Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function

Journal of Experimental Medicine

Volumn 193, Issue 11, 2001, Pages 1295-1301

  Levings, Megan K ^a   Sangregorio, Romina ^a   Roncarolo, Maria Grazia ^a  

^a SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

Author keywords

CTLA 4; Human; IL 2 receptor chain; Immune tolerance; Suppressor T lymphocytes

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CELL INTERACTION; CELL PROLIFERATION; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNOREGULATION; MEMORY CELL; PHENOTYPE; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; ANTIGENS, CD4; ANTIGENS, DIFFERENTIATION; CELL LINE; CYTOKINES; HUMANS; IMMUNOCONJUGATES; IMMUNOPHENOTYPING; INTERLEUKIN-10; ISOANTIGENS; LYMPHOCYTE ACTIVATION; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035806323     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.11.1295     Document Type: Article

References (23)

1. The role of different subsets of T regulatory cells in controlling autoimmunity
2. Regulatory T cells: Key controllers of immunologic self-tolerance
3. Regulatory T cells in autoimmmunity
4. T regulatory cells 1 inhibit a Th2-specific response in vivo
5. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
6. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
7. + T cells
8. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
9. + immunoregulatory T cells that control autoimmune diabetes
10. + regulatory cells that control intestinal inflammation
11. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
12. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
13. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
14. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
15. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
16. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
17. + immunoregulatory T cells is antigen nonspecific
18. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
19. + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells
20. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells
21. Rapid expansion of allospecific cytotoxic T cell clones using nonspecific feeder cell lines without further addition of exogenous IL-2
22. Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells
23. + T cells as a functionally and phenotypically distinct immunoregulatory T cell population