-
1
-
-
0024372274
-
Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant
-
Bohme J, Haskins K, Stecha P, et al. Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant. Science 1989;244:1179-83
-
(1989)
Science
, vol.244
, pp. 1179-1183
-
-
Bohme, J.1
Haskins, K.2
Stecha, P.3
-
2
-
-
0025334064
-
Tolerance in transgenic mice expressing major histocompatibility molecules extrathymically on pancreatic cells
-
Burkly LC, Lo D, Flavell RA. Tolerance in transgenic mice expressing major histocompatibility molecules extrathymically on pancreatic cells. Science 1990;248:1364-8
-
(1990)
Science
, vol.248
, pp. 1364-1368
-
-
Burkly, L.C.1
Lo, D.2
Flavell, R.A.3
-
3
-
-
0025572276
-
+ T cells induce wasting disease with multiple organ pathology: Prevention by the OX-22low subset
-
+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset. J Exp Med 1990;172:1701-8
-
(1990)
J Exp Med
, vol.172
, pp. 1701-1708
-
-
Powrie, F.1
Mason, D.2
-
4
-
-
0031739410
-
+ T cells: A population of T cells with immune regulatory activities in vitro
-
+ T cells: a population of T cells with immune regulatory activities in vitro. Eur J Immunol 1998;28:3435-47
-
(1998)
Eur J Immunol
, vol.28
, pp. 3435-3447
-
-
Read, S.1
Mauze, S.2
Asseman, C.3
-
5
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-64
-
(1995)
J Immunol
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
-
6
-
-
0029788211
-
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
-
Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996;184:387-96
-
(1996)
J Exp Med
, vol.184
, pp. 387-396
-
-
Asano, M.1
Toda, M.2
Sakaguchi, N.3
Sakaguchi, S.4
-
7
-
-
0031939403
-
+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
-
+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol 1998;160:1212-8
-
(1998)
J Immunol
, vol.160
, pp. 1212-1218
-
-
Suri-Payer, E.1
Amar, A.Z.2
Thornton, A.M.3
Shevach, E.M.4
-
8
-
-
0031821875
-
+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
-
+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998;188:287-96
-
(1998)
J Exp Med
, vol.188
, pp. 287-296
-
-
Thornton, A.M.1
Shevach, E.M.2
-
9
-
-
0021997185
-
Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease
-
Sakaguchi S, Fukuma K, Kuribayashi K, Masuda T. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J Exp Med 1985;161:72-87
-
(1985)
J Exp Med
, vol.161
, pp. 72-87
-
-
Sakaguchi, S.1
Fukuma, K.2
Kuribayashi, K.3
Masuda, T.4
-
10
-
-
0020451946
-
Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis
-
Sakaguchi S, Takahashi T, Nishizuka Y. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med 1982;156:1577-86
-
(1982)
J Exp Med
, vol.156
, pp. 1577-1586
-
-
Sakaguchi, S.1
Takahashi, T.2
Nishizuka, Y.3
-
11
-
-
0033103668
-
Peripheral autoantigen induces regulatory T cells that prevent autoimmunity
-
Seddon B, Mason D. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J Exp Med 1999;189:877-82
-
(1999)
J Exp Med
, vol.189
, pp. 877-882
-
-
Seddon, B.1
Mason, D.2
-
13
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-61
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
15
-
-
0035162560
-
Disruption of a new forkhead/ winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
-
Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/ winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001;27:68-73
-
(2001)
Nat Genet
, vol.27
, pp. 68-73
-
-
Brunkow, M.E.1
Jeffery, E.W.2
Hjerrild, K.A.3
-
16
-
-
0035163909
-
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
-
Wildin RS, Ramsdell F, Peake J, et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet 2001;27:18-20
-
(2001)
Nat Genet
, vol.27
, pp. 18-20
-
-
Wildin, R.S.1
Ramsdell, F.2
Peake, J.3
-
17
-
-
0035167967
-
-
Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001;27:20-1
-
Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001;27:20-1
-
-
-
-
18
-
-
33747602533
-
-
Torgerson TR. Regulatory T cells in human autoimmune diseases. Springer Semin Immunopathol 2006;28:63-76
-
Torgerson TR. Regulatory T cells in human autoimmune diseases. Springer Semin Immunopathol 2006;28:63-76
-
-
-
-
19
-
-
33745211931
-
Defective regulatory and effector T cell functions in patients with FOXP3 mutations
-
Bacchetta R, Passerini L, Gambineri E, et al. Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest 2006;116:1713-22
-
(2006)
J Clin Invest
, vol.116
, pp. 1713-1722
-
-
Bacchetta, R.1
Passerini, L.2
Gambineri, E.3
-
20
-
-
33847153417
-
Foxp3-dependent programme of regulatory T-cell differentiation
-
Gavin MA, Rasmussen JP, Fontenot JD, et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 2007;445:771-5
