-
1
-
-
30844456807
-
-
In: Jaffe, E.S., Harris, N.L., Stein, H., Vardiman, J.W., editors. Lyon, France: International Agency for Research on Cancer (IARC) Press. pp.
-
Vardiman JW, Brunning RD, Harris NL. World Health Organization classification of tumors: tumours of the haematopoietic and lymphoid tissues. In : Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. Lyon, France : International Agency for Research on Cancer (IARC) Press 2001. pp. 17 44.
-
(2001)
World Health Organization Classification of Tumors: Tumours of the Haematopoietic and Lymphoid Tissues.
, pp. 17-44
-
-
Vardiman, J.W.1
Brunning, R.D.2
Harris, N.L.3
-
2
-
-
0001639195
-
Some speculations on the myeloproliferative syndromes
-
Dameshek W. Some speculations on the myeloproliferative syndromes. Blood. 1951 6 : 372 75.
-
(1951)
Blood.
, vol.6
, pp. 372-375
-
-
Dameshek, W.1
-
3
-
-
38349060667
-
The history of myeloproliferative disorders: Before and after Dameshek
-
Tefferi A. The history of myeloproliferative disorders: before and after Dameshek. Leukemia. 2008 22 : 3 13.
-
(2008)
Leukemia.
, vol.22
, pp. 3-13
-
-
Tefferi, A.1
-
4
-
-
38349101871
-
Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms
-
Tefferi A, Vardiman JW. Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia. 2008 22 : 14 22.
-
(2008)
Leukemia.
, vol.22
, pp. 14-22
-
-
Tefferi, A.1
Vardiman, J.W.2
-
5
-
-
72849159485
-
Chromosome studies on normal and leukemic human leukocytes
-
Nowell PC, Hungerford DA. Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst. 1960 25 : 85 109.
-
(1960)
J Natl Cancer Inst.
, vol.25
, pp. 85-109
-
-
Nowell, P.C.1
Hungerford, D.A.2
-
6
-
-
0000286732
-
A minute chromosome in human granulocytic leukemia
-
Nowell PC, Hungerford DA. A minute chromosome in human granulocytic leukemia. Science. 1960 132 : 1497.
-
(1960)
Science.
, vol.132
, pp. 1497
-
-
Nowell, P.C.1
Hungerford, D.A.2
-
7
-
-
0025187837
-
Induction of a chronic myel-ogenous leukemia-like syndrome in mice with v-abl and BCR/ABL
-
Kelliher MA, McLaughlin J, Witte ON, Rosenberg N. Induction of a chronic myel-ogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc Natl Acad Sci USA. 1990 87 : 6649 53.
-
(1990)
Proc Natl Acad Sci USA.
, vol.87
, pp. 6649-6653
-
-
Kelliher, M.A.1
McLaughlin, J.2
Witte, O.N.3
Rosenberg, N.4
-
8
-
-
0025117392
-
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
-
Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science. 1990 247 : 824 30.
-
(1990)
Science.
, vol.247
, pp. 824-830
-
-
Daley, G.Q.1
Van Etten, R.A.2
Baltimore, D.3
-
9
-
-
0025271543
-
Bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice
-
Elefanty AG, Hariharan IK, Cory S. bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. EMBO J. 1990 9 : 1069 78.
-
(1990)
EMBO J.
, vol.9
, pp. 1069-1078
-
-
Elefanty, A.G.1
Hariharan, I.K.2
Cory, S.3
-
10
-
-
0027359443
-
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
-
Furitsu T, Tsujimura T, Tono T, Ikeda H, Kitayama H, Koshimizu U, Sugahara H, Butterfield JH, Ashman LK, Kanayama Y. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest. 1993 92 : 1736 44.
-
(1993)
J Clin Invest.
, vol.92
, pp. 1736-1744
-
-
Furitsu, T.1
Tsujimura, T.2
Tono, T.3
Ikeda, H.4
Kitayama, H.5
Koshimizu, U.6
Sugahara, H.7
Butterfield, J.H.8
Ashman, L.K.9
Kanayama, Y.10
-
11
-
-
0028224348
-
Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5; 12) chromosomal translocation
-
Golub TR, Barker GF, Lovett M, Gilliland DG. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5; 12) chromosomal translocation. Cell. 1994 77 : 307 16.
-
(1994)
Cell.
, vol.77
, pp. 307-316
-
-
Golub, T.R.1
Barker, G.F.2
Lovett, M.3
Gilliland, D.G.4
-
12
-
-
0344987881
-
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
-
Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, Cortes J, Kutok J, Clark J, Galinsky I, Griffin JD, Cross NC, Tefferi A, Malone J, Alam R, Schrier SL, Schmid J, Rose M, Vandenberghe P, Verhoef G, Boogaerts M, Wlodarska I, Kantarjian H, Marynen P, Coutre SE, Stone R, Gilliland DG. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 2003 348 : 1201 14.
-
(2003)
N Engl J Med.
, vol.348
, pp. 1201-1214
-
-
Cools, J.1
Deangelo, D.J.2
Gotlib, J.3
Stover, E.H.4
Legare, R.D.5
Cortes, J.6
Kutok, J.7
Clark, J.8
Galinsky, I.9
Griffin, J.D.10
Cross, N.C.11
Tefferi, A.12
Malone, J.13
Alam, R.14
Schrier, S.L.15
Schmid, J.16
Rose, M.17
Vandenberghe, P.18
Verhoef, G.19
Boogaerts, M.20
Wlodarska, I.21
Kantarjian, H.22
Marynen, P.23
Coutre, S.E.24
Stone, R.25
Gilliland, D.G.26
more..
-
13
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, D'Andrea A, Frohling S, Dohner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A, Griffin JD, Eck MJ, Sellers WR, Meyerson M, Golub TR, Lee SJ, Gilliland DG. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005 7 : 387 97.
-
(2005)
Cancer Cell.
, vol.7
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
Ebert, B.L.4
Wernig, G.5
Huntly, B.J.6
Boggon, T.J.7
Wlodarska, I.8
Clark, J.J.9
Moore, S.10
Adelsperger, J.11
Koo, S.12
Lee, J.C.13
Gabriel, S.14
Mercher, T.15
D'Andrea, A.16
Frohling, S.17
Dohner, K.18
Marynen, P.19
Vandenberghe, P.20
Mesa, R.A.21
Tefferi, A.22
Griffin, J.D.23
Eck, M.J.24
Sellers, W.R.25
Meyerson, M.26
Golub, T.R.27
Lee, S.J.28
Gilliland, D.G.29
more..
-
14
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C, Garcon L, Raslova H, Berger R, Bennaceur-Griscelli A, Villeval JL, Constantinescu SN, Casadevall N, Vainchenker W. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005 434 : 1144 8.
-
(2005)
Nature.
, vol.434
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
Staerk, J.4
Delhommeau, F.5
Lacout, C.6
Garcon, L.7
Raslova, H.8
Berger, R.9
Bennaceur-Griscelli, A.10
Villeval, J.L.11
Constantinescu, S.N.12
Casadevall, N.13
Vainchenker, W.14
-
15
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005 352 : 1779 90.
-
(2005)
N Engl J Med.
, vol.352
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.S.4
Tiedt, R.5
Passweg, J.R.6
Tichelli, A.7
Cazzola, M.8
Skoda, R.C.9
-
16
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, Vassiliou GS, Bench AJ, Boyd EM, Curtin N, Scott MA, Erber WN, Green AR. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005 365 : 1054 61.
-
(2005)
Lancet.
, vol.365
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
East, C.4
Fourouclas, N.5
Swanton, S.6
Vassiliou, G.S.7
Bench, A.J.8
Boyd, E.M.9
Curtin, N.10
Scott, M.A.11
Erber, W.N.12
Green, A.R.13
-
17
-
-
33746437130
-
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
-
Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, Cuker A, Wernig G, Moore S, Galinsky I, Deangelo DJ, Clark JJ, Lee SJ, Golub TR, Wadleigh M, Gilliland DG, Levine RL. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006 3 : e270.
-
(2006)
PLoS Med.
, vol.3
-
-
Pikman, Y.1
Lee, B.H.2
Mercher, T.3
McDowell, E.4
Ebert, B.L.5
Gozo, M.6
Cuker, A.7
Wernig, G.8
Moore, S.9
Galinsky, I.10
Deangelo, D.J.11
Clark, J.J.12
Lee, S.J.13
Golub, T.R.14
Wadleigh, M.15
Gilliland, D.G.16
Levine, R.L.17
-
18
-
-
33846660947
-
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
-
Scott LM, Tong W, Levine RL, Scott MA, Beer PA, Stratton MR, Futreal PA, Erber WN, McMullin MF, Harrison CN, Warren AJ, Gilliland DG, Lodish HF, Green AR. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med. 2007 356 : 459 68.
-
(2007)
N Engl J Med.
, vol.356
, pp. 459-468
-
-
Scott, L.M.1
Tong, W.2
Levine, R.L.3
Scott, M.A.4
Beer, P.A.5
Stratton, M.R.6
Futreal, P.A.7
Erber, W.N.8
McMullin, M.F.9
Harrison, C.N.10
Warren, A.J.11
Gilliland, D.G.12
Lodish, H.F.13
Green, A.R.14
-
19
-
-
33750534561
-
MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
-
Pardanani AD, Levine RL, Lasho T, Pikman Y, Mesa RA, Wadleigh M, Steensma DP, Elliott MA, Wolanskyj AP, Hogan WJ, McClure RF, Litzow MR, Gilliland DG, Tefferi A. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood. 2006 108 : 3472 6.
-
(2006)
Blood.
, vol.108
, pp. 3472-3476
-
-
Pardanani, A.D.1
Levine, R.L.2
Lasho, T.3
Pikman, Y.4
Mesa, R.A.5
Wadleigh, M.6
Steensma, D.P.7
Elliott, M.A.8
Wolanskyj, A.P.9
Hogan, W.J.10
McClure, R.F.11
Litzow, M.R.12
Gilliland, D.G.13
Tefferi, A.14
-
20
-
-
34548128326
-
Prevalence and clinicopatho-logic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera
-
Pardanani A, Lasho TL, Finke C, Hanson CA, Tefferi A. Prevalence and clinicopatho-logic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera. Leukemia. 2007 21 : 1960 3.
-
(2007)
Leukemia.
, vol.21
, pp. 1960-1963
-
-
Pardanani, A.1
Lasho, T.L.2
Finke, C.3
Hanson, C.A.4
Tefferi, A.5
-
21
-
-
38949160429
-
Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders
-
Pietra D, Li S, Brisci A, Passamonti F, Rumi E, Theocharides A, Ferrari M, Gisslinger H, Kralovics R, Cremonesi L, Skoda R, Cazzola M. Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders. Blood. 2008 111 : 1686 9.
-
(2008)
Blood.
, vol.111
, pp. 1686-1689
-
-
Pietra, D.1
Li, S.2
Brisci, A.3
Passamonti, F.4
Rumi, E.5
Theocharides, A.6
Ferrari, M.7
Gisslinger, H.8
Kralovics, R.9
Cremonesi, L.10
Skoda, R.11
Cazzola, M.12
-
22
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, Zimmermann J, Lydon NB. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996 2 : 561 6.
-
(1996)
Nat Med.
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
Zimmermann, J.7
Lydon, N.B.8
-
23
-
-
0037103624
-
Response to imatinib mesy-late in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
-
Apperley JF, Gardembas M, Melo JV, Russell-Jones R, Bain BJ, Baxter EJ, Chase A, Chessells JM, Colombat M, Dearden CE, Dimitrijevic S, Mahon FX, Marin D, Nikolova Z, Olavarria E, Silberman S, Schultheis B, Cross NC, Goldman JM. Response to imatinib mesy-late in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N Engl J Med. 2002 347 : 481 7.
-
(2002)
N Engl J Med.
, vol.347
, pp. 481-487
-
-
Apperley, J.F.1
Gardembas, M.2
Melo, J.V.3
Russell-Jones, R.4
Bain, B.J.5
Baxter, E.J.6
Chase, A.7
Chessells, J.M.8
Colombat, M.9
Dearden, C.E.10
Dimitrijevic, S.11
Mahon, F.X.12
Marin, D.13
Nikolova, Z.14
Olavarria, E.15
Silberman, S.16
Schultheis, B.17
Cross, N.C.18
Goldman, J.M.19
-
25
-
-
0015694748
-
Letter: A new consistent chromosomal abnormality in chronic myeloge-nous leukaemia identified by quinacrine fluorescence and Giemsa staining
-
Rowley JD. Letter: a new consistent chromosomal abnormality in chronic myeloge-nous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973 243 : 290 3.
-
(1973)
Nature.
, vol.243
, pp. 290-293
-
-
Rowley, J.D.1
-
26
-
-
0019966986
-
Chromosomal localization of human cellular homologues of two viral oncogenes
-
Heisterkamp N, Groffen J, Stephenson JR, Spurr NK, Goodfellow PN, Solomon E, Carritt B, Bodmer WF. Chromosomal localization of human cellular homologues of two viral oncogenes. Nature. 1982 299 : 747 9.
-
(1982)
Nature.
, vol.299
, pp. 747-749
-
-
Heisterkamp, N.1
Groffen, J.2
Stephenson, J.R.3
Spurr, N.K.4
Goodfellow, P.N.5
Solomon, E.6
Carritt, B.7
Bodmer, W.F.8
-
27
-
-
0020333906
-
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
-
de Klein A, van Kessel AG, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D, Spurr NK, Heisterkamp N, Groffen J, Stephenson JR. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982 300 : 765 7.
-
(1982)
Nature.
, vol.300
, pp. 765-767
-
-
De Klein, A.1
Van Kessel, A.G.2
Grosveld, G.3
Bartram, C.R.4
Hagemeijer, A.5
Bootsma, D.6
Spurr, N.K.7
Heisterkamp, N.8
Groffen, J.9
Stephenson, J.R.10
-
28
-
-
0021346853
-
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
-
Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell. 1984 36 : 93 9.
-
(1984)
Cell.
, vol.36
, pp. 93-99
-
-
Groffen, J.1
Stephenson, J.R.2
Heisterkamp, N.3
De Klein, A.4
Bartram, C.R.5
Grosveld, G.6
-
29
-
-
0021811764
-
Structural organization of the bcr gene and its role in the Ph' translocation
-
Heisterkamp N, Stam K, Groffen J, de Klein A, Grosveld G. Structural organization of the bcr gene and its role in the Ph' translocation. Nature. 1985 315 : 758 61.
-
(1985)
Nature.
, vol.315
, pp. 758-761
-
-
Heisterkamp, N.1
Stam, K.2
Groffen, J.3
De Klein, A.4
Grosveld, G.5
-
30
-
-
0024437543
-
Lineage-specific requirement of c-abl function in normal hematopoiesis
-
Caracciolo D, Valtieri M, Venturelli D, Peschle C, Gewirtz AM, Calabretta B. Lineage-specific requirement of c-abl function in normal hematopoiesis. Science. 1989 245 : 1107 10.
-
(1989)
Science.
, vol.245
, pp. 1107-1110
-
-
Caracciolo, D.1
Valtieri, M.2
Venturelli, D.3
Peschle, C.4
Gewirtz, A.M.5
Calabretta, B.6
-
32
-
-
25144502829
-
Enabling death by the Abl tyrosine kinase: Mechanisms for nuclear shuttling of c-Abl in response to DNA damage
-
Yoshida K, Miki Y. Enabling death by the Abl tyrosine kinase: mechanisms for nuclear shuttling of c-Abl in response to DNA damage. Cell Cycle. 2005 4 : 777 9.
-
(2005)
Cell Cycle.
, vol.4
, pp. 777-779
-
-
Yoshida, K.1
Miki, Y.2
-
33
-
-
14744306701
-
Stress and death: Breaking up the c-Abl/14-3-3 complex in apop-tosis
-
Pendergast AM. Stress and death: breaking up the c-Abl/14-3-3 complex in apop-tosis. Nat Cell Biol. 2005 7 : 213 4.
-
(2005)
Nat Cell Biol.
, vol.7
, pp. 213-214
-
-
Pendergast, A.M.1
-
34
-
-
16844379909
-
Insights into selective activation of p53 DNA binding by c-Abl
-
Wei G, Li AG, Liu X. Insights into selective activation of p53 DNA binding by c-Abl. J Biol Chem. 2005 280 : 12271 8.
-
(2005)
J Biol Chem.
, vol.280
, pp. 12271-12278
-
-
Wei, G.1
Li, A.G.2
Liu, X.3
-
35
-
-
1342300625
-
Mechanisms of transformation by the BCR-ABL oncogene: New perspectives in the post-imatinib era
-
Van Etten RA. Mechanisms of transformation by the BCR-ABL oncogene: new perspectives in the post-imatinib era. Leuk Res. 2004 28 : S21 8.
-
(2004)
Leuk Res.
, vol.28
-
-
Van Etten, R.A.1
-
36
-
-
0023273390
-
The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia
-
Bernards A, Rubin CM, Westbrook CA, Paskind M, Baltimore D. The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia. Mol Cell Biol. 1987 7 : 3231 6.
-
(1987)
Mol Cell Biol.
, vol.7
, pp. 3231-3236
-
-
Bernards, A.1
Rubin, C.M.2
Westbrook, C.A.3
Paskind, M.4
Baltimore, D.5
-
38
-
-
0026495870
-
Minor BCR (m-bcr) rearrangements may appear in major BCR (M-bcr)-positive CML cases
-
Karlic H, Grill R, Schlogl E. Minor BCR (m-bcr) rearrangements may appear in major BCR (M-bcr)-positive CML cases. Hematol Pathol. 1992 6 : 203 7.
-
(1992)
Hematol Pathol.
, vol.6
, pp. 203-207
-
-
Karlic, H.1
Grill, R.2
Schlogl, E.3
-
39
-
-
0028804957
-
Minor breakpoint cluster region (m-BCR) positive chronic myeloid leukaemia with an acute lymphoblastic leukaemia onset: A case report
-
Costello RT, Gabert J, Brunel V, Sainty D, Arnoulet C, Mozziconacci MJ, Camerlo J, Perret C, Gastaut JA, Bouabdallah R. Minor breakpoint cluster region (m-BCR) positive chronic myeloid leukaemia with an acute lymphoblastic leukaemia onset: a case report. Br J Haematol. 1995 91 : 428 30.
-
(1995)
Br J Haematol.
, vol.91
, pp. 428-430
-
-
Costello, R.T.1
Gabert, J.2
Brunel, V.3
Sainty, D.4
Arnoulet, C.5
Mozziconacci, M.J.6
Camerlo, J.7
Perret, C.8
Gastaut, J.A.9
Bouabdallah, R.10
-
40
-
-
0025221936
-
New type of Bcr/Abl junction in Philadelphia chromosome-positive chronic myelogenous leukemia
-
Saglio G, Guerrasio A, Rosso C, Zaccaria A, Tassinari A, Serra A, Rege-Cambrin G, Mazza U, Gavosto F. New type of Bcr/Abl junction in Philadelphia chromosome-positive chronic myelogenous leukemia. Blood. 1990 76 : 1819 24.
-
(1990)
Blood.
, vol.76
, pp. 1819-1824
-
-
Saglio, G.1
Guerrasio, A.2
Rosso, C.3
Zaccaria, A.4
Tassinari, A.5
Serra, A.6
Rege-Cambrin, G.7
Mazza, U.8
Gavosto, F.9
-
41
-
-
0025614040
-
The location of the Philadelphia chromosomal breakpoint site and prognosis in chronic granulocytic leukemia
-
Tefferi A, Bren GD, Wagner KV, Schaid DJ, Ash RC, Thibodeau SN. The location of the Philadelphia chromosomal breakpoint site and prognosis in chronic granulocytic leukemia. Leukemia. 1990 4 : 839 42.
-
(1990)
Leukemia.
, vol.4
, pp. 839-842
-
-
Tefferi, A.1
Bren, G.D.2
Wagner, K.V.3
Schaid, D.J.4
Ash, R.C.5
Thibodeau, S.N.6
-
42
-
-
0022352068
-
Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome
-
Stam K, Heisterkamp N, Grosveld G, de Klein A, Verma RS, Coleman M, Dosik H, Groffen J. Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome. N Engl J Med. 1985 313 : 1429 33.
-
(1985)
N Engl J Med.
, vol.313
, pp. 1429-1433
-
-
Stam, K.1
Heisterkamp, N.2
Grosveld, G.3
De Klein, A.4
Verma, R.S.5
Coleman, M.6
Dosik, H.7
Groffen, J.8
-
43
-
-
0022544401
-
The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene
-
Ben-Neriah Y, Daley GQ, Mes-Masson AM, Witte ON, Baltimore D. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science. 1986 233 : 212 4.
-
(1986)
Science.
, vol.233
, pp. 212-214
-
-
Ben-Neriah, Y.1
Daley, G.Q.2
Mes-Masson, A.M.3
Witte, O.N.4
Baltimore, D.5
-
44
-
-
0022182626
-
Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products
-
Konopka JB, Witte ON. Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products. Mol Cell Biol. 1985 5 : 3116 23.
-
(1985)
Mol Cell Biol.
, vol.5
, pp. 3116-3123
-
-
Konopka, J.B.1
Witte, O.N.2
-
45
-
-
0025348013
-
Tyrosine kinase activity and transformation potency of bcr-abl onco-gene products
-
Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl onco-gene products. Science. 1990 247 : 1079 82.
-
(1990)
Science.
, vol.247
, pp. 1079-1082
-
-
Lugo, T.G.1
Pendergast, A.M.2
Muller, A.J.3
Witte, O.N.4
-
46
-
-
0025766195
-
BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner
-
Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON. BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell. 1991 66 : 161 71.
-
(1991)
Cell.
, vol.66
, pp. 161-171
-
-
Pendergast, A.M.1
Muller, A.J.2
Havlik, M.H.3
Maru, Y.4
Witte, O.N.5
-
47
-
-
0029669975
-
The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway
-
Sattler M, Salgia R, Okuda K, Uemura N, Durstin MA, Pisick E, Xu G, Li JL, Prasad KV, Griffin JD. The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway. Oncogene. 1996 12 : 839 46.
-
(1996)
Oncogene.
, vol.12
, pp. 839-846
-
-
Sattler, M.1
Salgia, R.2
Okuda, K.3
Uemura, N.4
Durstin, M.A.5
Pisick, E.6
Xu, G.7
Li, J.L.8
Prasad, K.V.9
Griffin, J.D.10
-
48
-
-
14644425319
-
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
-
Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 2005 5 : 172 83.
-
(2005)
Nat Rev Cancer.
, vol.5
, pp. 172-183
-
-
Ren, R.1
-
49
-
-
1242307380
-
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
-
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia. 2004 18 : 189 218.
-
(2004)
Leukemia.
, vol.18
, pp. 189-218
-
-
Steelman, L.S.1
Pohnert, S.C.2
Shelton, J.G.3
Franklin, R.A.4
Bertrand, F.E.5
McCubrey, J.A.6
-
50
-
-
0030031766
-
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-pheny-laminopyrimidine derivative
-
Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Druker BJ, Lydon NB. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-pheny-laminopyrimidine derivative. Cancer Res. 1996 56 : 100 4.
-
(1996)
Cancer Res.
, vol.56
, pp. 100-104
-
-
Buchdunger, E.1
Zimmermann, J.2
Mett, H.3
Meyer, T.4
Muller, M.5
Druker, B.J.6
Lydon, N.B.7
-
51
-
-
0028968622
-
Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2- phenylaminopyrimidine class
-
Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Regenass U, Lydon NB. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2- phenylaminopyrimidine class. Proc Natl Acad Sci USA. 1995 92 : 2558 62.
-
(1995)
Proc Natl Acad Sci USA.
, vol.92
, pp. 2558-2562
-
-
Buchdunger, E.1
Zimmermann, J.2
Mett, H.3
Meyer, T.4
Muller, M.5
Regenass, U.6
Lydon, N.B.7
-
53
-
-
0034254249
-
Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
-
Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood. 2000 96 : 925 32.
-
(2000)
Blood.
, vol.96
, pp. 925-932
-
-
Heinrich, M.C.1
Griffith, D.J.2
Druker, B.J.3
Wait, C.L.4
Ott, K.A.5
Zigler, A.J.6
-
54
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
-
Schindler T, Bornmann W, Pellicena P, Miller WT, Clarkson B, Kuriyan J. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science. 2000 289 : 1938 42.
-
(2000)
Science.
, vol.289
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
55
-
-
0035810147
-
Efficacy, safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL. Efficacy, safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001 344 : 1031 7.
-
(2001)
N Engl J Med.
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
56
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, Talpaz M. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001 344 : 1038 42.
-
(2001)
N Engl J Med.
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
Resta, D.J.4
Reese, S.F.5
Ford, J.M.6
Capdeville, R.7
Talpaz, M.8
-
57
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian H, Sawyers C, Hochhaus A, Guilhot F, Schiffer C, Gambacorti-Passerini C, Niederwieser D, Resta D, Capdeville R, Zoellner U, Talpaz M, Druker B, Goldman J, O'Brien SG, Russell N, Fischer T, Ottmann O, Cony-Makhoul P, Facon T, Stone R, Miller C, Tallman M, Brown R, Schuster M, Loughran T, Gratwohl A, Mandelli F, Saglio G, Lazzarino M, Russo D, Baccarani M, Morra E. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med. 2002 346 : 645 52.
-
(2002)
N Engl J Med.
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
Guilhot, F.4
Schiffer, C.5
Gambacorti-Passerini, C.6
Niederwieser, D.7
Resta, D.8
Capdeville, R.9
Zoellner, U.10
Talpaz, M.11
Druker, B.12
Goldman, J.13
O'Brien, S.G.14
Russell, N.15
Fischer, T.16
Ottmann, O.17
Cony-Makhoul, P.18
Facon, T.19
Stone, R.20
Miller, C.21
Tallman, M.22
Brown, R.23
Schuster, M.24
Loughran, T.25
Gratwohl, A.26
Mandelli, F.27
Saglio, G.28
Lazzarino, M.29
Russo, D.30
Baccarani, M.31
Morra, E.32
more..
-
58
-
-
0037085785
-
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
-
Talpaz M, Silver RT, Druker BJ, Goldman JM, Gambacorti-Passerini C, Guilhot F, Schiffer CA, Fischer T, Deininger MW, Lennard AL, Hochhaus A, Ottmann OG, Gratwohl A, Baccarani M, Stone R, Tura S, Mahon FX, Fernandes-Reese S, Gathmann I, Capdeville R, Kantarjian HM, Sawyers CL. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood. 2002 99 : 1928 37.
-
(2002)
Blood.
, vol.99
, pp. 1928-1937
-
-
Talpaz, M.1
Silver, R.T.2
Druker, B.J.3
Goldman, J.M.4
Gambacorti-Passerini, C.5
Guilhot, F.6
Schiffer, C.A.7
Fischer, T.8
Deininger, M.W.9
Lennard, A.L.10
Hochhaus, A.11
Ottmann, O.G.12
Gratwohl, A.13
Baccarani, M.14
Stone, R.15
Tura, S.16
Mahon, F.X.17
Fernandes-Reese, S.18
Gathmann, I.19
Capdeville, R.20
Kantarjian, H.M.21
Sawyers, C.L.22
more..
-
59
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
-
Sawyers CL, Hochhaus A, Feldman E, Goldman JM, Miller CB, Ottmann OG, Schiffer CA, Talpaz M, Guilhot F, Deininger MW, Fischer T, O'Brien SG, Stone RM, Gambacorti-Passerini CB, Russell NH, Reiffers JJ, Shea TC, Chapuis B, Coutre S, Tura S, Morra E, Larson RA, Saven A, Peschel C, Gratwohl A, Mandelli F, Ben-Am M, Gathmann I, Capdeville R, Paquette RL, Druker BJ. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood. 2002 99 : 3530 9.
-
(2002)
Blood.
, vol.99
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
Goldman, J.M.4
Miller, C.B.5
Ottmann, O.G.6
Schiffer, C.A.7
Talpaz, M.8
Guilhot, F.9
Deininger, M.W.10
Fischer, T.11
O'Brien, S.G.12
Stone, R.M.13
Gambacorti-Passerini, C.B.14
Russell, N.H.15
Reiffers, J.J.16
Shea, T.C.17
Chapuis, B.18
Coutre, S.19
Tura, S.20
Morra, E.21
Larson, R.A.22
Saven, A.23
Peschel, C.24
Gratwohl, A.25
Mandelli, F.26
Ben-Am, M.27
Gathmann, I.28
Capdeville, R.29
Paquette, R.L.30
Druker, B.J.31
more..
-
60
-
-
0037092980
-
Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase
-
Kantarjian HM, Cortes J, O'Brien S, Giles FJ, Albitar M, Rios MB, Shan J, Faderl S, Garcia-Manero G, Thomas DA, Resta D, Talpaz M. Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase. Blood. 2002 99 : 3547 53.
-
(2002)
Blood.
, vol.99
, pp. 3547-3553
-
-
Kantarjian, H.M.1
Cortes, J.2
O'Brien, S.3
Giles, F.J.4
Albitar, M.5
Rios, M.B.6
Shan, J.7
Faderl, S.8
Garcia-Manero, G.9
Thomas, D.A.10
Resta, D.11
Talpaz, M.12
-
61
-
-
0035992318
-
Treatment of philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate
-
Kantarjian HM, O'Brien S, Cortes JE, Smith TL, Rios MB, Shan J, Yang Y, Giles FJ, Thomas DA, Faderl S, Garcia-Manero G, Jeha S, Wierda W, Issa JP, Kornblau SM, Keating M, Resta D, Capdeville R, Talpaz M. Treatment of philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate. Clin Cancer Res. 2002 8 : 2167 76.
-
(2002)
Clin Cancer Res.
, vol.8
, pp. 2167-2176
-
-
Kantarjian, H.M.1
O'Brien, S.2
Cortes, J.E.3
Smith, T.L.4
Rios, M.B.5
Shan, J.6
Yang, Y.7
Giles, F.J.8
Thomas, D.A.9
Faderl, S.10
Garcia-Manero, G.11
Jeha, S.12
Wierda, W.13
Issa, J.P.14
Kornblau, S.M.15
Keating, M.16
Resta, D.17
Capdeville, R.18
Talpaz, M.19
-
62
-
-
0037105560
-
A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias
-
Ottmann OG, Druker BJ, Sawyers CL, Goldman JM, Reiffers J, Silver RT, Tura S, Fischer T, Deininger MW, Schiffer CA, Baccarani M, Gratwohl A, Hochhaus A, Hoelzer D, Fernandes-Reese S, Gathmann I, Capdeville R, O'Brien SG. A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood. 2002 100 : 1965 71.
-
(2002)
Blood.
, vol.100
, pp. 1965-1971
-
-
Ottmann, O.G.1
Druker, B.J.2
Sawyers, C.L.3
Goldman, J.M.4
Reiffers, J.5
Silver, R.T.6
Tura, S.7
Fischer, T.8
Deininger, M.W.9
Schiffer, C.A.10
Baccarani, M.11
Gratwohl, A.12
Hochhaus, A.13
Hoelzer, D.14
Fernandes-Reese, S.15
Gathmann, I.16
Capdeville, R.17
O'Brien, S.G.18
-
63
-
-
0035960428
-
Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase i study
-
van Oosterom AT, Judson I, Verweij J, Stroobants S, Donato di Paola E, Dimitrijevic S, Martens M, Webb A, Sciot R, Van Glabbeke M, Silberman S, Nielsen OS. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet. 2001 358 : 1421 3.
-
(2001)
Lancet.
, vol.358
, pp. 1421-1423
-
-
Van Oosterom, A.T.1
Judson, I.2
Verweij, J.3
Stroobants, S.4
Donato Di Paola, E.5
Dimitrijevic, S.6
Martens, M.7
Webb, A.8
Sciot, R.9
Van Glabbeke, M.10
Silberman, S.11
Nielsen, O.S.12
-
64
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stro-mal tumors
-
Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stro-mal tumors. N Engl J Med. 2002 347 : 472 80.
-
(2002)
N Engl J Med.
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
Von Mehren, M.2
Blanke, C.D.3
Van Den Abbeele, A.D.4
Eisenberg, B.5
Roberts, P.J.6
Heinrich, M.C.7
Tuveson, D.A.8
Singer, S.9
Janicek, M.10
Fletcher, J.A.11
Silverman, S.G.12
Silberman, S.L.13
Capdeville, R.14
Kiese, B.15
Peng, B.16
Dimitrijevic, S.17
Druker, B.J.18
Corless, C.19
Fletcher, C.D.20
Joensuu, H.21
more..
-
65
-
-
0037018763
-
Treatment of hypereosinophilic syndrome with imatinib mesilate
-
Gleich GJ, Leiferman KM, Pardanani A, Tefferi A, Butterfield JH. Treatment of hypereosinophilic syndrome with imatinib mesilate. Lancet. 2002 359 : 1577 8.
-
(2002)
Lancet.
, vol.359
, pp. 1577-1578
-
-
Gleich, G.J.1
Leiferman, K.M.2
Pardanani, A.3
Tefferi, A.4
Butterfield, J.H.5
-
66
-
-
0038386031
-
Imatinib therapy for hypere-osinophilic syndrome and other eosinophilic disorders
-
Pardanani A, Reeder T, Porrata LF, Li CY, Tazelaar HD, Baxter EJ, Witzig TE, Cross NC, Tefferi A. Imatinib therapy for hypere-osinophilic syndrome and other eosinophilic disorders. Blood. 2003 101 : 3391 7.
-
(2003)
Blood.
, vol.101
, pp. 3391-3397
-
-
Pardanani, A.1
Reeder, T.2
Porrata, L.F.3
Li, C.Y.4
Tazelaar, H.D.5
Baxter, E.J.6
Witzig, T.E.7
Cross, N.C.8
Tefferi, A.9
-
67
-
-
0041656424
-
Imatinib for systemic mast-cell disease
-
Pardanani A, Elliott M, Reeder T, Li C-Y, Baxter EJ, Cross NCP, Tefferi A. Imatinib for systemic mast-cell disease. Lancet. 2003 362 : 535 6.
-
(2003)
Lancet.
, vol.362
, pp. 535-536
-
-
Pardanani, A.1
Elliott, M.2
Reeder, T.3
Li, C.-Y.4
Baxter, E.J.5
Cross, N.C.P.6
Tefferi, A.7
-
68
-
-
10744228486
-
CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mas-tocytosis associated with eosinophilia and predicts response to imatinib therapy
-
Pardanani A, Ketterling RP, Brockman SR, Flynn HC, Paternoster SF, Shearer BM, Reeder TL, Li CY, Cross NCP, Cools J, Gilliland DG, Dewald GW, Tefferi A. CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mas-tocytosis associated with eosinophilia and predicts response to imatinib therapy. Blood. 2003 102 : 3093 6.
-
(2003)
Blood.
, vol.102
, pp. 3093-3096
-
-
Pardanani, A.1
Ketterling, R.P.2
Brockman, S.R.3
Flynn, H.C.4
Paternoster, S.F.5
Shearer, B.M.6
Reeder, T.L.7
Li, C.Y.8
Cross, N.C.P.9
Cools, J.10
Gilliland, D.G.11
Dewald, G.W.12
Tefferi, A.13
-
69
-
-
8644263305
-
FIP1L1-PDGFRA fusion: Prevalence and clinico-pathologic correlates in 89 consecutive patients with moderate to severe eosinophilia
-
Pardanani A, Brockman SR, Paternoster SF, Flynn HC, Ketterling RP, Lasho TL, Ho CL, Li CY, Dewald GW, Tefferi A. FIP1L1-PDGFRA fusion: prevalence and clinico-pathologic correlates in 89 consecutive patients with moderate to severe eosinophilia. Blood. 2004 104 : 3038 45.
-
(2004)
Blood.
, vol.104
, pp. 3038-3045
-
-
Pardanani, A.1
Brockman, S.R.2
Paternoster, S.F.3
Flynn, H.C.4
Ketterling, R.P.5
Lasho, T.L.6
Ho, C.L.7
Li, C.Y.8
Dewald, G.W.9
Tefferi, A.10
-
70
-
-
33747154547
-
Evolving concepts in the management of chronic myeloid leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
-
Baccarani M, Saglio G, Goldman J, Hochhaus A, Simonsson B, Appelbaum F, Apperley J, Cervantes F, Cortes J, Deininger M, Gratwohl A, Guilhot F, Horowitz M, Hughes T, Kantarjian H, Larson R, Niederwieser D, Silver R, Hehlmann R. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood. 2006 108 : 1809 20.
-
(2006)
Blood.
, vol.108
, pp. 1809-1820
-
-
Baccarani, M.1
Saglio, G.2
Goldman, J.3
Hochhaus, A.4
Simonsson, B.5
Appelbaum, F.6
Apperley, J.7
Cervantes, F.8
Cortes, J.9
Deininger, M.10
Gratwohl, A.11
Guilhot, F.12
Horowitz, M.13
Hughes, T.14
Kantarjian, H.15
Larson, R.16
Niederwieser, D.17
Silver, R.18
Hehlmann, R.19
-
71
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
Druker BJ, Guilhot F, O'Brien SG, Gathmann I, Kantarjian H, Gattermann N, Deininger MW, Silver RT, Goldman JM, Stone RM, Cervantes F, Hochhaus A, Powell BL, Gabrilove JL, Rousselot P, Reiffers J, Cornelissen JJ, Hughes T, Agis H, Fischer T, Verhoef G, Shepherd J, Saglio G, Gratwohl A, Nielsen JL, Radich JP, Simonsson B, Taylor K, Baccarani M, So C, Letvak L, Larson RA. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006 355 : 2408 17.
-
(2006)
N Engl J Med.
, vol.355
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
Gathmann, I.4
Kantarjian, H.5
Gattermann, N.6
Deininger, M.W.7
Silver, R.T.8
Goldman, J.M.9
Stone, R.M.10
Cervantes, F.11
Hochhaus, A.12
Powell, B.L.13
Gabrilove, J.L.14
Rousselot, P.15
Reiffers, J.16
Cornelissen, J.J.17
Hughes, T.18
Agis, H.19
Fischer, T.20
Verhoef, G.21
Shepherd, J.22
Saglio, G.23
Gratwohl, A.24
Nielsen, J.L.25
Radich, J.P.26
Simonsson, B.27
Taylor, K.28
Baccarani, M.29
So, C.30
Letvak, L.31
Larson, R.A.32
more..
-
72
-
-
33646259689
-
Anticipating clinical resistance to target-directed agents: The BCR-ABL paradigm
-
Azam M, Daley GQ. Anticipating clinical resistance to target-directed agents: the BCR-ABL paradigm. Mol Diagn Ther. 2006 10 : 67 76.
-
(2006)
Mol Diagn Ther.
, vol.10
, pp. 67-76
-
-
Azam, M.1
Daley, G.Q.2
-
73
-
-
35448967331
-
Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
-
Apperley JF. Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol. 2007 8 : 1018 29.
-
(2007)
Lancet Oncol.
, vol.8
, pp. 1018-1029
-
-
Apperley, J.F.1
-
74
-
-
34548825795
-
Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia
-
O'Hare T, Eide CA, Deininger MW. Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood. 2007 110 : 2242 9.
-
(2007)
Blood.
, vol.110
, pp. 2242-2249
-
-
O'Hare, T.1
Eide, C.A.2
Deininger, M.W.3
-
75
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science. 2004 305 : 399 401.
-
(2004)
Science.
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
76
-
-
33745164854
-
Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance
-
rd., Bohacek RS, Wang Y, Sundaramoorthi R, Sliz P, Veach DR, Bornmann WG, Clarkson B, Dalgarno DC, Sawyer TK, Daley GQ. Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proc Natl Acad Sci USA. 2006 103 : 9244 9.
-
(2006)
Proc Natl Acad Sci USA.
, vol.103
, pp. 9244-9249
-
-
Azam, M.1
Nardi, V.2
Shakespeare, W.C.3
Metcalf III, C.A.4
Bohacek, R.S.5
Wang, Y.6
Sundaramoorthi, R.7
Sliz, P.8
Veach, D.R.9
Bornmann, W.G.10
Clarkson, B.11
Dalgarno, D.C.12
Sawyer, T.K.13
Daley, G.Q.14
-
77
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
-
Kantarjian H, Giles F, Wunderle L, Bhalla K, O'Brien S, Wassmann B, Tanaka C, Manley P, Rae P, Mietlowski W, Bochinski K, Hochhaus A, Griffin JD, Hoelzer D, Albitar M, Dugan M, Cortes J, Alland L, Ottmann OG. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med. 2006 354 : 2542 51.
-
(2006)
N Engl J Med.
, vol.354
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
Bhalla, K.4
O'Brien, S.5
Wassmann, B.6
Tanaka, C.7
Manley, P.8
Rae, P.9
Mietlowski, W.10
Bochinski, K.11
Hochhaus, A.12
Griffin, J.D.13
Hoelzer, D.14
Albitar, M.15
Dugan, M.16
Cortes, J.17
Alland, L.18
Ottmann, O.G.19
-
78
-
-
33745102555
-
Dasatinib in ima-tinib-resistant Philadelphia chromosome-positive leukemias
-
Talpaz M, Shah NP, Kantarjian H, Donato N, Nicoll J, Paquette R, Cortes J, O'Brien S, Nicaise C, Bleickardt E, Blackwood-Chirchir MA, Iyer V, Chen TT, Huang F, Decillis AP, Sawyers CL. Dasatinib in ima-tinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006 354 : 2531 41.
-
(2006)
N Engl J Med.
, vol.354
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
Donato, N.4
Nicoll, J.5
Paquette, R.6
Cortes, J.7
O'Brien, S.8
Nicaise, C.9
Bleickardt, E.10
Blackwood-Chirchir, M.A.11
Iyer, V.12
Chen, T.T.13
Huang, F.14
Decillis, A.P.15
Sawyers, C.L.16
-
79
-
-
33745081606
-
Circumventing resistance to kinase-inhibitor therapy
-
Druker BJ. Circumventing resistance to kinase-inhibitor therapy. N Engl J Med. 2006 354 : 2594 6.
-
(2006)
N Engl J Med.
, vol.354
, pp. 2594-2596
-
-
Druker, B.J.1
-
80
-
-
23344440655
-
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
-
Carter TA, Wodicka LM, Shah NP, Velasco AM, Fabian MA, Treiber DK, Milanov ZV, Atteridge CE, Biggs WH, 3rd., Edeen PT, Floyd M, Ford JM, Grotzfeld RM, Herrgard S, Insko DE, Mehta SA, Patel HK, Pao W, Sawyers CL, Varmus H, Zarrinkar PP, Lockhart DJ. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci USA. 2005 102 : 11011 6.
-
(2005)
Proc Natl Acad Sci USA.
, vol.102
, pp. 11011-11016
-
-
Carter, T.A.1
Wodicka, L.M.2
Shah, N.P.3
Velasco, A.M.4
Fabian, M.A.5
Treiber, D.K.6
Milanov, Z.V.7
Atteridge, C.E.8
Biggs III, W.H.9
Edeen, P.T.10
Floyd, M.11
Ford, J.M.12
Grotzfeld, R.M.13
Herrgard, S.14
Insko, D.E.15
Mehta, S.A.16
Patel, H.K.17
Pao, W.18
Sawyers, C.L.19
Varmus, H.20
Zarrinkar, P.P.21
Lockhart, D.J.22
more..
-
81
-
-
50649118068
-
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on hedgehog pathway activation
-
Dierks C, Beigi R, Guo GR, Zirlik K, Stegert MR, Manley P, Trussell C, Schmitt-Graeff A, Landwerlin K, Veelken H, Warmuth M. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on hedgehog pathway activation. Cancer Cell. 2008 14 : 238 49.
-
(2008)
Cancer Cell.
, vol.14
, pp. 238-249
-
-
Dierks, C.1
Beigi, R.2
Guo, G.R.3
Zirlik, K.4
Stegert, M.R.5
Manley, P.6
Trussell, C.7
Schmitt-Graeff, A.8
Landwerlin, K.9
Veelken, H.10
Warmuth, M.11
-
82
-
-
47649127591
-
Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders
-
Walz C, Cross NC, Van Etten RA, Reiter A. Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders. Leukemia. 2008 22 : 1320 34.
-
(2008)
Leukemia.
, vol.22
, pp. 1320-1334
-
-
Walz, C.1
Cross, N.C.2
Van Etten, R.A.3
Reiter, A.4
-
84
-
-
0028936278
-
The novel activation of ABL by fusion to an ets-related gene, TEL
-
Papadopoulos P, Ridge SA, Boucher CA, Stocking C, Wiedemann LM. The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer Res. 1995 55 : 34 8.
-
(1995)
Cancer Res.
, vol.55
, pp. 34-38
-
-
Papadopoulos, P.1
Ridge, S.A.2
Boucher, C.A.3
Stocking, C.4
Wiedemann, L.M.5
-
85
-
-
0035150370
-
Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia
-
Van Limbergen H, Beverloo HB, van Drunen E, Janssens A, Hahlen K, Poppe B, Van Roy N, Marynen P, De Paepe A, Slater R, Speleman F. Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia. Genes Chromosomes Cancer. 2001 30 : 274 82.
-
(2001)
Genes Chromosomes Cancer.
, vol.30
, pp. 274-282
-
-
Van Limbergen, H.1
Beverloo, H.B.2
Van Drunen, E.3
Janssens, A.4
Hahlen, K.5
Poppe, B.6
Van Roy, N.7
Marynen, P.8
De Paepe, A.9
Slater, R.10
Speleman, F.11
-
86
-
-
0036436878
-
Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukaemia cell line
-
Griesinger F, Janke A, Podleschny M, Bohlander SK. Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukaemia cell line. Br J Haematol. 2002 119 : 454 8.
-
(2002)
Br J Haematol.
, vol.119
, pp. 454-458
-
-
Griesinger, F.1
Janke, A.2
Podleschny, M.3
Bohlander, S.K.4
-
87
-
-
0029898682
-
Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia
-
Golub TR, Goga A, Barker GF, Afar DE, McLaughlin J, Bohlander SK, Rowley JD, Witte ON, Gilliland DG. Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia. Mol Cell Biol. 1996 16 : 4107 16.
-
(1996)
Mol Cell Biol.
, vol.16
, pp. 4107-4116
-
-
Golub, T.R.1
Goga, A.2
Barker, G.F.3
Afar, D.E.4
McLaughlin, J.5
Bohlander, S.K.6
Rowley, J.D.7
Witte, O.N.8
Gilliland, D.G.9
-
88
-
-
0036566196
-
Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9; 12) translocation
-
O'Brien SG, Vieira SA, Connors S, Bown N, Chang J, Capdeville R, Melo JV. Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9; 12) translocation. Blood. 2002 99 : 3465 7.
-
(2002)
Blood.
, vol.99
, pp. 3465-3467
-
-
O'Brien, S.G.1
Vieira, S.A.2
Connors, S.3
Bown, N.4
Chang, J.5
Capdeville, R.6
Melo, J.V.7
-
89
-
-
0035986747
-
Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia
-
La Starza R, Trubia M, Testoni N, Ottaviani E, Belloni E, Crescenzi B, Martelli M, Flandrin G, Pelicci PG, Mecucci C. Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia. Haematologica. 2002 87 : 789 94.
-
(2002)
Haematologica.
, vol.87
, pp. 789-794
-
-
La Starza, R.1
Trubia, M.2
Testoni, N.3
Ottaviani, E.4
Belloni, E.5
Crescenzi, B.6
Martelli, M.7
Flandrin, G.8
Pelicci, P.G.9
Mecucci, C.10
-
90
-
-
0030780203
-
BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion
-
Andreasson P, Johansson B, Carlsson M, Jarlsfelt I, Fioretos T, Mitelman F, Hoglund M. BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion. Genes Chromosomes Cancer. 1997 20 : 299 304.
-
(1997)
Genes Chromosomes Cancer.
, vol.20
, pp. 299-304
-
-
Andreasson, P.1
Johansson, B.2
Carlsson, M.3
Jarlsfelt, I.4
Fioretos, T.5
Mitelman, F.6
Hoglund, M.7
-
91
-
-
0038683894
-
Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate
-
Barbouti A, Ahlgren T, Johansson B, Hoglund M, Lassen C, Turesson I, Mitelman F, Fioretos T. Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate. Br J Haematol. 2003 122 : 85 93.
-
(2003)
Br J Haematol.
, vol.122
, pp. 85-93
-
-
Barbouti, A.1
Ahlgren, T.2
Johansson, B.3
Hoglund, M.4
Lassen, C.5
Turesson, I.6
Mitelman, F.7
Fioretos, T.8
-
92
-
-
0037110168
-
Chronic myelocytic leukemia with eosinophilia, t(9; 12)(q34; p13), and ETV6-ABL gene rearrangement: Case report and review of the literature
-
Keung YK, Beaty M, Steward W, Jackle B, Pettnati M. Chronic myelocytic leukemia with eosinophilia, t(9; 12)(q34; p13), and ETV6-ABL gene rearrangement: case report and review of the literature. Cancer Genet Cytogenet. 2002 138 : 139 42.
-
(2002)
Cancer Genet Cytogenet.
, vol.138
, pp. 139-142
-
-
Keung, Y.K.1
Beaty, M.2
Steward, W.3
Jackle, B.4
Pettnati, M.5
-
93
-
-
0037097596
-
The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9; 12) translo-cations in human leukemia, induces distinct myeloproliferative disease in mice
-
Million RP, Aster J, Gilliland DG, Van Etten RA. The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9; 12) translo-cations in human leukemia, induces distinct myeloproliferative disease in mice. Blood. 2002 99 : 4568 77.
