Activation of FIP1L1-PDGFRα requires disruption of the juxtamembrane domain of PDGFRα and is FIP1L1-independent

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 21, 2006, Pages 8078-8083

  Stover, Elizabeth H ^a,b   Chen, Jing ^d   Folens, Cedric ^e   Lee, Benjamin H ^a   Mentens, Nicole ^e   Marynen, Peter ^e   Williams, Ifor R ^d   Gilliland, D Gary ^a,b,c   Cools, Jan ^e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Fusion gene; Leukemia; Oncogene; Tyrosine kinase

Indexed keywords

HYBRID PROTEIN; PROTEIN TYROSINE KINASE; TRYPTOPHAN; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; FIP1L1 PROTEIN, HUMAN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHROMOSOME DELETION 4; DIMERIZATION; ENZYME ACTIVATION; EOSINOPHILIC LEUKEMIA; FUSION GENE; GENE ACTIVATION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; MOUSE; NONHUMAN; ONCOGENE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; BONE MARROW TRANSPLANTATION; CELL CULTURE; CELL MEMBRANE; CHEMISTRY; ENZYMOLOGY; LEUKEMIA; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL LINE, TUMOR; CELL MEMBRANE; CELLS, CULTURED; DIMERIZATION; HUMANS; LEUKEMIA; MICE; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA;

EID: 33744484267     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0601192103     Document Type: Article

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