998)
Nat. Med.
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
McGowan, E.3
Yu, X.4
Benkovic, S.5
Jantzen, P.6
Wright, K.7
Saad, I.8
Mueller, R.9
Morgan, D.10
Sanders, S.11
Zehr, C.12
O'Campo, K.13
Hardy, J.14
Prada, C.-M.15
Eckman, C.16
Younkin, S.17
Hsiao, K.18
Duff, K.19
-
44
-
-
16944365745
-
Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins
-
Xia, W., Zhang, J., Kholodenko, D., Citron, M., Podlisny, M. B., Teplow, D. B., Haass, C., Seubert, P., Koo, E. H., and Selkoe, D. J. (1997) Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J. Biol. Chem. 272, 7977-7982.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 7977-7982
-
-
Xia, W.1
Zhang, J.2
Kholodenko, D.3
Citron, M.4
Podlisny, M.B.5
Teplow, D.B.6
Haass, C.7
Seubert, P.8
Koo, E.H.9
Selkoe, D.J.10
-
45
-
-
0030667339
-
α-Secretase-derived product of β-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease
-
Ancolio, K., Marambaud, P., Dauch, P., and Checler, F. (1997) α-Secretase-derived product of β-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease. J. Neurochem. 69, 2494-2499.
-
(1997)
J. Neurochem.
, vol.69
, pp. 2494-2499
-
-
Ancolio, K.1
Marambaud, P.2
Dauch, P.3
Checler, F.4
-
46
-
-
14444267540
-
Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid β peptides: Their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases
-
Barelli, H., Lebeau, A., Vizzavona, J., Delaere, P., Chevallier, N., Drouot, C., Marambaud, P., Ancolio, K., Buxbaum, J. D., Khorkova, O., Heroux, J., Sahasrabudhe, S., Martinez, J., Warter, J.-M., Mohr, M., and Checler, F. (1997) Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid β peptides: Their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases. Mol. Med. 3, 695-707.
-
(1997)
Mol. Med.
, vol.3
, pp. 695-707
-
-
Barelli, H.1
Lebeau, A.2
Vizzavona, J.3
Delaere, P.4
Chevallier, N.5
Drouot, C.6
Marambaud, P.7
Ancolio, K.8
Buxbaum, J.D.9
Khorkova, O.10
Heroux, J.11
Sahasrabudhe, S.12
Martinez, J.13
Warter, J.-M.14
Mohr, M.15
Checler, F.16
-
47
-
-
12644258498
-
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
-
Tomita, T., Maruyama, K., Saido, T. C., Kume, H., Shinozaki, K. T. S., Capell, A., Walter, J., Grünberg, J., Haass, C., Iwatsubo, T., and Obata, K. (1997) The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc. Natl. Acad. Sci. U.S.A. 94, 2025-2030.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 2025-2030
-
-
Tomita, T.1
Maruyama, K.2
Saido, T.C.3
Kume, H.4
Shinozaki, K.T.S.5
Capell, A.6
Walter, J.7
Grünberg, J.8
Haass, C.9
Iwatsubo, T.10
Obata, K.11
-
48
-
-
0032501149
-
Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPα secretion: Control by the proteasome
-
Marambaud, P., Alves da Costa, C., Ancolio, K., and Checler, F. (1998) Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPα secretion: Control by the proteasome. Biochem. Biophys. Res. Commun. 252, 134-138.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.252
, pp. 134-138
-
-
Marambaud, P.1
Alves Da Costa, C.2
Ancolio, K.3
Checler, F.4
-
49
-
-
0032556859
-
Deficiency of presenilin 1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Von Figura, K., and Van Leuven, F. (1998) Deficiency of presenilin 1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Von Figura, K.6
Van Leuven, F.7
-
50
-
-
0033535504
-
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., Goale, A., and Kopan, R. (1999) A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature 398, 518-522.