-
(2007)
Nature
, vol.445
, pp. 771-775
-
-
Gavin, M.A.1
Rasmussen, J.P.2
Fontenot, J.D.3
-
21
-
-
36048978911
-
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
-
Hill JA, Feuerer M, Tash K, et al. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 2007;27:786-800
-
(2007)
Immunity
, vol.27
, pp. 786-800
-
-
Hill, J.A.1
Feuerer, M.2
Tash, K.3
-
22
-
-
33846485153
-
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
-
Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007;8:191-7
-
(2007)
Nat Immunol
, vol.8
, pp. 191-197
-
-
Kim, J.M.1
Rasmussen, J.P.2
Rudensky, A.Y.3
-
23
-
-
0018841766
-
Breeding of a non-obese, diabetic strain of mice
-
Makino S, Kunimoto K, Muraoka Y, et al. Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu 1980;29:1-13
-
(1980)
Jikken Dobutsu
, vol.29
, pp. 1-13
-
-
Makino, S.1
Kunimoto, K.2
Muraoka, Y.3
-
24
-
-
36549038975
-
Animal models of spontaneous autoimmune disease: Type 1 diabetes in the nonobese diabetic mouse
-
Giarratana N, Penna G, Adorini L. Animal models of spontaneous autoimmune disease: type 1 diabetes in the nonobese diabetic mouse. Methods Mol Biol 2007;380:285-311
-
(2007)
Methods Mol Biol
, vol.380
, pp. 285-311
-
-
Giarratana, N.1
Penna, G.2
Adorini, L.3
-
25
-
-
0034652317
-
Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes
-
Yu L, Robles DT Abiru N, et al. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci USA 2000;97:1701-6
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1701-1706
-
-
Yu, L.1
Robles, D.T.2
Abiru, N.3
-
26
-
-
0032214715
-
Local expression of TNFα in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens
-
Green EA, Eynon EE, Flavell RA. Local expression of TNFα in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens. Immunity 1998;9:733-43
-
(1998)
Immunity
, vol.9
, pp. 733-743
-
-
Green, E.A.1
Eynon, E.E.2
Flavell, R.A.3
-
27
-
-
0027378612
-
Following a diabetogenic T cell from genesis through pathogenesis
-
Katz JD, Wang B, Haskins K, et al. Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993;74:1089-100
-
(1993)
Cell
, vol.74
, pp. 1089-1100
-
-
Katz, J.D.1
Wang, B.2
Haskins, K.3
-
28
-
-
0032526566
-
The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice
-
Wong FS, Visintin I, Wen L, et al. The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice. J Exp Med 1998;187:1985-93
-
(1998)
J Exp Med
, vol.187
, pp. 1985-1993
-
-
Wong, F.S.1
Visintin, I.2
Wen, L.3
-
29
-
-
0031406387
-
Genetic control of diabetes progression
-
Gonzalez A, Katz JD, Mattei MG, et al. Genetic control of diabetes progression. Immunity 1997;7:873-83
-
(1997)
Immunity
, vol.7
, pp. 873-883
-
-
Gonzalez, A.1
Katz, J.D.2
Mattei, M.G.3
-
30
-
-
0028446546
-
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model
-
von Herrath MG, Dockter J, Oldstone MB. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity 1994;1:231-42
-
(1994)
Immunity
, vol.1
, pp. 231-242
-
-
von Herrath, M.G.1
Dockter, J.2
Oldstone, M.B.3
-
31
-
-
0025754853
-
Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response
-
Oldstone MB, Nerenberg M, Southern P, et al. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 1991;65:319-31
-
(1991)
Cell
, vol.65
, pp. 319-331
-
-
Oldstone, M.B.1
Nerenberg, M.2
Southern, P.3
-
32
-
-
0033529927
-
The role of MHC class II molecules in susceptibility to type I diabetes: Identification of peptide epitopes and characterization of the T cell repertoire
-
Chao CC, Sytwu HK, Chen EL, et al. The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoire. Proc Natl Acad Sci USA 1999;96:9299-304
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 9299-9304
-
-
Chao, C.C.1
Sytwu, H.K.2
Chen, E.L.3
-
33
-
-
0025755292
-
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice
-
Ohashi PS, Oehen S, Buerki K, et al. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991;65:305-17
-
(1991)
Cell
, vol.65
, pp. 305-317
-
-
Ohashi, P.S.1
Oehen, S.2
Buerki, K.3
-
34
-
-
0030945996
-
Bystander activation of cytotoxic T cells: Studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model
-
Ehl S, Hombach J, Aichele P, et al. Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. J Exp Med 1997;185:1241-51
-
(1997)
J Exp Med
, vol.185
, pp. 1241-1251
-
-
Ehl, S.1
Hombach, J.2
Aichele, P.3
-
36
-
-
0032472406
-
Changes in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model
-
Sarukhan A, Lanoue A, Franzke A, et al. Changes in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model. EMBO J 1998;17:71-80
-
(1998)
EMBO J
, vol.17
, pp. 71-80
-
-
Sarukhan, A.1
Lanoue, A.2
Franzke, A.3
-
37
-
-
0033995129
-
Monitoring gene expression of TNFR family members by β-cells during development of autoimmune diabetes
-
Walter U, Franzke A, Sarukhan A, et al. Monitoring gene expression of TNFR family members by β-cells during development of autoimmune diabetes. Eur J Immunol 2000;30:1224-32
-
(2000)
Eur J Immunol
, vol.30
, pp. 1224-1232
-
-
Walter, U.1
Franzke, A.2
Sarukhan, A.3
-
38
-
-
0028582150
-
On the various manifestations of spontaneous autoimmune diabetes in rodent models
-
Degermann S, Reilly C, Scott B, et al. On the various manifestations of spontaneous autoimmune diabetes in rodent models. Eur J Immunol 1994;24:3155-60
-
(1994)
Eur J Immunol
, vol.24
, pp. 3155-3160
-
-
Degermann, S.1
Reilly, C.2
Scott, B.3
-
39
-
-
0029060005
-
+ T cells specific for a pancreatic beta cell neo-antigen
-
+ T cells specific for a pancreatic beta cell neo-antigen. Immunity 1995;2:573-85
-
(1995)
Immunity
, vol.2
, pp. 573-585
-
-
Forster, I.1
Hirose, R.2
Arbeit, J.M.3
-
40
-
-
1342302114
-
The TCR-HA, INS-HA transgenic model of autoimmune diabetes: Limitations and expectations
-
Apostolou I, Von Boehmer H. The TCR-HA, INS-HA transgenic model of autoimmune diabetes: limitations and expectations. J Autoimmun 2004;22:111-4
-
(2004)
J Autoimmun
, vol.22
, pp. 111-114
-
-
Apostolou, I.1
Von Boehmer, H.2
-
41
-
-
0032873317
-
Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet beta-cells
-
Sarukhan A, Lechner O, von Boehmer H. Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet beta-cells. Eur J Immunol 1999;29:3410-6
-
(1999)
Eur J Immunol
, vol.29
, pp. 3410-3416
-
-
Sarukhan, A.1
Lechner, O.2
von Boehmer, H.3
-
42
-
-
0029812040
-
Constitutive class I-restricted exogenous presentation of self antigens in vivo
-
Kurts C, Heath WR, Carbone FR, et al. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J Exp Med 1996;184:923-30
-
(1996)
J Exp Med
, vol.184
, pp. 923-930
-
-
Kurts, C.1
Heath, W.R.2
Carbone, F.R.3
-
43
-
-
45949090105
-
Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21
-
Clough LE, Wang CJ, Schmidt EM, et al. Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21. J Immunol 2008;180:5393-401
-
(2008)
J Immunol
, vol.180
, pp. 5393-5401
-
-
Clough, L.E.1
Wang, C.J.2
Schmidt, E.M.3
-
44
-
-
0029978038
-
Checkpoints in the progression of autoimmune disease: Lessons from diabetes models
-
Andre I, Gonzalez A, Wang B, et al. Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc Natl Acad Sci USA 1996;93:2260-3
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 2260-2263
-
-
Andre, I.1
Gonzalez, A.2
Wang, B.3
-
45
-
-
0024312829
-
The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice
-
Signore A, Pozzilli P, Gale EA, et al. The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice. Diabetologia 1989;32:282-9
-
(1989)
Diabetologia
, vol.32
, pp. 282-289
-
-
Signore, A.1
Pozzilli, P.2
Gale, E.A.3
-
46
-
-
0021875480
-
In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis
-
Bottazzo GF, Dean BM, McNally JM, et al. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 1985;313:353-60
-
(1985)
N Engl J Med
, vol.313
, pp. 353-360
-
-
Bottazzo, G.F.1
Dean, B.M.2
McNally, J.M.3
-
47
-
-
0024500755
-
T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice
-
Boitard C, Yasunami R, Dardenne M, Bach JF. T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J Exp Med 1989;169:1669-80
-
(1989)
J Exp Med
, vol.169
, pp. 1669-1680
-
-
Boitard, C.1
Yasunami, R.2
Dardenne, M.3
Bach, J.F.4
-
48
-
-
0029053581
-
+ β islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice
-
+ β islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice. J Exp Med 1995;182:87-97
-
(1995)
J Exp Med
, vol.182
, pp. 87-97
-
-
Akhtar, I.1
Gold, J.P.2
Pan, L.Y.3
-
49
-
-
0033682056
-
+ immunoregulatory T cells that control autoimmune diabetes
-
+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000; 12:431-40
-
(2000)
Immunity
, vol.12
, pp. 431-440
-
-
Salomon, B.1
Lenschow, D.J.2
Rhee, L.3
-
53
-
-
0021716386
-
Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide
-
Harada M, Makino S. Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide. Diabetologia 1984;27:604-6
-
(1984)
Diabetologia
, vol.27
, pp. 604-606
-
-
Harada, M.1
Makino, S.2
-
54
-
-
0023894971
-
Anti-suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice
-
Yasunami R, Bach JF. Anti-suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice. Eur J Immunol 1988;18:481-4
-
(1988)
Eur J Immunol
, vol.18
, pp. 481-484
-
-
Yasunami, R.1
Bach, J.F.2
-
55
-
-
0036721772
-