-
(2002)
Blood.
, vol.99
, pp. 4568-4577
-
-
Million, R.P.1
Aster, J.2
Gilliland, D.G.3
Van Etten, R.A.4
-
94
-
-
52949127317
-
The JAK kinases: Not just another kinase drug discovery target
-
in press.
-
Wilks AF. The JAK kinases: not just another kinase drug discovery target. Semin Cell Dev Biol. 2008 in press.
-
(2008)
Semin Cell Dev Biol.
-
-
Wilks, A.F.1
-
95
-
-
0026081302
-
Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase
-
Wilks AF, Harpur AG, Kurban RR, Ralph SJ, Zurcher G, Ziemiecki A. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol Cell Biol. 1991 11 : 2057 65.
-
(1991)
Mol Cell Biol.
, vol.11
, pp. 2057-2065
-
-
Wilks, A.F.1
Harpur, A.G.2
Kurban, R.R.3
Ralph, S.J.4
Zurcher, G.5
Ziemiecki, A.6
-
96
-
-
0031017533
-
Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways
-
Luo H, Rose P, Barber D, Hanratty WP, Lee S, Roberts TM, D'Andrea AD, Dearolf CR. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol Cell Biol. 1997 17 : 1562 71.
-
(1997)
Mol Cell Biol.
, vol.17
, pp. 1562-1571
-
-
Luo, H.1
Rose, P.2
Barber, D.3
Hanratty, W.P.4
Lee, S.5
Roberts, T.M.6
D'Andrea, A.D.7
Dearolf, C.R.8
-
97
-
-
34547108380
-
JAK-STAT signaling: From interferons to cytokines
-
Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. J Biol Chem. 2007 282 : 20059 63.
-
(2007)
J Biol Chem.
, vol.282
, pp. 20059-20063
-
-
Schindler, C.1
Levy, D.E.2
Decker, T.3
-
98
-
-
52449119447
-
Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers
-
Jeong EG, Kim MS, Nam HK, Min CK, Lee S, Chung YJ, Yoo NJ, Lee SH. Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers. Clin Cancer Res. 2008 14 : 3716 21.
-
(2008)
Clin Cancer Res.
, vol.14
, pp. 3716-3721
-
-
Jeong, E.G.1
Kim, M.S.2
Nam, H.K.3
Min, C.K.4
Lee, S.5
Chung, Y.J.6
Yoo, N.J.7
Lee, S.H.8
-
99
-
-
47149087181
-
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia
-
Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont DH, McLellan MD, Payton JE, Westervelt P, DiPersio JF, Link DC, Walter MJ, Graubert TA, Watson M, Baty J, Heath S, Shannon WD, Nagarajan R, Bloomfield CD, Mardis ER, Wilson RK, Ley TJ. Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood. 2008 111 : 4797 808.
-
(2008)
Blood.
, vol.111
, pp. 4797-4808
-
-
Tomasson, M.H.1
Xiang, Z.2
Walgren, R.3
Zhao, Y.4
Kasai, Y.5
Miner, T.6
Ries, R.E.7
Lubman, O.8
Fremont, D.H.9
McLellan, M.D.10
Payton, J.E.11
Westervelt, P.12
Dipersio, J.F.13
Link, D.C.14
Walter, M.J.15
Graubert, T.A.16
Watson, M.17
Baty, J.18
Heath, S.19
Shannon, W.D.20
Nagarajan, R.21
Bloomfield, C.D.22
Mardis, E.R.23
Wilson, R.K.24
Ley, T.J.25
more..
-
100
-
-
42249091014
-
Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
-
Flex E, Petrangeli V, Stella L, Chiaretti S, Hornakova T, Knoops L, Ariola C, Fodale V, Clappier E, Paoloni F, Martinelli S, Fragale A, Sanchez M, Tavolaro S, Messina M, Cazzaniga G, Camera A, Pizzolo G, Tornesello A, Vignetti M, Battistini A, Cave H, Gelb BD, Renauld JC, Biondi A, Constantinescu SN, Foa R, Tartaglia M. Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia. J Exp Med. 2008 205 : 751 8.
-
(2008)
J Exp Med.
, vol.205
, pp. 751-758
-
-
Flex, E.1
Petrangeli, V.2
Stella, L.3
Chiaretti, S.4
Hornakova, T.5
Knoops, L.6
Ariola, C.7
Fodale, V.8
Clappier, E.9
Paoloni, F.10
Martinelli, S.11
Fragale, A.12
Sanchez, M.13
Tavolaro, S.14
Messina, M.15
Cazzaniga, G.16
Camera, A.17
Pizzolo, G.18
Tornesello, A.19
Vignetti, M.20
Battistini, A.21
Cave, H.22
Gelb, B.D.23
Renauld, J.C.24
Biondi, A.25
Constantinescu, S.N.26
Foa, R.27
Tartaglia, M.28
more..
-
101
-
-
47149115129
-
Identification of somatic JAK1 mutations in patients with acute myeloid leukemia
-
Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner TL, McLellan MD, DiPersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, Heath SE, Nagarajan R, Mardis ER, Wilson RK, Ley TJ, Tomasson MH. Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. Blood. 2008 111 : 4809 12.
-
(2008)
Blood.
, vol.111
, pp. 4809-4812
-
-
Xiang, Z.1
Zhao, Y.2
Mitaksov, V.3
Fremont, D.H.4
Kasai, Y.5
Molitoris, A.6
Ries, R.E.7
Miner, T.L.8
McLellan, M.D.9
Dipersio, J.F.10
Link, D.C.11
Payton, J.E.12
Graubert, T.A.13
Watson, M.14
Shannon, W.15
Heath, S.E.16
Nagarajan, R.17
Mardis, E.R.18
Wilson, R.K.19
Ley, T.J.20
Tomasson, M.H.21
more..
-
102
-
-
33745713168
-
Activating alleles of JAK3 in acute megakaryoblastic leukemia
-
Walters DK, Mercher T, Gu TL, O'Hare T, Tyner JW, Loriaux M, Goss VL, Lee KA, Eide CA, Wong MJ, Stoffregen EP, McGreevey L, Nardone J, Moore SA, Crispino J, Boggon TJ, Heinrich MC, Deininger MW, Polakiewicz RD, Gilliland DG, Druker BJ. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 2006 10 : 65 75.
-
(2006)
Cancer Cell.
, vol.10
, pp. 65-75
-
-
Walters, D.K.1
Mercher, T.2
Gu, T.L.3
O'Hare, T.4
Tyner, J.W.5
Loriaux, M.6
Goss, V.L.7
Lee, K.A.8
Eide, C.A.9
Wong, M.J.10
Stoffregen, E.P.11
McGreevey, L.12
Nardone, J.13
Moore, S.A.14
Crispino, J.15
Boggon, T.J.16
Heinrich, M.C.17
Deininger, M.W.18
Polakiewicz, R.D.19
Gilliland, D.G.20
Druker, B.J.21
more..
-
103
-
-
21344440357
-
The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both 殿typical- myeloproliferative disorders and myelodysplastic syndromes
-
Steensma DP, Dewald GW, Lasho TL, Powell HL, McClure RF, Levine RL, Gilliland DG, Tefferi A. The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both 殿typical- myeloproliferative disorders and myelodysplastic syndromes. Blood. 2005 106 : 1207 9.
-
(2005)
Blood.
, vol.106
, pp. 1207-1209
-
-
Steensma, D.P.1
Dewald, G.W.2
Lasho, T.L.3
Powell, H.L.4
McClure, R.F.5
Levine, R.L.6
Gilliland, D.G.7
Tefferi, A.8
-
104
-
-
33744500207
-
JAK2 V617F is a rare finding in de novoacute myeloid leukemia, but STAT3 activation is common and remains unexplained
-
Steensma DP, McClure RF, Karp JE, Tefferi A, Lasho TL, Powell HL, DeWald GW, Kaufmann SH. JAK2 V617F is a rare finding in de novoacute myeloid leukemia, but STAT3 activation is common and remains unexplained. Leukemia. 2006 20 : 971 8.
-
(2006)
Leukemia.
, vol.20
, pp. 971-978
-
-
Steensma, D.P.1
McClure, R.F.2
Karp, J.E.3
Tefferi, A.4
Lasho, T.L.5
Powell, H.L.6
Dewald, G.W.7
Kaufmann, S.H.8
-
105
-
-
54349086521
-
Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
-
Bercovich D, Ganmore I, Scott LM, Wainreb G, Birger Y, Elimelech A, Shochat C, Cazzaniga G, Biondi A, Basso G, Cario G, Schrappe M, Stanulla M, Strehl S, Haas OA, Mann G, Binder V, Borkhardt A, Kempski H, Trka J, Bielorei B, Avigad S, Stark B, Smith O, Dastugue N, Bourquin JP, Tal NB, Green AR, Izraeli S. Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet. 2008 372 : 1484 92.
-
(2008)
Lancet.
, vol.372
, pp. 1484-1492
-
-
Bercovich, D.1
Ganmore, I.2
Scott, L.M.3
Wainreb, G.4
Birger, Y.5
Elimelech, A.6
Shochat, C.7
Cazzaniga, G.8
Biondi, A.9
Basso, G.10
Cario, G.11
Schrappe, M.12
Stanulla, M.13
Strehl, S.14
Haas, O.A.15
Mann, G.16
Binder, V.17
Borkhardt, A.18
Kempski, H.19
Trka, J.20
Bielorei, B.21
Avigad, S.22
Stark, B.23
Smith, O.24
Dastugue, N.25
Bourquin, J.P.26
Tal, N.B.27
Green, A.R.28
Izraeli, S.29
more..
-
106
-
-
0030852328
-
Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9; 12) in a lymphoid and t(9; 15; 12) in a myeloid leukemia
-
Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, Philip P, Monpoux F, Van Rompaey L, Baens M, Van den Berghe H, Marynen P. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9; 12) in a lymphoid and t(9; 15; 12) in a myeloid leukemia. Blood. 1997 90 : 2535 40.
-
(1997)
Blood.
, vol.90
, pp. 2535-2540
-
-
Peeters, P.1
Raynaud, S.D.2
Cools, J.3
Wlodarska, I.4
Grosgeorge, J.5
Philip, P.6
Monpoux, F.7
Van Rompaey, L.8
Baens, M.9
Van Den Berghe, H.10
Marynen, P.11
-
107
-
-
15444339209
-
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
-
Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffe M, Berthou C, Lessard M, Berger R, Ghysdael J, Bernard OA. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science. 1997 278 : 1309 12.
-
(1997)
Science.
, vol.278
, pp. 1309-1312
-
-
Lacronique, V.1
Boureux, A.2
Valle, V.D.3
Poirel, H.4
Quang, C.T.5
Mauchauffe, M.6
Berthou, C.7
Lessard, M.8
Berger, R.9
Ghysdael, J.10
Bernard, O.A.11
-
108
-
-
20144389913
-
The t(8; 9)(p22; p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2
-
Reiter A, Walz C, Watmore A, Schoch C, Blau I, Schlegelberger B, Berger U, Telford N, Aruliah S, Yin JA, Vanstraelen D, Barker HF, Taylor PC, O'Driscoll A, Benedetti F, Rudolph C, Kolb HJ, Hochhaus A, Hehlmann R, Chase A, Cross NC. The t(8; 9)(p22; p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2. Cancer Res. 2005 65 : 2662 7.
-
(2005)
Cancer Res.
, vol.65
, pp. 2662-2667
-
-
Reiter, A.1
Walz, C.2
Watmore, A.3
Schoch, C.4
Blau, I.5
Schlegelberger, B.6
Berger, U.7
Telford, N.8
Aruliah, S.9
Yin, J.A.10
Vanstraelen, D.11
Barker, H.F.12
Taylor, P.C.13
O'Driscoll, A.14
Benedetti, F.15
Rudolph, C.16
Kolb, H.J.17
Hochhaus, A.18
Hehlmann, R.19
Chase, A.20
Cross, N.C.21
more..
-
109
-
-
26944481210
-
PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8; 9) translocation
-
Murati A, Gelsi-Boyer V, Adelaide J, Perot C, Talmant P, Giraudier S, Lode L, Letessier A, Delaval B, Brunel V, Imbert M, Garand R, Xerri L, Birnbaum D, Mozziconacci MJ, Chaffanet M. PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8; 9) translocation. Leukemia. 2005 19 : 1692 6.
-
(2005)
Leukemia.
, vol.19
, pp. 1692-1696
-
-
Murati, A.1
Gelsi-Boyer, V.2
Adelaide, J.3
Perot, C.4
Talmant, P.5
Giraudier, S.6
Lode, L.7
Letessier, A.8
Delaval, B.9
Brunel, V.10
Imbert, M.11
Garand, R.12
Xerri, L.13
Birnbaum, D.14
Mozziconacci, M.J.15
Chaffanet, M.16
-
110
-
-
27944481825
-
The t(8; 9)(p22; p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene
-
Bousquet M, Quelen C, De Mas V, Duchayne E, Roquefeuil B, Delsol G, Laurent G, Dastugue N, Brousset P. The t(8; 9)(p22; p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. Oncogene. 2005 24 : 7248 52.
-
(2005)
Oncogene.
, vol.24
, pp. 7248-7252
-
-
Bousquet, M.1
Quelen, C.2
De Mas, V.3
Duchayne, E.4
Roquefeuil, B.5
Delsol, G.6
Laurent, G.7
Dastugue, N.8
Brousset, P.9
-
111
-
-
33644552449
-
A t(8; 9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma
-
Adelaide J, Perot C, Gelsi-Boyer V, Pautas C, Murati A, Copie-Bergman C, Imbert M, Chaffanet M, Birnbaum D, Mozziconacci MJ. A t(8; 9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma. Leukemia. 2006 20 : 536 7.
-
(2006)
Leukemia.
, vol.20
, pp. 536-537
-
-
Adelaide, J.1
Perot, C.2
Gelsi-Boyer, V.3
Pautas, C.4
Murati, A.5
Copie-Bergman, C.6
Imbert, M.7
Chaffanet, M.8
Birnbaum, D.9
Mozziconacci, M.J.10
-
112
-
-
25844469587
-
A BCR-JAK2 fusion gene as the result of a t(9; 22)(p24; q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia
-
Griesinger F, Hennig H, Hillmer F, Podleschny M, Steffens R, Pies A, Wormann B, Haase D, Bohlander SK. A BCR-JAK2 fusion gene as the result of a t(9; 22)(p24; q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia. Genes Chromosomes Cancer. 2005 44 : 329 33.
-
(2005)
Genes Chromosomes Cancer.
, vol.44
, pp. 329-333
-
-
Griesinger, F.1
Hennig, H.2
Hillmer, F.3
Podleschny, M.4
Steffens, R.5
Pies, A.6
Wormann, B.7
Haase, D.8
Bohlander, S.K.9
-
113
-
-
50249116142
-
Novel SSBP2-JAK2 fusion gene resulting from a t(5; 9)(q14.1; p24.1) in pre-B acute lymphocytic leukemia
-
Poitras JL, Dal Cin P, Aster JC, DeAngelo DJ, Morton CC. Novel SSBP2-JAK2 fusion gene resulting from a t(5; 9)(q14.1; p24.1) in pre-B acute lymphocytic leukemia. Genes Chromosomes Cancer. 2008 47 : 884 9.
-
(2008)
Genes Chromosomes Cancer.
, vol.47
, pp. 884-889
-
-
Poitras, J.L.1
Dal Cin, P.2
Aster, J.C.3
Deangelo, D.J.4
Morton, C.C.5
-
114
-
-
43949133894
-
A BCR-JAK2 fusion gene as the result of a t(9; 22)(p24; q11) in a patient with acute myeloid leukemia
-
Cirmena G, Aliano S, Fugazza G, Bruzzone R, Garuti A, Bocciardi R, Bacigalupo A, Ravazzolo R, Ballestrero A, Sessarego M. A BCR-JAK2 fusion gene as the result of a t(9; 22)(p24; q11) in a patient with acute myeloid leukemia. Cancer Genet Cytogenet. 2008 183 : 105 8.
-
(2008)
Cancer Genet Cytogenet.
, vol.183
, pp. 105-108
-
-
Cirmena, G.1
Aliano, S.2
Fugazza, G.3
Bruzzone, R.4
Garuti, A.5
Bocciardi, R.6
Bacigalupo, A.7
Ravazzolo, R.8
Ballestrero, A.9
Sessarego, M.10
-
115
-
-
0034660270
-
TEL-JAK2 transgenic mice develop T-cell leukemia
-
Carron C, Cormier F, Janin A, Lacronique V, Giovannini M, Daniel MT, Bernard O, Ghysdael J. TEL-JAK2 transgenic mice develop T-cell leukemia. Blood. 2000 95 : 3891 9.
-
(2000)
Blood.
, vol.95
, pp. 3891-3899
-
-
Carron, C.1
Cormier, F.2
Janin, A.3
Lacronique, V.4
Giovannini, M.5
Daniel, M.T.6
Bernard, O.7
Ghysdael, J.8
-
116
-
-
33644976909
-
A transgenic mouse model for TEL-JAK2-induced B-cell lymphoma/leukemia
-
dos Santos NR, Ghysdael J. A transgenic mouse model for TEL-JAK2-induced B-cell lymphoma/leukemia. Leukemia. 2006 20 : 182 5.
-
(2006)
Leukemia.
, vol.20
, pp. 182-185
-
-
Dos Santos, N.R.1
Ghysdael, J.2
-
117
-
-
33750936941
-
Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo
-
Kennedy JA, Barabe F, Patterson BJ, Bayani J, Squire JA, Barber DL, Dick JE. Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo. Proc Natl Acad Sci USA. 2006 103 : 16930 5.
-
(2006)
Proc Natl Acad Sci USA.
, vol.103
, pp. 16930-16935
-
-
Kennedy, J.A.1
Barabe, F.2
Patterson, B.J.3
Bayani, J.4
Squire, J.A.5
Barber, D.L.6
Dick, J.E.7
-
118
-
-
50249116142
-
Novel SSBP2-JAK2 fusion gene resulting from a t(5; 9)(q14.1; p24.1) in pre-B acute lymphocytic leukemia
-
Poitras JL, Cin PD, Aster JC, Deangelo DJ, Morton CC. Novel SSBP2-JAK2 fusion gene resulting from a t(5; 9)(q14.1; p24.1) in pre-B acute lymphocytic leukemia. Genes Chromosomes Cancer. 2008 47 : 884 9.
-
(2008)
Genes Chromosomes Cancer.
, vol.47
, pp. 884-889
-
-
Poitras, J.L.1
Cin, P.D.2
Aster, J.C.3
Deangelo, D.J.4
Morton, C.C.5
-
119
-
-
21344467318
-
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
-
Jones AV, Kreil S, Zoi K, Waghorn K, Curtis C, Zhang L, Score J, Seear R, Chase AJ, Grand FH, White H, Zoi C, Loukopoulos D, Terpos E, Vervessou EC, Schultheis B, Emig M, Ernst T, Lengfelder E, Hehlmann R, Hochhaus A, Oscier D, Silver RT, Reiter A, Cross NC. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood. 2005 106 : 2162 8.
-
(2005)
Blood.
, vol.106
, pp. 2162-2168
-
-
Jones, A.V.1
Kreil, S.2
Zoi, K.3
Waghorn, K.4
Curtis, C.5
Zhang, L.6
Score, J.7
Seear, R.8
Chase, A.J.9
Grand, F.H.10
White, H.11
Zoi, C.12
Loukopoulos, D.13
Terpos, E.14
Vervessou, E.C.15
Schultheis, B.16
Emig, M.17
Ernst, T.18
Lengfelder, E.19
Hehlmann, R.20
Hochhaus, A.21
Oscier, D.22
Silver, R.T.23
Reiter, A.24
Cross, N.C.25
more..
-
120
-
-
33644987681
-
Absence of the JAK2 V617F activating mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma
-
Melzner I, Weniger MA, Menz CK, Moller P. Absence of the JAK2 V617F activating mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma. Leukemia. 2006 20 : 157 8.
-
(2006)
Leukemia.
, vol.20
, pp. 157-158
-
-
Melzner, I.1
Weniger, M.A.2
Menz, C.K.3
Moller, P.4
-
121
-
-
30644470844
-
JAK2 V617F mutation is uncommon in non-Hodgkin lymphomas
-
Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. JAK2 V617F mutation is uncommon in non-Hodgkin lymphomas. Leuk Lymphoma. 2006 47 : 313 4.
-
(2006)
Leuk Lymphoma.
, vol.47
, pp. 313-314
-
-
Lee, J.W.1
Soung, Y.H.2
Kim, S.Y.3
Nam, S.W.4
Park, W.S.5
Lee, J.Y.6
Yoo, N.J.7
Lee, S.H.8
-
122
-
-
27244450310
-
The V617F mutation in Jak2 is not found in childhood acute lym-phoblastic leukaemia
-
Sulong S, Case M, Minto L, Wilkins B, Hall A, Irving J. The V617F mutation in Jak2 is not found in childhood acute lym-phoblastic leukaemia. Br J Haematol. 2005 130 : 964 5.
-
(2005)
Br J Haematol.
, vol.130
, pp. 964-965
-
-
Sulong, S.1
Case, M.2
Minto, L.3
Wilkins, B.4
Hall, A.5
Irving, J.6
-
123
-
-
25844518265
-
The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia
-
Levine RL, Loriaux M, Huntly BJ, Loh ML, Beran M, Stoffregen E, Berger R, Clark JJ, Willis SG, Nguyen KT, Flores NJ, Estey E, Gattermann N, Armstrong S, Look AT, Griffin JD, Bernard OA, Heinrich MC, Gilliland DG, Druker B, Deininger MW. The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood. 2005 106 : 3377 9.
-
(2005)
Blood.
, vol.106
, pp. 3377-3379
-
-
Levine, R.L.1
Loriaux, M.2
Huntly, B.J.3
Loh, M.L.4
Beran, M.5
Stoffregen, E.6
Berger, R.7
Clark, J.J.8
Willis, S.G.9
Nguyen, K.T.10
Flores, N.J.11
Estey, E.12
Gattermann, N.13
Armstrong, S.14
Look, A.T.15
Griffin, J.D.16
Bernard, O.A.17
Heinrich, M.C.18
Gilliland, D.G.19
Druker, B.20
Deininger, M.W.21
more..
-
124
-
-
85052273511
-
Absence of JAK2 V617F mutation in gastric cancers
-
Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. Absence of JAK2 V617F mutation in gastric cancers. Acta Oncol. 2006 45 : 222 3.
-
(2006)
Acta Oncol.
, vol.45
, pp. 222-223
-
-
Lee, J.W.1
Soung, Y.H.2
Kim, S.Y.3
Nam, S.W.4
Park, W.S.5
Lee, J.Y.6
Yoo, N.J.7
Lee, S.H.8
-
125
-
-
33644752653
-
The JAK2 V617F mutation in de novoacute myelogenous leukemias
-
Lee JW, Kim YG, Soung YH, Han KJ, Kim SY, Rhim HS, Min WS, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH. The JAK2 V617F mutation in de novoacute myelogenous leukemias. Oncogene. 2006 25 : 1434 6.
-
(2006)
Oncogene.
, vol.25
, pp. 1434-1436
-
-
Lee, J.W.1
Kim, Y.G.2
Soung, Y.H.3
Han, K.J.4
Kim, S.Y.5
Rhim, H.S.6
Min, W.S.7
Nam, S.W.8
Park, W.S.9
Lee, J.Y.10
Yoo, N.J.11
Lee, S.H.12
-
126
-
-
27144466017
-
The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders
-
Scott LM, Campbell PJ, Baxter EJ, Todd T, Stephens P, Edkins S, Wooster R, Stratton MR, Futreal PA, Green AR. The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders. Blood. 2005 106 : 2920 1.
-
(2005)
Blood.
, vol.106
, pp. 2920-2921
-
-
Scott, L.M.1
Campbell, P.J.2
Baxter, E.J.3
Todd, T.4
Stephens, P.5
Edkins, S.6
Wooster, R.7
Stratton, M.R.8
Futreal, P.A.9
Green, A.R.10
-
127
-
-
32944477304
-
Concomitant neutrophil JAK2 mutation screening and PRV-1 expression analysis in myeloproliferative disorders and secondary polycythaemia
-
Tefferi A, Sirhan S, Lasho TL, Schwager SM, Li CY, Dingli D, Wolanskyj AP, Steensma DP, Mesa R, Gilliland DG. Concomitant neutrophil JAK2 mutation screening and PRV-1 expression analysis in myeloproliferative disorders and secondary polycythaemia. Br J Haematol. 2005 131 : 166 71.
-
(2005)
Br J Haematol.
