Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase

Blood

Volumn 88, Issue 3, 1996, Pages 995-1004

  Kitayama, Hitoshi ^b   Tsujimura, Tohru ^b   Matsumura, Itaru ^b   Oritani, Kenji ^b   Ikeda, Hirokazu ^b   Ishikawa, Jun ^b   Okabe, Masaru ^b   Suzuki, Misao ^b   Yamamura, Ken Ichi ^b   Matsuzawa, Yuji ^b   Kitamura, Yukihiko ^b   Kanakura, Yuzuru ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; RECOMBINANT INTERLEUKIN 3; RECOMBINANT INTERLEUKIN 6; RECOMBINANT STEM CELL FACTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; COLONY FORMING UNIT GM; CONTROLLED STUDY; GENE MUTATION; GENE TRANSFER; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LEUKEMOGENESIS; LYMPHOMA; MALIGNANT TRANSFORMATION; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; RETROVIRUS; TRANSGENIC MOUSE;

EID: 10144261890     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.3.995.bloodjournal883995     Document Type: Article

References (68)

1. Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203, 1990
2. Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A: The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335:88, 1988
3. Geissler EN, Ryan MA, Housman DE: The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55:185, 1988
4. Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A: Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 6:3341, 1987
5. Qiu FH, Ray P, Brown K, Barker PE, Jhanwar S, Ruddle FH, Besmer P: Primary structure of c-kit: Relationship with the CSF-1/ PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus. EMBO J 7:1003, 1988
6. Yarden Y, Ullrich A: Growth factor receptor tyrosine kinases. Annu Rev Biochem 57:443, 1988
7. Zsebo KM, Wypych J, McNiece IK, Lu HS, Smith KA, Karkare SB, Sachdev RK, Yuschenkoff VN, Birkett NC, Williams LR, Satyagal VN, Tung W, Bosselman RA, Mendiaz EA, Langley KE: Identification, purification and biological characterization of hematopoietic stem cell factor from buffalo liver-conditioned medium. Cell 63:195, 1990
8. Anderson DM, Lyman SD, Baird A, Wignall JM, Eisenman J, Rauch C, March CJ, Boswell HS, Gimpel SD, Cosman D, Williams DE: Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. Cell 63:235, 1990
9. Huang E, Nocka K, Beier DR, Chu TY, Buck J, Lahm HW, Wellner D, Leder P, Besmer P: The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 63:225, 1990
10. Witte ON: Steel locus defines new multipotent growth factor. Cell 63:5, 1990
11. Schlessinger J, Ullrich A: Growth factor signaling by receptor tyrosine kinases. Neuron 9:383, 1992
12. Fantl WJ, Johnson DE, Williams LT: Signalling by receptor tyrosine kinases. Annu Rev Biochem 62:453, 1993
13. Rottapel R, Reedijk M, Williams DE, Lyman SD, Anderson DM, Pawson T, Bernstein A: The Steel/W transduction pathway: KIT autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the steel factor. Mol Cell Biol 11:3043, 1991
14. Reith AD, Ellis C, Lyman SD, Anderson DM, Williams DE, Bernstein A, Pawson T: Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J 9:2451, 1991
15. Cutler RL, Liu L, Damen JE, Krystal G: Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hematopoietic cells. J Biol Chem 268:21462, 1993
16. vav, in human hematopoietic cells. J Biol Chem 267:18021, 1992
17. Yi T, Ihle JN: Association of hematopoietic cell phosphatase with c-kit after stimulation with c-kit ligand. Mol Cell Biol 13:3350, 1993
18. Serve H, Hsu YC, Besmer P: Tyrosine residue 719 of the c-kit receptor is essential for binding of the p85 subunit of phosphati-dylinositol(PI) 3-kinase and for c-kit associated PI3-kinase activity in COS-1 cells. J Biol Chem 269:6026, 1994
19. ras GTPase-activating protein. Proc Natl Acad Sci USA 89:1587, 1992
20. Reith AD, Bernstein A: Molecular biology of the W and steel loci, in Genome Analysis, vol 3. Genes and Phenotypes. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1991, p105
21. Russel ES: Hereditary anemias of the mouse: A review for geneticists. Adv Genet 20:357, 1979
22. Kitamura Y: Heterogeneity of mast cells and phenotypic change between subpopulations. Ann Rev Immunol 7:59, 1989
23. d mice. Am J Pathol 127:191, 1987
