The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): A novel translocation involving the FGFR1 gene

British Journal of Haematology

Volumn 111, Issue 2, 2000, Pages 647-649

  Dürig, Jan ^a   Rosenthal, Christoph ^a   Halfmeyer, Katja ^a   Wiemann, Martin ^b   Novotny, Jürgen ^a   Bingmann, Dieter ^b   Dührsen, Ulrich ^a   Schirrmacher, Karin ^b  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Chromosome 19; Chromosome 8; FGFR1 gene; Myeloproliferative disorder; Translocation

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR;

AGED; ARTICLE; CARBOXY TERMINAL SEQUENCE; CASE REPORT; CHROMOSOME 19; CHROMOSOME 8; CHROMOSOME REARRANGEMENT; CLINICAL FEATURE; GENE LOCUS; GENE TRANSLOCATION; HUMAN; MALE; MYELOPROLIFERATIVE DISORDER; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

AGED; CHROMOSOMES, HUMAN, PAIR 19; CHROMOSOMES, HUMAN, PAIR 8; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MYELOPROLIFERATIVE DISORDERS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTORS, FIBROBLAST GROWTH FACTOR; TRANSLOCATION, GENETIC;

EID: 0034529640     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02355.x     Document Type: Article

References (7)

1. t(6;8), t(8;9) and t(8;13) translocations associated with myeloproliferative disorders have close or identical breakpoints on chromosome 8p11-12
2. FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)
3. Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder associated-t(8;13) translocation
4. Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12)
5. The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
6. Two color FISH to detect FGFR1 rearrangements in myeloproliferative disorders: Identification of the t(8;17)(p11;q25) as a new cytogenetic variant
7. FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome