Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth

Journal of Biological Chemistry

Volumn 281, Issue 49, 2006, Pages 37372-37380

  DeBerardinis, Ralph J ^a,b   Lum, Julian J ^a   Thompson, Craig B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL GROWTH; CELL PROLIFERATION; GROWTH FACTOR; HEMATOPOIETIC CELLS;

CYTOLOGY; GROWTH KINETICS; LIPIDS; METABOLISM; NEUROLOGY; NUTRITION; PROTEINS; RNA;

ENZYME IMMOBILIZATION;

CARNITINE PALMITOYLTRANSFERASE; CARNITINE PALMITYL TRANSFERASE 1A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; HEMATOPOIETIC CELL; LIPID METABOLISM; LIPOGENESIS; LIPOLYSIS; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BONE MARROW CELLS; CARNITINE O-PALMITOYLTRANSFERASE; CELL DIVISION; CELL LINE; FEMALE; GENE EXPRESSION; LIPID METABOLISM; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION;

EID: 33846005164     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M608372200     Document Type: Article

References (52)

1. Lohr, D., Venkov, P., and Zlatanova, J. (1995) FASEB J. 9, 777-787
2. Hedeskov, C. J. (1968) Biochem. J. 110, 373-380
3. Whetton, A. D., Bazill, G. W., and Dexter, T. M. (1984) EMBO J. 3, 409-413
4. Vander Heiden, M. G., Plas, D. R., Rathmell, J. C., Fox, C. J., Harris, M. H., and Thompson, C. B. (2001) Mol. Cell. Biol. 21, 5899-5912
5. Cooper, E. H., Barkhan, P., and Hale, A. J. (1963) Br. J. Haematol. 9, 101-111
6. Wang, T., Marquardt, C., and Foker, J. (1976) Nature 261, 702-705
7. Hume, D. A., Radik, J. L., Ferber, E., and Weidemann, M. J. (1978) Biochem. J. 174, 703-709
8. Frauwirth, K. A., and Thompson, C. B. (2004) J. Immunol. 172, 4661-4665
9. Kenny, J. J., Martinez-Maza, O., Fehniger, T., and Ashman, R. F. (1979) J. Immunol. 122, 1278-1284
10. Cantley, L. C. (2002) Science 296, 1655-1657
11. Plas, D. R., Talapatra, S., Edinger, A. L., Rathmell, J. C., and Thompson, C. B. (2001) J. Biol. Chem. 276, 12041-12048
12. Gottlob, K., Majewski, N., Kennedy, S., Kandel, E., Robey, R. B., and Hay, N. (2001) Genes Dev. 15, 1406-1418
13. Cantrell, D. A. (2003) Curr. Opin. Immunol. 15, 294-298
14. Luo, J., Manning, B. D., and Cantley, L. C. (2003) Cancer Cell 4, 257-262
15. Franke, T. F., Hornik, C. P., Segev, L., Shostak, G. A., and Sugimoto, C. (2003) Oncogene 22, 8983-8998
16. Bachman, K. E., Argani, P., Samuels, Y., Silliman, N., Ptak, J., Szabo, S., Konishi, H., Karakas, B., Blair, B. G., Lin, C., Peters, B. A., Velculescu, V. E., and Park, B. H. (2004) Cancer Biol. Ther. 3, 772-775
17. Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A., Powell, S. M., Riggins, G. J., Willson, J. K., Markowitz, S., Kinzler, K. W., Vogelstein, B., and Velculescu, V. E. (2004) Science 304, 554
18. Warburg, O. (1925) Klin. Wochenschr. Berl. 4, 534-536
19. Plas, D. R., and Thompson, C. B. (2005) Oncogene 24, 7435-7442
20. Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., and Pasternack, G. R. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 6379-6383
21. Pizer, E. S., Wood, F. D., Heine, H. S., Romantsev, F. E., Pasternack, G. R., and Kuhajda, F. P. (1996) Cancer Res. 56, 1189-1193
22. Kohn, A. D., Summers, S. A., Birnbaum, M. J., and Roth, R. A. (1996) J. Biol. Chem. 271, 31372-31378