24. Besmer P, Murphy JE, George PC, Qiu F, Bergold PJ, Lederman L, Snyder Jr HW, Brodeur D, Zuckerman EE, Hardy WD: A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 320:415, 1986
25. Bargmann CI, Hung MC, Weinberg RA: Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell 45:649, 1986
26. Weiner DB, Liu J, Cohen JA, Williams WV, Greene MI: A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Nature 339:230, 1989
27. Woolford JW, McAuliffe A, Rohrschneider LR: Activation of the feline c-fms proto-oncogene: Multiple alterations are required to generate a fully transformed phenotype. Cell 55:965, 1988
28. Roussel M, Downing J, Rettenmier CW, Sherr CJ: A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential. Cell 55:979, 1988
29. Kuriu A, Ikeda H, Kanakura Y, Griffin JD, Druker B, Yagura H, Kitayama H, Ishikawa J, Nishiura T, Kanayama Y, Yonezawa T, Tarui S: Proliferation of human myeloid leukemia cell line associated with the tyrosine phosphorylation and activation of the proto-oncogene c-kit product. Blood 78:2834, 1991
30. Ikeda H, Kanakura Y, Tamaki T, Kuriu A, Kitayama H, Ishikawa J, Kanayama Y, Yonezawa T, Tarui S, Griffin JD: Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells. Blood 78:2962, 1991
31. Furitsu T, Tsujimura T, Tono T, Ikeda H, Kitayama H, Koshimizu U, Sugahara H, Butterfield JH, Ashman LK, Kanayama Y, Matsuzawa Y, Kitamura Y, Kanakura Y: Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest 92:1736, 1993
32. Tsujimura T, Furitsu T, Morimoto M, Kanayama Y, Nomura S, Matsuzawa Y, Kitamura Y, Kanakura Y: Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat mastcytoma cell line RBL-2H3. Int Arch Allergy Immunol 106:377, 1995
33. Tsujimura T, Furitsu T, Morimoto M, Isozaki K, Nomura S, Matsuzawa Y, Kitamura Y, Kanakura Y: Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastcytoma cell line P-815 generated by a point mutation. Blood 83:2619, 1994
34. Kitayama H, Kanakura Y, Furitsu T, Tsujimura T, Oritani K, Ikeda H, Sugahara H, Mitsui H, Kanayama Y, Kitamura Y, Matsuzawa Y: Constitutively activating muations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoieitc cell lines. Blood 85:790, 1995
35. Ogawa M, Matsuzaki Y, Nishikawa S, Hayashi S-I, Kunisada T, Sudo T, Kina H, Nakauchi H, Nishikawa S-I: Expression and function of c-kit in hematopoietic progenitor cells. J Exp Med 174:63, 1991
36. Laker C, Stocking C, Bergholz U, Hess N, DeLamarter JF, Ostertag W: Autocrine stimulation after transfer of the granulocyte/ macrophage colony-stimulating factor gene and autonomous growth are distinct but interdependent steps in the oncogenic pathway. Proc Natl Acad Sci USA 84:8458, 1987
37. Kanakura Y, Druker B, Cannistra SA, Furukawa Y, Torimoto Y, Griffin JD: Signal transduction of the human granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins. Blood 76:706, 1990
38. Kanakura Y, Drucker B, Decarlo J, Cannistra SA, Griffin JD: Phorbor 12-myristate acetate 13-acetate inhibits granulocyte-macrophage colony-stimulating factor induced protein tyrosine phosphorylation in a human factor-dependent cell line. J Biol Chem 266:490, 1991
39. Shimizu A, Takahashi N, Yaoita Y, Honjo T: Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell 28:499, 1982
40. Malissen M, Minard K, Mjolsness S, Kronenberg M, Goverman J, Hunkapiller T, Prystowsky MB, Yoshikai Y, Fitch F, Mak TW, Hood L: Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the βpolypeptide. Cell 37:1101, 1984
41. Coffman RL: Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol Rev 69:5, 1982
42. Tokushima M, Koarada S, Hirose S, Gotoh Y, Nishimura H, Shirai T, Miyake K, Kimoto M: In vivo induction of IgG anti-DNA antibody by autoreactive mixed haplotype A beta Z/A alpha of MHC class II molecule-apecific CD4+ T-cell clones. Immunology 83:221, 1994
43. Springer T, Galfre G, Secher DS, Milstei C: Mac-1 : A macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol 9:301, 1979
44. Julita M, Kroese F, Julita K, Stall A, Fiering L, Herzenberg L, Berg E, Butcher E: Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-gamma. Eur J Immunol 19:1819, 1988
45. Ortega G, Korty PE, Shevach EM, Malek TR: Role of Ly-6 lymphocyte activation I: Characterization of a monoclonal antibody to a nonpolymorphic Ly-6 specificity. J Immunol 19:1819, 1986
46. Mann R, Mulligan RC, Baltimore D: Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell 33:153, 1983
47. Palacios R, Steinmetz M: IL3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Cell 41:727, 1985
48. Nakahata T, Ogawa M: Identification in culture of a class of hemopoietic colony-forming units with extensive capability to self-renew and generate multipotential hemopoietic colonies. Proc Natl Acad Sci USA 79:3843, 1982
49. Suematsu S, Matsuzaka T, Matsuda T, Ohno S, Miyazaki J, Yamamura K, Hirano T, Kishimoto T: Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin-6 transgenic mice. Proc Natl Acad Sci USA 89:232, 1992
50. Yamamura K, Kikutani H, Takahashi N, Taga T, Akira S, Kawai K, Fukuchi K, Kumahara Y, Honjo T, Kishimoto T: Introduction of human γ 1 immunoglobulin genes into fertilized mouse eggs. J Biochem 96:357, 1984
51. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Press, 1989
52. Southern PJ, Berg P: Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J Mol Apl Gen 1:327, 1982
53. Krantz SB: Erythropoietin. Blood 77:419, 1991
54. Miller M, Kennewell A, Symonds G: Transformation of murine pre-B-lymphocytes by v-erbB: Progression to growth factor independence and tumorigenicity. Leukemia 6:18, 1992
55. Borzillo GV, Sherr CJ: Early pre-B-cell transformation induced by v-fms oncogens in long-term mouse bone marrow cultures. Mol Cell Biol 9:3973, 1989
56. Fichelson S, Vigon I, Dusanter I, Charon M, Velu T, Baillou C, Gisselbrecht S, Lemoine FM: In vitro transformation of murine pro-B and pre-B cells by v-mpl, a truncated form of a cytokine receptor. J Immunol 154:1577, 1995
57. Whitlock CA, Ziegler SF, Witte ON: Progression of the transformed phenotype in clonal lines of Abelson virus-infected lymphocytes. Mol Cell Biol 3:596, 1983
58. Schwartz RC, Stanton LW, Riley SC, Marcu KB, Witte ON: Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells. Mol Cell Biol 6:3221, 1986
59. Young JC, Witte ON: Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures. Mol Cell Biol 8:4079, 1988
60. Kamps MP, Baltimore D: E2A-Pbx1, the t(1;19) translocation protein of human pre-B cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice. Mol Cell Biol 13:351, 1993
61. Watowich SS, Yoshimura A, Longmore GD, Holton DJ, Yoshimura Y, Lodish HF: Homodimerization and constitutive activation of the erythropoietin receptor. Proc Natl Acad Sci USA 89:2140, 1992
62. Mulligan LM, Kwok JBJ, Healey CS, Elsdon MJ, Eng C, Gardner E, Love DR, Mole SE, Moore JK, Papi L, Ponder MA, Telenius H, Tunnacliffe A, Ponder BAJ: Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363:458, 1993
63. Mulligan LM, Eng C, Healey CS, Clayton D, Kwok JBJ, Gardner E, Ponder MA, Frilling A, Jackson CE, Lehnert H, Neumann HPH, Thibodeau SN, Ponder BAJ: Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN2A and FMTC. Nat Genet 6:70, 1994
64. Hofstra RMW, Landsvater RM, Ceccherini I, Stulp RP, Stelwagen T, Luo Y, Pasini B, Hoppener JWM, van Amstel HKP, Romeo G, Lips CJM, Buys CHCM: A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature 367:375, 1994
65. Carlson KM, Dou S, Chi D, Scavarda N, Toshima K, Jackson CE, Wells Jr SA, Goodfellow PJ, Donis-Keller H: Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B. Proc Natl Acad Sci USA 91:1579, 1994
66. Santoro M, Carlomagno F, Romano A, Bottaro DP, Dathan NA, Grieco M, Fusco A, Vecchio G, Matoskova B, Kraus MH, DiFiore PP: Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Science 267:381, 1995
67. Songyang Z, Carraway III KL, Eck MJ, Harrison SC, Feldoman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP, Eng C, Lorenzo MJ, Ponder BAJ, Mayer BJ, Cantly LC: Catalytic specificity of protein-tyrosine kinase is critical for selective signalling. Nature 373:536, 1995
68. Nagata H, Worobec AS, Oh CK, Chowdhury BA, Tannenbaum S, Suzuki Y, Metcalfe DD: Identification of a point mutation in the catalytic domain of the proto-oncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci USA 92:10560, 1995