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Volumn 13, Issue 2, 2009, Pages 215-237

Molecular drug targets in myeloproliferative neoplasms: Mutant ABL1, JAK2, MPL, KIT, PDGFRA, PDGFRB and FGFR1

Author keywords

Eosinophilia; Mastocytosis; Myelofibrosis; Polycythemia; Thrombocythemia; V617F

Indexed keywords


EID: 61349124230     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00559.x     Document Type: Article
Times cited : (42)

References (313)
  • 2
    • 0001639195 scopus 로고
    • Some speculations on the myeloproliferative syndromes
    • Dameshek W. Some speculations on the myeloproliferative syndromes. Blood. 1951 6 : 372 75.
    • (1951) Blood. , vol.6 , pp. 372-375
    • Dameshek, W.1
  • 3
    • 38349060667 scopus 로고    scopus 로고
    • The history of myeloproliferative disorders: Before and after Dameshek
    • Tefferi A. The history of myeloproliferative disorders: before and after Dameshek. Leukemia. 2008 22 : 3 13.
    • (2008) Leukemia. , vol.22 , pp. 3-13
    • Tefferi, A.1
  • 4
    • 38349101871 scopus 로고    scopus 로고
    • Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms
    • Tefferi A, Vardiman JW. Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia. 2008 22 : 14 22.
    • (2008) Leukemia. , vol.22 , pp. 14-22
    • Tefferi, A.1    Vardiman, J.W.2
  • 5
    • 72849159485 scopus 로고
    • Chromosome studies on normal and leukemic human leukocytes
    • Nowell PC, Hungerford DA. Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst. 1960 25 : 85 109.
    • (1960) J Natl Cancer Inst. , vol.25 , pp. 85-109
    • Nowell, P.C.1    Hungerford, D.A.2
  • 6
    • 0000286732 scopus 로고
    • A minute chromosome in human granulocytic leukemia
    • Nowell PC, Hungerford DA. A minute chromosome in human granulocytic leukemia. Science. 1960 132 : 1497.
    • (1960) Science. , vol.132 , pp. 1497
    • Nowell, P.C.1    Hungerford, D.A.2
  • 7
    • 0025187837 scopus 로고
    • Induction of a chronic myel-ogenous leukemia-like syndrome in mice with v-abl and BCR/ABL
    • Kelliher MA, McLaughlin J, Witte ON, Rosenberg N. Induction of a chronic myel-ogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc Natl Acad Sci USA. 1990 87 : 6649 53.
    • (1990) Proc Natl Acad Sci USA. , vol.87 , pp. 6649-6653
    • Kelliher, M.A.1    McLaughlin, J.2    Witte, O.N.3    Rosenberg, N.4
  • 8
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science. 1990 247 : 824 30.
    • (1990) Science. , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 9
    • 0025271543 scopus 로고
    • Bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice
    • Elefanty AG, Hariharan IK, Cory S. bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. EMBO J. 1990 9 : 1069 78.
    • (1990) EMBO J. , vol.9 , pp. 1069-1078
    • Elefanty, A.G.1    Hariharan, I.K.2    Cory, S.3
  • 10
    • 0027359443 scopus 로고
    • Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
    • Furitsu T, Tsujimura T, Tono T, Ikeda H, Kitayama H, Koshimizu U, Sugahara H, Butterfield JH, Ashman LK, Kanayama Y. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest. 1993 92 : 1736 44.
    • (1993) J Clin Invest. , vol.92 , pp. 1736-1744
    • Furitsu, T.1    Tsujimura, T.2    Tono, T.3    Ikeda, H.4    Kitayama, H.5    Koshimizu, U.6    Sugahara, H.7    Butterfield, J.H.8    Ashman, L.K.9    Kanayama, Y.10
  • 11
    • 0028224348 scopus 로고
    • Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5; 12) chromosomal translocation
    • Golub TR, Barker GF, Lovett M, Gilliland DG. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5; 12) chromosomal translocation. Cell. 1994 77 : 307 16.
    • (1994) Cell. , vol.77 , pp. 307-316
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3    Gilliland, D.G.4
  • 20
    • 34548128326 scopus 로고    scopus 로고
    • Prevalence and clinicopatho-logic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera
    • Pardanani A, Lasho TL, Finke C, Hanson CA, Tefferi A. Prevalence and clinicopatho-logic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera. Leukemia. 2007 21 : 1960 3.
    • (2007) Leukemia. , vol.21 , pp. 1960-1963
    • Pardanani, A.1    Lasho, T.L.2    Finke, C.3    Hanson, C.A.4    Tefferi, A.5
  • 25
    • 0015694748 scopus 로고
    • Letter: A new consistent chromosomal abnormality in chronic myeloge-nous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley JD. Letter: a new consistent chromosomal abnormality in chronic myeloge-nous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973 243 : 290 3.
    • (1973) Nature. , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 28
    • 0021346853 scopus 로고
    • Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
    • Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell. 1984 36 : 93 9.
    • (1984) Cell. , vol.36 , pp. 93-99
    • Groffen, J.1    Stephenson, J.R.2    Heisterkamp, N.3    De Klein, A.4    Bartram, C.R.5    Grosveld, G.6
  • 29
    • 0021811764 scopus 로고
    • Structural organization of the bcr gene and its role in the Ph' translocation
    • Heisterkamp N, Stam K, Groffen J, de Klein A, Grosveld G. Structural organization of the bcr gene and its role in the Ph' translocation. Nature. 1985 315 : 758 61.
    • (1985) Nature. , vol.315 , pp. 758-761
    • Heisterkamp, N.1    Stam, K.2    Groffen, J.3    De Klein, A.4    Grosveld, G.5
  • 32
    • 25144502829 scopus 로고    scopus 로고
    • Enabling death by the Abl tyrosine kinase: Mechanisms for nuclear shuttling of c-Abl in response to DNA damage
    • Yoshida K, Miki Y. Enabling death by the Abl tyrosine kinase: mechanisms for nuclear shuttling of c-Abl in response to DNA damage. Cell Cycle. 2005 4 : 777 9.
    • (2005) Cell Cycle. , vol.4 , pp. 777-779
    • Yoshida, K.1    Miki, Y.2
  • 33
    • 14744306701 scopus 로고    scopus 로고
    • Stress and death: Breaking up the c-Abl/14-3-3 complex in apop-tosis
    • Pendergast AM. Stress and death: breaking up the c-Abl/14-3-3 complex in apop-tosis. Nat Cell Biol. 2005 7 : 213 4.
    • (2005) Nat Cell Biol. , vol.7 , pp. 213-214
    • Pendergast, A.M.1
  • 34
    • 16844379909 scopus 로고    scopus 로고
    • Insights into selective activation of p53 DNA binding by c-Abl
    • Wei G, Li AG, Liu X. Insights into selective activation of p53 DNA binding by c-Abl. J Biol Chem. 2005 280 : 12271 8.
    • (2005) J Biol Chem. , vol.280 , pp. 12271-12278
    • Wei, G.1    Li, A.G.2    Liu, X.3
  • 35
    • 1342300625 scopus 로고    scopus 로고
    • Mechanisms of transformation by the BCR-ABL oncogene: New perspectives in the post-imatinib era
    • Van Etten RA. Mechanisms of transformation by the BCR-ABL oncogene: new perspectives in the post-imatinib era. Leuk Res. 2004 28 : S21 8.
    • (2004) Leuk Res. , vol.28
    • Van Etten, R.A.1
  • 36
    • 0023273390 scopus 로고
    • The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia
    • Bernards A, Rubin CM, Westbrook CA, Paskind M, Baltimore D. The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia. Mol Cell Biol. 1987 7 : 3231 6.
    • (1987) Mol Cell Biol. , vol.7 , pp. 3231-3236
    • Bernards, A.1    Rubin, C.M.2    Westbrook, C.A.3    Paskind, M.4    Baltimore, D.5
  • 38
    • 0026495870 scopus 로고
    • Minor BCR (m-bcr) rearrangements may appear in major BCR (M-bcr)-positive CML cases
    • Karlic H, Grill R, Schlogl E. Minor BCR (m-bcr) rearrangements may appear in major BCR (M-bcr)-positive CML cases. Hematol Pathol. 1992 6 : 203 7.
    • (1992) Hematol Pathol. , vol.6 , pp. 203-207
    • Karlic, H.1    Grill, R.2    Schlogl, E.3
  • 41
    • 0025614040 scopus 로고
    • The location of the Philadelphia chromosomal breakpoint site and prognosis in chronic granulocytic leukemia
    • Tefferi A, Bren GD, Wagner KV, Schaid DJ, Ash RC, Thibodeau SN. The location of the Philadelphia chromosomal breakpoint site and prognosis in chronic granulocytic leukemia. Leukemia. 1990 4 : 839 42.
    • (1990) Leukemia. , vol.4 , pp. 839-842
    • Tefferi, A.1    Bren, G.D.2    Wagner, K.V.3    Schaid, D.J.4    Ash, R.C.5    Thibodeau, S.N.6
  • 42
    • 0022352068 scopus 로고
    • Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome
    • Stam K, Heisterkamp N, Grosveld G, de Klein A, Verma RS, Coleman M, Dosik H, Groffen J. Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome. N Engl J Med. 1985 313 : 1429 33.