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
Mumm, J.S.6
Schroeter, E.H.7
Schrijvers, V.8
Wolfe, M.S.9
Ray, W.J.10
Goale, A.11
Kopan, R.12
-
51
-
-
0000138540
-
Effects of PS1 deficiency on membrane protein trafficking in neurons
-
Naruse, S., Thinakaran, G., Luo, J.-J., Kusiak, J. W. T. T., Iwatsubo, T., Qian, X., Ginty, D. D., Price, D. L., Borchelt, D. R., Wong, P. C., and Sisodia, S. S. (1998) Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 20, 1213-1221.
-
(1998)
Neuron
, vol.20
, pp. 1213-1221
-
-
Naruse, S.1
Thinakaran, G.2
Luo, J.-J.3
Kusiak, J.W.T.T.4
Iwatsubo, T.5
Qian, X.6
Ginty, D.D.7
Price, D.L.8
Borchelt, D.R.9
Wong, P.C.10
Sisodia, S.S.11
-
52
-
-
0031950118
-
Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and trigger increased Aβ42 secretion by human cells
-
Marambaud, P., Ancolio, K., Lopez-Perez, E., and Checler, F. (1998) Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and trigger increased Aβ42 secretion by human cells. Mol. Med. 4, 147-157.
-
(1998)
Mol. Med.
, vol.4
, pp. 147-157
-
-
Marambaud, P.1
Ancolio, K.2
Lopez-Perez, E.3
Checler, F.4
-
53
-
-
0029671219
-
2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3
-
2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271, 521-525.
-
(1996)
Science
, vol.271
, pp. 521-525
-
-
Vito, P.1
Lacana, E.2
D'Adamio, L.3
-
54
-
-
10544224542
-
Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
-
Wolozin, B., Iwasaki, K., Vito, P., Ganjei, J. K., Lacana, E., Sunderland, T., Zhao, B., Kusiak, J. W., Wasco, W., and D'Adamio, L. (1996) Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation. Science 274, 1710-1713.
-
(1996)
Science
, vol.274
, pp. 1710-1713
-
-
Wolozin, B.1
Iwasaki, K.2
Vito, P.3
Ganjei, J.K.4
Lacana, E.5
Sunderland, T.6
Zhao, B.7
Kusiak, J.W.8
Wasco, W.9
D'Adamio, L.10
-
55
-
-
0030771534
-
Increased apoptosis arising from increased expression of the Alzheimer's disease associated presenilin-2 mutation (N141I)
-
Janicki, S., and Monteiro, M. J. (1997) Increased apoptosis arising from increased expression of the Alzheimer's disease associated presenilin-2 mutation (N141I). J. Cell Biol. 139, 485-495.
-
(1997)
J. Cell Biol.
, vol.139
, pp. 485-495
-
-
Janicki, S.1
Monteiro, M.J.2
-
56
-
-
0030580281
-
Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells
-
Deng, G., Pike, C. J., and Cotman, C. W. (1996) Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett. 397, 50-54.
-
(1996)
FEBS Lett.
, vol.397
, pp. 50-54
-
-
Deng, G.1
Pike, C.J.2
Cotman, C.W.3
-
57
-
-
0029856850
-
Requirement of the familial Alzheimer's disease gene ps2 for apoptosis. Opposing effect of ALG-3
-
Vito, P., Wolozin, B., Ganjei, J. K., Iwasaki, K., Lacana, E., and D'Adamio, L. (1996) Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3. J Biol. Chem. 271, 31025-31028.
-
(1996)
J Biol. Chem.
, vol.271
, pp. 31025-31028
-
-
Vito, P.1
Wolozin, B.2
Ganjei, J.K.3
Iwasaki, K.4
Lacana, E.5
D'Adamio, L.6
-
58
-
-
0030680151
-
Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage
-
Vito, P., Ghayur, T., and D'Adamio, L. (1997) Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage. J. Biol. Chem. 272, 28315-28320.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28315-28320
-
-
Vito, P.1
Ghayur, T.2
D'Adamio, L.3
-
59
-
-
0033573936
-
Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis
-
Walter, J., Schindzielorz, A., Grünberg, J., and Haass, C. (1999) Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis. Proc. Natl. Acad. Sci. U.S.A. 96, 1391-1396.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 1391-1396
-
-
Walter, J.1
Schindzielorz, A.2
Grünberg, J.3
Haass, C.4
-
60
-
-
0030868903
-
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
-
Kim, T.-W., Pettingell, W. H., Jung, Y.-K., Kovacs, D. M., and Tanzi, R. E. (1997) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277, 373-376.