+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7
-
+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol 2002;169:2461-5
-
(2002)
J Immunol
, vol.169
, pp. 2461-2465
-
-
Szanya, V.1
Ermann, J.2
Taylor, C.3
-
56
-
-
5144228520
-
+ regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice
-
+ regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice. Proc Natl Acad Sci USA 2004;101(Suppl 2):14580-5
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.SUPPL. 2
, pp. 14580-14585
-
-
You, S.1
Slehoffer, G.2
Barriot, S.3
-
57
-
-
4344657757
-
+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion
-
+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion. J Immunol 2004;173:2942-51
-
(2004)
J Immunol
, vol.173
, pp. 2942-2951
-
-
Sarween, N.1
Chodos, A.2
Raykundalia, C.3
-
58
-
-
29244482759
-
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
-
Tang Q, Adams JY, Tooley AJ, et al. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol 2006;7:83-92
-
(2006)
Nat Immunol
, vol.7
, pp. 83-92
-
-
Tang, Q.1
Adams, J.Y.2
Tooley, A.J.3
-
59
-
-
33746933464
-
Regulatory and effector T cell activation levels are prime determinants of in vivo immune regulation
-
Billiard F, Litvinova E, Saadoun D, et al. Regulatory and effector T cell activation levels are prime determinants of in vivo immune regulation. J Immunol 2006;177:2167-74
-
(2006)
J Immunol
, vol.177
, pp. 2167-2174
-
-
Billiard, F.1
Litvinova, E.2
Saadoun, D.3
-
60
-
-
2442522323
-
Autoreactive T cells in healthy individuals
-
Danke NA, Koelle DM, Yee C, et al. Autoreactive T cells in healthy individuals. J Immunol 2004;172:5967-72
-
(2004)
J Immunol
, vol.172
, pp. 5967-5972
-
-
Danke, N.A.1
Koelle, D.M.2
Yee, C.3
-
61
-
-
76549198972
-
Pathologic anatomy of the pancreas in juvenile diabetes mellitus
-
Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965;14:619-33
-
(1965)
Diabetes
, vol.14
, pp. 619-633
-
-
Gepts, W.1
-
62
-
-
0023849461
-
Factors associated with early remission of type I diabetes in children treated with cyclosporine
-
Bougneres PF, Carel JC, Castano L, et al. Factors associated with early remission of type I diabetes in children treated with cyclosporine. N Engl J Med 1988;318:663-70
-
(1988)
N Engl J Med
, vol.318
, pp. 663-670
-
-
Bougneres, P.F.1
Carel, J.C.2
Castano, L.3
-
63
-
-
0025022560
-
Examination of islets in the pancreas biopsy specimens from newly diagnosed type 1 (insulin-dependent) diabetic patients
-
Hanafusa T, Miyazaki A, Miyagawa J, et al. Examination of islets in the pancreas biopsy specimens from newly diagnosed type 1 (insulin-dependent) diabetic patients. Diabetologia 1990;33:105-11
-
(1990)
Diabetologia
, vol.33
, pp. 105-111
-
-
Hanafusa, T.1
Miyazaki, A.2
Miyagawa, J.3
-
64
-
-
0037125972
-
Tumor necrosis factor-α regulation of CD4+CD25+ T cell levels in NOD mice
-
Wu AJ, Hua H, Munson SH, McDevitt HO. Tumor necrosis factor-α regulation of CD4+CD25+ T cell levels in NOD mice. Proc Natl Acad Sci USA 2002;99:12287-92
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12287-12292
-
-
Wu, A.J.1
Hua, H.2
Munson, S.H.3
McDevitt, H.O.4
-
66
-
-
38449090623
-
Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes
-
Tritt M, Sgouroudis E, d'Hennezel E, et al. Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes 2008;57:113-23
-
(2008)
Diabetes
, vol.57
, pp. 113-123
-
-
Tritt, M.1
Sgouroudis, E.2
d'Hennezel, E.3
-
67
-
-
36749031198
-
Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes
-
Feuerer M, Jiang W, Holler PD, et al. Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci USA 2007;104:18181-6
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 18181-18186
-
-
Feuerer, M.1
Jiang, W.2
Holler, P.D.3
-
68
-
-
1942453326
-
Homeostatic expansion of T cells during immune insufficiency generates autoimmunity
-
King C, Ilic A, Koelsch K, Sarvetnick N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 2004;117:265-77
-
(2004)
Cell
, vol.117
, pp. 265-277
-
-
King, C.1
Ilic, A.2
Koelsch, K.3
Sarvetnick, N.4
-
69
-
-
18244400088
-
Single cell analysis shows decreasing FoxP3 and TGFβ1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes
-
Pop SM, Wong CP, Culton DA, et al. Single cell analysis shows decreasing FoxP3 and TGFβ1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med 2005;201:1333-46
-
(2005)
J Exp Med
, vol.201
, pp. 1333-1346
-
-
Pop, S.M.1
Wong, C.P.2
Culton, D.A.3
-
70
-
-
0141992907
-
Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development
-
Gregori S, Giarratana N, Smiroldo S, Adorini L. Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J Immunol 2003;171:4040-7