    • (1985) N Engl J Med. , vol.313 , pp. 1429-1433
    • Stam, K.1    Heisterkamp, N.2    Grosveld, G.3    De Klein, A.4    Verma, R.S.5    Coleman, M.6    Dosik, H.7    Groffen, J.8
  • 43
    • 0022544401 scopus 로고
    • The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene
    • Ben-Neriah Y, Daley GQ, Mes-Masson AM, Witte ON, Baltimore D. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science. 1986 233 : 212 4.
    • (1986) Science. , vol.233 , pp. 212-214
    • Ben-Neriah, Y.1    Daley, G.Q.2    Mes-Masson, A.M.3    Witte, O.N.4    Baltimore, D.5
  • 44
    • 0022182626 scopus 로고
    • Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products
    • Konopka JB, Witte ON. Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products. Mol Cell Biol. 1985 5 : 3116 23.
    • (1985) Mol Cell Biol. , vol.5 , pp. 3116-3123
    • Konopka, J.B.1    Witte, O.N.2
  • 45
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl onco-gene products
    • Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl onco-gene products. Science. 1990 247 : 1079 82.
    • (1990) Science. , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3    Witte, O.N.4
  • 46
    • 0025766195 scopus 로고
    • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner
    • Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON. BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell. 1991 66 : 161 71.
    • (1991) Cell. , vol.66 , pp. 161-171
    • Pendergast, A.M.1    Muller, A.J.2    Havlik, M.H.3    Maru, Y.4    Witte, O.N.5
  • 47
    • 0029669975 scopus 로고    scopus 로고
    • The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway
    • Sattler M, Salgia R, Okuda K, Uemura N, Durstin MA, Pisick E, Xu G, Li JL, Prasad KV, Griffin JD. The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway. Oncogene. 1996 12 : 839 46.
    • (1996) Oncogene. , vol.12 , pp. 839-846
    • Sattler, M.1    Salgia, R.2    Okuda, K.3    Uemura, N.4    Durstin, M.A.5    Pisick, E.6    Xu, G.7    Li, J.L.8    Prasad, K.V.9    Griffin, J.D.10
  • 48
    • 14644425319 scopus 로고    scopus 로고
    • Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
    • Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 2005 5 : 172 83.
    • (2005) Nat Rev Cancer. , vol.5 , pp. 172-183
    • Ren, R.1
  • 50
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-pheny-laminopyrimidine derivative
    • Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Druker BJ, Lydon NB. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-pheny-laminopyrimidine derivative. Cancer Res. 1996 56 : 100 4.
    • (1996) Cancer Res. , vol.56 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Muller, M.5    Druker, B.J.6    Lydon, N.B.7
  • 51
    • 0028968622 scopus 로고
    • Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2- phenylaminopyrimidine class
    • Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Regenass U, Lydon NB. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2- phenylaminopyrimidine class. Proc Natl Acad Sci USA. 1995 92 : 2558 62.
    • (1995) Proc Natl Acad Sci USA. , vol.92 , pp. 2558-2562
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Muller, M.5    Regenass, U.6    Lydon, N.B.7
  • 52
    • 0035871874 scopus 로고    scopus 로고
    • ARG tyrosine kinase activity is inhibited by STI571
    • Okuda K, Weisberg E, Gilliland DG, Griffin JD. ARG tyrosine kinase activity is inhibited by STI571. Blood. 2001 97 : 2440 8.
    • (2001) Blood. , vol.97 , pp. 2440-2448
    • Okuda, K.1    Weisberg, E.2    Gilliland, D.G.3    Griffin, J.D.4
  • 53
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
    • Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood. 2000 96 : 925 32.
    • (2000) Blood. , vol.96 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3    Wait, C.L.4    Ott, K.A.5    Zigler, A.J.6
  • 56
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, Talpaz M. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001 344 : 1038 42.
    • (2001) N Engl J Med. , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3    Resta, D.J.4    Reese, S.F.5    Ford, J.M.6    Capdeville, R.7    Talpaz, M.8
  • 72
    • 33646259689 scopus 로고    scopus 로고
    • Anticipating clinical resistance to target-directed agents: The BCR-ABL paradigm
    • Azam M, Daley GQ. Anticipating clinical resistance to target-directed agents: the BCR-ABL paradigm. Mol Diagn Ther. 2006 10 : 67 76.
    • (2006) Mol Diagn Ther. , vol.10 , pp. 67-76
    • Azam, M.1    Daley, G.Q.2
  • 73
    • 35448967331 scopus 로고    scopus 로고
    • Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
    • Apperley JF. Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol. 2007 8 : 1018 29.
    • (2007) Lancet Oncol. , vol.8 , pp. 1018-1029
    • Apperley, J.F.1
  • 74
    • 34548825795 scopus 로고    scopus 로고
    • Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia
    • O'Hare T, Eide CA, Deininger MW. Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood. 2007 110 : 2242 9.
    • (2007) Blood. , vol.110 , pp. 2242-2249
    • O'Hare, T.1    Eide, C.A.2    Deininger, M.W.3
  • 75
  • 79
    • 33745081606 scopus 로고    scopus 로고
    • Circumventing resistance to kinase-inhibitor therapy
    • Druker BJ. Circumventing resistance to kinase-inhibitor therapy. N Engl J Med. 2006 354 : 2594 6.
    • (2006) N Engl J Med. , vol.354 , pp. 2594-2596
    • Druker, B.J.1
  • 82
    • 47649127591 scopus 로고    scopus 로고
    • Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders
    • Walz C, Cross NC, Van Etten RA, Reiter A. Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders. Leukemia. 2008 22 : 1320 34.
    • (2008) Leukemia. , vol.22 , pp. 1320-1334
    • Walz, C.1    Cross, N.C.2    Van Etten, R.A.3    Reiter, A.4
  • 83
    • 0031881865 scopus 로고    scopus 로고
    • The second ETV6 allele is not necessarily deleted in acute leukemias with a ETV6/ABL fusion
    • Hannemann JR, Healy LE, Ridge SA, Wiedemann LM. The second ETV6 allele is not necessarily deleted in acute leukemias with a ETV6/ABL fusion. Genes Chromosomes Cancer. 1998 21 : 256 9.
    • (1998) Genes Chromosomes Cancer. , vol.21 , pp. 256-259
    • Hannemann, J.R.1    Healy, L.E.2    Ridge, S.A.3    Wiedemann, L.M.4
  • 86
    • 0036436878 scopus 로고    scopus 로고
    • Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukaemia cell line
    • Griesinger F, Janke A, Podleschny M, Bohlander SK. Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukaemia cell line. Br J Haematol. 2002 119 : 454 8.
    • (2002) Br J Haematol. , vol.119 , pp. 454-458
    • Griesinger, F.1    Janke, A.2    Podleschny, M.3    Bohlander, S.K.4
  • 88
    • 0036566196 scopus 로고    scopus 로고
    • Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9; 12) translocation
    • O'Brien SG, Vieira SA, Connors S, Bown N, Chang J, Capdeville R, Melo JV. Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9; 12) translocation. Blood. 2002 99 : 3465 7.
    • (2002) Blood. , vol.99 , pp. 3465-3467
    • O'Brien, S.G.1    Vieira, S.A.2    Connors, S.3    Bown, N.4    Chang, J.5    Capdeville, R.6    Melo, J.V.7
  • 92
    • 0037110168 scopus 로고    scopus 로고
    • Chronic myelocytic leukemia with eosinophilia, t(9; 12)(q34; p13), and ETV6-ABL gene rearrangement: Case report and review of the literature
    • Keung YK, Beaty M, Steward W, Jackle B, Pettnati M. Chronic myelocytic leukemia with eosinophilia, t(9; 12)(q34; p13), and ETV6-ABL gene rearrangement: case report and review of the literature. Cancer Genet Cytogenet. 2002 138 : 139 42.
    • (2002) Cancer Genet Cytogenet. , vol.138 , pp. 139-142
    • Keung, Y.K.1    Beaty, M.2    Steward, W.3    Jackle, B.4    Pettnati, M.5
  • 93
    • 0037097596 scopus 로고    scopus 로고
    • The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9; 12) translo-cations in human leukemia, induces distinct myeloproliferative disease in mice
    • Million RP, Aster J, Gilliland DG, Van Etten RA. The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9; 12) translo-cations in human leukemia, induces distinct myeloproliferative disease in mice. Blood. 2002 99 : 4568 77.
    • (2002) Blood. , vol.99 , pp. 4568-4577
    • Million, R.P.1    Aster, J.2    Gilliland, D.G.3    Van Etten, R.A.4
  • 94
    • 52949127317 scopus 로고    scopus 로고
    • The JAK kinases: Not just another kinase drug discovery target
    • in press.
    • Wilks AF. The JAK kinases: not just another kinase drug discovery target. Semin Cell Dev Biol. 2008 in press.