-
(1997)
Science
, vol.277
, pp. 373-376
-
-
Kim, T.-W.1
Pettingell, W.H.2
Jung, Y.-K.3
Kovacs, D.M.4
Tanzi, R.E.5
-
61
-
-
0030917601
-
Alzheimer's presenilin mutation sensitizes naural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: Involvement of calcium and oxyradicals
-
Guo, Q., Sopher, B. L., Furukawa, K., Pham, D. G., Robinson, N., Martin, G. M., and Mattson, M. P. (1997) Alzheimer's presenilin mutation sensitizes naural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17, 4212-4222.
-
(1997)
J. Neurosci.
, vol.17
, pp. 4212-4222
-
-
Guo, Q.1
Sopher, B.L.2
Furukawa, K.3
Pham, D.G.4
Robinson, N.5
Martin, G.M.6
Mattson, M.P.7
-
62
-
-
0032400818
-
Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer's disease mutant does not enhance apoptosis
-
Bursztajn, S., DeSouza, R., McPhie, D. L., Berman, S. A., Shioi, J., Robakis, N. K., and Neve, R. L. (1998) Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer's disease mutant does not enhance apoptosis. J. Neurosci. 18, 9790-9799.
-
(1998)
J. Neurosci.
, vol.18
, pp. 9790-9799
-
-
Bursztajn, S.1
DeSouza, R.2
McPhie, D.L.3
Berman, S.A.4
Shioi, J.5
Robakis, N.K.6
Neve, R.L.7
-
63
-
-
0033555896
-
Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro
-
Hong, C.-S., Caromile, L., Nomata, Y., Mori, H., Bredesen, D. E., and Koo, E. H. (1999) Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro. J. Neurosci. 19, 637-643.
-
(1999)
J. Neurosci.
, vol.19
, pp. 637-643
-
-
Hong, C.-S.1
Caromile, L.2
Nomata, Y.3
Mori, H.4
Bredesen, D.E.5
Koo, E.H.6
-
64
-
-
0029116848
-
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
-
Levitan, D., and Greenwald, I. (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377, 351-354.
-
(1995)
Nature
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenwald, I.2
-
65
-
-
0031108103
-
Human presenilin-1 but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegant Notch signalling independently of proteolytic processing
-
Baumeister, R., Leimer, U., Zweckbronner, I., Jakubek, C., Grünberg, J., and Haass, C. (1997) Human presenilin-1 but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegant Notch signalling independently of proteolytic processing. Genes Func. 1, 149-159.
-
(1997)
Genes Func.
, vol.1
, pp. 149-159
-
-
Baumeister, R.1
Leimer, U.2
Zweckbronner, I.3
Jakubek, C.4
Grünberg, J.5
Haass, C.6
-
66
-
-
0029906585
-
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
-
Levitan, D., Doyle, T. G., Brousseau, D., Lee, M. K., Thinakaran, G., Slunt, H. H., Sisodia, S. S., and Greenwald, I. (1996) Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 93, 14940-14944.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 14940-14944
-
-
Levitan, D.1
Doyle, T.G.2
Brousseau, D.3
Lee, M.K.4
Thinakaran, G.5
Slunt, H.H.6
Sisodia, S.S.7
Greenwald, I.8
-
67
-
-
17744401440
-
Presenilin 1 is required for Notch1 and DII 1 expression in the paraaxial mesoderm
-
Wong, P. C., Zheng, H., Chen, H., Becher, M. W., Sirinathsinghji, D. J. S., Trumbauer, M. E., Chen, H. Y, Price, D. L., Van der Ploeg, L. H. T., and Sisodia, S. S. (1997) Presenilin 1 is required for Notch1 and DII 1 expression in the paraaxial mesoderm. Nature 387, 288-292.
-
(1997)
Nature
, vol.387
, pp. 288-292
-
-
Wong, P.C.1
Zheng, H.2
Chen, H.3
Becher, M.W.4
Sirinathsinghji, D.J.S.5
Trumbauer, M.E.6
Chen, H.Y.7
Price, D.L.8
Van Der Ploeg, L.H.T.9
Sisodia, S.S.10
-
68
-
-
0030779784
-
Skeletal and CNS detects in presenilin-1-deficient mice
-
Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D., and Tonegawa, S., (1997) Skeletal and CNS detects in presenilin-1-deficient mice. Cell 89, 629-639.
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.5
Tonegawa, S.6
-
69
-
-
0032032847
-
Mutant human presenilin 1 protects presenilin-1 null mouse against embryonic lethality and elevates Aβ1-42/43 expression
-
Qian, S., Jiang, P., Guan, X., Sing, G., Trumbauer, S. M., Yu, H., Chen, H. Y., Van der Ploeg, L. H. T., and Zheng, H. (1998) Mutant human presenilin 1 protects presenilin-1 null mouse against embryonic lethality and elevates Aβ1-42/43 expression. Neuron 20, 611-617.
-
(1998)
Neuron
, vol.20
, pp. 611-617
-
-
Qian, S.1
Jiang, P.2
Guan, X.3
Sing, G.4
Trumbauer, S.M.5
Yu, H.6
Chen, H.Y.7
Van Der Ploeg, L.H.T.8
Zheng, H.9
-
70
-
-
0032032019
-
An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1 - deficient embryos
-
Davis, J. A., Naruse, S., Chen, H., Eckman, C., Younkin, S., Price, D. L., Borchelt, D. R., Sisodia, S. S., and Wong, P. C. (1998) An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1 - deficient embryos. Neuron 20, 603-609.
-
(1998)
Neuron
, vol.20
, pp. 603-609
-
-
Davis, J.A.1
Naruse, S.2
Chen, H.3
Eckman, C.4
Younkin, S.5
Price, D.L.6
Borchelt, D.R.7
Sisodia, S.S.8
Wong, P.C.9
-
71
-
-
17344372115
-
Interaction of presenilins with the filamin family of actin-binding proteins
-
Zhang, W., Han, S. W., McKeel, D. W., Goate, A., and Wu, J. Y. (1998) Interaction of presenilins with the filamin family of actin-binding proteins. J. Neurosci. 18, 914-922.
-
(1998)
J. Neurosci.
, vol.18
, pp. 914-922
-
-
Zhang, W.1
Han, S.W.2
McKeel, D.W.3
Goate, A.4
Wu, J.Y.5
-
72
-
-
0033535508
-
Presenilin is required for activity and nuclear access of Notch in Drosophila
-
Struhl, G., and Greenwald, I. (1999) Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398, 522-525.
-
(1999)
Nature
, vol.398
, pp. 522-525
-
-
Struhl, G.1
Greenwald, I.2
-
73
-
-
0033535555
-
Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants
-
Ye, Y., Lukinova, N., and Fortini, M. E. (1999) Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants. Nature 398, 525-529.
-
(1999)
Nature
, vol.398
, pp. 525-529
-
-
Ye, Y.1
Lukinova, N.2
Fortini, M.E.3
-
74
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
-
Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature 398, 513-517.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
75
-
-
0027420369
-
Tau protein and the neurofibrillary pathology of Alzheimer's disease
-
Goedert, M. (1993) Tau protein and the neurofibrillary pathology of Alzheimer's disease. TINS 16, 460-465.
-
(1993)
TINS
, vol.16
, pp. 460-465
-
-
Goedert, M.1
|