-
(2003)
J Immunol
, vol.171
, pp. 4040-4047
-
-
Gregori, S.1
Giarratana, N.2
Smiroldo, S.3
Adorini, L.4
-
71
-
-
34447103406
-
An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice
-
Thomas DC, Mellanby RJ, Phillips JM, Cooke A. An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice. Immunology 2007;121:565-76
-
(2007)
Immunology
, vol.121
, pp. 565-576
-
-
Thomas, D.C.1
Mellanby, R.J.2
Phillips, J.M.3
Cooke, A.4
-
72
-
-
43049174722
-
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
-
Tang Q, Adams JY, Penaranda C, et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 2008;28:687-97
-
(2008)
Immunity
, vol.28
, pp. 687-697
-
-
Tang, Q.1
Adams, J.Y.2
Penaranda, C.3
-
73
-
-
33847246293
-
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
-
Yamanouchi J, Rainbow D, Serra P, et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 2007;39:329-37
-
(2007)
Nat Genet
, vol.39
, pp. 329-337
-
-
Yamanouchi, J.1
Rainbow, D.2
Serra, P.3
-
74
-
-
0036141438
-
Multiple immuno-regulatory defects in type-1 diabetes
-
Kukreja A, Cost G, Marker J, et al. Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest 2002;109:131-40
-
(2002)
J Clin Invest
, vol.109
, pp. 131-140
-
-
Kukreja, A.1
Cost, G.2
Marker, J.3
-
76
-
-
12144249838
-
Defective suppressor function in CD4+CD25+ T-cells from patients with type 1 diabetes
-
Lindley S, Dayan CM, Bishop A, et al. Defective suppressor function in CD4+CD25+ T-cells from patients with type 1 diabetes. Diabetes 2005;54:92-9
-
(2005)
Diabetes
, vol.54
, pp. 92-99
-
-
Lindley, S.1
Dayan, C.M.2
Bishop, A.3
-
77
-
-
17844364504
-
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes
-
Brusko TM, Wasserfall CH, Clare-Salzler MJ, et al. Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes 2005;54:1407-14
-
(2005)
Diabetes
, vol.54
, pp. 1407-1414
-
-
Brusko, T.M.1
Wasserfall, C.H.2
Clare-Salzler, M.J.3
-
78
-
-
33847373481
-
No alterations in the frequency of FOXP3+ regulatory T-cells in Type 1 diabetes
-
Brusko T, Wasserfall C, McGrail K, et al. No alterations in the frequency of FOXP3+ regulatory T-cells in Type 1 diabetes. Diabetes 2007;56:604-12
-
(2007)
Diabetes
, vol.56
, pp. 604-612
-
-
Brusko, T.1
Wasserfall, C.2
McGrail, K.3
-
79
-
-
33845691031
-
A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: Report of the Immunology of Diabetes Society T cell Workshop
-
Tree TI, Roep BO, Peakman M. A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T cell Workshop. Ann NY Acad Sci 2006;1079:9-18
-
(2006)
Ann NY Acad Sci
, vol.1079
, pp. 9-18
-
-
Tree, T.I.1
Roep, B.O.2
Peakman, M.3
-
80
-
-
33745817085
-
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
-
Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006;203:1701-11
-
(2006)
J Exp Med
, vol.203
, pp. 1701-1711
-
-
Liu, W.1
Putnam, A.L.2
Xu-Yu, Z.3
-
81
-
-
33846915972
-
The CD4+ regulatory T-cells is decreased in adults with latent autoimmune diabetes
-
Yang Z, Zhou Z, Huang G, et al. The CD4+ regulatory T-cells is decreased in adults with latent autoimmune diabetes. Diabetes Res Clin Pract 2007;76:126-31
-
(2007)
Diabetes Res Clin Pract
, vol.76
, pp. 126-131
-
-
Yang, Z.1
Zhou, Z.2
Huang, G.3
-
82
-
-
20944444896
-
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells
-
You S, Belghith M, Cobbold S, et al. Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells. Diabetes 2005;54:1415-22
-
(2005)
Diabetes
, vol.54
, pp. 1415-1422
-
-
You, S.1
Belghith, M.2
Cobbold, S.3
-
83
-
-
10344245538
-
A sudden decline in active membrane-bound TGF-β impairs both T regulatory cell function and protection against autoimmune diabetes
-
Gregg RK, Jain R, Schoenleber SJ, et al. A sudden decline in active membrane-bound TGF-β impairs both T regulatory cell function and protection against autoimmune diabetes. J Immunol 2004;173:7308-16
-
(2004)
J Immunol
, vol.173
, pp. 7308-7316
-
-
Gregg, R.K.1
Jain, R.2
Schoenleber, S.J.3
-
84
-
-
15444363794
-
T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells
-
Fahlen L, Read S, Gorelik L, et al. T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells. J Exp Med 2005;201:737-46
-
(2005)
J Exp Med
, vol.201
, pp. 737-746
-
-
Fahlen, L.1
Read, S.2
Gorelik, L.3
-
85
-
-
33747030655
-
Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice
-
Alard P, Manirarora JN, Parnell SA, et al. Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice. Diabetes 2006;55:2098-105
-
(2006)
Diabetes
, vol.55
, pp. 2098-2105
-
-
Alard, P.1
Manirarora, J.N.2
Parnell, S.A.3
-
86
-
-
0842308786
-
CD4+ CD25+ Treg: Divide and rule?