    • (2008) Semin Cell Dev Biol.
    • Wilks, A.F.1
  • 95
    • 0026081302 scopus 로고
    • Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase
    • Wilks AF, Harpur AG, Kurban RR, Ralph SJ, Zurcher G, Ziemiecki A. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol Cell Biol. 1991 11 : 2057 65.
    • (1991) Mol Cell Biol. , vol.11 , pp. 2057-2065
    • Wilks, A.F.1    Harpur, A.G.2    Kurban, R.R.3    Ralph, S.J.4    Zurcher, G.5    Ziemiecki, A.6
  • 97
    • 34547108380 scopus 로고    scopus 로고
    • JAK-STAT signaling: From interferons to cytokines
    • Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. J Biol Chem. 2007 282 : 20059 63.
    • (2007) J Biol Chem. , vol.282 , pp. 20059-20063
    • Schindler, C.1    Levy, D.E.2    Decker, T.3
  • 103
    • 21344440357 scopus 로고    scopus 로고
    • The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both 殿typical- myeloproliferative disorders and myelodysplastic syndromes
    • Steensma DP, Dewald GW, Lasho TL, Powell HL, McClure RF, Levine RL, Gilliland DG, Tefferi A. The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both 殿typical- myeloproliferative disorders and myelodysplastic syndromes. Blood. 2005 106 : 1207 9.
    • (2005) Blood. , vol.106 , pp. 1207-1209
    • Steensma, D.P.1    Dewald, G.W.2    Lasho, T.L.3    Powell, H.L.4    McClure, R.F.5    Levine, R.L.6    Gilliland, D.G.7    Tefferi, A.8
  • 113
    • 50249116142 scopus 로고    scopus 로고
    • Novel SSBP2-JAK2 fusion gene resulting from a t(5; 9)(q14.1; p24.1) in pre-B acute lymphocytic leukemia
    • Poitras JL, Dal Cin P, Aster JC, DeAngelo DJ, Morton CC. Novel SSBP2-JAK2 fusion gene resulting from a t(5; 9)(q14.1; p24.1) in pre-B acute lymphocytic leukemia. Genes Chromosomes Cancer. 2008 47 : 884 9.
    • (2008) Genes Chromosomes Cancer. , vol.47 , pp. 884-889
    • Poitras, J.L.1    Dal Cin, P.2    Aster, J.C.3    Deangelo, D.J.4    Morton, C.C.5
  • 116
    • 33644976909 scopus 로고    scopus 로고
    • A transgenic mouse model for TEL-JAK2-induced B-cell lymphoma/leukemia
    • dos Santos NR, Ghysdael J. A transgenic mouse model for TEL-JAK2-induced B-cell lymphoma/leukemia. Leukemia. 2006 20 : 182 5.
    • (2006) Leukemia. , vol.20 , pp. 182-185
    • Dos Santos, N.R.1    Ghysdael, J.2
  • 117
    • 33750936941 scopus 로고    scopus 로고
    • Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo
    • Kennedy JA, Barabe F, Patterson BJ, Bayani J, Squire JA, Barber DL, Dick JE. Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo. Proc Natl Acad Sci USA. 2006 103 : 16930 5.
    • (2006) Proc Natl Acad Sci USA. , vol.103 , pp. 16930-16935
    • Kennedy, J.A.1    Barabe, F.2    Patterson, B.J.3    Bayani, J.4    Squire, J.A.5    Barber, D.L.6    Dick, J.E.7
  • 118
    • 50249116142 scopus 로고    scopus 로고
    • Novel SSBP2-JAK2 fusion gene resulting from a t(5; 9)(q14.1; p24.1) in pre-B acute lymphocytic leukemia
    • Poitras JL, Cin PD, Aster JC, Deangelo DJ, Morton CC. Novel SSBP2-JAK2 fusion gene resulting from a t(5; 9)(q14.1; p24.1) in pre-B acute lymphocytic leukemia. Genes Chromosomes Cancer. 2008 47 : 884 9.
    • (2008) Genes Chromosomes Cancer. , vol.47 , pp. 884-889
    • Poitras, J.L.1    Cin, P.D.2    Aster, J.C.3    Deangelo, D.J.4    Morton, C.C.5
  • 120
    • 33644987681 scopus 로고    scopus 로고
    • Absence of the JAK2 V617F activating mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma
    • Melzner I, Weniger MA, Menz CK, Moller P. Absence of the JAK2 V617F activating mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma. Leukemia. 2006 20 : 157 8.
    • (2006) Leukemia. , vol.20 , pp. 157-158
    • Melzner, I.1    Weniger, M.A.2    Menz, C.K.3    Moller, P.4
  • 122
    • 27244450310 scopus 로고    scopus 로고
    • The V617F mutation in Jak2 is not found in childhood acute lym-phoblastic leukaemia
    • Sulong S, Case M, Minto L, Wilkins B, Hall A, Irving J. The V617F mutation in Jak2 is not found in childhood acute lym-phoblastic leukaemia. Br J Haematol. 2005 130 : 964 5.
    • (2005) Br J Haematol. , vol.130 , pp. 964-965
    • Sulong, S.1    Case, M.2    Minto, L.3    Wilkins, B.4    Hall, A.5    Irving, J.6
  • 130
    • 33750304807 scopus 로고    scopus 로고
    • JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less?
    • Verstovsek S, Silver RT, Cross NC, Tefferi A. JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less? Leukemia. 2006 20 : 2067.
    • (2006) Leukemia. , vol.20 , pp. 2067
    • Verstovsek, S.1    Silver, R.T.2    Cross, N.C.3    Tefferi, A.4
  • 131
    • 33644533192 scopus 로고    scopus 로고
    • JAK2 V617F mutation in classic chronic myeloproliferative diseases: A report on a series of 349 patients
    • Vizmanos JL, Ormazabal C, Larrayoz MJ, Cross NC, Calasanz MJ. JAK2 V617F mutation in classic chronic myeloproliferative diseases: a report on a series of 349 patients. Leukemia. 2006 20 : 534 5.
    • (2006) Leukemia. , vol.20 , pp. 534-535
    • Vizmanos, J.L.1    Ormazabal, C.2    Larrayoz, M.J.3    Cross, N.C.4    Calasanz, M.J.5
  • 132
    • 33744490974 scopus 로고    scopus 로고
    • Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
    • Wernig G, Mercher T, Okabe R, Levine RL, Lee BH, Gilliland DG. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood. 2006 107 : 4274 81.
    • (2006) Blood. , vol.107 , pp. 4274-4281
    • Wernig, G.1    Mercher, T.2    Okabe, R.3    Levine, R.L.4    Lee, B.H.5    Gilliland, D.G.6
  • 133
    • 33745721197 scopus 로고    scopus 로고
    • JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
    • Lacout C, Pisani DF, Tulliez M, Moreau Gachelin F, Vainchenker W, Villeval JL. JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood. 2006 108 : 1652 60.
    • (2006) Blood. , vol.108 , pp. 1652-1660
    • Lacout, C.1    Pisani, D.F.2    Tulliez, M.3    Moreau Gachelin, F.4    Vainchenker, W.5    Villeval, J.L.6
  • 134
    • 43249084493 scopus 로고    scopus 로고
    • Ratio of mutant JAK2-V617F to wild type JAK2 determines the MPD phenotypes in transgenic mice
    • Tiedt R, Hao-Shen H, Sobas MA, Looser R, Dirnhofer S, Schwaller J, Skoda RC. Ratio of mutant JAK2-V617F to wild type JAK2 determines the MPD phenotypes in transgenic mice. Blood. 2008 111 : 3931 40.
    • (2008) Blood. , vol.111 , pp. 3931-3940
    • Tiedt, R.1    Hao-Shen, H.2    Sobas, M.A.3    Looser, R.4    Dirnhofer, S.5    Schwaller, J.6    Skoda, R.C.7
  • 138
    • 42449124578 scopus 로고    scopus 로고
    • Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, predicts inferior overall and leukemia-free survival
    • Tefferi A, Lasho TL, Huang J, Finke C, Hanson CA, Mesa RA, Pardanani A. Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, predicts inferior overall and leukemia-free survival. Leukemia. 2008 22 : 756 61.
    • (2008) Leukemia. , vol.22 , pp. 756-761
    • Tefferi, A.1    Lasho, T.L.2    Huang, J.3    Finke, C.4    Hanson, C.A.5    Mesa, R.A.6    Pardanani, A.7
  • 142
    • 51649087754 scopus 로고    scopus 로고
    • JAK2 stimulates homologous recombination and genetic instability: Potential implication in the heterogeneity of myeloproliferative disorders
    • Plo I, Nakatake M, Malivert L, de Villartay JP, Giraudier S, Villeval JL, Wiesmuller L, Vainchenker W. JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders. Blood. 2008 112 : 1402 12.