, vol.131
, pp. 166-171
-
-
Tefferi, A.1
Sirhan, S.2
Lasho, T.L.3
Schwager, S.M.4
Li, C.Y.5
Dingli, D.6
Wolanskyj, A.P.7
Steensma, D.P.8
Mesa, R.9
Gilliland, D.G.10
-
128
-
-
25844432737
-
Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2
-
Kralovics R, Teo SS, Buser AS, Brutsche M, Tiedt R, Tichelli A, Passamonti F, Pietra D, Cazzola M, Skoda RC. Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2. Blood. 2005 106 : 3374 6.
-
(2005)
Blood.
, vol.106
, pp. 3374-3376
-
-
Kralovics, R.1
Teo, S.S.2
Buser, A.S.3
Brutsche, M.4
Tiedt, R.5
Tichelli, A.6
Passamonti, F.7
Pietra, D.8
Cazzola, M.9
Skoda, R.C.10
-
129
-
-
85044550232
-
High occurrence of JAK2 V617 mutation in refractory anemia with ringed sideroblasts associated with marked thrombocytosis
-
Renneville A, Quesnel B, Charpentier A, Terriou L, Crinquette A, Lai JL, Cossement C, Lionne-Huyghe P, Rose C, Bauters F, Preudhomme C. High occurrence of JAK2 V617 mutation in refractory anemia with ringed sideroblasts associated with marked thrombocytosis. Leukemia. 2006 20 : 2067 70.
-
(2006)
Leukemia.
, vol.20
, pp. 2067-2070
-
-
Renneville, A.1
Quesnel, B.2
Charpentier, A.3
Terriou, L.4
Crinquette, A.5
Lai, J.L.6
Cossement, C.7
Lionne-Huyghe, P.8
Rose, C.9
Bauters, F.10
Preudhomme, C.11
-
130
-
-
33750304807
-
JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less?
-
Verstovsek S, Silver RT, Cross NC, Tefferi A. JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less? Leukemia. 2006 20 : 2067.
-
(2006)
Leukemia.
, vol.20
, pp. 2067
-
-
Verstovsek, S.1
Silver, R.T.2
Cross, N.C.3
Tefferi, A.4
-
131
-
-
33644533192
-
JAK2 V617F mutation in classic chronic myeloproliferative diseases: A report on a series of 349 patients
-
Vizmanos JL, Ormazabal C, Larrayoz MJ, Cross NC, Calasanz MJ. JAK2 V617F mutation in classic chronic myeloproliferative diseases: a report on a series of 349 patients. Leukemia. 2006 20 : 534 5.
-
(2006)
Leukemia.
, vol.20
, pp. 534-535
-
-
Vizmanos, J.L.1
Ormazabal, C.2
Larrayoz, M.J.3
Cross, N.C.4
Calasanz, M.J.5
-
132
-
-
33744490974
-
Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
-
Wernig G, Mercher T, Okabe R, Levine RL, Lee BH, Gilliland DG. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood. 2006 107 : 4274 81.
-
(2006)
Blood.
, vol.107
, pp. 4274-4281
-
-
Wernig, G.1
Mercher, T.2
Okabe, R.3
Levine, R.L.4
Lee, B.H.5
Gilliland, D.G.6
-
133
-
-
33745721197
-
JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
-
Lacout C, Pisani DF, Tulliez M, Moreau Gachelin F, Vainchenker W, Villeval JL. JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood. 2006 108 : 1652 60.
-
(2006)
Blood.
, vol.108
, pp. 1652-1660
-
-
Lacout, C.1
Pisani, D.F.2
Tulliez, M.3
Moreau Gachelin, F.4
Vainchenker, W.5
Villeval, J.L.6
-
134
-
-
43249084493
-
Ratio of mutant JAK2-V617F to wild type JAK2 determines the MPD phenotypes in transgenic mice
-
Tiedt R, Hao-Shen H, Sobas MA, Looser R, Dirnhofer S, Schwaller J, Skoda RC. Ratio of mutant JAK2-V617F to wild type JAK2 determines the MPD phenotypes in transgenic mice. Blood. 2008 111 : 3931 40.
-
(2008)
Blood.
, vol.111
, pp. 3931-3940
-
-
Tiedt, R.1
Hao-Shen, H.2
Sobas, M.A.3
Looser, R.4
Dirnhofer, S.5
Schwaller, J.6
Skoda, R.C.7
-
135
-
-
38349035684
-
Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
-
Shide K, Shimoda HK, Kumano T, Karube K, Kameda T, Takenaka K, Oku S, Abe H, Katayose KS, Kubuki Y, Kusumoto K, Hasuike S, Tahara Y, Nagata K, Matsuda T, Ohshima K, Harada M, Shimoda K. Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F. Leukemia. 2008 22 : 87 95.
-
(2008)
Leukemia.
, vol.22
, pp. 87-95
-
-
Shide, K.1
Shimoda, H.K.2
Kumano, T.3
Karube, K.4
Kameda, T.5
Takenaka, K.6
Oku, S.7
Abe, H.8
Katayose, K.S.9
Kubuki, Y.10
Kusumoto, K.11
Hasuike, S.12
Tahara, Y.13
Nagata, K.14
Matsuda, T.15
Ohshima, K.16
Harada, M.17
Shimoda, K.18
-
136
-
-
34249071097
-
Clinical correlates of JAK2V617F allele burden in essential thrombocythemia
-
Kittur J, Knudson RA, Lasho TL, Finke CM, Gangat N, Wolanskyj AP, Li CY, Wu W, Ketterling RP, Pardanani A, Tefferi A. Clinical correlates of JAK2V617F allele burden in essential thrombocythemia. Cancer. 2007 109 : 2279 84.
-
(2007)
Cancer.
, vol.109
, pp. 2279-2284
-
-
Kittur, J.1
Knudson, R.A.2
Lasho, T.L.3
Finke, C.M.4
Gangat, N.5
Wolanskyj, A.P.6
Li, C.Y.7
Wu, W.8
Ketterling, R.P.9
Pardanani, A.10
Tefferi, A.11
-
137
-
-
34548131123
-
Bone marrow JAK2V617F allele burden and clinical correlates in polycythemia vera
-
Tefferi A, Strand JJ, Lasho TL, Knudson RA, Finke CM, Gangat N, Pardanani A, Hanson CA, Ketterling RP. Bone marrow JAK2V617F allele burden and clinical correlates in polycythemia vera. Leukemia. 2007 21 : 2074 5.
-
(2007)
Leukemia.
, vol.21
, pp. 2074-2075
-
-
Tefferi, A.1
Strand, J.J.2
Lasho, T.L.3
Knudson, R.A.4
Finke, C.M.5
Gangat, N.6
Pardanani, A.7
Hanson, C.A.8
Ketterling, R.P.9
-
138
-
-
42449124578
-
Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, predicts inferior overall and leukemia-free survival
-
Tefferi A, Lasho TL, Huang J, Finke C, Hanson CA, Mesa RA, Pardanani A. Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, predicts inferior overall and leukemia-free survival. Leukemia. 2008 22 : 756 61.
-
(2008)
Leukemia.
, vol.22
, pp. 756-761
-
-
Tefferi, A.1
Lasho, T.L.2
Huang, J.3
Finke, C.4
Hanson, C.A.5
Mesa, R.A.6
Pardanani, A.7
-
139
-
-
34547953018
-
Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia
-
Vannucchi AM, Antonioli E, Guglielmelli P, Rambaldi A, Barosi G, Marchioli R, Marfisi RM, Finazzi G, Guerini V, Fabris F, Randi ML, De Stefano V, Caberlon S, Tafuri A, Ruggeri M, Specchia G, Liso V, Rossi E, Pogliani E, Gugliotta L, Bosi A, Barbui T. Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia. Blood. 2007 110 : 840 6.
-
(2007)
Blood.
, vol.110
, pp. 840-846
-
-
Vannucchi, A.M.1
Antonioli, E.2
Guglielmelli, P.3
Rambaldi, A.4
Barosi, G.5
Marchioli, R.6
Marfisi, R.M.7
Finazzi, G.8
Guerini, V.9
Fabris, F.10
Randi, M.L.11
De Stefano, V.12
Caberlon, S.13
Tafuri, A.14
Ruggeri, M.15
Specchia, G.16
Liso, V.17
Rossi, E.18
Pogliani, E.19
Gugliotta, L.20
Bosi, A.21
Barbui, T.22
more..
-
140
-
-
34547936938
-
The JAK2 617V>F mutation triggers erythropoietin hypersensitiv-ity and terminal erythroid amplification in primary cells from patients with polycythemia vera
-
Dupont S, Masse A, James C, Teyssandier I, Lecluse Y, Larbret F, Ugo V, Saulnier P, Koscielny S, Le Couedic JP, Casadevall N, Vainchenker W, Delhommeau F. The JAK2 617V>F mutation triggers erythropoietin hypersensitiv-ity and terminal erythroid amplification in primary cells from patients with polycythemia vera. Blood. 2007 110 : 1013 21.
-
(2007)
Blood.
, vol.110
, pp. 1013-1021
-
-
Dupont, S.1
Masse, A.2
James, C.3
Teyssandier, I.4
Lecluse, Y.5
Larbret, F.6
Ugo, V.7
Saulnier, P.8
Koscielny, S.9
Le Couedic, J.P.10
Casadevall, N.11
Vainchenker, W.12
Delhommeau, F.13
-
141
-
-
17644424955
-
A gain of function mutation in Jak2 is frequently found in patients with myeloproliferative disorders
-
Kralovics R, Passamonti F, Buser AS, Soon-Siong T, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC. A gain of function mutation in Jak2 is frequently found in patients with myeloproliferative disorders. N Engl J Med. 2005 352 : 1779 90.
-
(2005)
N Engl J Med.
, vol.352
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Soon-Siong, T.4
Tiedt, R.5
Passweg, J.R.6
Tichelli, A.7
Cazzola, M.8
Skoda, R.C.9
-
142
-
-
51649087754
-
JAK2 stimulates homologous recombination and genetic instability: Potential implication in the heterogeneity of myeloproliferative disorders
-
Plo I, Nakatake M, Malivert L, de Villartay JP, Giraudier S, Villeval JL, Wiesmuller L, Vainchenker W. JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders. Blood. 2008 112 : 1402 12.
-
(2008)
Blood.
, vol.112
, pp. 1402-1412
-
-
Plo, I.1
Nakatake, M.2
Malivert, L.3
De Villartay, J.P.4
Giraudier, S.5
Villeval, J.L.6
Wiesmuller, L.7
Vainchenker, W.8
-
143
-
-
33748684367
-
The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera
-
Lippert E, Boissinot M, Kralovics R, Girodon F, Dobo I, Praloran V, Boiret-Dupre N, Skoda RC, Hermouet S. The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera. Blood. 2006 108 : 1865 7.
-
(2006)
Blood.
, vol.108
, pp. 1865-1867
-
-
Lippert, E.1
Boissinot, M.2
Kralovics, R.3
Girodon, F.4
Dobo, I.5
Praloran, V.6
Boiret-Dupre, N.7
Skoda, R.C.8
Hermouet, S.9
-
144
-
-
33749358349
-
Progenitors homozygous for the V617F JAK2 mutation occur in most patients with polycythemia vera, but not essential thrombocythemia
-
Scott LM, Scott MA, Campbell PJ, Green AR. Progenitors homozygous for the V617F JAK2 mutation occur in most patients with polycythemia vera, but not essential thrombocythemia. Blood. 2006 108 : 2435 7.
-
(2006)
Blood.
, vol.108
, pp. 2435-2437
-
-
Scott, L.M.1
Scott, M.A.2
Campbell, P.J.3
Green, A.R.4
-
145
-
-
33646546386
-
The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation
-
Jamieson CH, Gotlib J, Durocher JA, Chao MP, Mariappan MR, Lay M, Jones C, Zehnder JL, Lilleberg SL, Weissman IL. The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci USA. 2006 103 : 6224 9.
-
(2006)
Proc Natl Acad Sci USA.
, vol.103
, pp. 6224-6229
-
-
Jamieson, C.H.1
Gotlib, J.2
Durocher, J.A.3
Chao, M.P.4
Mariappan, M.R.5
Lay, M.6
Jones, C.7
Zehnder, J.L.8
Lilleberg, S.L.9
Weissman, I.L.10
-
146
-
-
25444516768
-
JAK2 mutations in myeloproliferative disorders
-
Tefferi A, Lasho TL, Gilliland G. JAK2 mutations in myeloproliferative disorders. N Engl J Med. 2005 353 : 1416 7.
-
(2005)
N Engl J Med.
, vol.353
, pp. 1416-1417
-
-
Tefferi, A.1
Lasho, T.L.2
Gilliland, G.3
-
147
-
-
33846007215
-
Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis
-
Delhommeau F, Dupont S, Tonetti C, Masse A, Godin I, Le Couedic JP, Debili N, Saulnier P, Casadevall N, Vainchenker W, Giraudier S. Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis. Blood. 2007 109 : 71 7.
-
(2007)
Blood.
, vol.109
, pp. 71-77
-
-
Delhommeau, F.1
Dupont, S.2
Tonetti, C.3
Masse, A.4
Godin, I.5
Le Couedic, J.P.6
Debili, N.7
Saulnier, P.8
Casadevall, N.9
Vainchenker, W.10
Giraudier, S.11
-
148
-
-
27244432586
-
Mutation studies in CD3+, CD19+ and CD34+ cell fractions in myeloproliferative disorders with homozygous JAK2(V617F) in granulocytes
-
Lasho TL, Mesa R, Gilliland DG, Tefferi A. Mutation studies in CD3+, CD19+ and CD34+ cell fractions in myeloproliferative disorders with homozygous JAK2(V617F) in granulocytes. Br J Haematol. 2005 130 : 797 9.
-
(2005)
Br J Haematol.
, vol.130
, pp. 797-799
-
-
Lasho, T.L.1
Mesa, R.2
Gilliland, D.G.3
Tefferi, A.4
-
149
-
-
33745623666
-
Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders
-
Bellanne-Chantelot C, Chaumarel I, Labopin M, Bellanger F, Barbu V, De Toma C, Delhommeau F, Casadevall N, Vainchenker W, Thomas G, Najman A. Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders. Blood. 2006 108 : 346 52.
-
(2006)
Blood.
, vol.108
, pp. 346-352
-
-
Bellanne-Chantelot, C.1
Chaumarel, I.2
Labopin, M.3
Bellanger, F.4
Barbu, V.5
De Toma, C.6
Delhommeau, F.7
Casadevall, N.8
Vainchenker, W.9
Thomas, G.10
Najman, A.11
-
150
-
-
33750611344
-
Involvement of various hematopoietic cell lineages by the JAK2V617F mutation in polycythemia vera
-
Ishii T, Bruno E, Hoffman R, Xu M. Involvement of various hematopoietic cell lineages by the JAK2V617F mutation in polycythemia vera. Blood. 2006 108 : 3128 34.
-
(2006)
Blood.
, vol.108
, pp. 3128-3134
-
-
Ishii, T.1
Bruno, E.2
Hoffman, R.3
Xu, M.4
-
151
-
-
34748912399
-
Extending Jak2V617F and MplW515 mutation analysis to single hematopoietic colonies and B and T lymphocytes
-
Pardanani A, Lasho TL, Finke C, Mesa RA, Hogan WJ, Ketterling RP, Gilliland DG, Tefferi A. Extending Jak2V617F and MplW515 mutation analysis to single hematopoietic colonies and B and T lymphocytes. Stem Cells. 2007 25 : 2358 62.
-
(2007)
Stem Cells.
, vol.25
, pp. 2358-2362
-
-
Pardanani, A.1
Lasho, T.L.2
Finke, C.3
Mesa, R.A.4
Hogan, W.J.5
Ketterling, R.P.6
Gilliland, D.G.7
Tefferi, A.8
-
152
-
-
33747199312
-
Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders
-
Kralovics R, Teo SS, Li S, Theocharides A, Buser AS, Tichelli A, Skoda RC. Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders. Blood. 2006 108 : 1377 80.
-
(2006)
Blood.
, vol.108
, pp. 1377-1380
-
-
Kralovics, R.1
Teo, S.S.2
Li, S.3
Theocharides, A.4
Buser, A.S.5
Tichelli, A.6
Skoda, R.C.7
-
153
-
-
33845755386
-
Polycythemia vera is not initiated by JAK2(V617F) mutation
-
Nussenzveig RH, Swierczek SI, Jelinek J, Gaikwad A, Liu E, Verstovsek S, Prchal JF, Prchal JT. Polycythemia vera is not initiated by JAK2(V617F) mutation. Exp Hematol. 2007 35 : 32 8.
-
(2007)
Exp Hematol.
, vol.35
, pp. 32-38
-
-
Nussenzveig, R.H.1
Swierczek, S.I.2
Jelinek, J.3
Gaikwad, A.4
Liu, E.5
Verstovsek, S.6
Prchal, J.F.7
Prchal, J.T.8
-
154
-
-
34347394712
-
Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation
-
Theocharides A, Boissinot M, Girodon F, Garand R, Teo SS, Lippert E, Talmant P, Tichelli A, Hermouet S, Skoda RC. Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation. Blood. 2007 110 : 375 9.
-
(2007)
Blood.
, vol.110
, pp. 375-379
-
-
Theocharides, A.1
Boissinot, M.2
Girodon, F.3
Garand, R.4
Teo, S.S.5
Lippert, E.6
Talmant, P.7
Tichelli, A.8
Hermouet, S.9
Skoda, R.C.10
-
155
-
-
33749434271
-
Mutation of JAK2 in the myeloproliferative disorders: Timing, clonality studies, cytogenetic associations, and role in leukemic transformation
-
Campbell PJ, Baxter EJ, Beer PA, Scott LM, Bench AJ, Huntly BJP, Erber WN, Kusec R, Larsen TS, Glraudler S, Le Bousse-Kerdlles M-C, Grlesshammer M, Reilly JT, Cheung BY, Harrison CN, Green AR. Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation. Blood. 2006 108 : 3548 55.
-
(2006)
Blood.
, vol.108
, pp. 3548-3555
-
-
Campbell, P.J.1
Baxter, E.J.2
Beer, P.A.3
Scott, L.M.4
Bench, A.J.5
Huntly, B.J.P.6
Erber, W.N.7
Kusec, R.8
Larsen, T.S.9
Glraudler, S.10
Le Bousse-Kerdlles, M.-C.11
Grlesshammer, M.12
Reilly, J.T.13
Cheung, B.Y.14
Harrison, C.N.15
Green, A.R.16
-
156
-
-
41949128334
-
Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders
-
Pardananl A, Frldley BL, Lasho TL, Gllllland DG, Tefferi A. Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders. Blood. 2008 111 : 2785 9.
-
(2008)
Blood.
, vol.111
, pp. 2785-2789
-
-
Pardananl, A.1
Frldley, B.L.2
Lasho, T.L.3
Gllllland, D.G.4
Tefferi, A.5
-
157
-
-
33751234537
-
Report on two novel nucleotide exchanges in the JAK2 pseudokinase domain: D620E and E627E
-
Schnlttger S, Bacher U, Kern W, Schroder M, Haferlach T, Schoch C. Report on two novel nucleotide exchanges in the JAK2 pseudokinase domain: D620E and E627E. Leukemia. 2006 20 : 2195 7.
-
(2006)
Leukemia.
, vol.20
, pp. 2195-2197
-
-
Schnlttger, S.1
Bacher, U.2
Kern, W.3
Schroder, M.4
Haferlach, T.5
Schoch, C.6
-
158
-
-
33751246214
-
Detection of a new JAK2 D620E mutation in addition to V617F in a patient with polycythemia vera
-
Grunebach F, Bross-Bach U, Kanz L, Brossart P. Detection of a new JAK2 D620E mutation in addition to V617F in a patient with polycythemia vera. Leukemia. 2006 20 : 2210 1.
-
(2006)
Leukemia.
, vol.20
, pp. 2210-2211
-
-
Grunebach, F.1
Bross-Bach, U.2
Kanz, L.3
Brossart, P.4
-
159
-
-
33847393317
-
Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia
-
Mallnge S, Ben-Abdelall R, Settegrana C, Radford-Welss I, Debre M, Beldjord K, Maclntyre EA, Vllleval JL, Valnchenker W, Berger R, Bernard OA, Delabesse E, Penard-Lacronlque V. Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia. Blood. 2007 109 : 2202 4.
-
(2007)
Blood.
, vol.109
, pp. 2202-2204
-
-
Mallnge, S.1
Ben-Abdelall, R.2
Settegrana, C.3
Radford-Welss, I.4
Debre, M.5
Beldjord, K.6
MacLntyre, E.A.7
Vllleval, J.L.8
Valnchenker, W.9
Berger, R.10
Bernard, O.A.11
Delabesse, E.12
Penard-Lacronlque, V.13
-
160
-
-
33846135053
-
The investigation of JAK2 mutation in Chinese myeloproliferative diseases-identification of a novel C616Y point mutation in a PV patient
-
Zhang SJ, LI JY, LI WD, Song JH, Xu W, Qiu HX. The investigation of JAK2 mutation in Chinese myeloproliferative diseases-identification of a novel C616Y point mutation in a PV patient. Int J Lab Hematol. 2007 29 : 71 2.
-
(2007)
Int J Lab Hematol.
, vol.29
, pp. 71-72
-
-
Zhang, S.J.1
Li, J.Y.2
Li, W.D.3
Song, J.H.4
Xu, W.5
Qiu, H.X.6
-
161
-
-
34249747986
-
JAK2 V617F due to a novel TG -> CT mutation at nucleotides 1848-1849: Diagnostic implication
-
Wong CL, Ma ES, Wang CL, Lam HY, Ma SY. JAK2 V617F due to a novel TG -> CT mutation at nucleotides 1848-1849: diagnostic implication. Leukemia. 2007 21 : 1344 6.
-
(2007)
Leukemia.
, vol.21
, pp. 1344-1346
-
-
Wong, C.L.1
Ma, E.S.2
Wang, C.L.3
Lam, H.Y.4
Ma, S.Y.5
-
162
-
-
38949171700
-
JAK2 mutations other than V617F: A novel mutation and mini review
-
Karow A, Waller C, Relmann C, Niemeyer CM, Kratz CP. JAK2 mutations other than V617F: a novel mutation and mini review. Leuk Res. 2008 32 : 365 6.
-
(2008)
Leuk Res.
, vol.32
, pp. 365-366
-
-
Karow, A.1
Waller, C.2
Relmann, C.3
Niemeyer, C.M.4
Kratz, C.P.5
-
163
-
-
31444432749
-
Mutational screen reveals a novel JAK2 mutation, L611S, in a child with acute lymphoblastic leukemia
-
Kratz CP, Boll S, Kontny U, Schrappe M, Niemeyer CM, Stanulla M. Mutational screen reveals a novel JAK2 mutation, L611S, in a child with acute lymphoblastic leukemia. Leukemia. 2006 20 : 381 3.
-
(2006)
Leukemia.
, vol.20
, pp. 381-383
-
-
Kratz, C.P.1
Boll, S.2
Kontny, U.3
Schrappe, M.4
Niemeyer, C.M.5
Stanulla, M.6
-
164
-
-
33750627651
-
JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model
-
Mercher T, Wernig G, Moore SA, Levine RL, Gu TL, Frohling S, Cullen D, Polakiewicz RD, Bernard OA, Boggon TJ, Lee BH, Gilliland DG. JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model. Blood. 2006 108 : 2770 9.
-
(2006)
Blood.
, vol.108
, pp. 2770-2779
-
-
Mercher, T.1
Wernig, G.2
Moore, S.A.3
Levine, R.L.4
Gu, T.L.5
Frohling, S.6
Cullen, D.7
Polakiewicz, R.D.8
Bernard, O.A.9
Boggon, T.J.10
Lee, B.H.11
Gilliland, D.G.12
-
165
-
-
33846660947
-
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
-
Scott LM, Tong W, Levine RL, Scott MA, Beer PA, Stratton MR, Futreal PA, Erber WN, McMullin MF, Harrison CN, Warren AJ, Gilliland DG, Lodish HF, Green AR. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med. 2007 356 : 459 68.
-
(2007)
N Engl J Med.
, vol.356
, pp. 459-468
-
-
Scott, L.M.1
Tong, W.2
Levine, R.L.3
Scott, M.A.4
Beer, P.A.5
Stratton, M.R.6
Futreal, P.A.7
Erber, W.N.8
McMullin, M.F.9
Harrison, C.N.10
Warren, A.J.11
Gilliland, D.G.12
Lodish, H.F.13
Green, A.R.14
-
166
-
-
34848910714
-
Prevalance of JAK2 V617F and exon 12 mutations in polycythaemia vera
-
Scott LM, Beer PA, Bench AJ, Erber WN, Green AR. Prevalance of JAK2 V617F and exon 12 mutations in polycythaemia vera. Br J Haematol. 2007 139 : 511 2.
-
(2007)
Br J Haematol.
