A fourth case of BCR-FGFR1 positive CML-like disease with t(8;22) translocation showing an extensive deletion on the derivative chromosome 8p

Hematology Journal

Volumn 3, Issue 6, 2002, Pages 315-316

  Pini, Massimo ^a   Gottardi, Enrico ^b   Scaravaglio, Patrizia ^b   Giugliano, Emilia ^b   Libener, Roberta ^a   Beraldi, Anna ^a   Muzio, Alberto ^c   Cornaglia, Elisa ^a   Saglio, Giuseppe ^b   Levis, Alessandro ^a  

^a C Arrigo Children's Hospital   (Italy)

^b SAN LUIGI GONZAGA HOSPITAL   (Italy)

^c Ospedale S Spirito Casale Monferrato   (Italy)

Author keywords

Chromosome translocation; Myeloproliferative disorder; Neoplasms

Indexed keywords

BCR ABL PROTEIN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; HYBRID PROTEIN; HYDROXYUREA; IMATINIB; NUCLEOTIDE; PROTEIN TYROSINE KINASE INHIBITOR;

AGED; BIOCHEMISTRY; BLOOD ANALYSIS; CASE REPORT; CHROMOSOME 8P; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CHROMOSOME TRANSLOCATION 22; CHROMOSOME TRANSLOCATION 8; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; FATIGUE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE DELETION; GENETIC TRANSCRIPTION; HUMAN; LETTER; LEUKOCYTE COUNT; LEUKOCYTOSIS; MYELOPROLIFERATIVE DISORDER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SPLENOMEGALY; SWEATING; TREATMENT PLANNING;

AGED; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 8; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENE REARRANGEMENT; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MYELOPROLIFERATIVE DISORDERS; ONCOGENE PROTEINS; ONCOGENE PROTEINS, FUSION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCR; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTORS, FIBROBLAST GROWTH FACTOR; TRANSLOCATION, GENETIC;

EID: 0036972521     PISSN: 14664860     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.thj.6200201     Document Type: Letter

References (4)

1. Demiroglu A, Steer EJ, Heath C, Taylor K, Bentley M, Allen SL et al. The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion protein. Blood 2001; 98: 3778-3783.
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3. Sinclair PB, Nacheva EP, Leversha M, Telford N, Chang J, Reid A, et al. Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia, Blood 2000; 95: 738-744.
4. Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, Yeh BK, et al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 1997; 276: 955-960.