    • (2008) Blood. , vol.112 , pp. 1402-1412
    • Plo, I.1    Nakatake, M.2    Malivert, L.3    De Villartay, J.P.4    Giraudier, S.5    Villeval, J.L.6    Wiesmuller, L.7    Vainchenker, W.8
  • 144
    • 33749358349 scopus 로고    scopus 로고
    • Progenitors homozygous for the V617F JAK2 mutation occur in most patients with polycythemia vera, but not essential thrombocythemia
    • Scott LM, Scott MA, Campbell PJ, Green AR. Progenitors homozygous for the V617F JAK2 mutation occur in most patients with polycythemia vera, but not essential thrombocythemia. Blood. 2006 108 : 2435 7.
    • (2006) Blood. , vol.108 , pp. 2435-2437
    • Scott, L.M.1    Scott, M.A.2    Campbell, P.J.3    Green, A.R.4
  • 146
    • 25444516768 scopus 로고    scopus 로고
    • JAK2 mutations in myeloproliferative disorders
    • Tefferi A, Lasho TL, Gilliland G. JAK2 mutations in myeloproliferative disorders. N Engl J Med. 2005 353 : 1416 7.
    • (2005) N Engl J Med. , vol.353 , pp. 1416-1417
    • Tefferi, A.1    Lasho, T.L.2    Gilliland, G.3
  • 148
    • 27244432586 scopus 로고    scopus 로고
    • Mutation studies in CD3+, CD19+ and CD34+ cell fractions in myeloproliferative disorders with homozygous JAK2(V617F) in granulocytes
    • Lasho TL, Mesa R, Gilliland DG, Tefferi A. Mutation studies in CD3+, CD19+ and CD34+ cell fractions in myeloproliferative disorders with homozygous JAK2(V617F) in granulocytes. Br J Haematol. 2005 130 : 797 9.
    • (2005) Br J Haematol. , vol.130 , pp. 797-799
    • Lasho, T.L.1    Mesa, R.2    Gilliland, D.G.3    Tefferi, A.4
  • 150
    • 33750611344 scopus 로고    scopus 로고
    • Involvement of various hematopoietic cell lineages by the JAK2V617F mutation in polycythemia vera
    • Ishii T, Bruno E, Hoffman R, Xu M. Involvement of various hematopoietic cell lineages by the JAK2V617F mutation in polycythemia vera. Blood. 2006 108 : 3128 34.
    • (2006) Blood. , vol.108 , pp. 3128-3134
    • Ishii, T.1    Bruno, E.2    Hoffman, R.3    Xu, M.4
  • 152
    • 33747199312 scopus 로고    scopus 로고
    • Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders
    • Kralovics R, Teo SS, Li S, Theocharides A, Buser AS, Tichelli A, Skoda RC. Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders. Blood. 2006 108 : 1377 80.
    • (2006) Blood. , vol.108 , pp. 1377-1380
    • Kralovics, R.1    Teo, S.S.2    Li, S.3    Theocharides, A.4    Buser, A.S.5    Tichelli, A.6    Skoda, R.C.7
  • 156
    • 41949128334 scopus 로고    scopus 로고
    • Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders
    • Pardananl A, Frldley BL, Lasho TL, Gllllland DG, Tefferi A. Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders. Blood. 2008 111 : 2785 9.
    • (2008) Blood. , vol.111 , pp. 2785-2789
    • Pardananl, A.1    Frldley, B.L.2    Lasho, T.L.3    Gllllland, D.G.4    Tefferi, A.5
  • 157
    • 33751234537 scopus 로고    scopus 로고
    • Report on two novel nucleotide exchanges in the JAK2 pseudokinase domain: D620E and E627E
    • Schnlttger S, Bacher U, Kern W, Schroder M, Haferlach T, Schoch C. Report on two novel nucleotide exchanges in the JAK2 pseudokinase domain: D620E and E627E. Leukemia. 2006 20 : 2195 7.
    • (2006) Leukemia. , vol.20 , pp. 2195-2197
    • Schnlttger, S.1    Bacher, U.2    Kern, W.3    Schroder, M.4    Haferlach, T.5    Schoch, C.6
  • 158
    • 33751246214 scopus 로고    scopus 로고
    • Detection of a new JAK2 D620E mutation in addition to V617F in a patient with polycythemia vera
    • Grunebach F, Bross-Bach U, Kanz L, Brossart P. Detection of a new JAK2 D620E mutation in addition to V617F in a patient with polycythemia vera. Leukemia. 2006 20 : 2210 1.
    • (2006) Leukemia. , vol.20 , pp. 2210-2211
    • Grunebach, F.1    Bross-Bach, U.2    Kanz, L.3    Brossart, P.4
  • 160
    • 33846135053 scopus 로고    scopus 로고
    • The investigation of JAK2 mutation in Chinese myeloproliferative diseases-identification of a novel C616Y point mutation in a PV patient
    • Zhang SJ, LI JY, LI WD, Song JH, Xu W, Qiu HX. The investigation of JAK2 mutation in Chinese myeloproliferative diseases-identification of a novel C616Y point mutation in a PV patient. Int J Lab Hematol. 2007 29 : 71 2.
    • (2007) Int J Lab Hematol. , vol.29 , pp. 71-72
    • Zhang, S.J.1    Li, J.Y.2    Li, W.D.3    Song, J.H.4    Xu, W.5    Qiu, H.X.6
  • 161
    • 34249747986 scopus 로고    scopus 로고
    • JAK2 V617F due to a novel TG -> CT mutation at nucleotides 1848-1849: Diagnostic implication
    • Wong CL, Ma ES, Wang CL, Lam HY, Ma SY. JAK2 V617F due to a novel TG -> CT mutation at nucleotides 1848-1849: diagnostic implication. Leukemia. 2007 21 : 1344 6.
    • (2007) Leukemia. , vol.21 , pp. 1344-1346
    • Wong, C.L.1    Ma, E.S.2    Wang, C.L.3    Lam, H.Y.4    Ma, S.Y.5
  • 162
    • 38949171700 scopus 로고    scopus 로고
    • JAK2 mutations other than V617F: A novel mutation and mini review
    • Karow A, Waller C, Relmann C, Niemeyer CM, Kratz CP. JAK2 mutations other than V617F: a novel mutation and mini review. Leuk Res. 2008 32 : 365 6.
    • (2008) Leuk Res. , vol.32 , pp. 365-366
    • Karow, A.1    Waller, C.2    Relmann, C.3    Niemeyer, C.M.4    Kratz, C.P.5
  • 163
    • 31444432749 scopus 로고    scopus 로고
    • Mutational screen reveals a novel JAK2 mutation, L611S, in a child with acute lymphoblastic leukemia
    • Kratz CP, Boll S, Kontny U, Schrappe M, Niemeyer CM, Stanulla M. Mutational screen reveals a novel JAK2 mutation, L611S, in a child with acute lymphoblastic leukemia. Leukemia. 2006 20 : 381 3.
    • (2006) Leukemia. , vol.20 , pp. 381-383
    • Kratz, C.P.1    Boll, S.2    Kontny, U.3    Schrappe, M.4    Niemeyer, C.M.5    Stanulla, M.6
  • 172
    • 39749106134 scopus 로고    scopus 로고
    • Lineage distribution of JAK2 exon12 mutations and JAK2-V617F in patients with polycythemia vera
    • Li S, Kralovics R, De Libero G, Tichelli A, Skoda RC. Lineage distribution of JAK2 exon12 mutations and JAK2-V617F in patients with polycythemia vera. ASH Ann Meet Abstr. 2007 110 : 1527.
    • (2007) ASH Ann Meet Abstr. , vol.110 , pp. 1527
    • Li, S.1    Kralovics, R.2    De Libero, G.3    Tichelli, A.4    Skoda, R.C.5
  • 176
    • 33646490285 scopus 로고    scopus 로고
    • Lineage-specific hemato-poietic growth factors
    • Kaushansky K. Lineage-specific hemato-poietic growth factors. N Engl J Med. 2006 354 : 2034 45.
    • (2006) N Engl J Med. , vol.354 , pp. 2034-2045
    • Kaushansky, K.1
  • 177
    • 34249981792 scopus 로고    scopus 로고
    • Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones
    • Abkowitz JL, Chen J. Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones. Blood. 2007 109 : 5186 90.
    • (2007) Blood. , vol.109 , pp. 5186-5190
    • Abkowitz, J.L.1    Chen, J.2
  • 179
    • 2542502506 scopus 로고    scopus 로고
    • Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoi-etin
    • Ding J, Komatsu H, Wakita A, Kato-Uranishi M, Ito M, Satoh A, Tsuboi K, Nitta M, Miyazaki H, Iida S, Ueda R. Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoi-etin. Blood. 2004 103 : 4198 200.
    • (2004) Blood. , vol.103 , pp. 4198-4200
    • Ding, J.1    Komatsu, H.2    Wakita, A.3    Kato-Uranishi, M.4    Ito, M.5    Satoh, A.6    Tsuboi, K.7    Nitta, M.8    Miyazaki, H.9    Iida, S.10    Ueda, R.11
  • 182
    • 33745693042 scopus 로고    scopus 로고
    • MPL mutations in 23 patients suffering from congenital amegakaryocytic throm-bocytopenia: The type of mutation predicts the course of the disease
    • Germeshausen M, Ballmaier M, Welte K. MPL mutations in 23 patients suffering from congenital amegakaryocytic throm-bocytopenia: the type of mutation predicts the course of the disease. Hum Mutat. 2006 27 : 296.
    • (2006) Hum Mutat. , vol.27 , pp. 296
    • Germeshausen, M.1    Ballmaier, M.2    Welte, K.3
  • 189
    • 62549109475 scopus 로고    scopus 로고
    • UPD1p indicates the presence of MPL W515L mutation in RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation
    • in press.
    • Szpurka H, Gondek LP, Mohan SR, Hsi ED, Theil KS, Maciejewski JP. UPD1p indicates the presence of MPL W515L mutation in RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation. Leukemia. 2008 in press.
    • (2008) Leukemia.
    • Szpurka, H.1    Gondek, L.P.2    Mohan, S.R.3    Hsi, E.D.4    Theil, K.S.5    MacIejewski, J.P.6
  • 192
    • 34548786770 scopus 로고    scopus 로고
    • Demonstration of MPLW515K, but not JAK2V617F, in in vitro expanded CD4+ T lymphocytes
    • Pardanani A, Lasho TL, Finke C, Markovic SN, Tefferi A. Demonstration of MPLW515K, but not JAK2V617F, in in vitro expanded CD4+ T lymphocytes. Leukemia. 2007 21 : 2206 7.
    • (2007) Leukemia. , vol.21 , pp. 2206-2207
    • Pardanani, A.1    Lasho, T.L.2    Finke, C.3    Markovic, S.N.4    Tefferi, A.5
  • 193
    • 33750550297 scopus 로고    scopus 로고
    • Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: Chronology of clonal emergence and changes in mutant allele burden over time
    • Lasho TL, Pardanani A, McClure RF, Mesa RA, Levine RL, Gary Gilliland D, Tefferi A. Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: chronology of clonal emergence and changes in mutant allele burden over time. Br J Haematol. 2006 135 : 683 7.
    • (2006) Br J Haematol. , vol.135 , pp. 683-687
    • Lasho, T.L.1    Pardanani, A.2    McClure, R.F.3    Mesa, R.A.4    Levine, R.L.5    Gary Gilliland, D.6    Tefferi, A.7
  • 203
    • 42449124578 scopus 로고    scopus 로고
    • Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival
    • Tefferi A, Lasho TL, Huang J, Finke C, Mesa RA, Li CY, Wu W, Hanson CA, Pardanani A. Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival. Leukemia. 2008 22 : 756 61.
    • (2008) Leukemia. , vol.22 , pp. 756-761
    • Tefferi, A.1    Lasho, T.L.2    Huang, J.3    Finke, C.4    Mesa, R.A.5    Li, C.Y.6    Wu, W.7    Hanson, C.A.8    Pardanani, A.9
  • 204
    • 38349053791 scopus 로고    scopus 로고
    • JAK2 inhibitor therapy in myeloproliferative disorders: Rationale, preclinical studies and ongoing clinical trials
    • Pardanani A. JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials. Leukemia. 2008 22 : 23 30.
    • (2008) Leukemia. , vol.22 , pp. 23-30
    • Pardanani, A.1
  • 205
    • 49449100990 scopus 로고    scopus 로고
    • TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation negative patients
    • Lasho TL, Tefferi A, Hood JD, Verstovsek S, Gilliland DG, Pardanani A. TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation negative patients. Leukemia. 2008 22 : 1790 2.
    • (2008) Leukemia. , vol.22 , pp. 1790-1792
    • Lasho, T.L.1    Tefferi, A.2    Hood, J.D.3    Verstovsek, S.4    Gilliland, D.G.5    Pardanani, A.6
  • 207
    • 47049098437 scopus 로고    scopus 로고
    • Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders
    • Hexner EO, Serdikoff C, Jan M, Swider CR, Robinson C, Yang S, Angeles T, Emerson SG, Carroll M, Ruggeri B, Dobrzanski P. Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders. Blood. 2008 111 : 5663 71.
    • (2008) Blood. , vol.111 , pp. 5663-5671
    • Hexner, E.O.1    Serdikoff, C.2    Jan, M.3    Swider, C.R.4    Robinson, C.5    Yang, S.6    Angeles, T.7    Emerson, S.G.8    Carroll, M.9    Ruggeri, B.10    Dobrzanski, P.11
  • 213
    • 39749118802 scopus 로고    scopus 로고
    • INCB018424, an oral, selective JAK2 inhibitor, shows significant clinical activity in a phase I/II study in patients with primary myelofibrosis (PMF) and post polycythemia vera/essential thrombocythemia myelofibrosis (post-PV/ET MF)
    • Verstovsek S, Kantarjian H, Pardanani A, Thomas D, Cortes J, Mesa R, Redman J, Staschen C-M, Fridman J, Vaddi K, Tefferi A. INCB018424, an oral, selective JAK2 inhibitor, shows significant clinical activity in a phase I/II study in patients with primary myelofibrosis (PMF) and post polycythemia vera/essential thrombocythemia myelofibrosis (post-PV/ET MF). ASH Annu Meet Abstr. 2007 110 : 558.
    • (2007) ASH Annu Meet Abstr. , vol.110 , pp. 558
    • Verstovsek, S.1    Kantarjian, H.2    Pardanani, A.3    Thomas, D.4    Cortes, J.5    Mesa, R.6    Redman, J.7    Staschen, C.-M.8    Fridman, J.9    Vaddi, K.10    Tefferi, A.11
  • 214
    • 44349110913 scopus 로고    scopus 로고
    • Phase II study of CEP701, an orally available JAK2 inhibitor, in patients with primary myelofibrosis and post polycythemia vera/essential thrombocythemia myelofi-brosis
    • Verstovsek S, Tefferi A, Kornblau S, Thomas D, Cortes J, Ravandi-Kashani F, Garcia-Manero G, Kantarjian H. Phase II study of CEP701, an orally available JAK2 inhibitor, in patients with primary myelofibrosis and post polycythemia vera/essential thrombocythemia myelofi-brosis. ASH Annu Meet Abstr. 2007 110 : 3543.
    • (2007) ASH Annu Meet Abstr. , vol.110 , pp. 3543
    • Verstovsek, S.1    Tefferi, A.2    Kornblau, S.3    Thomas, D.4    Cortes, J.5    Ravandi-Kashani, F.6    Garcia-Manero, G.7    Kantarjian, H.8
  • 215
    • 0028229976 scopus 로고
    • Ligand-inde-pendent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation
    • Tsujimura T, Furitsu T, Morimoto M, Isozaki K, Nomura S, Matsuzawa Y, Kitamura Y, Kanakura Y. Ligand-inde-pendent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation. Blood. 1994 83 : 2619 26.
    • (1994) Blood. , vol.83 , pp. 2619-2626
    • Tsujimura, T.1    Furitsu, T.2    Morimoto, M.3    Isozaki, K.4    Nomura, S.5    Matsuzawa, Y.6    Kitamura, Y.7    Kanakura, Y.8
  • 216
    • 0028856070 scopus 로고
    • Identification of a point mutation in the catalytic domain of the pro-tooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder
    • Nagata H, Worobec AS, Oh CK, Chowdhury BA, Tannenbaum S, Suzuki Y, Metcalfe DD. Identification of a point mutation in the catalytic domain of the pro-tooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci USA. 1995 92 : 10560 4.
    • (1995) Proc Natl Acad Sci USA. , vol.92 , pp. 10560-10564
    • Nagata, H.1    Worobec, A.S.2    Oh, C.K.3    Chowdhury, B.A.4    Tannenbaum, S.5    Suzuki, Y.6    Metcalfe, D.D.7
  • 217
    • 18744382426 scopus 로고    scopus 로고
    • C-kit Mutations in patients with childhood-onset mastocytosis and geno-type-phenotype correlation
    • Yanagihori H, Oyama N, Nakamura K, Kaneko F. c-kit Mutations in patients with childhood-onset mastocytosis and geno-type-phenotype correlation. J Mol Diagn. 2005 7 : 252 7.
    • (2005) J Mol Diagn. , vol.7 , pp. 252-257
    • Yanagihori, H.1    Oyama, N.2    Nakamura, K.3    Kaneko, F.4
  • 218
    • 0032456567 scopus 로고    scopus 로고
    • Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: A possible explanation for divergent clinical behavior
    • Buttner C, Henz BM, Welker P, Sepp NT, Grabbe J. Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: a possible explanation for divergent clinical behavior. J Invest Dermatol. 1998 111 : 1227 31.
    • (1998) J Invest Dermatol. , vol.111 , pp. 1227-1231
    • Buttner, C.1    Henz, B.M.2    Welker, P.3    Sepp, N.T.4    Grabbe, J.5
  • 220
    • 0009013631 scopus 로고    scopus 로고
    • Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: Establishment of clonality in a human mast cell neoplasm
    • Longley BJ, Tyrrell L, Lu SZ, Ma YS, Langley K, Ding TG, Duffy T, Jacobs P, Tang LH, Modlin I. Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat Genet. 1996 12 : 312 4.