, vol.139
, pp. 511-512
-
-
Scott, L.M.1
Beer, P.A.2
Bench, A.J.3
Erber, W.N.4
Green, A.R.5
-
167
-
-
42349112583
-
Two novel JAK2 exon 12 mutations in JAK2V617F-negative poly-cythaemia vera patients
-
Butcher CM, Hahn U, To LB, Gecz J, Wilkins EJ, Scott HS, Bardy PG, D'Andrea RJ. Two novel JAK2 exon 12 mutations in JAK2V617F-negative poly-cythaemia vera patients. Leukemia. 2008 22 : 870 3.
-
(2008)
Leukemia.
, vol.22
, pp. 870-873
-
-
Butcher, C.M.1
Hahn, U.2
To, L.B.3
Gecz, J.4
Wilkins, E.J.5
Scott, H.S.6
Bardy, P.G.7
D'Andrea, R.J.8
-
168
-
-
38949160429
-
Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders
-
Pietra D, Li S, Brisci A, Passamonti F, Rumi E, Theocharides A, Ferrari M, Gisslinger H, Kralovics R, Cremonesi L, Skoda R, Cazzola M. Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders. Blood. 2008 111 : 1686 9.
-
(2008)
Blood.
, vol.111
, pp. 1686-1689
-
-
Pietra, D.1
Li, S.2
Brisci, A.3
Passamonti, F.4
Rumi, E.5
Theocharides, A.6
Ferrari, M.7
Gisslinger, H.8
Kralovics, R.9
Cremonesi, L.10
Skoda, R.11
Cazzola, M.12
-
169
-
-
37049013530
-
The frequency of JAK2 exon 12 mutations in idiopathic erythrocytosis patients with low serum erythropoietin levels
-
Percy MJ, Scott LM, Erber WN, Harrison CN, Reilly JT, Jones FG, Green AR, McMullin MF. The frequency of JAK2 exon 12 mutations in idiopathic erythrocytosis patients with low serum erythropoietin levels. Haematologica. 2007 92 : 1607 14.
-
(2007)
Haematologica.
, vol.92
, pp. 1607-1614
-
-
Percy, M.J.1
Scott, L.M.2
Erber, W.N.3
Harrison, C.N.4
Reilly, J.T.5
Jones, F.G.6
Green, A.R.7
McMullin, M.F.8
-
170
-
-
37049009294
-
JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis
-
Martinez-Aviles L, Besses C, Alvarez-Larran A, Cervantes F, Hernandez-Boluda JC, Bellosillo B. JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis. Haematologica. 2007 92 : 1717 8.
-
(2007)
Haematologica.
, vol.92
, pp. 1717-1718
-
-
Martinez-Aviles, L.1
Besses, C.2
Alvarez-Larran, A.3
Cervantes, F.4
Hernandez-Boluda, J.C.5
Bellosillo, B.6
-
171
-
-
34548042964
-
Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombo-cythemia, and primary myelofibrosis: Rec-ommendations from an ad hoc international expert panel
-
Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA, Barosi G, Verstovsek S, Birgegard G, Mesa R, Reilly JT, Gisslinger H, Vannucchi AM, Cervantes F, Finazzi G, Hoffman R, Gilliland DG, Bloomfield CD, Vardiman JW. Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombo-cythemia, and primary myelofibrosis: rec-ommendations from an ad hoc international expert panel. Blood. 2007 110 : 1092 7.
-
(2007)
Blood.
, vol.110
, pp. 1092-1097
-
-
Tefferi, A.1
Thiele, J.2
Orazi, A.3
Kvasnicka, H.M.4
Barbui, T.5
Hanson, C.A.6
Barosi, G.7
Verstovsek, S.8
Birgegard, G.9
Mesa, R.10
Reilly, J.T.11
Gisslinger, H.12
Vannucchi, A.M.13
Cervantes, F.14
Finazzi, G.15
Hoffman, R.16
Gilliland, D.G.17
Bloomfield, C.D.18
Vardiman, J.W.19
-
172
-
-
39749106134
-
Lineage distribution of JAK2 exon12 mutations and JAK2-V617F in patients with polycythemia vera
-
Li S, Kralovics R, De Libero G, Tichelli A, Skoda RC. Lineage distribution of JAK2 exon12 mutations and JAK2-V617F in patients with polycythemia vera. ASH Ann Meet Abstr. 2007 110 : 1527.
-
(2007)
ASH Ann Meet Abstr.
, vol.110
, pp. 1527
-
-
Li, S.1
Kralovics, R.2
De Libero, G.3
Tichelli, A.4
Skoda, R.C.5
-
173
-
-
39749108113
-
Frequency of JAK2 exon 12 mutations in JAK2 exon 14 V617F-negative patients: High frequency in et patients
-
Duke VM, Gurunlian N, Yogashangari B, Colley T, McNamara C, Hoffbrand AV, Foroni L. Frequency of JAK2 exon 12 mutations in JAK2 exon 14 V617F-negative patients: high frequency in ET patients. ASH Ann Meet Abstr. 2007 110 : 2539.
-
(2007)
ASH Ann Meet Abstr.
, vol.110
, pp. 2539
-
-
Duke, V.M.1
Gurunlian, N.2
Yogashangari, B.3
Colley, T.4
McNamara, C.5
Hoffbrand, A.V.6
Foroni, L.7
-
174
-
-
34948822857
-
A new JAK2 gene mutation in patients with polycythemia vera and splanchnic vein thrombosis
-
Colaizzo D, Amitrano L, Tiscia GL, Grandone E, Guardascione MA, Margaglione M. A new JAK2 gene mutation in patients with polycythemia vera and splanchnic vein thrombosis. Blood. 2007 110 : 2768 9.
-
(2007)
Blood.
, vol.110
, pp. 2768-2769
-
-
Colaizzo, D.1
Amitrano, L.2
Tiscia, G.L.3
Grandone, E.4
Guardascione, M.A.5
Margaglione, M.6
-
175
-
-
0028199208
-
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
-
Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature. 1994 369 : 565 8.
-
(1994)
Nature.
, vol.369
, pp. 565-568
-
-
Lok, S.1
Kaushansky, K.2
Holly, R.D.3
Kuijper, J.L.4
Lofton-Day, C.E.5
Oort, P.J.6
Grant, F.J.7
Heipel, M.D.8
Burkhead, S.K.9
Kramer, J.M.10
-
176
-
-
33646490285
-
Lineage-specific hemato-poietic growth factors
-
Kaushansky K. Lineage-specific hemato-poietic growth factors. N Engl J Med. 2006 354 : 2034 45.
-
(2006)
N Engl J Med.
, vol.354
, pp. 2034-2045
-
-
Kaushansky, K.1
-
177
-
-
34249981792
-
Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones
-
Abkowitz JL, Chen J. Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones. Blood. 2007 109 : 5186 90.
-
(2007)
Blood.
, vol.109
, pp. 5186-5190
-
-
Abkowitz, J.L.1
Chen, J.2
-
178
-
-
0024378304
-
The human homolog of the myeloproliferative virus maps to chromosome band 1p34
-
Le Coniat M, Souyri M, Vigon I, Wendling F, Tambourin P, Berger R. The human homolog of the myeloproliferative virus maps to chromosome band 1p34. Hum Genet. 1989 83 : 194 6.
-
(1989)
Hum Genet.
, vol.83
, pp. 194-196
-
-
Le Coniat, M.1
Souyri, M.2
Vigon, I.3
Wendling, F.4
Tambourin, P.5
Berger, R.6
-
179
-
-
2542502506
-
Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoi-etin
-
Ding J, Komatsu H, Wakita A, Kato-Uranishi M, Ito M, Satoh A, Tsuboi K, Nitta M, Miyazaki H, Iida S, Ueda R. Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoi-etin. Blood. 2004 103 : 4198 200.
-
(2004)
Blood.
, vol.103
, pp. 4198-4200
-
-
Ding, J.1
Komatsu, H.2
Wakita, A.3
Kato-Uranishi, M.4
Ito, M.5
Satoh, A.6
Tsuboi, K.7
Nitta, M.8
Miyazaki, H.9
Iida, S.10
Ueda, R.11
-
180
-
-
0033019932
-
Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia
-
Ihara K, Ishii E, Eguchi M, Takada H, Suminoe A, Good RA, Hara T. Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia. Proc Natl Acad Sci USA. 1999 96 : 3132 6.
-
(1999)
Proc Natl Acad Sci USA.
, vol.96
, pp. 3132-3136
-
-
Ihara, K.1
Ishii, E.2
Eguchi, M.3
Takada, H.4
Suminoe, A.5
Good, R.A.6
Hara, T.7
-
181
-
-
0035174334
-
C-mpl mutations are the cause of congenital amegakaryocytic thrombocytope-nia
-
Ballmaier M, Germeshausen M, Schulze H, Cherkaoui K, Lang S, Gaudig A, Krukemeier S, Eilers M, Strauss G, Welte K. c-mpl mutations are the cause of congenital amegakaryocytic thrombocytope-nia. Blood. 2001 97 : 139 46.
-
(2001)
Blood.
, vol.97
, pp. 139-146
-
-
Ballmaier, M.1
Germeshausen, M.2
Schulze, H.3
Cherkaoui, K.4
Lang, S.5
Gaudig, A.6
Krukemeier, S.7
Eilers, M.8
Strauss, G.9
Welte, K.10
-
182
-
-
33745693042
-
MPL mutations in 23 patients suffering from congenital amegakaryocytic throm-bocytopenia: The type of mutation predicts the course of the disease
-
Germeshausen M, Ballmaier M, Welte K. MPL mutations in 23 patients suffering from congenital amegakaryocytic throm-bocytopenia: the type of mutation predicts the course of the disease. Hum Mutat. 2006 27 : 296.
-
(2006)
Hum Mutat.
, vol.27
, pp. 296
-
-
Germeshausen, M.1
Ballmaier, M.2
Welte, K.3
-
183
-
-
3843052277
-
Mpl Baltimore: A thrombopoi-etin receptor polymorphism associated with thrombocytosis
-
Moliterno AR, Williams DM, Gutierrez-Alamillo LI, Salvatori R, Ingersoll RG, Spivak JL. Mpl Baltimore: a thrombopoi-etin receptor polymorphism associated with thrombocytosis. Proc Natl Acad Sci USA. 2004 101 : 11444 7.
-
(2004)
Proc Natl Acad Sci USA.
, vol.101
, pp. 11444-11447
-
-
Moliterno, A.R.1
Williams, D.M.2
Gutierrez-Alamillo, L.I.3
Salvatori, R.4
Ingersoll, R.G.5
Spivak, J.L.6
-
184
-
-
33750534561
-
MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
-
Pardanani AD, Levine RL, Lasho TL, Pikman Y, Mesa RA, Wadleigh M, Steensma DP, Elliott MA, Wolanskyj AP Hogan WJ, McClure RF, Litzow MR, Gilliland DG, Tefferi A. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood. 2006 108 : 3472 6.
-
(2006)
Blood.
, vol.108
, pp. 3472-3476
-
-
Pardanani, A.D.1
Levine, R.L.2
Lasho, T.L.3
Pikman, Y.4
Mesa, R.A.5
Wadleigh, M.6
Steensma, D.P.7
Elliott, M.A.8
Wolanskyj, A.P.9
Hogan, W.J.10
McClure, R.F.11
Litzow, M.R.12
Gilliland, D.G.13
Tefferi, A.14
-
185
-
-
39749178544
-
Detection of three different MPLW515 mutations in 10.1% of all JAK2 V617 unmutated et and 9.3% of all JAK2 V617F unmutated OMF: A study of 387 patients
-
Schnittger S, Haferlach C, Beelen DW, Bojko P, Dengler R, Diestelrath A, Eckart MJ, Eckert R, Fries S, Kochling G, Laubenstein HP, Planker M, Pihusch R, Kern W, Haferlach T. Detection of three different MPLW515 mutations in 10.1% of all JAK2 V617 unmutated ET and 9.3% of all JAK2 V617F unmutated OMF: a study of 387 patients. ASH Ann Meet Abstr. 2007 110 : 2546.
-
(2007)
ASH Ann Meet Abstr.
, vol.110
, pp. 2546
-
-
Schnittger, S.1
Haferlach, C.2
Beelen, D.W.3
Bojko, P.4
Dengler, R.5
Diestelrath, A.6
Eckart, M.J.7
Eckert, R.8
Fries, S.9
Kochling, G.10
Laubenstein, H.P.11
Planker, M.12
Pihusch, R.13
Kern, W.14
Haferlach, T.15
-
186
-
-
39749133771
-
Clinical significance of MPL mutations in essential thrombocythemia: Analysis of the PT-1 cohort
-
Beer P, Campbell P, Erber W, Scott L, Bench A, Bareford D, Bridget W, Wheatley K, Buck G, Harrison C, Green A. Clinical significance of MPL mutations in essential thrombocythemia: analysis of the PT-1 cohort. ASH Ann Meet Abstr. 2007 110 : 677.
-
(2007)
ASH Ann Meet Abstr.
, vol.110
, pp. 677
-
-
Beer, P.1
Campbell, P.2
Erber, W.3
Scott, L.4
Bench, A.5
Bareford, D.6
Bridget, W.7
Wheatley, K.8
Buck, G.9
Harrison, C.10
Green, A.11
-
187
-
-
39749170672
-
The clinical phenotype of patients with essential thrombocythemia harboring MPL 515W>L/K mutation
-
Vannucchi AM, Antonioli E, Pancrazzi A, Guglielmelli P, Di Lollo S, Alterini R, Guerini V, Baroni G, Rambaldi A, Bosi A, Barbui T. The clinical phenotype of patients with essential thrombocythemia harboring MPL 515W>L/K mutation. ASH Annu Meet Abstr. 2007 110 : 678.
-
(2007)
ASH Annu Meet Abstr.
, vol.110
, pp. 678
-
-
Vannucchi, A.M.1
Antonioli, E.2
Pancrazzi, A.3
Guglielmelli, P.4
Di Lollo, S.5
Alterini, R.6
Guerini, V.7
Baroni, G.8
Rambaldi, A.9
Bosi, A.10
Barbui, T.11
-
188
-
-
34047211223
-
Anaemia characterises patients with myelofibrosis harbouring Mpl mutation
-
Guglielmelli P, Pancrazzi A, Bergamaschi G, Rosti V, Villani L, Antonioli E, Bosi A, Barosi G, Vannucchi AM. Anaemia characterises patients with myelofibrosis harbouring Mpl mutation. Br J Haematol. 2007 137 : 244 7.
-
(2007)
Br J Haematol.
, vol.137
, pp. 244-247
-
-
Guglielmelli, P.1
Pancrazzi, A.2
Bergamaschi, G.3
Rosti, V.4
Villani, L.5
Antonioli, E.6
Bosi, A.7
Barosi, G.8
Vannucchi, A.M.9
-
189
-
-
62549109475
-
UPD1p indicates the presence of MPL W515L mutation in RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation
-
in press.
-
Szpurka H, Gondek LP, Mohan SR, Hsi ED, Theil KS, Maciejewski JP. UPD1p indicates the presence of MPL W515L mutation in RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation. Leukemia. 2008 in press.
-
(2008)
Leukemia.
-
-
Szpurka, H.1
Gondek, L.P.2
Mohan, S.R.3
Hsi, E.D.4
Theil, K.S.5
MacIejewski, J.P.6
-
190
-
-
34748912399
-
Extending Jak2V617F and Mpl515 mutation analysis to single myeloid colonies and T and B lymphocytes
-
Pardanani A, Lasho TL, Finke C, Mesa RA, Hogan WJ, Ketterling RP, Gilliland DG, Tefferi A. Extending Jak2V617F and Mpl515 mutation analysis to single myeloid colonies and T and B lymphocytes. Stem Cells. 2007 25 : 2358 62.
-
(2007)
Stem Cells.
, vol.25
, pp. 2358-2362
-
-
Pardanani, A.1
Lasho, T.L.2
Finke, C.3
Mesa, R.A.4
Hogan, W.J.5
Ketterling, R.P.6
Gilliland, D.G.7
Tefferi, A.8
-
191
-
-
36348999273
-
Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis
-
Chaligne R, James C, Tonetti C, Besancenot R, Le Couedic JP, Fava F, Mazurier F, Godin I, Maloum K, Larbret F, Lecluse Y, Vainchenker W, Giraudier S. Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis. Blood. 2007 110 : 3735 43.
-
(2007)
Blood.
, vol.110
, pp. 3735-3743
-
-
Chaligne, R.1
James, C.2
Tonetti, C.3
Besancenot, R.4
Le Couedic, J.P.5
Fava, F.6
Mazurier, F.7
Godin, I.8
Maloum, K.9
Larbret, F.10
Lecluse, Y.11
Vainchenker, W.12
Giraudier, S.13
-
192
-
-
34548786770
-
Demonstration of MPLW515K, but not JAK2V617F, in in vitro expanded CD4+ T lymphocytes
-
Pardanani A, Lasho TL, Finke C, Markovic SN, Tefferi A. Demonstration of MPLW515K, but not JAK2V617F, in in vitro expanded CD4+ T lymphocytes. Leukemia. 2007 21 : 2206 7.
-
(2007)
Leukemia.
, vol.21
, pp. 2206-2207
-
-
Pardanani, A.1
Lasho, T.L.2
Finke, C.3
Markovic, S.N.4
Tefferi, A.5
-
193
-
-
33750550297
-
Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: Chronology of clonal emergence and changes in mutant allele burden over time
-
Lasho TL, Pardanani A, McClure RF, Mesa RA, Levine RL, Gary Gilliland D, Tefferi A. Concurrent MPL515 and JAK2V617F mutations in myelofibrosis: chronology of clonal emergence and changes in mutant allele burden over time. Br J Haematol. 2006 135 : 683 7.
-
(2006)
Br J Haematol.
, vol.135
, pp. 683-687
-
-
Lasho, T.L.1
Pardanani, A.2
McClure, R.F.3
Mesa, R.A.4
Levine, R.L.5
Gary Gilliland, D.6
Tefferi, A.7
-
194
-
-
31544477194
-
The clinical phenotype of wild-type, heterozygous, and homozygous JAK2V617F in polycythemia vera
-
Tefferi A, Lasho TL, Schwager SM, Strand JS, Elliott M, Mesa R, Li CY, Wadleigh M, Lee SJ, Gilliland DG. The clinical phenotype of wild-type, heterozygous, and homozygous JAK2V617F in polycythemia vera. Cancer. 2006 106 : 631 5.
-
(2006)
Cancer.
, vol.106
, pp. 631-635
-
-
Tefferi, A.1
Lasho, T.L.2
Schwager, S.M.3
Strand, J.S.4
Elliott, M.5
Mesa, R.6
Li, C.Y.7
Wadleigh, M.8
Lee, S.J.9
Gilliland, D.G.10
-
195
-
-
34548136101
-
Prospective identification of high-risk polycythemia vera patients based on JAK2(V617F) allele burden
-
Vannucchi AM, Antonioli E, Guglielmelli P, Longo G, Pancrazzi A, Ponziani V, Bogani C, Ferrini PR, Rambaldi A, Guerini V, Bosi A, Barbui T. Prospective identification of high-risk polycythemia vera patients based on JAK2(V617F) allele burden. Leukemia. 2007 21 : 1952 9.
-
(2007)
Leukemia.
, vol.21
, pp. 1952-1959
-
-
Vannucchi, A.M.1
Antonioli, E.2
Guglielmelli, P.3
Longo, G.4
Pancrazzi, A.5
Ponziani, V.6
Bogani, C.7
Ferrini, P.R.8
Rambaldi, A.9
Guerini, V.10
Bosi, A.11
Barbui, T.12
-
196
-
-
27744606173
-
JAK2 mutation in essential thrombocythaemia: Clinical associations and long-term prognostic relevance
-
Wolanskyj AP, Lasho TL, Schwager SM, McClure RF, Wadleigh M, Lee SJ, Gary Gilliland D, Tefferi A. JAK2 mutation in essential thrombocythaemia: clinical associations and long-term prognostic relevance. Br J Haematol. 2005 131 : 208 13.
-
(2005)
Br J Haematol.
, vol.131
, pp. 208-213
-
-
Wolanskyj, A.P.1
Lasho, T.L.2
Schwager, S.M.3
McClure, R.F.4
Wadleigh, M.5
Lee, S.J.6
Gary Gilliland, D.7
Tefferi, A.8
-
197
-
-
27144443646
-
Clinical implications of the JAK2 V617F mutation in essential thrombocythemia
-
Antonioli E, Guglielmelli P, Pancrazzi A, Bogani C, Verrucci M, Ponziani V, Longo G, Bosi A, Vannucchi AM. Clinical implications of the JAK2 V617F mutation in essential thrombocythemia. Leukemia. 2005 19 : 1847 9.
-
(2005)
Leukemia.
, vol.19
, pp. 1847-1849
-
-
Antonioli, E.1
Guglielmelli, P.2
Pancrazzi, A.3
Bogani, C.4
Verrucci, M.5
Ponziani, V.6
Longo, G.7
Bosi, A.8
Vannucchi, A.M.9
-
198
-
-
28244442441
-
Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: A prospective study
-
Campbell PJ, Scott LM, Buck G, Wheatley K, East CL, Marsden JT, Duffy A, Boyd EM, Bench AJ, Scott MA, Vassiliou GS, Milligan DW, Smith SR, Erber WN, Bareford D, Wilkins BS, Reilly JT, Harrison CN, Green AR. Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study. Lancet. 2005 366 : 1945 53.
-
(2005)
Lancet.
, vol.366
, pp. 1945-1953
-
-
Campbell, P.J.1
Scott, L.M.2
Buck, G.3
Wheatley, K.4
East, C.L.5
Marsden, J.T.6
Duffy, A.7
Boyd, E.M.8
Bench, A.J.9
Scott, M.A.10
Vassiliou, G.S.11
Milligan, D.W.12
Smith, S.R.13
Erber, W.N.14
Bareford, D.15
Wilkins, B.S.16
Reilly, J.T.17
Harrison, C.N.18
Green, A.R.19
-
199
-
-
30844444135
-
The JAK2 tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: Lineage specificity and clinical correlates
-
Tefferi A, Lasho TL, Schwager SM, Steensma DP, Mesa RA, Li CY, Wadleigh M, Gary Gilliland D. The JAK2 tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates. Br J Haematol. 2005 131 : 320 8.
-
(2005)
Br J Haematol.
, vol.131
, pp. 320-328
-
-
Tefferi, A.1
Lasho, T.L.2
Schwager, S.M.3
Steensma, D.P.4
Mesa, R.A.5
Li, C.Y.6
Wadleigh, M.7
Gary Gilliland, D.8
-
200
-
-
37049039725
-
JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis
-
Barosi G, Bergamaschi G, Marchetti M, Vannucchi AM, Guglielmelli P, Antonioli E, Massa M, Rosti V, Campanelli R, Villani L, Viarengo G, Gattoni E, Gerli G, Specchia G, Tinelli C, Rambaldi A, Barbui T. JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis. Blood. 2007 110 : 4030 6.
-
(2007)
Blood.
, vol.110
, pp. 4030-4036
-
-
Barosi, G.1
Bergamaschi, G.2
Marchetti, M.3
Vannucchi, A.M.4
Guglielmelli, P.5
Antonioli, E.6
Massa, M.7
Rosti, V.8
Campanelli, R.9
Villani, L.10
Viarengo, G.11
Gattoni, E.12
Gerli, G.13
Specchia, G.14
Tinelli, C.15
Rambaldi, A.16
Barbui, T.17
-
201
-
-
33744505451
-
Prevalence of the activating JAK2 tyrosine kinase mutation V617F in the Budd-Chiari Syndrome
-
Patel RK, Lea NC, Heneghan MA, Westwood NB, Milojkovic D, Thanigaikumar M, Yallop D, Arya R, Pagliuca A, Gaken J, Wendon J, Heaton ND, Mufti GJ. Prevalence of the activating JAK2 tyrosine kinase mutation V617F in the Budd-Chiari Syndrome. Gastroenterology. 2006 130 : 2031 8.
-
(2006)
Gastroenterology.
, vol.130
, pp. 2031-2038
-
-
Patel, R.K.1
Lea, N.C.2
Heneghan, M.A.3
Westwood, N.B.4
Milojkovic, D.5
Thanigaikumar, M.6
Yallop, D.7
Arya, R.8
Pagliuca, A.9
Gaken, J.10
Wendon, J.11
Heaton, N.D.12
Mufti, G.J.13
-
202
-
-
33344471678
-
V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis
-
Campbell PJ, Griesshammer M, Dohner K, Dohner H, Kusec R, Hasselbalch HC, Larsen TS, Pallisgaard N, Giraudier S, Le Bousse-Kerdiles MC, Desterke C, Guerton B, Dupriez B, Bordessoule D, Fenaux P, Kiladjian JJ, Viallard JF, Briere J, Harrison CN, Green AR, Reilly JT. V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis. Blood. 2006 107 : 2098 100.
-
(2006)
Blood.