-
Walker LS. CD4+ CD25+ Treg: divide and rule? Immunology 2004;111:129-37
-
(2004)
Immunology
, vol.111
, pp. 129-137
-
-
Walker, L.S.1
-
87
-
-
23844478869
-
Natural recovery and protection from autoimmune encephalomyelitis: Contribution of CD4+CD25+ regulatory cells within the central nervous system
-
McGeachy MJ, Stephens LA, Anderton SM. Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system. J Immunol 2005;175:3025-32
-
(2005)
J Immunol
, vol.175
, pp. 3025-3032
-
-
McGeachy, M.J.1
Stephens, L.A.2
Anderton, S.M.3
-
88
-
-
4444300314
-
CD4+CD25 + regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid
-
van Amelsfort JM, Jacobs KM, Bijlsma JW, et al. CD4+CD25 + regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum 2004;50:2775-85
-
(2004)
Arthritis Rheum
, vol.50
, pp. 2775-2785
-
-
van Amelsfort, J.M.1
Jacobs, K.M.2
Bijlsma, J.W.3
-
89
-
-
0141449974
-
CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses
-
Suvas S, Kumaraguru U, Pack CD, et al. CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J Exp Med 2003;198:889-901
-
(2003)
J Exp Med
, vol.198
, pp. 889-901
-
-
Suvas, S.1
Kumaraguru, U.2
Pack, C.D.3
-
90
-
-
0036883944
-
Inhibition of human CD4+CD25+high regulatory T cell function
-
Baecher-Allan C, Viglietta V, Hafler DA. Inhibition of human CD4+CD25+high regulatory T cell function. J Immunol 2002;169:6210-7
-
(2002)
J Immunol
, vol.169
, pp. 6210-6217
-
-
Baecher-Allan, C.1
Viglietta, V.2
Hafler, D.A.3
-
91
-
-
0141703239
-
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes
-
Green EA, Gorelik L, McGregor CM, et al. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes. Proc Natl Acad Sci USA 2003;100:10878-83
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10878-10883
-
-
Green, E.A.1
Gorelik, L.2
McGregor, C.M.3
-
92
-
-
0037025990
-
Pancreatic lymph nodes are required for priming of β cell reactive T cells in NOD mice
-
Gagnerault MC, Luan JJ, Lotton C, Lepault F. Pancreatic lymph nodes are required for priming of β cell reactive T cells in NOD mice. J Exp Med 2002;196:369-77
-
(2002)
J Exp Med
, vol.196
, pp. 369-377
-
-
Gagnerault, M.C.1
Luan, J.J.2
Lotton, C.3
Lepault, F.4
-
93
-
-
0034597789
-
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
-
Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000;408:57-63
-
(2000)
Nature
, vol.408
, pp. 57-63
-
-
Parrish-Novak, J.1
Dillon, S.R.2
Nelson, A.3
-
94
-
-
33846196712
-
IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes
-
Peluso I, Fantini MC, Fina D, et al. IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes. J Immunol 2007;178:732-9
-
(2007)
J Immunol
, vol.178
, pp. 732-739
-
-
Peluso, I.1
Fantini, M.C.2
Fina, D.3
-
95
-
-
34247186263
-
Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes
-
Asano K, Ikegami H, Fujisawa T, et al. Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes. Hum Immunol 2007;68:384-91
-
(2007)
Hum Immunol
, vol.68
, pp. 384-391
-
-
Asano, K.1
Ikegami, H.2
Fujisawa, T.3
-
96
-
-
2942692039
-
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
-
Tarbell KV, Yamazaki S, Olson K, et al. CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med 2004;199:1467-77
-
(2004)
J Exp Med
, vol.199
, pp. 1467-1477
-
-
Tarbell, K.V.1
Yamazaki, S.2
Olson, K.3
-
97
-
-
2942642383
-
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
-
Tang Q, Henriksen KJ, Bi M, et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 2004;199:1455-65
-
(2004)
J Exp Med
, vol.199
, pp. 1455-1465
-
-
Tang, Q.1
Henriksen, K.J.2
Bi, M.3
-
98
-
-
33846410255
-
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice
-
Tarbell KV, Petit L, Zuo X, et al. Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med 2007;204:191-201
-
(2007)
J Exp Med
, vol.204
, pp. 191-201
-
-
Tarbell, K.V.1
Petit, L.2
Zuo, X.3
-
99
-
-
0042512461
-
Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
-
Yamazaki S, Iyoda T, Tarbell K, et al. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med 2003;198:235-47
-
(2003)
J Exp Med
, vol.198
, pp. 235-247
-
-
Yamazaki, S.1
Iyoda, T.2
Tarbell, K.3
-
100
-
-
3242801352
-
Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells
-
Hoffmann P, Eder R, Kunz-Schughart LA, et al. Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells. Blood 2004;104:895-903
-
(2004)
Blood
, vol.104
, pp. 895-903
-
-
Hoffmann, P.1
Eder, R.2
Kunz-Schughart, L.A.3
-
101
-
-
0035806323
-
Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
-
Levings MK, Sangregorio R, Roncarolo MG. Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001;193:1295-302
-
(2001)
J Exp Med
, vol.193
, pp. 1295-1302
-
-
Levings, M.K.1
Sangregorio, R.2
Roncarolo, M.G.3
-
102
-
-
0036909464
-
A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-term growth of CD4 T lymphocytes
-