    • (1996) Nat Genet. , vol.12 , pp. 312-314
    • Longley, B.J.1    Tyrrell, L.2    Lu, S.Z.3    Ma, Y.S.4    Langley, K.5    Ding, T.G.6    Duffy, T.7    Jacobs, P.8    Tang, L.H.9    Modlin, I.10
  • 222
    • 1842579440 scopus 로고    scopus 로고
    • A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib
    • Akin C, Fumo G, Yavuz AS, Lipsky PE, Neckers L, Metcalfe DD. A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib. Blood. 2004 103 : 3222 5.
    • (2004) Blood. , vol.103 , pp. 3222-3225
    • Akin, C.1    Fumo, G.2    Yavuz, A.S.3    Lipsky, P.E.4    Neckers, L.5    Metcalfe, D.D.6
  • 224
    • 38349179274 scopus 로고    scopus 로고
    • Sensitive and reliable detection of Kit point mutation Asp 816 to Val in pathological material
    • Kahler C, Didlaukat S, Feller AC, Merz H. Sensitive and reliable detection of Kit point mutation Asp 816 to Val in pathological material. Diagn Pathol. 2007 2 : 37.
    • (2007) Diagn Pathol. , vol.2 , pp. 37
    • Kahler, C.1    Didlaukat, S.2    Feller, A.C.3    Merz, H.4
  • 225
    • 0032948780 scopus 로고    scopus 로고
    • Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms
    • Ma Y, Longley BJ, Wang X, Blount JL, Langley K, Caughey GH. Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms. J Invest Dermatol. 1999 112 : 165 70.
    • (1999) J Invest Dermatol. , vol.112 , pp. 165-170
    • Ma, Y.1    Longley, B.J.2    Wang, X.3    Blount, J.L.4    Langley, K.5    Caughey, G.H.6
  • 227
    • 0023919865 scopus 로고
    • Localization of the human c-kit pro-tooncogene on the q11-q12 region of chromosome 4
    • d'Auriol L, Mattei MG, Andre C, Galibert F. Localization of the human c-kit pro-tooncogene on the q11-q12 region of chromosome 4. Hum Genet. 1988 78 : 374 6.
    • (1988) Hum Genet. , vol.78 , pp. 374-376
    • D'Auriol, L.1    Mattei, M.G.2    Andre, C.3    Galibert, F.4
  • 228
    • 27744551009 scopus 로고    scopus 로고
    • Structure and regulation of Kit protein-tyrosine kinase-the stem cell factor receptor
    • Roskoski R Jr. Structure and regulation of Kit protein-tyrosine kinase-the stem cell factor receptor. Biochem Biophys Res Commun. 2005 338 : 1307 15.
    • (2005) Biochem Biophys Res Commun. , vol.338 , pp. 1307-1315
    • Roskoski Jr., R.1
  • 229
    • 0025828970 scopus 로고
    • Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter
    • Geissler EN, Liao M, Brook JD, Martin FH, Zsebo KM, Housman DE, Galli SJ. Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter. Somat Cell Mol Genet. 1991 17 : 207 14.
    • (1991) Somat Cell Mol Genet. , vol.17 , pp. 207-214
    • Geissler, E.N.1    Liao, M.2    Brook, J.D.3    Martin, F.H.4    Zsebo, K.M.5    Housman, D.E.6    Galli, S.J.7
  • 231
    • 0026539871 scopus 로고
    • Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization
    • Mathew S, Murty VV, Hunziker W, Chaganti RS. Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization. Genomics. 1992 14 : 775 9.
    • (1992) Genomics. , vol.14 , pp. 775-779
    • Mathew, S.1    Murty, V.V.2    Hunziker, W.3    Chaganti, R.S.4
  • 232
    • 23944452835 scopus 로고    scopus 로고
    • KIT (CD117): A review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation
    • Miettinen M, Lasota J. KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol. 2005 13 : 205 20.
    • (2005) Appl Immunohistochem Mol Morphol. , vol.13 , pp. 205-220
    • Miettinen, M.1    Lasota, J.2
  • 233
    • 9744246909 scopus 로고    scopus 로고
    • Signal transduction viathe stem cell factor receptor/c-Kit
    • Ronnstrand L. Signal transduction viathe stem cell factor receptor/c-Kit. Cell Mol Life Sci. 2004 61 : 2535 48.
    • (2004) Cell Mol Life Sci. , vol.61 , pp. 2535-2548
    • Ronnstrand, L.1
  • 234
    • 0033956308 scopus 로고    scopus 로고
    • Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mas-tocytosis
    • Akin C, Kirshenbaum AS, Semere T, Worobec AS, Scott LM, Metcalfe DD. Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mas-tocytosis. Exp Hematol. 2000 28 : 140 7.
    • (2000) Exp Hematol. , vol.28 , pp. 140-147
    • Akin, C.1    Kirshenbaum, A.S.2    Semere, T.3    Worobec, A.S.4    Scott, L.M.5    Metcalfe, D.D.6
  • 235
    • 0037100321 scopus 로고    scopus 로고
    • Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene
    • Yavuz AS, Lipsky PE, Yavuz S, Metcalfe DD, Akin C. Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene. Blood. 2002 100 : 661 5.
    • (2002) Blood. , vol.100 , pp. 661-665
    • Yavuz, A.S.1    Lipsky, P.E.2    Yavuz, S.3    Metcalfe, D.D.4    Akin, C.5
  • 236
    • 8744225522 scopus 로고    scopus 로고
    • Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis
    • Taylor ML, Sehgal D, Raffeld M, Obiakor H, Akin C, Mage RG, Metcalfe DD. Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis. J Mol Diagn. 2004 6 : 335 42.
    • (2004) J Mol Diagn. , vol.6 , pp. 335-342
    • Taylor, M.L.1    Sehgal, D.2    Raffeld, M.3    Obiakor, H.4    Akin, C.5    Mage, R.G.6    Metcalfe, D.D.7
  • 237
    • 0029962928 scopus 로고    scopus 로고
    • A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenic-ity, and differentiation of mast cells
    • Piao X, Bernstein A. A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenic-ity, and differentiation of mast cells. Blood. 1996 87 : 3117 23.
    • (1996) Blood. , vol.87 , pp. 3117-3123
    • Piao, X.1    Bernstein, A.2
  • 240
    • 0346035004 scopus 로고    scopus 로고
    • Constitutively active mutant D816VKit induces megakayocyte and mast cell differentiation of early haemopoietic cells from murine foetal liver
    • Ferrao PT, Gonda TJ, Ashman LK. Constitutively active mutant D816VKit induces megakayocyte and mast cell differentiation of early haemopoietic cells from murine foetal liver. Leuk Res. 2003 27 : 547 55.
    • (2003) Leuk Res. , vol.27 , pp. 547-555
    • Ferrao, P.T.1    Gonda, T.J.2    Ashman, L.K.3
  • 242
    • 0028895383 scopus 로고
    • Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells
    • Serve H, Yee NS, Stella G, Sepp-Lorenzino L, Tan JC, Besmer P. Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J. 1995 14 : 473 83.
    • (1995) EMBO J. , vol.14 , pp. 473-483
    • Serve, H.1    Yee, N.S.2    Stella, G.3    Sepp-Lorenzino, L.4    Tan, J.C.5    Besmer, P.6
  • 243
    • 0032476674 scopus 로고    scopus 로고
    • Kit signaling through PI 3-kinase and Src kinase pathways: An essential role for Rac1 and JNK activation in mast cell proliferation
    • Timokhina I, Kissel H, Stella G, Besmer P. Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation. EMBO J. 1998 17 : 6250 62.
    • (1998) EMBO J. , vol.17 , pp. 6250-6262
    • Timokhina, I.1    Kissel, H.2    Stella, G.3    Besmer, P.4
  • 244
    • 14944351399 scopus 로고    scopus 로고
    • PKCdelta plays opposite roles in growth mediated by wild-type Kit and an oncogenic Kit mutant
    • Jelacic T, Linnekin D. PKCdelta plays opposite roles in growth mediated by wild-type Kit and an oncogenic Kit mutant. Blood. 2005 105 : 1923 9.
    • (2005) Blood. , vol.105 , pp. 1923-1929
    • Jelacic, T.1    Linnekin, D.2
  • 246
    • 15244341289 scopus 로고    scopus 로고
    • A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors
    • Tanaka A, Konno M, Muto S, Kambe N, Morii E, Nakahata T, Itai A, Matsuda H. A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Blood. 2005 105 : 2324 31.
    • (2005) Blood. , vol.105 , pp. 2324-2331
    • Tanaka, A.1    Konno, M.2    Muto, S.3    Kambe, N.4    Morii, E.5    Nakahata, T.6    Itai, A.7    Matsuda, H.8
  • 249
    • 34347253239 scopus 로고    scopus 로고
    • Sensitivity of human cells bearing onco-genic mutant kit isoforms to the novel tyrosine kinase inhibitor INNO-406
    • Pan J, Quintas-Cardama A, Manshouri T, Cortes J, Kantarjian H, Verstovsek S. Sensitivity of human cells bearing onco-genic mutant kit isoforms to the novel tyrosine kinase inhibitor INNO-406. Cancer Sci. 2007 98 : 1223 5.