23. Sul, H. S., Latasa, M. J., Moon, Y., and Kim, K. H. (2000) J. Nutr. 130, 2S Suppl., 315S-320
24. Van de Sande, T., De Schrijver, E., Heyns, W., Verhoeven, G., and Swinnen, J. V. (2002) Cancer Res. 62, 642-646
25. McGarry, J. D., Mannaerts, G. P., and Foster, D. W. (1977) J. Clin. Invest. 60, 265-270
26. McGarry, J. D., Leatherman, G. F., and Foster, D. W. (1978) J. Biol. Chem. 253, 4128-4136
27. Ramsay, R. R., and Zammit, V. A. (2004) Mol. Aspects Med. 25, 475-493
28. Foster, D. W. (2004) Ann. N. Y. Acad. Sci. 1033, 1-16
29. Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T., and Thompson, C. B. (2005) Cell 120, 237-248
30. Bligh, E. G., and Dyer, W. J. (1959) Can. J. Biochem. Physiol. 37, 911-917
31. Brivet, M., Slama, A., Saudubray, J. M., Legrand, A., and Lemonnier, A. (1995) Ann. Clin. Biochem. 32, 154-159
32. Buzzai, M., Bauer, D. E., Jones, R. G., Deberardinis, R. J., Hatzivassiliou, G., Elstrom, R. L., and Thompson, C. B. (2005) Oncogene 24, 4165-4173
33. Edinger, A. L., and Thompson, C. B. (2002) Mol. Biol. Cell 13, 2276-2288
34. Fox, C. J., Hammerman, P. S., Cinalli, R. M., Master, S. R., Chodosh, L. A., and Thompson, C. B. (2003) Genes Dev. 17, 1841-1854
35. Bauer, D. E., Hatzivassiliou, G., Zhao, F., Andreadis, C., and Thompson, C. B. (2005) Oncogene 24, 6314-6322
36. Rathmell, J. C., Vander Heiden, M. G., Harris, M. H., Frauwirth, K. A., and Thompson, C. B. (2000) Mol. Cell 6, 683-692
37. Guppy, M., Greiner, E., and Brand, K. (1993) Eur. J. Biochem. 212, 95-99
38. Schmelzle, T., and Hall, M. N. (2000) Cell 103, 253-262
39. Rajasekhar, V. K., Viale, A., Socci, N. D., Wiedmann, M., Hu, X., and Holland, E. C. (2003) Mol. Cell 12, 889-901
40. Ruderman, N. B., Saha, A. K., Vavvas, D., and Witters, L. A. (1999) Am. J. Physiol. 276, E1-E18
41. Tamas, P., Hawley, S. A., Clarke, R. G., Mustard, K. J., Green, K., Hardie, D. G., and Cantrell, D. A. (2006) J. Exp. Med. 203, 1665-1670
42. Hardie, D. G., and Pan, D. A. (2002) Biochem. Soc. Trans. 30, 1064-1070
43. Abu-Elheiga, L., Jayakumar, A., Baldini, A., Chirala, S. S., and Wakil, S. J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 4011-4015
44. Abu-Elheiga, L., Almarza-Ortega, D. B., Baldini, A., and Wakil, S. J. (1997) J. Biol. Chem. 272, 10669-10677
45. Abu-Elheiga, L., Brinkley, W. R., Zhong, L., Chirala, S. S., Woldegiorgis, G., and Wakil, S. J. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1444-1449
46. Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A., and Wakil, S. J. (2001) Science 291, 2613-2616
47. Abu-Elheiga, L., Oh, W., Kordari, P., and Wakil, S. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 10207-10212
48. Paumen, M. B., Ishida, Y., Muramatsu, M., Yamamoto, M., and Honjo, T. (1997) J. Biol. Chem. 272, 3324-3329
49. Brachat, A., Pierrat, B., Brungger, A., and Heim, J. (2000) Oncogene 19, 5073-5082
50. Vats, D., Mukundan, L., Odegaard, J. I., Zhang, L., Smith, K. L., Morel, C. R., Greaves, D. R., Murray, P. J., and Chawla, A. (2006) Cell Metab. 4, 13-24
51. Altomare, D. A., and Testa, J. R. (2005) Oncogene 24, 7455-7464
52. Elstrom, R. L., Bauer, D. E., Buzzai, M., Karnauskas, R., Harris, M. H., Plas, D. R., Zhuang, H., Cinalli, R. M., Alavi, A., Rudin, C. M., and Thompson, C. B. (2004) Cancer Res. 64, 3892-3899