, vol.107
, pp. 2098-2100
-
-
Campbell, P.J.1
Griesshammer, M.2
Dohner, K.3
Dohner, H.4
Kusec, R.5
Hasselbalch, H.C.6
Larsen, T.S.7
Pallisgaard, N.8
Giraudier, S.9
Le Bousse-Kerdiles, M.C.10
Desterke, C.11
Guerton, B.12
Dupriez, B.13
Bordessoule, D.14
Fenaux, P.15
Kiladjian, J.J.16
Viallard, J.F.17
Briere, J.18
Harrison, C.N.19
Green, A.R.20
Reilly, J.T.21
more..
-
203
-
-
42449124578
-
Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival
-
Tefferi A, Lasho TL, Huang J, Finke C, Mesa RA, Li CY, Wu W, Hanson CA, Pardanani A. Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival. Leukemia. 2008 22 : 756 61.
-
(2008)
Leukemia.
, vol.22
, pp. 756-761
-
-
Tefferi, A.1
Lasho, T.L.2
Huang, J.3
Finke, C.4
Mesa, R.A.5
Li, C.Y.6
Wu, W.7
Hanson, C.A.8
Pardanani, A.9
-
204
-
-
38349053791
-
JAK2 inhibitor therapy in myeloproliferative disorders: Rationale, preclinical studies and ongoing clinical trials
-
Pardanani A. JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials. Leukemia. 2008 22 : 23 30.
-
(2008)
Leukemia.
, vol.22
, pp. 23-30
-
-
Pardanani, A.1
-
205
-
-
49449100990
-
TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation negative patients
-
Lasho TL, Tefferi A, Hood JD, Verstovsek S, Gilliland DG, Pardanani A. TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation negative patients. Leukemia. 2008 22 : 1790 2.
-
(2008)
Leukemia.
, vol.22
, pp. 1790-1792
-
-
Lasho, T.L.1
Tefferi, A.2
Hood, J.D.3
Verstovsek, S.4
Gilliland, D.G.5
Pardanani, A.6
-
206
-
-
39749141118
-
A phase i study of XL019, a selective JAK2 inhibitor, in patients with primary myelofibrosis and post-polycythemia vera/essential thrombocythemia myelofibrosis
-
Verstovsek S, Pardanani AD, Shah NP, Sokol L, Wadleigh M, Gilliland DG, List AF, Tefferi A, Kantarjian HM, Bui LA, Clary DO. A phase I study of XL019, a selective JAK2 inhibitor, in patients with primary myelofibrosis and post-polycythemia vera/essential thrombocythemia myelofibrosis. ASH Ann Meet Abstr. 2007 110 : 553.
-
(2007)
ASH Ann Meet Abstr.
, vol.110
, pp. 553
-
-
Verstovsek, S.1
Pardanani, A.D.2
Shah, N.P.3
Sokol, L.4
Wadleigh, M.5
Gilliland, D.G.6
List, A.F.7
Tefferi, A.8
Kantarjian, H.M.9
Bui, L.A.10
Clary, D.O.11
-
207
-
-
47049098437
-
Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders
-
Hexner EO, Serdikoff C, Jan M, Swider CR, Robinson C, Yang S, Angeles T, Emerson SG, Carroll M, Ruggeri B, Dobrzanski P. Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders. Blood. 2008 111 : 5663 71.
-
(2008)
Blood.
, vol.111
, pp. 5663-5671
-
-
Hexner, E.O.1
Serdikoff, C.2
Jan, M.3
Swider, C.R.4
Robinson, C.5
Yang, S.6
Angeles, T.7
Emerson, S.G.8
Carroll, M.9
Ruggeri, B.10
Dobrzanski, P.11
-
208
-
-
77950917992
-
SB1518: A potent and orally active JAK2 inhibitor for the treatment of myeloproliferative disorders
-
Goh KC, Ong WC, Hu C, Hentze H, Liang AL, Stunkel W, Tan YC, Sangthongpitag K, Goh SK, Sieh S, Bonday ZQ, William AD, Lee A, Llanchard S, Liu TC, Sattler M, Griffin JD, Dymock BW, Kantharaj E, Wood JM. SB1518: a potent and orally active JAK2 inhibitor for the treatment of myeloproliferative disorders. Blood. 2007 110 : 165a 6a.
-
(2007)
Blood.
, vol.110
-
-
Goh, K.C.1
Ong, W.C.2
Hu, C.3
Hentze, H.4
Liang, A.L.5
Stunkel, W.6
Tan, Y.C.7
Sangthongpitag, K.8
Goh, S.K.9
Sieh, S.10
Bonday, Z.Q.11
William, A.D.12
Lee, A.13
Llanchard, S.14
Liu, T.C.15
Sattler, M.16
Griffin, J.D.17
Dymock, B.W.18
Kantharaj, E.19
Wood, J.M.20
more..
-
209
-
-
34447627350
-
TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations
-
Pardanani A, Hood J, Lasho T, Levine RL, Martin MB, Noronha G, Finke C, Mak CC, Mesa R, Zhu H, Soll R, Gilliland DG, Tefferi A. TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia. 2007 21 : 1658 68.
-
(2007)
Leukemia.
, vol.21
, pp. 1658-1668
-
-
Pardanani, A.1
Hood, J.2
Lasho, T.3
Levine, R.L.4
Martin, M.B.5
Noronha, G.6
Finke, C.7
Mak, C.C.8
Mesa, R.9
Zhu, H.10
Soll, R.11
Gilliland, D.G.12
Tefferi, A.13
-
210
-
-
49449100990
-
Primary cell experiments with TG101348, a JAK2-selective inhibitor, in the presence of myeloproliferative disorder-associated JAK2V617F, MPLW515L/K, and JAK2 exon 12 mutations
-
Lasho TL, Finke C, Hood JD, Soll R, Noronha G, Mesa RA, Jamieson C, Verstovsek S, Cortes J, Kantarjian H, Gilliland DG, Tefferi A, Pardanani A. Primary cell experiments with TG101348, a JAK2-selective inhibitor, in the presence of myeloproliferative disorder-associated JAK2V617F, MPLW515L/K, and JAK2 exon 12 mutations. Leukemia. 2008 22 : 1790 2.
-
(2008)
Leukemia.
, vol.22
, pp. 1790-1792
-
-
Lasho, T.L.1
Finke, C.2
Hood, J.D.3
Soll, R.4
Noronha, G.5
Mesa, R.A.6
Jamieson, C.7
Verstovsek, S.8
Cortes, J.9
Kantarjian, H.10
Gilliland, D.G.11
Tefferi, A.12
Pardanani, A.13
-
211
-
-
41249099841
-
Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera
-
Wernig G, Kharas MG, Okabe R, Moore SA, Leeman DS, Cullen DE, Gozo M, McDowell EP, Levine RL, Doukas J, Mak CC, Noronha G, Martin M, Ko YD, Lee BH, Soll R, Tefferi A, Hood JD, Gilliland DG. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell. 2008 13 : 311 20.
-
(2008)
Cancer Cell.
, vol.13
, pp. 311-320
-
-
Wernig, G.1
Kharas, M.G.2
Okabe, R.3
Moore, S.A.4
Leeman, D.S.5
Cullen, D.E.6
Gozo, M.7
McDowell, E.P.8
Levine, R.L.9
Doukas, J.10
Mak, C.C.11
Noronha, G.12
Martin, M.13
Ko, Y.D.14
Lee, B.H.15
Soll, R.16
Tefferi, A.17
Hood, J.D.18
Gilliland, D.G.19
-
212
-
-
41249098776
-
Selective inhibition of JAK2 driven erythroid differentiation of polycythemia vera progenitors
-
Geron I, Abrahamsson A, Barroga C, Kavelerchik E, Gotlib JR, Hood JD, Durocher J, Mak CC, Noronha G, Soll R, Tefferi A, Kaushansky K, Jamieson CHM. Selective inhibition of JAK2 driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell. 2008 13 : 321 30.
-
(2008)
Cancer Cell.
, vol.13
, pp. 321-330
-
-
Geron, I.1
Abrahamsson, A.2
Barroga, C.3
Kavelerchik, E.4
Gotlib, J.R.5
Hood, J.D.6
Durocher, J.7
Mak, C.C.8
Noronha, G.9
Soll, R.10
Tefferi, A.11
Kaushansky, K.12
Jamieson, C.H.M.13
-
213
-
-
39749118802
-
INCB018424, an oral, selective JAK2 inhibitor, shows significant clinical activity in a phase I/II study in patients with primary myelofibrosis (PMF) and post polycythemia vera/essential thrombocythemia myelofibrosis (post-PV/ET MF)
-
Verstovsek S, Kantarjian H, Pardanani A, Thomas D, Cortes J, Mesa R, Redman J, Staschen C-M, Fridman J, Vaddi K, Tefferi A. INCB018424, an oral, selective JAK2 inhibitor, shows significant clinical activity in a phase I/II study in patients with primary myelofibrosis (PMF) and post polycythemia vera/essential thrombocythemia myelofibrosis (post-PV/ET MF). ASH Annu Meet Abstr. 2007 110 : 558.
-
(2007)
ASH Annu Meet Abstr.
, vol.110
, pp. 558
-
-
Verstovsek, S.1
Kantarjian, H.2
Pardanani, A.3
Thomas, D.4
Cortes, J.5
Mesa, R.6
Redman, J.7
Staschen, C.-M.8
Fridman, J.9
Vaddi, K.10
Tefferi, A.11
-
214
-
-
44349110913
-
Phase II study of CEP701, an orally available JAK2 inhibitor, in patients with primary myelofibrosis and post polycythemia vera/essential thrombocythemia myelofi-brosis
-
Verstovsek S, Tefferi A, Kornblau S, Thomas D, Cortes J, Ravandi-Kashani F, Garcia-Manero G, Kantarjian H. Phase II study of CEP701, an orally available JAK2 inhibitor, in patients with primary myelofibrosis and post polycythemia vera/essential thrombocythemia myelofi-brosis. ASH Annu Meet Abstr. 2007 110 : 3543.
-
(2007)
ASH Annu Meet Abstr.
, vol.110
, pp. 3543
-
-
Verstovsek, S.1
Tefferi, A.2
Kornblau, S.3
Thomas, D.4
Cortes, J.5
Ravandi-Kashani, F.6
Garcia-Manero, G.7
Kantarjian, H.8
-
215
-
-
0028229976
-
Ligand-inde-pendent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation
-
Tsujimura T, Furitsu T, Morimoto M, Isozaki K, Nomura S, Matsuzawa Y, Kitamura Y, Kanakura Y. Ligand-inde-pendent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation. Blood. 1994 83 : 2619 26.
-
(1994)
Blood.
, vol.83
, pp. 2619-2626
-
-
Tsujimura, T.1
Furitsu, T.2
Morimoto, M.3
Isozaki, K.4
Nomura, S.5
Matsuzawa, Y.6
Kitamura, Y.7
Kanakura, Y.8
-
216
-
-
0028856070
-
Identification of a point mutation in the catalytic domain of the pro-tooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder
-
Nagata H, Worobec AS, Oh CK, Chowdhury BA, Tannenbaum S, Suzuki Y, Metcalfe DD. Identification of a point mutation in the catalytic domain of the pro-tooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci USA. 1995 92 : 10560 4.
-
(1995)
Proc Natl Acad Sci USA.
, vol.92
, pp. 10560-10564
-
-
Nagata, H.1
Worobec, A.S.2
Oh, C.K.3
Chowdhury, B.A.4
Tannenbaum, S.5
Suzuki, Y.6
Metcalfe, D.D.7
-
217
-
-
18744382426
-
C-kit Mutations in patients with childhood-onset mastocytosis and geno-type-phenotype correlation
-
Yanagihori H, Oyama N, Nakamura K, Kaneko F. c-kit Mutations in patients with childhood-onset mastocytosis and geno-type-phenotype correlation. J Mol Diagn. 2005 7 : 252 7.
-
(2005)
J Mol Diagn.
, vol.7
, pp. 252-257
-
-
Yanagihori, H.1
Oyama, N.2
Nakamura, K.3
Kaneko, F.4
-
218
-
-
0032456567
-
Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: A possible explanation for divergent clinical behavior
-
Buttner C, Henz BM, Welker P, Sepp NT, Grabbe J. Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: a possible explanation for divergent clinical behavior. J Invest Dermatol. 1998 111 : 1227 31.
-
(1998)
J Invest Dermatol.
, vol.111
, pp. 1227-1231
-
-
Buttner, C.1
Henz, B.M.2
Welker, P.3
Sepp, N.T.4
Grabbe, J.5
-
219
-
-
13044305857
-
Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis
-
Longley BJ Jr., Metcalfe DD, Tharp M, Wang X, Tyrrell L, Lu SZ, Heitjan D, Ma Y. Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis. Proc Natl Acad Sci USA. 1999 96 : 1609 14.
-
(1999)
Proc Natl Acad Sci USA.
, vol.96
, pp. 1609-1614
-
-
Longley Jr., B.J.1
Metcalfe, D.D.2
Tharp, M.3
Wang, X.4
Tyrrell, L.5
Lu, S.Z.6
Heitjan, D.7
Ma, Y.8
-
220
-
-
0009013631
-
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: Establishment of clonality in a human mast cell neoplasm
-
Longley BJ, Tyrrell L, Lu SZ, Ma YS, Langley K, Ding TG, Duffy T, Jacobs P, Tang LH, Modlin I. Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat Genet. 1996 12 : 312 4.
-
(1996)
Nat Genet.
, vol.12
, pp. 312-314
-
-
Longley, B.J.1
Tyrrell, L.2
Lu, S.Z.3
Ma, Y.S.4
Langley, K.5
Ding, T.G.6
Duffy, T.7
Jacobs, P.8
Tang, L.H.9
Modlin, I.10
-
221
-
-
0031039992
-
A new c-kit mutation in a case of aggressive mast cell disease
-
Pignon JM, Giraudier S, Duquesnoy P, Jouault H, Imbert M, Vainchenker W, Vernant JP, Tulliez M. A new c-kit mutation in a case of aggressive mast cell disease. Br J Haematol. 1997 96 : 374 6.
-
(1997)
Br J Haematol.
, vol.96
, pp. 374-376
-
-
Pignon, J.M.1
Giraudier, S.2
Duquesnoy, P.3
Jouault, H.4
Imbert, M.5
Vainchenker, W.6
Vernant, J.P.7
Tulliez, M.8
-
222
-
-
1842579440
-
A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib
-
Akin C, Fumo G, Yavuz AS, Lipsky PE, Neckers L, Metcalfe DD. A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib. Blood. 2004 103 : 3222 5.
-
(2004)
Blood.
, vol.103
, pp. 3222-3225
-
-
Akin, C.1
Fumo, G.2
Yavuz, A.S.3
Lipsky, P.E.4
Neckers, L.5
Metcalfe, D.D.6
-
223
-
-
33749368009
-
KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: A prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients
-
Garcia-Montero AC, Jara-Acevedo M, Teodosio C, Sanchez ML, Nunez R, Prados A, Aldanondo I, Sanchez L, Dominguez M, Botana LM, Sanchez-Jimenez F, Sotlar K, Almeida J, Escribano L, Orfao A. KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients. Blood. 2006 108 : 2366 72.
-
(2006)
Blood.
, vol.108
, pp. 2366-2372
-
-
Garcia-Montero, A.C.1
Jara-Acevedo, M.2
Teodosio, C.3
Sanchez, M.L.4
Nunez, R.5
Prados, A.6
Aldanondo, I.7
Sanchez, L.8
Dominguez, M.9
Botana, L.M.10
Sanchez-Jimenez, F.11
Sotlar, K.12
Almeida, J.13
Escribano, L.14
Orfao, A.15
-
224
-
-
38349179274
-
Sensitive and reliable detection of Kit point mutation Asp 816 to Val in pathological material
-
Kahler C, Didlaukat S, Feller AC, Merz H. Sensitive and reliable detection of Kit point mutation Asp 816 to Val in pathological material. Diagn Pathol. 2007 2 : 37.
-
(2007)
Diagn Pathol.
, vol.2
, pp. 37
-
-
Kahler, C.1
Didlaukat, S.2
Feller, A.C.3
Merz, H.4
-
225
-
-
0032948780
-
Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms
-
Ma Y, Longley BJ, Wang X, Blount JL, Langley K, Caughey GH. Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms. J Invest Dermatol. 1999 112 : 165 70.
-
(1999)
J Invest Dermatol.
, vol.112
, pp. 165-170
-
-
Ma, Y.1
Longley, B.J.2
Wang, X.3
Blount, J.L.4
Langley, K.5
Caughey, G.H.6
-
226
-
-
2742529418
-
Human protooncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand
-
Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A. Human protooncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 1987 6 : 3341 51.
-
(1987)
EMBO J.
, vol.6
, pp. 3341-3351
-
-
Yarden, Y.1
Kuang, W.J.2
Yang-Feng, T.3
Coussens, L.4
Munemitsu, S.5
Dull, T.J.6
Chen, E.7
Schlessinger, J.8
Francke, U.9
Ullrich, A.10
-
227
-
-
0023919865
-
Localization of the human c-kit pro-tooncogene on the q11-q12 region of chromosome 4
-
d'Auriol L, Mattei MG, Andre C, Galibert F. Localization of the human c-kit pro-tooncogene on the q11-q12 region of chromosome 4. Hum Genet. 1988 78 : 374 6.
-
(1988)
Hum Genet.
, vol.78
, pp. 374-376
-
-
D'Auriol, L.1
Mattei, M.G.2
Andre, C.3
Galibert, F.4
-
228
-
-
27744551009
-
Structure and regulation of Kit protein-tyrosine kinase-the stem cell factor receptor
-
Roskoski R Jr. Structure and regulation of Kit protein-tyrosine kinase-the stem cell factor receptor. Biochem Biophys Res Commun. 2005 338 : 1307 15.
-
(2005)
Biochem Biophys Res Commun.
, vol.338
, pp. 1307-1315
-
-
Roskoski Jr., R.1
-
229
-
-
0025828970
-
Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter
-
Geissler EN, Liao M, Brook JD, Martin FH, Zsebo KM, Housman DE, Galli SJ. Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter. Somat Cell Mol Genet. 1991 17 : 207 14.
-
(1991)
Somat Cell Mol Genet.
, vol.17
, pp. 207-214
-
-
Geissler, E.N.1
Liao, M.2
Brook, J.D.3
Martin, F.H.4
Zsebo, K.M.5
Housman, D.E.6
Galli, S.J.7
-
230
-
-
0025065459
-
Primary structure and functional expression of rat and human stem cell factor DNAs
-
Martin FH, Suggs SV, Langley KE, Lu HS, Ting J, Okino KH, Morris CF, McNiece IK, Jacobsen FW, Mendiaz EA. Primary structure and functional expression of rat and human stem cell factor DNAs. Cell. 1990 63 : 203 11.
-
(1990)
Cell.
, vol.63
, pp. 203-211
-
-
Martin, F.H.1
Suggs, S.V.2
Langley, K.E.3
Lu, H.S.4
Ting, J.5
Okino, K.H.6
Morris, C.F.7
McNiece, I.K.8
Jacobsen, F.W.9
Mendiaz, E.A.10
-
231
-
-
0026539871
-
Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization
-
Mathew S, Murty VV, Hunziker W, Chaganti RS. Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization. Genomics. 1992 14 : 775 9.
-
(1992)
Genomics.
, vol.14
, pp. 775-779
-
-
Mathew, S.1
Murty, V.V.2
Hunziker, W.3
Chaganti, R.S.4
-
232
-
-
23944452835
-
KIT (CD117): A review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation
-
Miettinen M, Lasota J. KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol. 2005 13 : 205 20.
-
(2005)
Appl Immunohistochem Mol Morphol.
, vol.13
, pp. 205-220
-
-
Miettinen, M.1
Lasota, J.2
-
233
-
-
9744246909
-
Signal transduction viathe stem cell factor receptor/c-Kit
-
Ronnstrand L. Signal transduction viathe stem cell factor receptor/c-Kit. Cell Mol Life Sci. 2004 61 : 2535 48.
-
(2004)
Cell Mol Life Sci.
, vol.61
, pp. 2535-2548
-
-
Ronnstrand, L.1
-
234
-
-
0033956308
-
Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mas-tocytosis
-
Akin C, Kirshenbaum AS, Semere T, Worobec AS, Scott LM, Metcalfe DD. Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mas-tocytosis. Exp Hematol. 2000 28 : 140 7.
-
(2000)
Exp Hematol.
, vol.28
, pp. 140-147
-
-
Akin, C.1
Kirshenbaum, A.S.2
Semere, T.3
Worobec, A.S.4
Scott, L.M.5
Metcalfe, D.D.6
-
235
-
-
0037100321
-
Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene
-
Yavuz AS, Lipsky PE, Yavuz S, Metcalfe DD, Akin C. Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene. Blood. 2002 100 : 661 5.
-
(2002)
Blood.
, vol.100
, pp. 661-665
-
-
Yavuz, A.S.1
Lipsky, P.E.2
Yavuz, S.3
Metcalfe, D.D.4
Akin, C.5
-
236
-
-
8744225522
-
Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis
-
Taylor ML, Sehgal D, Raffeld M, Obiakor H, Akin C, Mage RG, Metcalfe DD. Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis. J Mol Diagn. 2004 6 : 335 42.
-
(2004)
J Mol Diagn.
, vol.6
, pp. 335-342
-
-
Taylor, M.L.1
Sehgal, D.2
Raffeld, M.3
Obiakor, H.4
Akin, C.5
Mage, R.G.6
Metcalfe, D.D.7
-
237
-
-
0029962928
-
A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenic-ity, and differentiation of mast cells
-
Piao X, Bernstein A. A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenic-ity, and differentiation of mast cells. Blood. 1996 87 : 3117 23.
-
(1996)
Blood.
, vol.87
, pp. 3117-3123
-
-
Piao, X.1
Bernstein, A.2
-
238
-
-
10144261890
-
Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase
-
Kitayama H, Tsujimura T, Matsumura I, Oritani K, Ikeda H, Ishikawa J, Okabe M, Suzuki M, Yamamura K, Matsuzawa Y, Kitamura Y, Kanakura Y. Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase. Blood. 1996 88 : 995 1004.
-
(1996)
Blood.
, vol.88
, pp. 995-1004
-
-
Kitayama, H.1
Tsujimura, T.2
Matsumura, I.3
Oritani, K.4
Ikeda, H.5
Ishikawa, J.6
Okabe, M.7
Suzuki, M.8
Yamamura, K.9
Matsuzawa, Y.10
Kitamura, Y.11
Kanakura, Y.12
-
239
-
-
29144489542
-
Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation
-
Zappulla JP, Dubreuil P, Desbois S, Letard S, Hamouda NB, Daeron M, Delsol G, Arock M, Liblau RS. Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation. J Exp Med. 2005 202 : 1635 41.
-
(2005)
J Exp Med.
, vol.202
, pp. 1635-1641
-
-
Zappulla, J.P.1
Dubreuil, P.2
Desbois, S.3
Letard, S.4
Hamouda, N.B.5
Daeron, M.6
Delsol, G.7
Arock, M.8
Liblau, R.S.9
-
240
-
-
0346035004
-
Constitutively active mutant D816VKit induces megakayocyte and mast cell differentiation of early haemopoietic cells from murine foetal liver
-
Ferrao PT, Gonda TJ, Ashman LK. Constitutively active mutant D816VKit induces megakayocyte and mast cell differentiation of early haemopoietic cells from murine foetal liver. Leuk Res. 2003 27 : 547 55.
-
(2003)
Leuk Res.
, vol.27
, pp. 547-555
-
-
Ferrao, P.T.1
Gonda, T.J.2
Ashman, L.K.3
-
241
-
-
0035883061
-
The Kit-activating mutation D816V enhances stem cell factor- dependent chemotaxis
-
Taylor ML, Dastych J, Sehgal D, Sundstrom M, Nilsson G, Akin C, Mage RG, Metcalfe DD. The Kit-activating mutation D816V enhances stem cell factor- dependent chemotaxis. Blood. 2001 98 : 1195 9.
-
(2001)
Blood.
, vol.98
, pp. 1195-1199
-
-
Taylor, M.L.1
Dastych, J.2
Sehgal, D.3
Sundstrom, M.4
Nilsson, G.5
Akin, C.6
Mage, R.G.7
Metcalfe, D.D.8
-
242
-
-
0028895383
-
Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells
-
Serve H, Yee NS, Stella G, Sepp-Lorenzino L, Tan JC, Besmer P. Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J. 1995 14 : 473 83.
-
(1995)
EMBO J.
, vol.14
, pp. 473-483
-
-
Serve, H.1
Yee, N.S.2
Stella, G.3
Sepp-Lorenzino, L.4
Tan, J.C.5
Besmer, P.6
-
243
-
-
0032476674
-
Kit signaling through PI 3-kinase and Src kinase pathways: An essential role for Rac1 and JNK activation in mast cell proliferation
-
Timokhina I, Kissel H, Stella G, Besmer P. Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation. EMBO J. 1998 17 : 6250 62.