    • (2007) Cancer Sci. , vol.98 , pp. 1223-1225
    • Pan, J.1    Quintas-Cardama, A.2    Manshouri, T.3    Cortes, J.4    Kantarjian, H.5    Verstovsek, S.6
  • 252
    • 33947520803 scopus 로고    scopus 로고
    • Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces ima-tinib-resistant constitutive KIT activation
    • Nakagomi N, Hirota S. Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces ima-tinib-resistant constitutive KIT activation. Lab Invest. 2007 87 : 365 71.
    • (2007) Lab Invest. , vol.87 , pp. 365-371
    • Nakagomi, N.1    Hirota, S.2
  • 256
    • 26944458584 scopus 로고    scopus 로고
    • The systemic mastocytosis-specific activating cKit mutation D816V can be inhibited by the tyrosine kinase inhibitor AMN107
    • von Bubnoff N, Gorantla SH, Kancha RK, Lordick F, Peschel C, Duyster J. The systemic mastocytosis-specific activating cKit mutation D816V can be inhibited by the tyrosine kinase inhibitor AMN107. Leukemia. 2005 19 : 1670 1.
    • (2005) Leukemia. , vol.19 , pp. 1670-1671
    • Von Bubnoff, N.1    Gorantla, S.H.2    Kancha, R.K.3    Lordick, F.4    Peschel, C.5    Duyster, J.6
  • 257
    • 31544459272 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
    • Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY, Bokemeyer C, Deininger MW, Druker BJ, Heinrich MC. Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res. 2006 66 : 473 81.
    • (2006) Cancer Res. , vol.66 , pp. 473-481
    • Schittenhelm, M.M.1    Shiraga, S.2    Schroeder, A.3    Corbin, A.S.4    Griffith, D.5    Lee, F.Y.6    Bokemeyer, C.7    Deininger, M.W.8    Druker, B.J.9    Heinrich, M.C.10
  • 258
    • 33645687784 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis
    • Shah NP, Lee FY, Luo R, Jiang Y, Donker M, Akin C. Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis. Blood. 2006 108 : 286 91.
    • (2006) Blood. , vol.108 , pp. 286-291
    • Shah, N.P.1    Lee, F.Y.2    Luo, R.3    Jiang, Y.4    Donker, M.5    Akin, C.6
  • 261
    • 22144455380 scopus 로고    scopus 로고
    • Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412
    • Growney JD, Clark JJ, Adelsperger J, Stone R, Fabbro D, Griffin JD, Gilliland DG. Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412. Blood. 2005 106 : 721 4.
    • (2005) Blood. , vol.106 , pp. 721-724
    • Growney, J.D.1    Clark, J.J.2    Adelsperger, J.3    Stone, R.4    Fabbro, D.5    Griffin, J.D.6    Gilliland, D.G.7
  • 265
    • 3242742988 scopus 로고    scopus 로고
    • FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia
    • Tefferi A, Lasho TL, Brockman SR, Elliott MA, Dispenzieri A, Pardanani A. FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia. Haematologica. 2004 89 : 871 3.
    • (2004) Haematologica. , vol.89 , pp. 871-873
    • Tefferi, A.1    Lasho, T.L.2    Brockman, S.R.3    Elliott, M.A.4    Dispenzieri, A.5    Pardanani, A.6
  • 270
    • 0942276859 scopus 로고    scopus 로고
    • Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome
    • Klion AD, Robyn J, Akin C, Noel P, Brown M, Law M, Metcalfe DD, Dunbar C, Nutman TB. Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome. Blood. 2004 103 : 473 8.
    • (2004) Blood. , vol.103 , pp. 473-478
    • Klion, A.D.1    Robyn, J.2    Akin, C.3    Noel, P.4    Brown, M.5    Law, M.6    Metcalfe, D.D.7    Dunbar, C.8    Nutman, T.B.9
  • 271
    • 13544267772 scopus 로고    scopus 로고
    • Myeloid blast crisis evolving during ima-tinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia
    • von Bubnoff N, Sandherr M, Schlimok G, Andreesen R, Peschel C, Duyster J. Myeloid blast crisis evolving during ima-tinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. Leukemia. 2005 19 : 286 7.
    • (2005) Leukemia. , vol.19 , pp. 286-287
    • Von Bubnoff, N.1    Sandherr, M.2    Schlimok, G.3    Andreesen, R.4    Peschel, C.5    Duyster, J.6
  • 272
    • 33746473457 scopus 로고    scopus 로고
    • Chronic eosinophilic leukaemia with FIP1L1-PDGFRA fusion and T674I mutation that evolved from Langerhans cell histiocytosis with eosinophilia after chemotherapy
    • Ohnishi H, Kandabashi K, Maeda Y, Kawamura M, Watanabe T. Chronic eosinophilic leukaemia with FIP1L1-PDGFRA fusion and T674I mutation that evolved from Langerhans cell histiocytosis with eosinophilia after chemotherapy. Br J Haematol. 2006 134 : 547 9.
    • (2006) Br J Haematol. , vol.134 , pp. 547-549
    • Ohnishi, H.1    Kandabashi, K.2    Maeda, Y.3    Kawamura, M.4    Watanabe, T.5
  • 275
    • 33745059630 scopus 로고    scopus 로고
    • The FIP1L1-PDGFRA T674I mutation can be inhibited by the tyrosine kinase inhibitor AMN107 (nilotinib)
    • author reply 4972.
    • von Bubnoff N, Gorantla SP, Thone S, Peschel C, Duyster J. The FIP1L1-PDGFRA T674I mutation can be inhibited by the tyrosine kinase inhibitor AMN107 (nilotinib). Blood. 2006 107 : 4970 1 author reply 4972.
    • (2006) Blood. , vol.107 , pp. 4970-4971
    • Von Bubnoff, N.1    Gorantla, S.P.2    Thone, S.3    Peschel, C.4    Duyster, J.5
  • 276
    • 33646152550 scopus 로고    scopus 로고
    • Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia
    • Score J, Curtis C, Waghorn K, Stalder M, Jotterand M, Grand FH, Cross NC. Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia. Leukemia. 2006 20 : 827 32.
    • (2006) Leukemia. , vol.20 , pp. 827-832
    • Score, J.1    Curtis, C.2    Waghorn, K.3    Stalder, M.4    Jotterand, M.5    Grand, F.H.6    Cross, N.C.7
  • 279
    • 0041335547 scopus 로고    scopus 로고
    • Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor alpha receptor: A new clinical target for STI571/Glivec
    • Trempat P, Villalva C, Laurent G, Armstrong F, Delsol G, Dastugue N, Brousset P. Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor alpha receptor: a new clinical target for STI571/Glivec. Oncogene. 2003 22 : 5702 6.
    • (2003) Oncogene. , vol.22 , pp. 5702-5706
    • Trempat, P.1    Villalva, C.2    Laurent, G.3    Armstrong, F.4    Delsol, G.5    Dastugue, N.6    Brousset, P.7
  • 280
    • 1942453753 scopus 로고    scopus 로고
    • Molecular and cytogenetic characterization of a novel translocation t(4; 22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia
    • Safley AM, Sebastian S, Collins TS, Tirado CA, Stenzel TT, Gong JZ, Goodman BK. Molecular and cytogenetic characterization of a novel translocation t(4; 22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia. Genes Chromosomes Cancer. 2004 40 : 44 50.
    • (2004) Genes Chromosomes Cancer. , vol.40 , pp. 44-50
    • Safley, A.M.1    Sebastian, S.2    Collins, T.S.3    Tirado, C.A.4    Stenzel, T.T.5    Gong, J.Z.6    Goodman, B.K.7
  • 281
    • 0029966854 scopus 로고    scopus 로고
    • The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways
    • Carroll M, Tomasson MH, Barker GF, Golub TR, Gilliland DG. The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. Proc Natl Acad Sci USA. 1996 93 : 14845 50.
    • (1996) Proc Natl Acad Sci USA. , vol.93 , pp. 14845-14850
    • Carroll, M.1    Tomasson, M.H.2    Barker, G.F.3    Golub, T.R.4    Gilliland, D.G.5
  • 282
    • 0030669455 scopus 로고    scopus 로고
    • Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myel-ogenous leukemia after clonal evolution
    • Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myel-ogenous leukemia after clonal evolution. Blood. 1997 90 : 4271 7.
    • (1997) Blood. , vol.90 , pp. 4271-4277
    • Abe, A.1    Emi, N.2    Tanimoto, M.3    Terasaki, H.4    Marunouchi, T.5    Saito, H.6
  • 284
    • 5644251199 scopus 로고    scopus 로고
    • NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5; 14)(q33; q24) and an imatinib-responsive myeloproliferative disorder
    • Vizmanos JL, Novo FJ, Roman JP, Baxter EJ, Lahortiga I, Larrayoz MJ, Odero MD, Giraldo P, Calasanz MJ, Cross NC. NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5; 14)(q33; q24) and an imatinib-responsive myeloproliferative disorder. Cancer Res. 2004 64 : 2673 6.
    • (2004) Cancer Res. , vol.64 , pp. 2673-2676
    • Vizmanos, J.L.1    Novo, F.J.2    Roman, J.P.3    Baxter, E.J.4    Lahortiga, I.5    Larrayoz, M.J.6    Odero, M.D.7    Giraldo, P.8    Calasanz, M.J.9    Cross, N.C.10
  • 286
    • 0344826038 scopus 로고    scopus 로고
    • Cloning of the t(1; 5)(q23; q33) in a myeloproliferative disorder associated with eosinophilia: Involvement of PDGFRB and response to imatinib
    • Wilkinson K, Velloso ER, Lopes LF, Lee C, Aster JC, Shipp MA, Aguiar RC. Cloning of the t(1; 5)(q23; q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. Blood. 2003 102 : 4187 90.
    • (2003) Blood. , vol.102 , pp. 4187-4190
    • Wilkinson, K.1    Velloso, E.R.2    Lopes, L.F.3    Lee, C.4    Aster, J.C.5    Shipp, M.A.6    Aguiar, R.C.7
  • 287
    • 0035889128 scopus 로고    scopus 로고
    • Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia
    • Magnusson MK, Meade KE, Brown KE, Arthur DC, Krueger LA, Barrett AJ, Dunbar CE. Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia. Blood. 2001 98 : 2518 25.
    • (2001) Blood. , vol.98 , pp. 2518-2525
    • Magnusson, M.K.1    Meade, K.E.2    Brown, K.E.3    Arthur, D.C.4    Krueger, L.A.5    Barrett, A.J.6    Dunbar, C.E.7
  • 288
    • 0031864246 scopus 로고    scopus 로고
    • Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5; 7)(q33; q11.2)
    • Ross TS, Bernard OA, Berger R, Gilliland DG. Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5; 7)(q33; q11.2). Blood. 1998 91 : 4419 26.
    • (1998) Blood. , vol.91 , pp. 4419-4426
    • Ross, T.S.1    Bernard, O.A.2    Berger, R.3    Gilliland, D.G.4
  • 290
    • 5644271514 scopus 로고    scopus 로고
    • P53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5; 15)(q33; q22) and an imatinib-responsive eosinophilic myeloproliferative disorder
    • Grand FH, Burgstaller S, Kuhr T, Baxter EJ, Webersinke G, Thaler J, Chase AJ, Cross NC. p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5; 15)(q33; q22) and an imatinib-responsive eosinophilic myeloproliferative disorder. Cancer Res. 2004 64 : 7216 9.
    • (2004) Cancer Res. , vol.64 , pp. 7216-7219
    • Grand, F.H.1    Burgstaller, S.2    Kuhr, T.3    Baxter, E.J.4    Webersinke, G.5    Thaler, J.6    Chase, A.J.7    Cross, N.C.8
  • 293
    • 6844255886 scopus 로고    scopus 로고
    • The t(8; 13)(p11; q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP
    • Smedley D, Hamoudi R, Clark J, Warren W, Abdul-Rauf M, Somers G, Venter D, Fagan K, Cooper C, Shipley J. The t(8; 13)(p11; q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP. Hum Mol Genet. 1998 7 : 637 42.
    • (1998) Hum Mol Genet. , vol.7 , pp. 637-642
    • Smedley, D.1    Hamoudi, R.2    Clark, J.3    Warren, W.4    Abdul-Rauf, M.5    Somers, G.6    Venter, D.7    Fagan, K.8    Cooper, C.9    Shipley, J.10
  • 295
    • 0030797764 scopus 로고    scopus 로고
    • Molecular characterization of the t(8; 13)(p11; q12) translocation associated with an atypical myeloproliferative disorder: Evidence for three discrete loci involved in myeloid leukemias on 8p11
    • Still IH, Chernova O, Hurd D, Stone RM, Cowell JK. Molecular characterization of the t(8; 13)(p11; q12) translocation associated with an atypical myeloproliferative disorder: evidence for three discrete loci involved in myeloid leukemias on 8p11. Blood. 1997 90 : 3136 41.
    • (1997) Blood. , vol.90 , pp. 3136-3141
    • Still, I.H.1    Chernova, O.2    Hurd, D.3    Stone, R.M.4    Cowell, J.K.5
  • 298
    • 0033558253 scopus 로고    scopus 로고
    • The t(6; 8)(q27; p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
    • Popovici C, Zhang B, Gregoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pebusque MJ. The t(6; 8)(q27; p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. Blood. 1999 93 : 1381 9.
    • (1999) Blood. , vol.93 , pp. 1381-1389
    • Popovici, C.1    Zhang, B.2    Gregoire, M.J.3    Jonveaux, P.4    Lafage-Pochitaloff, M.5    Birnbaum, D.6    Pebusque, M.J.7
  • 302
    • 0035159831 scopus 로고    scopus 로고
    • Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8; 22)(p11; q11) in a myeloproliferative disorder: The first fusion gene involving BCR but not ABL
    • Fioretos T, Panagopoulos I, Lassen C, Swedin A, Billstrom R, Isaksson M, Strombeck B, Olofsson T, Mitelman F, Johansson B. Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8; 22)(p11; q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL. Genes Chromosomes Cancer. 2001 32 : 302 10.
    • (2001) Genes Chromosomes Cancer. , vol.32 , pp. 302-310
    • Fioretos, T.1    Panagopoulos, I.2    Lassen, C.3    Swedin, A.4    Billstrom, R.5    Isaksson, M.6    Strombeck, B.7    Olofsson, T.8    Mitelman, F.9    Johansson, B.10
  • 303
    • 0037216062 scopus 로고    scopus 로고
    • Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8; 19)(p12; q13.3)
    • Guasch G, Popovici C, Mugneret F, Chaffanet M, Pontarotti P, Birnbaum D, Pebusque MJ. Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8; 19)(p12; q13.3). Blood. 2003 101 : 286 8.
    • (2003) Blood. , vol.101 , pp. 286-288
    • Guasch, G.1    Popovici, C.2    Mugneret, F.3    Chaffanet, M.4    Pontarotti, P.5    Birnbaum, D.6    Pebusque, M.J.7
  • 308
    • 0033578775 scopus 로고    scopus 로고
    • Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8; 13) translocation
    • Ollendorff V, Guasch G, Isnardon D, Galindo R, Birnbaum D, Pebusque MJ. Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8; 13) translocation. J Biol Chem. 1999 274 : 26922 30.
    • (1999) J Biol Chem. , vol.274 , pp. 26922-26930
    • Ollendorff, V.1    Guasch, G.2    Isnardon, D.3    Galindo, R.4    Birnbaum, D.5    Pebusque, M.J.6
  • 309
    • 0035167404 scopus 로고    scopus 로고
    • 8p12 stem cell myeloproliferative disorder: The FOP-fibroblast growth factor receptor 1 fusion protein of the t(6; 8) translocation induces cell survival mediated by mitogen-acti-vated protein kinase and phosphatidylinos-itol 3-kinase/Akt/mTOR pathways
    • Guasch G, Ollendorff V, Borg JP, Birnbaum D, Pebusque MJ. 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6; 8) translocation induces cell survival mediated by mitogen-acti-vated protein kinase and phosphatidylinos-itol 3-kinase/Akt/mTOR pathways. Mol Cell Biol. 2001 21 : 8129 42.
    • (2001) Mol Cell Biol. , vol.21 , pp. 8129-8142
    • Guasch, G.1    Ollendorff, V.2    Borg, J.P.3    Birnbaum, D.4    Pebusque, M.J.5
  • 310
    • 1642421743 scopus 로고    scopus 로고
    • Distinct stem cell myeloprolifer-ative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations
    • Roumiantsev S, Krause DS, Neumann CA, Dimitri CA, Asiedu F, Cross NC, Van Etten RA. Distinct stem cell myeloprolifer-ative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Cancer Cell. 2004 5 : 287 98.
    • (2004) Cancer Cell. , vol.5 , pp. 287-298
    • Roumiantsev, S.1    Krause, D.S.2    Neumann, C.A.3    Dimitri, C.A.4    Asiedu, F.5    Cross, N.C.6    Van Etten, R.A.7
  • 311
    • 0347597750 scopus 로고    scopus 로고
    • FOP-FGFR1 tyrosine kinase, the product of a t(6; 8) translocation, induces a fatal myeloproliferative disease in mice
    • Guasch G, Delaval B, Arnoulet C, Xie MJ, Xerri L, Sainty D, Birnbaum D, Pebusque MJ. FOP-FGFR1 tyrosine kinase, the product of a t(6; 8) translocation, induces a fatal myeloproliferative disease in mice. Blood. 2004 103 : 309 12.
    • (2004) Blood. , vol.103 , pp. 309-312
    • Guasch, G.1    Delaval, B.2    Arnoulet, C.3    Xie, M.J.4    Xerri, L.5    Sainty, D.6    Birnbaum, D.7    Pebusque, M.J.8


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