A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma [11]

Leukemia

Volumn 20, Issue 3, 2006, Pages 536-537

  Adelaide J ^a   Perot C ^b   Gelsi Boyer, V ^a,c   Pautas, C ^d   Murati, A ^a   Copie Bergman, C ^d   Imbert, M ^d   Chaffanet, M ^a   Birnbaum, D ^a   Mozziconacci, M J ^a  

^a INSTITUT PAOLI CALMETTES   (France)

^b HÔPITAL SAINT ANTOINE   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d HENRI MONDOR HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; ASPARAGINASE; CYCLOPHOSPHAMIDE; CYTARABINE; GENE PRODUCT; JANUS KINASE 2; KI 67 ANTIGEN; METHOTREXATE; PROTEIN P53; PROTEIN PCM1; STEROID; UNCLASSIFIED DRUG; VINCRISTINE;

ABDOMINAL RADIOGRAPHY; ADULT; AUTOLOGOUS STEM CELL TRANSPLANTATION; CANCER COMBINATION CHEMOTHERAPY; CANCER REGRESSION; CANCER RELAPSE; CASE REPORT; CHROMOSOME ANALYSIS; CHROMOSOME TRANSLOCATION 8; CHROMOSOME TRANSLOCATION 9; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DRUG MEGADOSE; ELECTROCORTICOGRAPHY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FUSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; LETTER; LYMPH NODE BIOPSY; LYMPH NODE CELL; LYMPHOCYTIC INFILTRATION; MAINTENANCE THERAPY; MALE; METAPHASE; MITOSIS; PATHOPHYSIOLOGY; PELVIS RADIOGRAPHY; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; RETREATMENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T CELL LYMPHOMA; THORAX RADIOGRAPHY; TREATMENT OUTCOME;

EID: 33644552449     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404104     Document Type: Letter

References (5)

1. Reiter A, Walz C, Watmore A, Schoch C, Blau I, Schlegelberger B et al. The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukaemia that fuses PCM1 to JAK2. Cancer Res 2005; 65: 2662-2667.
2. Murati A, Gelsi-Boyer V, Adelaide J, Perot C, Talmant P, Giraudier S et al. PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation. Leukemia 2005; 19: 1692-1696.
3. Bousquet M, Quelen C, De Mas V, Duchayne E, Roquefeuil B, Delsol G et al. The t(8;9)(p22;p24) translocation in atypical chronic myeloproliferative disorders yields a new PCM1-JAK2 fusion gene. Oncogene 2005; 24: 7248-7252.
4. Heiss S, Erdel M, Gunsilius E, Nachbaur D, Tzankov A. Myelodysplastic/ myeloproliferative disease with erythropoietic hyperplasia (erythroid preleukemia) and the unique translocation (8;9)(p23;p24): First description of a case. Hum Pathol 2005; 36: 1148-1151.
5. Tefferi A, Gilliland DG. The JAK2 V617F tyrosine kinase mutation in myeloproliferative disorders: Status report and immediate implications for disease classification and diagnosis. Mayo Clin Proc 2005; 80: 947-958.