Thomas AK, Maus MV, Shalaby WS, et al. A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-term growth of CD4 T lymphocytes. Clin Immunol 2002;105:259-72
-
(2002)
Clin Immunol
, vol.105
, pp. 259-272
-
-
Thomas, A.K.1
Maus, M.V.2
Shalaby, W.S.3
-
103
-
-
3142519564
-
In vitro-expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures
-
Godfrey WR, Ge YG, Spoden DJ, et al. In vitro-expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 2004;104:453-61
-
(2004)
Blood
, vol.104
, pp. 453-461
-
-
Godfrey, W.R.1
Ge, Y.G.2
Spoden, D.J.3
-
104
-
-
18144396195
-
In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
-
Earle KE, Tang Q, Zhou X, et al. In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation. Clin Immunol 2005;115:3-9
-
(2005)
Clin Immunol
, vol.115
, pp. 3-9
-
-
Earle, K.E.1
Tang, Q.2
Zhou, X.3
-
105
-
-
43049176667
-
Autologous umbilical cord blood infusion for type 1 diabetes
-
Haller MJ, Viener HL, Wasserfall C, et al. Autologous umbilical cord blood infusion for type 1 diabetes. Exp Hematol 2008;36:710-5
-
(2008)
Exp Hematol
, vol.36
, pp. 710-715
-
-
Haller, M.J.1
Viener, H.L.2
Wasserfall, C.3
-
107
-
-
36248970701
-
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
-
Awasthi A, Carrier Y, Peron JP, et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol 2007;8:1380-9
-
(2007)
Nat Immunol
, vol.8
, pp. 1380-1389
-
-
Awasthi, A.1
Carrier, Y.2
Peron, J.P.3
-
108
-
-
0030704726
-
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
-
Groux H, O'Garra A, Bigler M, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389:737-42
-
(1997)
Nature
, vol.389
, pp. 737-742
-
-
Groux, H.1
O'Garra, A.2
Bigler, M.3
-
109
-
-
0037018104
-
In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
-
Barrat FJ, Cua DJ, Boonstra A, et al. In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002;195:603-16
-
(2002)
J Exp Med
, vol.195
, pp. 603-616
-
-
Barrat, F.J.1
Cua, D.J.2
Boonstra, A.3
-
110
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
-
Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 2003;198:1875-86
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
-
111
-
-
2142645808
-
Cutting edge: TGF-β induces a regulatory phenotype in CD4+CD25-T cells through Foxp3 induction and down-regulation of Smad7
-
Fantini MC, Becker C, Monteleone G, et al. Cutting edge: TGF-β induces a regulatory phenotype in CD4+CD25-T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 2004;172:5149-53
-
(2004)
J Immunol
, vol.172
, pp. 5149-5153
-
-
Fantini, M.C.1
Becker, C.2
Monteleone, G.3
-
112
-
-
4744356110
-
TGF-β induces Foxp3+ T-regulatory cells from CD4+ CD25- precursors
-
Fu S, Zhang N, Yopp AC, et al. TGF-β induces Foxp3+ T-regulatory cells from CD4+ CD25- precursors. Am J Transplant 2004;4:1614-27
-
(2004)
Am J Transplant
, vol.4
, pp. 1614-1627
-
-
Fu, S.1
Zhang, N.2
Yopp, A.C.3
-
113
-
-
47549112840
-
IL-21 and TGF-β are required for differentiation of human T(H) 17 cells
-
Yang L, Anderson DE, Baecher-Allan C, et al. IL-21 and TGF-β are required for differentiation of human T(H) 17 cells. Nature 2008;454:350-2
-
(2008)
Nature
, vol.454
, pp. 350-352
-
-
Yang, L.1
Anderson, D.E.2
Baecher-Allan, C.3
-
115
-
-
2542420993
-
In vivo instruction of suppressor commitment in naive T cells
-
Apostolou I, von Boehmer, H. In vivo instruction of suppressor commitment in naive T cells. J Exp Med 2004;199:1401-8
-
(2004)
J Exp Med
, vol.199
, pp. 1401-1408
-
-
Apostolou, I.1
von Boehmer, H.2
-
116
-
-
29244435493
-
Inducing and expanding regulatory T cell populations by foreign antigen
-
Kretschmer K, Apostolou I, Hawiger D, et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 2005;6:1219-27
-
(2005)
Nat Immunol
, vol.6
, pp. 1219-1227
-
-
Kretschmer, K.1
Apostolou, I.2
Hawiger, D.3
-
117
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold KC, Hagopian, W, Auger JA, et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 2002;346:1692-8
-
(2002)
N Engl J Med
, vol.346
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
-
118
-
-
0032524957
-
Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets
-
Smith JA, Tang Q, Bluestone JA. Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets. J Immunol 1998;160:4841-9
-
(1998)
J Immunol
, vol.160
, pp. 4841-4849
-
-
Smith, J.A.1
Tang, Q.2
Bluestone, J.A.3
-
119
-
-
0030896612
-
Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy
-
Smith JA, Tso JY, Clark MR, et al. Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy. J Exp Med 1997;185:1413-22
-
(1997)
J Exp Med
, vol.185
, pp. 1413-1422
-
-
Smith, J.A.1
Tso, J.Y.2
Clark, M.R.3
-
120
-
-
0024588763
-
-
Hirsch R, Gress RE, Pluznik DH, et al. Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells. J Immunol 1989;142:737-43
-
