The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice

Journal of Experimental Medicine

Volumn 187, Issue 12, 1998, Pages 1985-1993

  Wong, F Susan ^a   Visintin, Irene ^a   Wen, Li ^a   Granata, Jennifer ^a   Flavell, Richard ^a   Janeway Jr , Charles A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Accelerated diabetes; B cells; Nonobese diabetic mice; Rat insulin promoter B7 1 transgene; T cells

Indexed keywords

B7 ANTIGEN; BETA 2 MICROGLOBULIN; CD4 ANTIGEN; CD8 ANTIGEN; INSULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CONTROLLED STUDY; GENE EXPRESSION; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE; TRANSGENE; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; AGE OF ONSET; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD80; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; HISTOCOMPATIBILITY ANTIGENS CLASS I; INCIDENCE; INSULIN; ISLETS OF LANGERHANS; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); SPLEEN;

EID: 0032526566     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.12.1985     Document Type: Article

References (29)

1. Miller, B.J., M.C. Appel, J.J. O'Neil, and L.S. Wicker. 1988. Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol. 140:52-58.
2. Bendelac, A., C. Carnaud, C. Boitard, and J.-F. Bach. 1987. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates: requirement for both L3T4+ and Lyt2+ T cells. J. Exp. Med. 166:823-832.
3. Serreze, D.V., E.H. Leiter, G.J. Christianson, D. Greiner, and D.C. Roopenian. 1994. Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulins resistant. Diabetes. 43:505-509.
4. Wicker, L.S., E.H. Leiter, J.A. Todd, R.J. Renjilian, E. Peterson, P.A. Fischer, P.L. Podolin, M. Zijlstra, R. Jaenisch, and L.B. Peterson. 1994. Beta 2-microglobulin-deficient NOD mice do not develop insulins or diabetes. Diabetes. 43: 500-504.
5. Katz, J., C. Benoist, and D. Mathis. 1993. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur. J. Immunol. 23:3358-3360.
6. Sumida, T., M. Furukawa, A. Sakamoto, T. Namekawa, T. Maeda, M. Zijlstra, I. Iwamoto, T. Koike, S. Yoshida, H. Tomioka, et al. 1994. Prevention of insulitis and diabetes in beta 2-microglobulin-deficient non-obese diabetic mice. Int. Immunol. 6:1445-1449.
7. Wang, B., A. Gonzalez, C. Benoist, and D. Mathis. 1996. The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus. Eur. J. Immunol. 26:1762-1769.
8. Serreze, D.V., H.D. Chapman, D.S. Varnum, I. Gerling, E.H. Leiter, and L.D. Shultz. 1997. Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent. J. Immunol. 158:3978-3986.
9. Kay, T.W., J.L. Parker, L.A. Stephens, H.E. Thomas, and J. Allison. 1996. RIP-beta 2-microglobulin transgene expression restores insulins, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice. J. Immunol. 157:3688-3693.
10. Shizuru, J.A., E.C. Taylor, B.A. Banks, A.K. Gregory, and C.G. Fathman. 1988. Immunotherapy of the nonobese dia-betic mouse: treatment with an antibody to T-helper lymphocytes. Science. 240:659-662.
11. Wong, F.S., I. Visintin, L. Wen, R.A. Flavell, and C.J. Janeway. 1996. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med. 183:67-76.
12. Peterson, J.D., and K. Haskins. 1996. Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones. Differential requirement for CD8 T-cells. Diabetes. 45:328-336.
13. Verdaguer, J., D. Schmidt, A. Amrani, B. Anderson, N. Averill, and P. Santamaria. 1997. Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. J. Exp. Med. 186:1663-1676.
14. Christianson, S.W., L.D. Shultz, and E.H. Leiter. 1993. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of GD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes. 42:44-55.
15. Serreze, D.V., H.D. Chapman, D.S. Varnum, M.S. Hanson, P.C. Reifsnyder, S.D. Richard, S.A. Fleming, E.H. Leiter, and L.D. Shultz. 1996. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice. J. Exp. Med. 184:2049-2053.
16. Noorchashm, H., N. Noorchashm, J. Kern, S.Y. Rostami, G.F. Barker, and A. Naji. 1997. B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice. Diabetes 46:941-946.
17. Akashi, T., N. Seiho, A. Keizo, S. Kondo, D. Kitamura, S. Wakana, J. Ono, M. Kikuchi, Y. Niho, and T. Watanabe. 1997. Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice. Int. Immunol. 9:1159-1164.
18. Bendelac, A., C. Bohard, P. Bedossa, H. Bazin, J.-F. Bach, and C. Carnaud. 1988. Adoptive T cell transfer ot autoimmune nonobese diabetic mouse diabetes does not require recruitment of host B lymphocytes. J. Immunol. 141:2625-2628.
19. Wong, S., S. Guerder, I. Visintin, E.P. Reich, K.E. Swenson, R.A. Flavell, and C.J. Janeway. 1995. Expression of the costimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse. Diabetes. 44:326-329.
20. Rahemtulla, A., L.W. Fung, M.W. Schilham, T.M. Kundig, S.R. Sambhara, A. Narendran, A. Arabian, A. Wakeham, C.J. Paige, R.M. Zinkernagel, et al. 1991. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature. 353:180-184.
21. Kitamura, D., J. Roes, R. Kuhn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature. 350:423-426.
22. Stephens, L.A., and T.W. Kay. 1995. Pancreatic expression of B7 co-stimulatory molecules in the non-obese diabetic mouse, Int. Immunol. 7:1885-1895.
23. Kurts, C., W.R. Heath, F.R. Carbone, J. Allison, J.F. Miller, and H. Kosaka. 1996. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184: 923-930.
24. Liu, Y., and C.J. Janeway. 1992. Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells. Proc. Natl. Acad. Sci. USA. 89:3845-3849.
25. Zijlstra, M., M. Bix, N.E. Simister, J.M. Lonng, D.H. Raulet, and R. Jaenisch. 1990. Beta 2-microglobulin deficient mice lack CD4-8+ cytolyric T cells. Nature. 344:742-746.
26. Locksley, R.M., S.L. Reiner, F. Hatam, D.R. Littman, and N. Killeen. 1993. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science. 261:1448-1451.
27. Chang, C.H., S. Guerder, S.C. Hong, W. van Ewijk, and R.A. Flavell. 1996. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment ot MHC class II expression. Immunity. 4:167-178.
28. Rohane, P.W., A. Shimada, D.T. Kim, C.T. Edwards, B. Charlton, L.D. Shultz, and C.G. Fathman. 1995. Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice. Diabetes. 44:550-554.
29. Yang, Y., B. Charlton, A. Shimada, C.R. Dal, and C.G. Fathman. 1996. Monoclonal T cells identified in early NOD islet infiltrates. Immunity. 4:189-194.