-
(1998)
EMBO J.
, vol.17
, pp. 6250-6262
-
-
Timokhina, I.1
Kissel, H.2
Stella, G.3
Besmer, P.4
-
244
-
-
14944351399
-
PKCdelta plays opposite roles in growth mediated by wild-type Kit and an oncogenic Kit mutant
-
Jelacic T, Linnekin D. PKCdelta plays opposite roles in growth mediated by wild-type Kit and an oncogenic Kit mutant. Blood. 2005 105 : 1923 9.
-
(2005)
Blood.
, vol.105
, pp. 1923-1929
-
-
Jelacic, T.1
Linnekin, D.2
-
245
-
-
38549089581
-
Activity of imatinib in systemic mastocyto-sis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion
-
Lahortiga I, Akin C, Cools J, Wilson TM, Mentens N, Arthur DC, Maric I, Noel P, Kocabas C, Marynen P, Lessin LS, Wlodarska I, Robyn J, Metcalfe DD. Activity of imatinib in systemic mastocyto-sis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion. Haematologica. 2008 93 : 49 56.
-
(2008)
Haematologica.
, vol.93
, pp. 49-56
-
-
Lahortiga, I.1
Akin, C.2
Cools, J.3
Wilson, T.M.4
Mentens, N.5
Arthur, D.C.6
Maric, I.7
Noel, P.8
Kocabas, C.9
Marynen, P.10
Lessin, L.S.11
Wlodarska, I.12
Robyn, J.13
Metcalfe, D.D.14
-
246
-
-
15244341289
-
A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors
-
Tanaka A, Konno M, Muto S, Kambe N, Morii E, Nakahata T, Itai A, Matsuda H. A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Blood. 2005 105 : 2324 31.
-
(2005)
Blood.
, vol.105
, pp. 2324-2331
-
-
Tanaka, A.1
Konno, M.2
Muto, S.3
Kambe, N.4
Morii, E.5
Nakahata, T.6
Itai, A.7
Matsuda, H.8
-
247
-
-
33746611521
-
Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells
-
Gabillot-Carre M, Lepelletier Y, Humbert M, de Sepuvelda P, Hamouda NB, Zappulla JP, Liblau R, Ribadeau-Dumas A, Machavoine F, Letard S, Baude C, Hermant A, Yang Y, Vargaftig J, Bodemer C, Morelon E, Lortholary O, Recher C, Laurent G, Dy M, Arock M, Dubreuil P, Hermine O. Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells. Blood. 2006 108 : 1065 72.
-
(2006)
Blood.
, vol.108
, pp. 1065-1072
-
-
Gabillot-Carre, M.1
Lepelletier, Y.2
Humbert, M.3
De Sepuvelda, P.4
Hamouda, N.B.5
Zappulla, J.P.6
Liblau, R.7
Ribadeau-Dumas, A.8
MacHavoine, F.9
Letard, S.10
Baude, C.11
Hermant, A.12
Yang, Y.13
Vargaftig, J.14
Bodemer, C.15
Morelon, E.16
Lortholary, O.17
Recher, C.18
Laurent, G.19
Dy, M.20
Arock, M.21
Dubreuil, P.22
Hermine, O.23
more..
-
248
-
-
33846019211
-
EXEL-0862, a novel tyrosine kinase inhibitor, induces apoptosis in vitro and ex vivoin human mast cells expressing the KIT D816V mutation
-
Pan J, Quintas-Cardama A, Kantarjian HM, Akin C, Manshouri T, Lamb P, Cortes JE, Tefferi A, Giles FJ, Verstovsek S. EXEL-0862, a novel tyrosine kinase inhibitor, induces apoptosis in vitro and ex vivoin human mast cells expressing the KIT D816V mutation. Blood. 2007 109 : 315 22.
-
(2007)
Blood.
, vol.109
, pp. 315-322
-
-
Pan, J.1
Quintas-Cardama, A.2
Kantarjian, H.M.3
Akin, C.4
Manshouri, T.5
Lamb, P.6
Cortes, J.E.7
Tefferi, A.8
Giles, F.J.9
Verstovsek, S.10
-
249
-
-
34347253239
-
Sensitivity of human cells bearing onco-genic mutant kit isoforms to the novel tyrosine kinase inhibitor INNO-406
-
Pan J, Quintas-Cardama A, Manshouri T, Cortes J, Kantarjian H, Verstovsek S. Sensitivity of human cells bearing onco-genic mutant kit isoforms to the novel tyrosine kinase inhibitor INNO-406. Cancer Sci. 2007 98 : 1223 5.
-
(2007)
Cancer Sci.
, vol.98
, pp. 1223-1225
-
-
Pan, J.1
Quintas-Cardama, A.2
Manshouri, T.3
Cortes, J.4
Kantarjian, H.5
Verstovsek, S.6
-
250
-
-
0344987886
-
Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit recep-tors found in mast cell neoplasms
-
Zermati Y, De Sepulveda P, Feger F, Letard S, Kersual J, Casteran N, Gorochov G, Dy M, Ribadeau Dumas A, Dorgham K, Parizot C, Bieche Y, Vidaud M, Lortholary O, Arock M, Hermine O, Dubreuil P. Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit recep-tors found in mast cell neoplasms. Oncogene. 2003 22 : 660 4.
-
(2003)
Oncogene.
, vol.22
, pp. 660-664
-
-
Zermati, Y.1
De Sepulveda, P.2
Feger, F.3
Letard, S.4
Kersual, J.5
Casteran, N.6
Gorochov, G.7
Dy, M.8
Ribadeau Dumas, A.9
Dorgham, K.10
Parizot, C.11
Bieche, Y.12
Vidaud, M.13
Lortholary, O.14
Arock, M.15
Hermine, O.16
Dubreuil, P.17
-
251
-
-
0043169405
-
Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit
-
Akin C, Brockow K, D'Ambrosio C, Kirshenbaum AS, Ma Y, Longley BJ, Metcalfe DD. Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit. Exp Hematol. 2003 31 : 686 92.
-
(2003)
Exp Hematol.
, vol.31
, pp. 686-692
-
-
Akin, C.1
Brockow, K.2
D'Ambrosio, C.3
Kirshenbaum, A.S.4
Ma, Y.5
Longley, B.J.6
Metcalfe, D.D.7
-
252
-
-
33947520803
-
Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces ima-tinib-resistant constitutive KIT activation
-
Nakagomi N, Hirota S. Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces ima-tinib-resistant constitutive KIT activation. Lab Invest. 2007 87 : 365 71.
-
(2007)
Lab Invest.
, vol.87
, pp. 365-371
-
-
Nakagomi, N.1
Hirota, S.2
-
253
-
-
0041656424
-
Imatinib for systemic mast-cell disease
-
Pardanani A, Elliott M, Reeder T, Li C Y, Baxter EJ, Cross NC, Tefferi A. Imatinib for systemic mast-cell disease. Lancet. 2003 362 : 535 6.
-
(2003)
Lancet.
, vol.362
, pp. 535-536
-
-
Pardanani, A.1
Elliott, M.2
Reeder, T.3
Li, C.Y.4
Baxter, E.J.5
Cross, N.C.6
Tefferi, A.7
-
254
-
-
33745863150
-
Imatinib mesylate in the treatment of systemic mastocytosis: A phase II trial
-
Droogendijk HJ, Kluin-Nelemans HJ, van Doormaal JJ, Oranje AP, van de Loosdrecht AA, van Daele PL. Imatinib mesylate in the treatment of systemic mastocytosis: a phase II trial. Cancer. 2006 107 : 345 51.
-
(2006)
Cancer.
, vol.107
, pp. 345-351
-
-
Droogendijk, H.J.1
Kluin-Nelemans, H.J.2
Van Doormaal, J.J.3
Oranje, A.P.4
Van De Loosdrecht, A.A.5
Van Daele, P.L.6
-
255
-
-
33748114504
-
Effects of AMN107, a novel aminopy-rimidine tyrosine kinase inhibitor, on human mast cells bearing wild-type or mutated codon 816 c-kit
-
Verstovsek S, Akin C, Manshouri T, Quintas-Cardama A, Huynh L, Manley P, Tefferi A, Cortes J, Giles FJ, Kantarjian H. Effects of AMN107, a novel aminopy-rimidine tyrosine kinase inhibitor, on human mast cells bearing wild-type or mutated codon 816 c-kit. Leuk Res. 2006 30 : 1365 70.
-
(2006)
Leuk Res.
, vol.30
, pp. 1365-1370
-
-
Verstovsek, S.1
Akin, C.2
Manshouri, T.3
Quintas-Cardama, A.4
Huynh, L.5
Manley, P.6
Tefferi, A.7
Cortes, J.8
Giles, F.J.9
Kantarjian, H.10
-
256
-
-
26944458584
-
The systemic mastocytosis-specific activating cKit mutation D816V can be inhibited by the tyrosine kinase inhibitor AMN107
-
von Bubnoff N, Gorantla SH, Kancha RK, Lordick F, Peschel C, Duyster J. The systemic mastocytosis-specific activating cKit mutation D816V can be inhibited by the tyrosine kinase inhibitor AMN107. Leukemia. 2005 19 : 1670 1.
-
(2005)
Leukemia.
, vol.19
, pp. 1670-1671
-
-
Von Bubnoff, N.1
Gorantla, S.H.2
Kancha, R.K.3
Lordick, F.4
Peschel, C.5
Duyster, J.6
-
257
-
-
31544459272
-
Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
-
Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY, Bokemeyer C, Deininger MW, Druker BJ, Heinrich MC. Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res. 2006 66 : 473 81.
-
(2006)
Cancer Res.
, vol.66
, pp. 473-481
-
-
Schittenhelm, M.M.1
Shiraga, S.2
Schroeder, A.3
Corbin, A.S.4
Griffith, D.5
Lee, F.Y.6
Bokemeyer, C.7
Deininger, M.W.8
Druker, B.J.9
Heinrich, M.C.10
-
258
-
-
33645687784
-
Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis
-
Shah NP, Lee FY, Luo R, Jiang Y, Donker M, Akin C. Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis. Blood. 2006 108 : 286 91.
-
(2006)
Blood.
, vol.108
, pp. 286-291
-
-
Shah, N.P.1
Lee, F.Y.2
Luo, R.3
Jiang, Y.4
Donker, M.5
Akin, C.6
-
259
-
-
52449085884
-
Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mas-tocytosis
-
Verstovsek S, Tefferi A, Jorge C, O'Brien S, Garcia-Manero G, Pardanani A, Akin C, Faderl S, Thomas D, Kantarjian H. Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mas-tocytosis. Clin Cancer Res. 2008 14 : 3906.
-
(2008)
Clin Cancer Res.
, vol.14
, pp. 3906
-
-
Verstovsek, S.1
Tefferi, A.2
Jorge, C.3
O'Brien, S.4
Garcia-Manero, G.5
Pardanani, A.6
Akin, C.7
Faderl, S.8
Thomas, D.9
Kantarjian, H.10
-
260
-
-
41849136506
-
Dasatinib therapy for systemic mastocyto-sis: Four cases
-
Purtill D, Cooney J, Sinniah R, Carnley B, Cull G, Augustson B, Cannell P. Dasatinib therapy for systemic mastocyto-sis: four cases. Eur J Haematol. 2008 80 : 456 8.
-
(2008)
Eur J Haematol.
, vol.80
, pp. 456-458
-
-
Purtill, D.1
Cooney, J.2
Sinniah, R.3
Carnley, B.4
Cull, G.5
Augustson, B.6
Cannell, P.7
-
261
-
-
22144455380
-
Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412
-
Growney JD, Clark JJ, Adelsperger J, Stone R, Fabbro D, Griffin JD, Gilliland DG. Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412. Blood. 2005 106 : 721 4.
-
(2005)
Blood.
, vol.106
, pp. 721-724
-
-
Growney, J.D.1
Clark, J.J.2
Adelsperger, J.3
Stone, R.4
Fabbro, D.5
Griffin, J.D.6
Gilliland, D.G.7
-
262
-
-
30444446680
-
PKC412 inhibits in vitro growth of neo-plastic human mast cells expressing the D816V-mutated variant of KIT: Comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects
-
Gleixner KV, Mayerhofer M, Aichberger KJ, Derdak S, Sonneck K, Bohm A, Gruze A, Samorapoompichit P, Manley PW, Fabbro D, Pickl WF, Sillaber C, Valent P. PKC412 inhibits in vitro growth of neo-plastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects. Blood. 2006 107 : 752 9.
-
(2006)
Blood.
, vol.107
, pp. 752-759
-
-
Gleixner, K.V.1
Mayerhofer, M.2
Aichberger, K.J.3
Derdak, S.4
Sonneck, K.5
Bohm, A.6
Gruze, A.7
Samorapoompichit, P.8
Manley, P.W.9
Fabbro, D.10
Pickl, W.F.11
Sillaber, C.12
Valent, P.13
-
263
-
-
27144506215
-
Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation
-
Gotlib J, Berube C, Growney JD, Chen CC, George TI, Williams C, Kajiguchi T, Ruan J, Lilleberg SL, Durocher JA, Lichy JH, Wang Y, Cohen PS, Arber DA, Heinrich MC, Neckers L, Galli SJ, Gilliland DG, Coutre SE. Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. Blood. 2005 106 : 2865 70.
-
(2005)
Blood.
, vol.106
, pp. 2865-2870
-
-
Gotlib, J.1
Berube, C.2
Growney, J.D.3
Chen, C.C.4
George, T.I.5
Williams, C.6
Kajiguchi, T.7
Ruan, J.8
Lilleberg, S.L.9
Durocher, J.A.10
Lichy, J.H.11
Wang, Y.12
Cohen, P.S.13
Arber, D.A.14
Heinrich, M.C.15
Neckers, L.16
Galli, S.J.17
Gilliland, D.G.18
Coutre, S.E.19
-
264
-
-
33644868101
-
Multilineage involvement of the fusion gene in patients with FIP1L1/ PDGFRA-positive hypereosinophilic syndrome
-
Robyn J, Lemery S, McCoy JP, Kubofcik J, Kim YJ, Pack S, Nutman TB, Dunbar C, Klion AD. Multilineage involvement of the fusion gene in patients with FIP1L1/ PDGFRA-positive hypereosinophilic syndrome. Br J Haematol. 2006 132 : 286 92.
-
(2006)
Br J Haematol.
, vol.132
, pp. 286-292
-
-
Robyn, J.1
Lemery, S.2
McCoy, J.P.3
Kubofcik, J.4
Kim, Y.J.5
Pack, S.6
Nutman, T.B.7
Dunbar, C.8
Klion, A.D.9
-
265
-
-
3242742988
-
FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia
-
Tefferi A, Lasho TL, Brockman SR, Elliott MA, Dispenzieri A, Pardanani A. FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia. Haematologica. 2004 89 : 871 3.
-
(2004)
Haematologica.
, vol.89
, pp. 871-873
-
-
Tefferi, A.1
Lasho, T.L.2
Brockman, S.R.3
Elliott, M.A.4
Dispenzieri, A.5
Pardanani, A.6
-
266
-
-
0142119964
-
PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRalpha-induced myeloproliferative disease
-
Cools J, Stover EH, Boulton CL, Gotlib J, Legare RD, Amaral SM, Curley DP, Duclos N, Rowan R, Kutok JL, Lee BH, Williams IR, Coutre SE, Stone RM, DeAngelo DJ, Marynen P, Manley PW, Meyer T, Fabbro D, Neuberg D, Weisberg E, Griffin JD, Gilliland DG. PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRalpha-induced myeloproliferative disease. Cancer Cell. 2003 3 : 459 69.
-
(2003)
Cancer Cell.
, vol.3
, pp. 459-469
-
-
Cools, J.1
Stover, E.H.2
Boulton, C.L.3
Gotlib, J.4
Legare, R.D.5
Amaral, S.M.6
Curley, D.P.7
Duclos, N.8
Rowan, R.9
Kutok, J.L.10
Lee, B.H.11
Williams, I.R.12
Coutre, S.E.13
Stone, R.M.14
Deangelo, D.J.15
Marynen, P.16
Manley, P.W.17
Meyer, T.18
Fabbro, D.19
Neuberg, D.20
Weisberg, E.21
Griffin, J.D.22
Gilliland, D.G.23
more..
-
267
-
-
0037596569
-
Discovery of a fusion kinase in EOL-1 cells and idiopathic hyper-eosinophilic syndrome
-
Griffin JH, Leung J, Bruner RJ, Caligiuri MA, Briesewitz R. Discovery of a fusion kinase in EOL-1 cells and idiopathic hyper-eosinophilic syndrome. Proc Natl Acad Sci USA. 2003 100 : 7830 5.
-
(2003)
Proc Natl Acad Sci USA.
, vol.100
, pp. 7830-7835
-
-
Griffin, J.H.1
Leung, J.2
Bruner, R.J.3
Caligiuri, M.A.4
Briesewitz, R.5
-
268
-
-
20844452877
-
Molecular characterization of the idiopathic hypereosinophilic syndrome (HES) in 35 French patients with normal conventional cytogenetics
-
Roche-Lestienne C, Lepers S, Soenen-Cornu V, Kahn JE, Lai JL, Hachulla E, Drupt F, Demarty AL, Roumier AS, Gardembas M, Dib M, Philippe N, Cambier N, Barete S, Libersa C, Bletry O, Hatron PY, Quesnel B, Rose C, Maloum K, Blanchet O, Fenaux P, Prin L, Preudhomme C. Molecular characterization of the idiopathic hypereosinophilic syndrome (HES) in 35 French patients with normal conventional cytogenetics. Leukemia. 2005 19 : 792 8.
-
(2005)
Leukemia.
, vol.19
, pp. 792-798
-
-
Roche-Lestienne, C.1
Lepers, S.2
Soenen-Cornu, V.3
Kahn, J.E.4
Lai, J.L.5
Hachulla, E.6
Drupt, F.7
Demarty, A.L.8
Roumier, A.S.9
Gardembas, M.10
Dib, M.11
Philippe, N.12
Cambier, N.13
Barete, S.14
Libersa, C.15
Bletry, O.16
Hatron, P.Y.17
Quesnel, B.18
Rose, C.19
Maloum, K.20
Blanchet, O.21
Fenaux, P.22
Prin, L.23
Preudhomme, C.24
more..
-
269
-
-
33744484267
-
Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent
-
Stover EH, Chen J, Folens C, Lee BH, Mentens N, Marynen P, Williams IR, Gilliland DG, Cools J. Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent. Proc Natl Acad Sci USA. 2006 103 : 8078 83.
-
(2006)
Proc Natl Acad Sci USA.
, vol.103
, pp. 8078-8083
-
-
Stover, E.H.1
Chen, J.2
Folens, C.3
Lee, B.H.4
Mentens, N.5
Marynen, P.6
Williams, I.R.7
Gilliland, D.G.8
Cools, J.9
-
270
-
-
0942276859
-
Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome
-
Klion AD, Robyn J, Akin C, Noel P, Brown M, Law M, Metcalfe DD, Dunbar C, Nutman TB. Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome. Blood. 2004 103 : 473 8.
-
(2004)
Blood.
, vol.103
, pp. 473-478
-
-
Klion, A.D.1
Robyn, J.2
Akin, C.3
Noel, P.4
Brown, M.5
Law, M.6
Metcalfe, D.D.7
Dunbar, C.8
Nutman, T.B.9
-
271
-
-
13544267772
-
Myeloid blast crisis evolving during ima-tinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia
-
von Bubnoff N, Sandherr M, Schlimok G, Andreesen R, Peschel C, Duyster J. Myeloid blast crisis evolving during ima-tinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. Leukemia. 2005 19 : 286 7.
-
(2005)
Leukemia.
, vol.19
, pp. 286-287
-
-
Von Bubnoff, N.1
Sandherr, M.2
Schlimok, G.3
Andreesen, R.4
Peschel, C.5
Duyster, J.6
-
272
-
-
33746473457
-
Chronic eosinophilic leukaemia with FIP1L1-PDGFRA fusion and T674I mutation that evolved from Langerhans cell histiocytosis with eosinophilia after chemotherapy
-
Ohnishi H, Kandabashi K, Maeda Y, Kawamura M, Watanabe T. Chronic eosinophilic leukaemia with FIP1L1-PDGFRA fusion and T674I mutation that evolved from Langerhans cell histiocytosis with eosinophilia after chemotherapy. Br J Haematol. 2006 134 : 547 9.
-
(2006)
Br J Haematol.
, vol.134
, pp. 547-549
-
-
Ohnishi, H.1
Kandabashi, K.2
Maeda, Y.3
Kawamura, M.4
Watanabe, T.5
-
273
-
-
33747203008
-
Sorafenib (BAY43-9006) is a potent inhibitor of FIP1L1-PDGFR{alpha} and the imatinib resistant FIP1L1-PDGFR{alpha} T674I mutant
-
Lierman E, Folens C, Stover EH, Mentens N, Van Miegroet H, Scheers W, Boogaerts M, Vandenberghe P, Marynen P, Cools J. Sorafenib (BAY43-9006) is a potent inhibitor of FIP1L1-PDGFR{alpha} and the imatinib resistant FIP1L1-PDGFR{alpha} T674I mutant. Blood. 2006 108 : 1374 6.
-
(2006)
Blood.
, vol.108
, pp. 1374-1376
-
-
Lierman, E.1
Folens, C.2
Stover, E.H.3
Mentens, N.4
Van Miegroet, H.5
Scheers, W.6
Boogaerts, M.7
Vandenberghe, P.8
Marynen, P.9
Cools, J.10
-
274
-
-
27144551665
-
The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo
-
Stover EH, Chen J, Lee BH, Cools J, McDowell E, Adelsperger J, Cullen D, Coburn A, Moore SA, Okabe R, Fabbro D, Manley PW, Griffin JD, Gilliland DG. The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo. Blood. 2005 106 : 3206 13.
-
(2005)
Blood.
, vol.106
, pp. 3206-3213
-
-
Stover, E.H.1
Chen, J.2
Lee, B.H.3
Cools, J.4
McDowell, E.5
Adelsperger, J.6
Cullen, D.7
Coburn, A.8
Moore, S.A.9
Okabe, R.10
Fabbro, D.11
Manley, P.W.12
Griffin, J.D.13
Gilliland, D.G.14
-
275
-
-
33745059630
-
The FIP1L1-PDGFRA T674I mutation can be inhibited by the tyrosine kinase inhibitor AMN107 (nilotinib)
-
author reply 4972.
-
von Bubnoff N, Gorantla SP, Thone S, Peschel C, Duyster J. The FIP1L1-PDGFRA T674I mutation can be inhibited by the tyrosine kinase inhibitor AMN107 (nilotinib). Blood. 2006 107 : 4970 1 author reply 4972.
-
(2006)
Blood.
, vol.107
, pp. 4970-4971
-
-
Von Bubnoff, N.1
Gorantla, S.P.2
Thone, S.3
Peschel, C.4
Duyster, J.5
-
276
-
-
33646152550
-
Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia
-
Score J, Curtis C, Waghorn K, Stalder M, Jotterand M, Grand FH, Cross NC. Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia. Leukemia. 2006 20 : 827 32.
-
(2006)
Leukemia.
, vol.20
, pp. 827-832
-
-
Score, J.1
Curtis, C.2
Waghorn, K.3
Stalder, M.4
Jotterand, M.5
Grand, F.H.6
Cross, N.C.7
-
277
-
-
70350186921
-
The t(4; 22)(q12; q11) in atypical chronic myeloid leukaemia fuses BCR to PDGFRA
-
Baxter EJ, Hochhaus A, Bolufer P, Reiter A, Fernandez JM, Senent L, Cervera J, Moscardo F, Sanz MA, Cross NC. The t(4; 22)(q12; q11) in atypical chronic myeloid leukaemia fuses BCR to PDGFRA. Hum Mol Genet. 2002 11 : 1391 7.
-
(2002)
Hum Mol Genet.
, vol.11
, pp. 1391-1397
-
-
Baxter, E.J.1
Hochhaus, A.2
Bolufer, P.3
Reiter, A.4
Fernandez, J.M.5
Senent, L.6
Cervera, J.7
Moscardo, F.8
Sanz, M.A.9
Cross, N.C.10
-
278
-
-
33748491495
-
Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9; 4)(q33; q12q25) and a CDK5RAP2-PDGFRA fusion gene
-
Walz C, Curtis C, Schnittger S, Schultheis B, Metzgeroth G, Schoch C, Lengfelder E, Erben P, Muller MC, Haferlach T, Hochhaus A, Hehlmann R, Cross NC, Reiter A. Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9; 4)(q33; q12q25) and a CDK5RAP2-PDGFRA fusion gene. Genes Chromosomes Cancer. 2006 45 : 950 6.
-
(2006)
Genes Chromosomes Cancer.