Hirsch R, Gress RE, Pluznik DH, et al. Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells. J Immunol 1989;142:737-43
-
-
-
-
121
-
-
0027083592
-
Remission of established disease in diabetic NOD mice induced by anti-CD3 monoclonal antibody]
-
Chatenoud L, Thervet E, Primo J, Bach JF. [Remission of established disease in diabetic NOD mice induced by anti-CD3 monoclonal antibody]. C R Acad Sci III 1992;315:225-8
-
(1992)
C R Acad Sci III
, vol.315
, pp. 225-228
-
-
Chatenoud, L.1
Thervet, E.2
Primo, J.3
Bach, J.F.4
-
122
-
-
0027958044
-
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
-
Chatenoud L, Thervet E, Primo J, Bach JF. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci USA 1994;91:123-7
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 123-127
-
-
Chatenoud, L.1
Thervet, E.2
Primo, J.3
Bach, J.F.4
-
123
-
-
0026546211
-
Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody
-
Herold KC, Bluestone JA, Montag AG, et al. Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody. Diabetes 1992;41:385-91
-
(1992)
Diabetes
, vol.41
, pp. 385-391
-
-
Herold, K.C.1
Bluestone, J.A.2
Montag, A.G.3
-
124
-
-
20044375937
-
A single course of anti-CD3 monoclonal antibody hOKT3γ1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
-
Herold KC, Gitelman SE, Masharani U, et al. A single course of anti-CD3 monoclonal antibody hOKT3γ1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 2005;54:1763-9
-
(2005)
Diabetes
, vol.54
, pp. 1763-1769
-
-
Herold, K.C.1
Gitelman, S.E.2
Masharani, U.3
-
125
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
Keymeulen B, Vandemeulebroucke E, Ziegler AG, et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 2005;352:2598-608
-
(2005)
N Engl J Med
, vol.352
, pp. 2598-2608
-
-
Keymeulen, B.1
Vandemeulebroucke, E.2
Ziegler, A.G.3
-
126
-
-
0037314237
-
Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala)
-
Herold KC, Burton JB, Francois F, et al. Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala). J Clin Invest 2003;111:409-18
-
(2003)
J Clin Invest
, vol.111
, pp. 409-418
-
-
Herold, K.C.1
Burton, J.B.2
Francois, F.3
-
127
-
-
0141796312
-
TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
-
Belghith M, Bluestone JA, Barriot S, et al. TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 2003;9:1202-08
-
(2003)
Nat Med
, vol.9
, pp. 1202-1208
-
-
Belghith, M.1
Bluestone, J.A.2
Barriot, S.3
-
128
-
-
34547204632
-
Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
-
You S, Leforban B, Garcia C, et al. Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci USA 2007; 104:6335-40
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 6335-6340
-
-
You, S.1
Leforban, B.2
Garcia, C.3
-
129
-
-
33646392755
-
Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
-
Bresson D, Togher L, Rodrigo E, et al. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest 2006;116:1371-81
-
(2006)
J Clin Invest
, vol.116
, pp. 1371-1381
-
-
Bresson, D.1
Togher, L.2
Rodrigo, E.3
-
130
-
-
34548751075
-
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts
-
Koulmanda M, Budo E, Bonner-Weir S, et al. Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci USA 2007;104:13074-9
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 13074-13079
-
-
Koulmanda, M.1
Budo, E.2
Bonner-Weir, S.3
-
131
-
-
0035132135
-
IL-15 and IL-2: A matter of life and death for T cells in vivo
-
Li XC, Demirci G, Ferrari-Lacraz S, et al. IL-15 and IL-2: a matter of life and death for T cells in vivo. Nat Med 2001;7:114-8
-
(2001)
Nat Med
, vol.7
, pp. 114-118
-
-
Li, X.C.1
Demirci, G.2
Ferrari-Lacraz, S.3
-
132
-
-
27544446622
-
Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
-
D'Cruz LM, Klein L. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 2005;6:1152-9
-
(2005)
Nat Immunol
, vol.6
, pp. 1152-1159
-
-
D'Cruz, L.M.1
Klein, L.2
-
134
-
-
33645465526
-
Selective stimulation of T cell subsets with antibody-cytokine immune complexes
-
Boyman O, Kovar M, Rubinstein MP, et al. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 2006;311:1924-7
-
(2006)
Science
, vol.311
, pp. 1924-1927
-
-
Boyman, O.1
Kovar, M.2
Rubinstein, M.P.3
-
135
-
-
27944454429
-
Where CD4+CD25+ T reg cells impinge on autoimmune diabetes
-
Chen Z, Herman AE, Matos M, et al. Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med 2005;202:1387-97
-
(2005)
J Exp Med
, vol.202
, pp. 1387-1397
-
-
Chen, Z.1
Herman, A.E.2
Matos, M.3
-
136
-
-
0036196305
-
Pancreatic lymph node-derived CD4+CD25+ Treg cells: Highly potent regulators of diabetes that require TRANCE-RANK signals
-
Green EA, Choi Y, Flavell RA. Pancreatic lymph node-derived CD4+CD25+ Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 2002;16:183-91
-
(2002)
Immunity
, vol.16
, pp. 183-191
-
-
Green, E.A.1
Choi, Y.2
Flavell, R.A.3
|