Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 24, 2006, Pages 9244-9249

  Azam, Mohammad ^a   Nardi, Valentina ^a   Shakespeare, William C ^b   Metcalf III, Chester A ^b   Bohacek, Regine S ^b   Wang, Yihan ^b   Sundaramoorthi, Raji ^b   Sliz, Piotr ^a   Veach, Darren R ^c   Bornmann, William G ^d   Clarkson, Bayard ^c   Dalgarno, David C ^b   Sawyer, Tomi K ^b   Daley, George Q ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b ARIAD PHARMACEUTICALS INC   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Chronic myelogenous leukemia; Combination chemotherapy; Imatinib; Kinase inhibitors

Indexed keywords

2 CYCLOPENTYL N [4 (DIMETHYLPHOSPHORYL)PHENYL] 9 ETHYL 9H PURIN 6 AMINE; 2 CYCLOPENTYL N [4 (DIPROPYLPHOSPHORYL)PHENYL] 9H PURIN 6 AMINE; 3 [2 [2 CYCLOPENTYL 6 [4 (DIMETHYLPHOSPHORYL)PHENYLAMINO] 9H PURIN 9 YL]ETHYL]PHENOL; 3 [2 [2 CYCLOPENTYL 6 [4 (DIPROPYLPHOSPHORYL)PHENYLAMINO] 9H PURIN 9 YL]ETHYL]PHENOL; 6 (2,6 DICHLOROPHENYL) 2 (3 HYDROXYMETHYLPHENYLAMINO) 8 METHYL 8H PYRIDO[2,3 D]PYRIMIDINE 7 ONE; 6 (2,6 DICHLOROPHENYL) 2 [3 (HYDROXYMETHYL)ANILINO] 8 METHYLPYRIDO[2,3 D]PYRIMIDIN 7(8H) ONE; [4 [2 CYCLOPENTYL 9 (3 HYDROXYPHENETHYL)PURIN 6 YLAMINO]PHENYL]DIMETHYLPHOSPHINE OXIDE; ABELSON KINASE; AP 23846; AP 23848; AP 23980; BCR ABL PROTEIN; ENZYME INHIBITOR; IMATINIB; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER RESISTANCE; CHRONIC MYELOID LEUKEMIA; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING; DRUG POTENCY; DRUG SELECTIVITY; DRUG TARGETING; ENZYME CONFORMATION; GENE MUTATION; MOLECULAR MODEL; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; DRUG RESISTANCE; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-ABL; PYRIDINES; PYRIMIDINES; SRC-FAMILY KINASES;

EID: 33745164854     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0600001103     Document Type: Article

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