, vol.45
, pp. 950-956
-
-
Walz, C.1
Curtis, C.2
Schnittger, S.3
Schultheis, B.4
Metzgeroth, G.5
Schoch, C.6
Lengfelder, E.7
Erben, P.8
Muller, M.C.9
Haferlach, T.10
Hochhaus, A.11
Hehlmann, R.12
Cross, N.C.13
Reiter, A.14
-
279
-
-
0041335547
-
Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor alpha receptor: A new clinical target for STI571/Glivec
-
Trempat P, Villalva C, Laurent G, Armstrong F, Delsol G, Dastugue N, Brousset P. Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor alpha receptor: a new clinical target for STI571/Glivec. Oncogene. 2003 22 : 5702 6.
-
(2003)
Oncogene.
, vol.22
, pp. 5702-5706
-
-
Trempat, P.1
Villalva, C.2
Laurent, G.3
Armstrong, F.4
Delsol, G.5
Dastugue, N.6
Brousset, P.7
-
280
-
-
1942453753
-
Molecular and cytogenetic characterization of a novel translocation t(4; 22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia
-
Safley AM, Sebastian S, Collins TS, Tirado CA, Stenzel TT, Gong JZ, Goodman BK. Molecular and cytogenetic characterization of a novel translocation t(4; 22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia. Genes Chromosomes Cancer. 2004 40 : 44 50.
-
(2004)
Genes Chromosomes Cancer.
, vol.40
, pp. 44-50
-
-
Safley, A.M.1
Sebastian, S.2
Collins, T.S.3
Tirado, C.A.4
Stenzel, T.T.5
Gong, J.Z.6
Goodman, B.K.7
-
281
-
-
0029966854
-
The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways
-
Carroll M, Tomasson MH, Barker GF, Golub TR, Gilliland DG. The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. Proc Natl Acad Sci USA. 1996 93 : 14845 50.
-
(1996)
Proc Natl Acad Sci USA.
, vol.93
, pp. 14845-14850
-
-
Carroll, M.1
Tomasson, M.H.2
Barker, G.F.3
Golub, T.R.4
Gilliland, D.G.5
-
282
-
-
0030669455
-
Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myel-ogenous leukemia after clonal evolution
-
Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myel-ogenous leukemia after clonal evolution. Blood. 1997 90 : 4271 7.
-
(1997)
Blood.
, vol.90
, pp. 4271-4277
-
-
Abe, A.1
Emi, N.2
Tanimoto, M.3
Terasaki, H.4
Marunouchi, T.5
Saito, H.6
-
283
-
-
11844290650
-
KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloprolifera-tive disease associated with a t(5; 14)(q33; q32)
-
Levine RL, Wadleigh M, Sternberg DW, Wlodarska I, Galinsky I, Stone RM, DeAngelo DJ, Gilliland DG, Cools J. KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloprolifera-tive disease associated with a t(5; 14)(q33; q32). Leukemia. 2005 19 : 27 30.
-
(2005)
Leukemia.
, vol.19
, pp. 27-30
-
-
Levine, R.L.1
Wadleigh, M.2
Sternberg, D.W.3
Wlodarska, I.4
Galinsky, I.5
Stone, R.M.6
Deangelo, D.J.7
Gilliland, D.G.8
Cools, J.9
-
284
-
-
5644251199
-
NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5; 14)(q33; q24) and an imatinib-responsive myeloproliferative disorder
-
Vizmanos JL, Novo FJ, Roman JP, Baxter EJ, Lahortiga I, Larrayoz MJ, Odero MD, Giraldo P, Calasanz MJ, Cross NC. NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5; 14)(q33; q24) and an imatinib-responsive myeloproliferative disorder. Cancer Res. 2004 64 : 2673 6.
-
(2004)
Cancer Res.
, vol.64
, pp. 2673-2676
-
-
Vizmanos, J.L.1
Novo, F.J.2
Roman, J.P.3
Baxter, E.J.4
Lahortiga, I.5
Larrayoz, M.J.6
Odero, M.D.7
Giraldo, P.8
Calasanz, M.J.9
Cross, N.C.10
-
285
-
-
5644284103
-
HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5; 17)(q33; p11.2)
-
Morerio C, Acquila M, Rosanda C, Rapella A, Dufour C, Locatelli F, Maserati E, Pasquali F, Panarello C. HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5; 17)(q33; p11.2). Cancer Res. 2004 64 : 2649 51.
-
(2004)
Cancer Res.
, vol.64
, pp. 2649-2651
-
-
Morerio, C.1
Acquila, M.2
Rosanda, C.3
Rapella, A.4
Dufour, C.5
Locatelli, F.6
Maserati, E.7
Pasquali, F.8
Panarello, C.9
-
286
-
-
0344826038
-
Cloning of the t(1; 5)(q23; q33) in a myeloproliferative disorder associated with eosinophilia: Involvement of PDGFRB and response to imatinib
-
Wilkinson K, Velloso ER, Lopes LF, Lee C, Aster JC, Shipp MA, Aguiar RC. Cloning of the t(1; 5)(q23; q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. Blood. 2003 102 : 4187 90.
-
(2003)
Blood.
, vol.102
, pp. 4187-4190
-
-
Wilkinson, K.1
Velloso, E.R.2
Lopes, L.F.3
Lee, C.4
Aster, J.C.5
Shipp, M.A.6
Aguiar, R.C.7
-
287
-
-
0035889128
-
Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia
-
Magnusson MK, Meade KE, Brown KE, Arthur DC, Krueger LA, Barrett AJ, Dunbar CE. Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia. Blood. 2001 98 : 2518 25.
-
(2001)
Blood.
, vol.98
, pp. 2518-2525
-
-
Magnusson, M.K.1
Meade, K.E.2
Brown, K.E.3
Arthur, D.C.4
Krueger, L.A.5
Barrett, A.J.6
Dunbar, C.E.7
-
288
-
-
0031864246
-
Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5; 7)(q33; q11.2)
-
Ross TS, Bernard OA, Berger R, Gilliland DG. Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5; 7)(q33; q11.2). Blood. 1998 91 : 4419 26.
-
(1998)
Blood.
, vol.91
, pp. 4419-4426
-
-
Ross, T.S.1
Bernard, O.A.2
Berger, R.3
Gilliland, D.G.4
-
289
-
-
0035877975
-
H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5; 10)(q33; q22)
-
Schwaller J, Anastasiadou E, Cain D, Kutok J, Wojiski S, Williams IR, LaStarza R, Crescenzi B, Sternberg DW, Andreasson P, Schiavo R, Siena S, Mecucci C, Gilliland DG. H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5; 10)(q33; q22). Blood. 2001 97 : 3910 8.
-
(2001)
Blood.
, vol.97
, pp. 3910-3918
-
-
Schwaller, J.1
Anastasiadou, E.2
Cain, D.3
Kutok, J.4
Wojiski, S.5
Williams, I.R.6
Lastarza, R.7
Crescenzi, B.8
Sternberg, D.W.9
Andreasson, P.10
Schiavo, R.11
Siena, S.12
Mecucci, C.13
Gilliland, D.G.14
-
290
-
-
5644271514
-
P53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5; 15)(q33; q22) and an imatinib-responsive eosinophilic myeloproliferative disorder
-
Grand FH, Burgstaller S, Kuhr T, Baxter EJ, Webersinke G, Thaler J, Chase AJ, Cross NC. p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5; 15)(q33; q22) and an imatinib-responsive eosinophilic myeloproliferative disorder. Cancer Res. 2004 64 : 7216 9.
-
(2004)
Cancer Res.
, vol.64
, pp. 7216-7219
-
-
Grand, F.H.1
Burgstaller, S.2
Kuhr, T.3
Baxter, E.J.4
Webersinke, G.5
Thaler, J.6
Chase, A.J.7
Cross, N.C.8
-
291
-
-
0033084227
-
TEL/PDGFbetaR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor
-
Tomasson MH, Williams IR, Hasserjian R, Udomsakdi C, McGrath SM, Schwaller J, Druker B, Gilliland DG. TEL/PDGFbetaR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor. Blood. 1999 93 : 1707 14.
-
(1999)
Blood.
, vol.93
, pp. 1707-1714
-
-
Tomasson, M.H.1
Williams, I.R.2
Hasserjian, R.3
Udomsakdi, C.4
McGrath, S.M.5
Schwaller, J.6
Druker, B.7
Gilliland, D.G.8
-
292
-
-
17344373285
-
FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8; 13) leukaemia/ lymphoma syndrome
-
Xiao S, Nalabolu SR, Aster JC, Ma J, Abruzzo L, Jaffe ES, Stone R, Weissman SM, Hudson TJ, Fletcher JA. FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8; 13) leukaemia/ lymphoma syndrome. Nat Genet. 1998 18 : 84 7.
-
(1998)
Nat Genet.
, vol.18
, pp. 84-87
-
-
Xiao, S.1
Nalabolu, S.R.2
Aster, J.C.3
Ma, J.4
Abruzzo, L.5
Jaffe, E.S.6
Stone, R.7
Weissman, S.M.8
Hudson, T.J.9
Fletcher, J.A.10
-
293
-
-
6844255886
-
The t(8; 13)(p11; q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP
-
Smedley D, Hamoudi R, Clark J, Warren W, Abdul-Rauf M, Somers G, Venter D, Fagan K, Cooper C, Shipley J. The t(8; 13)(p11; q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP. Hum Mol Genet. 1998 7 : 637 42.
-
(1998)
Hum Mol Genet.
, vol.7
, pp. 637-642
-
-
Smedley, D.1
Hamoudi, R.2
Clark, J.3
Warren, W.4
Abdul-Rauf, M.5
Somers, G.6
Venter, D.7
Fagan, K.8
Cooper, C.9
Shipley, J.10
-
294
-
-
0032510791
-
Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8; 13)
-
Popovici C, Adelaide J, Ollendorff V, Chaffanet M, Guasch G, Jacrot M, Leroux D, Birnbaum D, Pebusque MJ. Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8; 13). Proc Natl Acad Sci USA. 1998 95 : 5712 7.
-
(1998)
Proc Natl Acad Sci USA.
, vol.95
, pp. 5712-5717
-
-
Popovici, C.1
Adelaide, J.2
Ollendorff, V.3
Chaffanet, M.4
Guasch, G.5
Jacrot, M.6
Leroux, D.7
Birnbaum, D.8
Pebusque, M.J.9
-
295
-
-
0030797764
-
Molecular characterization of the t(8; 13)(p11; q12) translocation associated with an atypical myeloproliferative disorder: Evidence for three discrete loci involved in myeloid leukemias on 8p11
-
Still IH, Chernova O, Hurd D, Stone RM, Cowell JK. Molecular characterization of the t(8; 13)(p11; q12) translocation associated with an atypical myeloproliferative disorder: evidence for three discrete loci involved in myeloid leukemias on 8p11. Blood. 1997 90 : 3136 41.
-
(1997)
Blood.
, vol.90
, pp. 3136-3141
-
-
Still, I.H.1
Chernova, O.2
Hurd, D.3
Stone, R.M.4
Cowell, J.K.5
-
296
-
-
0032170974
-
Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8; 13)(p11; q12) myeloproliferative syndrome
-
Reiter A, Sohal J, Kulkarni S, Chase A, Macdonald DH, Aguiar RC, Goncalves C, Hernandez JM, Jennings BA, Goldman JM, Cross NC. Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8; 13)(p11; q12) myeloproliferative syndrome. Blood. 1998 92 : 1735 42.
-
(1998)
Blood.
, vol.92
, pp. 1735-1742
-
-
Reiter, A.1
Sohal, J.2
Kulkarni, S.3
Chase, A.4
MacDonald, D.H.5
Aguiar, R.C.6
Goncalves, C.7
Hernandez, J.M.8
Jennings, B.A.9
Goldman, J.M.10
Cross, N.C.11
-
297
-
-
14444277275
-
T(6; 8), t(8; 9) and t(8; 13) transloca-tions associated with stem cell myelopro-liferative disorders have close or identical breakpoints in chromosome region 8p11-12
-
Chaffanet M, Popovici C, Leroux D, Jacrot M, Adelaide J, Dastugue N, Gregoire MJ, Hagemeijer A, Lafage-Pochitaloff M, Birnbaum D, Pebusque MJ. t(6; 8), t(8; 9) and t(8; 13) transloca-tions associated with stem cell myelopro-liferative disorders have close or identical breakpoints in chromosome region 8p11-12. Oncogene. 1998 16 : 945 9.
-
(1998)
Oncogene.
, vol.16
, pp. 945-949
-
-
Chaffanet, M.1
Popovici, C.2
Leroux, D.3
Jacrot, M.4
Adelaide, J.5
Dastugue, N.6
Gregoire, M.J.7
Hagemeijer, A.8
Lafage-Pochitaloff, M.9
Birnbaum, D.10
Pebusque, M.J.11
-
298
-
-
0033558253
-
The t(6; 8)(q27; p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
-
Popovici C, Zhang B, Gregoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pebusque MJ. The t(6; 8)(q27; p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. Blood. 1999 93 : 1381 9.
-
(1999)
Blood.
, vol.93
, pp. 1381-1389
-
-
Popovici, C.1
Zhang, B.2
Gregoire, M.J.3
Jonveaux, P.4
Lafage-Pochitaloff, M.5
Birnbaum, D.6
Pebusque, M.J.7
-
299
-
-
0034529640
-
The 8p12 myeloproliferative disorder. t(8; 19) (p12; Q13.3): A novel translocation involving the FGFR1 gene
-
Mugneret F, Chaffanet M, Maynadie M, Guasch G, Favre B, Casasnovas O, Birnbaum D, Pebusque MJ. The 8p12 myeloproliferative disorder. t(8; 19) (p12; q13.3): a novel translocation involving the FGFR1 gene. Br J Haematol. 2000 111 : 647 9.
-
(2000)
Br J Haematol.
, vol.111
, pp. 647-649
-
-
Mugneret, F.1
Chaffanet, M.2
Maynadie, M.3
Guasch, G.4
Favre, B.5
Casasnovas, O.6
Birnbaum, D.7
Pebusque, M.J.8
-
300
-
-
84905515146
-
Identification of four new translocations involving FGFR1 in myeloid disorders
-
Sohal J, Chase A, Mould S, Corcoran M, Oscier D, Iqbal S, Parker S, Welborn J, Harris RI, Martinelli G, Montefusco V, Sinclair P, Wilkins BS, van den Berg H, Vanstraelen D, Goldman JM, Cross NC. Identification of four new translocations involving FGFR1 in myeloid disorders. Genes Chromosomes Cancer. 2001 32 : 155 63.
-
(2001)
Genes Chromosomes Cancer.
, vol.32
, pp. 155-163
-
-
Sohal, J.1
Chase, A.2
Mould, S.3
Corcoran, M.4
Oscier, D.5
Iqbal, S.6
Parker, S.7
Welborn, J.8
Harris, R.I.9
Martinelli, G.10
Montefusco, V.11
Sinclair, P.12
Wilkins, B.S.13
Van Den Berg, H.14
Vanstraelen, D.15
Goldman, J.M.16
Cross, N.C.17
-
301
-
-
0035895067
-
The t(8; 22) in chronic myeloid leukemia fuses BCR to FGFR1: Transforming activity and specific inhibition of FGFR1 fusion proteins
-
Demiroglu A, Steer EJ, Heath C, Taylor K, Bentley M, Allen SL, Koduru P, Brody JP, Hawson G, Rodwell R, Doody ML, Carnicero F, Reiter A, Goldman JM, Melo JV, Cross NC. The t(8; 22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins. Blood. 2001 98 : 3778 83.
-
(2001)
Blood.
, vol.98
, pp. 3778-3783
-
-
Demiroglu, A.1
Steer, E.J.2
Heath, C.3
Taylor, K.4
Bentley, M.5
Allen, S.L.6
Koduru, P.7
Brody, J.P.8
Hawson, G.9
Rodwell, R.10
Doody, M.L.11
Carnicero, F.12
Reiter, A.13
Goldman, J.M.14
Melo, J.V.15
Cross, N.C.16
-
302
-
-
0035159831
-
Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8; 22)(p11; q11) in a myeloproliferative disorder: The first fusion gene involving BCR but not ABL
-
Fioretos T, Panagopoulos I, Lassen C, Swedin A, Billstrom R, Isaksson M, Strombeck B, Olofsson T, Mitelman F, Johansson B. Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8; 22)(p11; q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL. Genes Chromosomes Cancer. 2001 32 : 302 10.
-
(2001)
Genes Chromosomes Cancer.
, vol.32
, pp. 302-310
-
-
Fioretos, T.1
Panagopoulos, I.2
Lassen, C.3
Swedin, A.4
Billstrom, R.5
Isaksson, M.6
Strombeck, B.7
Olofsson, T.8
Mitelman, F.9
Johansson, B.10
-
303
-
-
0037216062
-
Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8; 19)(p12; q13.3)
-
Guasch G, Popovici C, Mugneret F, Chaffanet M, Pontarotti P, Birnbaum D, Pebusque MJ. Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8; 19)(p12; q13.3). Blood. 2003 101 : 286 8.
-
(2003)
Blood.
, vol.101
, pp. 286-288
-
-
Guasch, G.1
Popovici, C.2
Mugneret, F.3
Chaffanet, M.4
Pontarotti, P.5
Birnbaum, D.6
Pebusque, M.J.7
-
304
-
-
0036972521
-
A fourth case of BCR-FGFR1 positive CML-like disease with t(8; 22) translocation showing an extensive deletion on the derivative chromosome 8p
-
Pini M, Gottardi E, Scaravaglio P, Giugliano E, Libener R, Baraldi A, Muzio A, Cornaglia E, Saglio G, Levis A. A fourth case of BCR-FGFR1 positive CML-like disease with t(8; 22) translocation showing an extensive deletion on the derivative chromosome 8p. Hematol J. 2002 3 : 315 6.
-
(2002)
Hematol J.
, vol.3
, pp. 315-316
-
-
Pini, M.1
Gottardi, E.2
Scaravaglio, P.3
Giugliano, E.4
Libener, R.5
Baraldi, A.6
Muzio, A.7
Cornaglia, E.8
Saglio, G.9
Levis, A.10
-
305
-
-
1942422114
-
Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome
-
Grand EK, Grand FH, Chase AJ, Ross FM, Corcoran MM, Oscier DG, Cross NC. Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. Genes Chromosomes Cancer. 2004 40 : 78 83.
-
(2004)
Genes Chromosomes Cancer.
, vol.40
, pp. 78-83
-
-
Grand, E.K.1
Grand, F.H.2
Chase, A.J.3
Ross, F.M.4
Corcoran, M.M.5
Oscier, D.G.6
Cross, N.C.7
-
306
-
-
19944432120
-
8p11 myeloproliferative syndrome with a novel t(7; 8) translocation leading to fusion of the FGFR1 and TIF1genes
-
Belloni E, Trubia M, Gasparini P, Micucci C, Tapinassi C, Confalonieri S, Nuciforo P, Martino B, Lo-Coco F, Pelicci PG, Di Fiore PP. 8p11 myeloproliferative syndrome with a novel t(7; 8) translocation leading to fusion of the FGFR1 and TIF1genes. Genes Chromosomes Cancer. 2005 42 : 320 5.
-
(2005)
Genes Chromosomes Cancer.
, vol.42
, pp. 320-325
-
-
Belloni, E.1
Trubia, M.2
Gasparini, P.3
Micucci, C.4
Tapinassi, C.5
Confalonieri, S.6
Nuciforo, P.7
Martino, B.8
Lo-Coco, F.9
Pelicci, P.G.10
Di Fiore, P.P.11
-
307
-
-
41349108673
-
The t(1; 9)(p34; q34) and t(8; 12)(p11; q15) fuse pre-mRNA processing proteins SFPQ (PSF) and CPSF6 to ABL and FGFR1
-
Hidalgo-Curtis C, Chase A, Drachenberg M, Roberts MW, Finkelstein JZ, Mould S, Oscier D, Cross NC, Grand FH. The t(1; 9)(p34; q34) and t(8; 12)(p11; q15) fuse pre-mRNA processing proteins SFPQ (PSF) and CPSF6 to ABL and FGFR1. Genes Chromosomes Cancer. 2008 47 : 379 85.
-
(2008)
Genes Chromosomes Cancer.
, vol.47
, pp. 379-385
-
-
Hidalgo-Curtis, C.1
Chase, A.2
Drachenberg, M.3
Roberts, M.W.4
Finkelstein, J.Z.5
Mould, S.6
Oscier, D.7
Cross, N.C.8
Grand, F.H.9
-
308
-
-
0033578775
-
Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8; 13) translocation
-
Ollendorff V, Guasch G, Isnardon D, Galindo R, Birnbaum D, Pebusque MJ. Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8; 13) translocation. J Biol Chem. 1999 274 : 26922 30.
-
(1999)
J Biol Chem.
, vol.274
, pp. 26922-26930
-
-
Ollendorff, V.1
Guasch, G.2
Isnardon, D.3
Galindo, R.4
Birnbaum, D.5
Pebusque, M.J.6
-
309
-
-
0035167404
-
8p12 stem cell myeloproliferative disorder: The FOP-fibroblast growth factor receptor 1 fusion protein of the t(6; 8) translocation induces cell survival mediated by mitogen-acti-vated protein kinase and phosphatidylinos-itol 3-kinase/Akt/mTOR pathways
-
Guasch G, Ollendorff V, Borg JP, Birnbaum D, Pebusque MJ. 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6; 8) translocation induces cell survival mediated by mitogen-acti-vated protein kinase and phosphatidylinos-itol 3-kinase/Akt/mTOR pathways. Mol Cell Biol. 2001 21 : 8129 42.
-
(2001)
Mol Cell Biol.
, vol.21
, pp. 8129-8142
-
-
Guasch, G.1
Ollendorff, V.2
Borg, J.P.3
Birnbaum, D.4
Pebusque, M.J.5
-
310
-
-
1642421743
-
Distinct stem cell myeloprolifer-ative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations
-
Roumiantsev S, Krause DS, Neumann CA, Dimitri CA, Asiedu F, Cross NC, Van Etten RA. Distinct stem cell myeloprolifer-ative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Cancer Cell. 2004 5 : 287 98.
-
(2004)
Cancer Cell.
, vol.5
, pp. 287-298
-
-
Roumiantsev, S.1
Krause, D.S.2
Neumann, C.A.3
Dimitri, C.A.4
Asiedu, F.5
Cross, N.C.6
Van Etten, R.A.7
-
311
-
-
0347597750
-
FOP-FGFR1 tyrosine kinase, the product of a t(6; 8) translocation, induces a fatal myeloproliferative disease in mice
-
Guasch G, Delaval B, Arnoulet C, Xie MJ, Xerri L, Sainty D, Birnbaum D, Pebusque MJ. FOP-FGFR1 tyrosine kinase, the product of a t(6; 8) translocation, induces a fatal myeloproliferative disease in mice. Blood. 2004 103 : 309 12.
-
(2004)
Blood.
, vol.103
, pp. 309-312
-
-
Guasch, G.1
Delaval, B.2
Arnoulet, C.3
Xie, M.J.4
Xerri, L.5
Sainty, D.6
Birnbaum, D.7
Pebusque, M.J.8
-
312
-
-
5144234541
-
PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder
-
Chen J, Deangelo DJ, Kutok JL, Williams IR, Lee BH, Wadleigh M, Duclos N, Cohen S, Adelsperger J, Okabe R, Coburn A, Galinsky I, Huntly B, Cohen PS, Meyer T, Fabbro D, Roesel J, Banerji L, Griffin JD, Xiao S, Fletcher JA, Stone RM, Gilliland DG. PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder. Proc Natl Acad Sci USA. 2004 101 : 14479 84.
-
(2004)
Proc Natl Acad Sci USA.
, vol.101
, pp. 14479-14484
-
-
Chen, J.1
Deangelo, D.J.2
Kutok, J.L.3
Williams, I.R.4
Lee, B.H.5
Wadleigh, M.6
Duclos, N.7
Cohen, S.8
Adelsperger, J.9
Okabe, R.10
Coburn, A.11
Galinsky, I.12
Huntly, B.13
Cohen, P.S.14
Meyer, T.15
Fabbro, D.16
Roesel, J.17
Banerji, L.18
Griffin, J.D.19
Xiao, S.20
Fletcher, J.A.21
Stone, R.M.22
Gilliland, D.G.23
more..
-
313
-
-
61349104536
-
-
C. E. Swerdlow, S.H., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J., Vardiman, J.W., editors. Lyon: International Agency for Research on Cancer
-
th ed. In: C. E. Swerdlow SH, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, editors. Lyon : International Agency for Research on Cancer 2008. pp. 18 30.
-
(2008)
th Ed.
, pp. 18-30
-
-
Vardiman, J.W.1
Brunning, R.D.2
Arber, D.A.3
Le Beau, M.M.4
Porwit, A.5
Tefferi, A.6
Bloomfield, C.D.7
Thiele, J.8
|