Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia

Haematologica

Volumn 87, Issue 8, 2002, Pages 789-794

  La Starza, Roberta ^a   Trubia, Maurizio ^a   Testoni, Nicoletta ^a   Ottaviani, Emanuela ^a   Belloni, Elena ^a   Crescenzi, Barbara ^a   Martelli, Massimo F ^a   Flandrin, Georges ^a   Giuseppe Pelicci, Pier ^a   Mecucci, Cristina ^a  

^a POLICLINICO MONTELUCE   (Italy)

Author keywords

Acute myeloid leukemia; ETV6 ABL1 rearrangement

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; CASE REPORT; CELL DIFFERENTIATION; CHIMERA; CLONAL ANERGY; CYTOGENETICS; FUSION GENE; GENE ACTIVATION; GENE REARRANGEMENT; GENETIC HETEROGENEITY; HUMAN; MALE; POLYMERASE CHAIN REACTION; PROTEIN FAMILY; SOLID TUMOR; BLOOD; BONE MARROW; CANCER STEM CELL; CELL CLONE; CELL LINEAGE; CHROMOSOME 12; CHROMOSOME 8; CHROMOSOME 9; CHROMOSOME ABERRATION; ENZYMOLOGY; EOSINOPHIL; EOSINOPHILIA; FLUORESCENCE IN SITU HYBRIDIZATION; GENE TRANSLOCATION; GENETICS; KARYOTYPING; MIDDLE AGED; ONCOGENE; PATHOLOGY; PHYSIOLOGY; REFRACTORY ANEMIA WITH EXCESS BLASTS; ULTRASTRUCTURE;

ADULT; ANEMIA, REFRACTORY, WITH EXCESS OF BLASTS; BONE MARROW; CASE REPORT; CELL LINEAGE; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 8; CHROMOSOMES, HUMAN, PAIR 9; CLONE CELLS; EOSINOPHILIA; EOSINOPHILS; GENES, ABL; GENETIC HETEROGENEITY; HUMAN; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MIDDLE AGE; ONCOGENE PROTEINS, FUSION; RNA, MESSENGER; RNA, NEOPLASM; SUPPORT, NON-U.S. GOV'T; TRANSLOCATION (GENETICS); TUMOR STEM CELLS; HUMANS; MIDDLE AGED; PROTEIN-TYROSINE KINASES; TRANSLOCATION, GENETIC;

MESSENGER RNA; ONCOPROTEIN; PROTEIN TYROSINE KINASE; RNA; TEL ABL FUSION PROTEIN, HUMAN; TEL-ABL FUSION PROTEIN, HUMAN;

EID: 0035986747     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
2. The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): Molecular cloning of both reciprocal transcripts
3. A new ETV6/TEL partner gene, ARG (abl-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation
4. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
5. Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12)
6. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma
7. Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: Cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma
8. Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25)
9. The novel activation of ABL by fusion to an etsrelated gene, TEL
10. Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia
11. Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia
12. BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion
13. ATEL/ABL fusion gene on chromosome 12p13 in a case of Ph-, BCR- atypical CML
14. Detection of dual TEL-ABL transcripts and a Tel-Abl protein containing-phosphotyrosine in a chronic myeloid leukemia patient
15. Successful use of the same slide for consecutive fluorescence in situ hybridization experiments
16. Genomic organization of TEL: The human ETS-variant gene 6
17. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
18. The t(5;14) chromosomal translocation in a case of acute lymphoblastic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene
19. Clonality analysis of hematopoietic cell lineages in acute myeloid leukemia and translocation (8;21): Only myeloid cells are part of the malignant clone
20. The abnormal eosinophils are part of the leukemic cell population in acute myelomonocytic leukemia with abnormal eosinophils (AML M4Eo) and carry the pericentric inversion 16: A combination of May-Grunwald-Giemsa staining and fluorescence in situ hybridization
21. TEL gene is involved in myelodysplastic syndromes with either the typical t(5;12)(q33;p13) translocation or its variant t(10;12)(q24;p13)
22. Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1
23. The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event
24. ETV6/ABL fusion is rare in Ph-negative chronic myeloid disorders