The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9;12) translocations in human leukemia, induces distinct myeloproliferative disease in mice

Blood

Volumn 99, Issue 12, 2002, Pages 4568-4577

  Million, Ryan P ^a,b   Aster, Jon ^a,b   Gary Gilliland, D ^a,b   Van Etten, Richard A ^a,b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c CENTER FOR BLOOD RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; HYBRID PROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE TEL ABL; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CHROMOSOME 12P; CHROMOSOME 9Q; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 9; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; LEUKEMOGENESIS; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL;

EID: 0037097596     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2001-12-0244     Document Type: Article

References (33)

1. Chronic myeloid leukemia
2. The P19O, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity
3. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
4. Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin 3 and granulocyte-macrophage colony-stimulating factor in mice: A novel model for chronic myelogenous leukemia
5. The Grb2 binding site is required for induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase
6. The Src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase
7. Fusion of the PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
8. Fusion of the TEL gene on 12p13 to the AML 1 gene on 21q22 in acute lymphoblastic leukemia
9. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion
10. The novel activation of ABL by fusion to an ets-related gene, TEL
11. Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia
12. Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia
13. - atypical CML
14. BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion
15. The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event
16. ETV6/ ABL fusion is rare in Ph-negative chronic myeloid disorders
17. Haemopoietic transformation by the TEL/ABL oncogene
18. A domain of TEL conserved in a subsel of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRβ oncoprotein
19. The TEL/platelet-derived growth factor β receptor (PDGF β R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF β R kinase-dependent signaling pathways
20. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myeloid and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion gene
21. A coiled coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins
22. p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines
23. The leukaemic oncoproteins Bcr-Abl and Tel-Abt (ETV6/ Abl) have altered substrate preferences and activate similar intracellular signalling pathways
24. Endotoxin, sepsis, and the primrose path
25. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
26. 2-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl
27. The 12;21 translocation involving TEL and deletion of the other TEL allele: Two frequently associated alterations found in childhood acute lymphoblastic leukemia
28. The second ETV6 allele is not necessarily deleted in acule leukemias with a ETV6/ ABL fusion
29. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
30. + cells present in autologous transplant of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML
31. Blast crisis in a murine model of chronic myelogenous leukemia
32. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
33. TEL/PDGFβR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor