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Volumn 4, Issue 10, 2004, Pages 1614-1627

TGF-β induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors

Author keywords

Cytokines; Suppression; T lymphocyte; Transcription factors

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CELL PROTEIN; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

EID: 4744356110     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2004.00566.x     Document Type: Article
Times cited : (461)

References (51)
  • 1
    • 0035806276 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade
    • Taylor PA, Noelle RJ, Blazar BR. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med 2001; 193: 1311-1318.
    • (2001) J Exp Med , vol.193 , pp. 1311-1318
    • Taylor, P.A.1    Noelle, R.J.2    Blazar, B.R.3
  • 2
    • 0037026001 scopus 로고    scopus 로고
    • CD4 (+) CD25 (+) immunoregulatory T cells: New therapeutics for graft-versus-host disease
    • Cohen JL, Trenado A, Vasey D, Klatzmann D, Salomon BL. CD4 (+) CD25 (+) immunoregulatory T cells: new therapeutics for graft-versus-host disease. J Exp Med 2002; 196: 401-406.
    • (2002) J Exp Med , vol.196 , pp. 401-406
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3    Klatzmann, D.4    Salomon, B.L.5
  • 3
    • 0029150110 scopus 로고
    • Immunologic self-tolerance, maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance, maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 4
    • 0035806244 scopus 로고    scopus 로고
    • Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood
    • Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G. Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood. J Exp Med 2001; 193: 1303-1310.
    • (2001) J Exp Med , vol.193 , pp. 1303-1310
    • Dieckmann, D.1    Plottner, H.2    Berchtold, S.3    Berger, T.4    Schuler, G.5
  • 5
    • 0035806323 scopus 로고    scopus 로고
    • Human CD4+CD25+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings MK, Sangregorio R, Roncarolo MG. Human CD4+CD25+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001; 193: 1295-1302.
    • (2001) J Exp Med , vol.193 , pp. 1295-1302
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 6
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4 (+) CD25 (+) T cells with regulatory properties isolated from peripheral blood
    • Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH. Identification and functional characterization of human CD4 (+) CD25 (+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001; 193: 1285-1294.
    • (2001) J Exp Med , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3    Tuettenberg, A.4    Knop, J.5    Enk, A.H.6
  • 7
    • 0033985780 scopus 로고    scopus 로고
    • Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific
    • Thornton AM, Shevach EM. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol 2000; 164: 183-190.
    • (2000) J Immunol , vol.164 , pp. 183-190
    • Thornton, A.M.1    Shevach, E.M.2
  • 8
    • 0742284032 scopus 로고    scopus 로고
    • CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential
    • Fu S, Yopp AC, Mao X et al. CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential. Am J Transplant 2004; 4: 65-78.
    • (2004) Am J Transplant , vol.4 , pp. 65-78
    • Fu, S.1    Yopp, A.C.2    Mao, X.3
  • 9
    • 0043244867 scopus 로고    scopus 로고
    • Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo
    • Walker LS, Chodos A, Eggena M, Dooms H, Abbas AK. Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J Exp Med 2003; 198: 249-258.
    • (2003) J Exp Med , vol.198 , pp. 249-258
    • Walker, L.S.1    Chodos, A.2    Eggena, M.3    Dooms, H.4    Abbas, A.K.5
  • 10
    • 0028152937 scopus 로고
    • Transforming growth factor beta: The good, the bad, and the ugly
    • Wahl SM. Transforming growth factor beta: the good, the bad, and the ugly. J Exp Med 1994; 180: 1587-1590.
    • (1994) J Exp Med , vol.180 , pp. 1587-1590
    • Wahl, S.M.1
  • 11
    • 0030604542 scopus 로고    scopus 로고
    • TGF-beta signaling. Receptors, transducers, and Mad proteins
    • Massague J. TGF-beta signaling. Receptors, transducers, and Mad proteins. Cell 1996; 85: 947-950.
    • (1996) Cell , vol.85 , pp. 947-950
    • Massague, J.1
  • 12
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-beta/Smad signaling system
    • Massague J, Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 2000; 19: 1745-1754.
    • (2000) EMBO J , vol.19 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 13
    • 0036372440 scopus 로고    scopus 로고
    • Transforming growth factor-beta in T-cell biology
    • Gorelik L, Flavell RA. Transforming growth factor-beta in T-cell biology. Nat Rev Immunol 2002; 2: 46-53.
    • (2002) Nat Rev Immunol , vol.2 , pp. 46-53
    • Gorelik, L.1    Flavell, R.A.2
  • 14
    • 0347407823 scopus 로고    scopus 로고
    • Transforming growth factor-beta inhibits human antigen-specific CD4+ T cell proliferation without modulating the cytokine response
    • Tiemessen MM, Kunzmann S, Schmidt-Weber CB et al. Transforming growth factor-beta inhibits human antigen-specific CD4+ T cell proliferation without modulating the cytokine response. Int Immunol 2003; 15: 1495-1504.
    • (2003) Int Immunol , vol.15 , pp. 1495-1504
    • Tiemessen, M.M.1    Kunzmann, S.2    Schmidt-Weber, C.B.3
  • 15
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells
    • Weiner HL. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev 2001; 182: 207-214.
    • (2001) Immunol Rev , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 16
    • 0036886390 scopus 로고    scopus 로고
    • The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells
    • Levings MK, Bacchetta R, Schulz U, Roncarolo MG. The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int Arch Allergy Immunol 2002; 129: 263-276.
    • (2002) Int Arch Allergy Immunol , vol.129 , pp. 263-276
    • Levings, M.K.1    Bacchetta, R.2    Schulz, U.3    Roncarolo, M.G.4
  • 17
    • 0347361653 scopus 로고    scopus 로고
    • The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets
    • Horwitz DA, Zheng SG, Gray JD. The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets. J Leukoc Biol 2003; 74: 471-478.
    • (2003) J Leukoc Biol , vol.74 , pp. 471-478
    • Horwitz, D.A.1    Zheng, S.G.2    Gray, J.D.3
  • 18
    • 0035876913 scopus 로고    scopus 로고
    • A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood
    • Yamagiwa S, Gray JD, Hashimoto S, Horwitz DA. A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol 2001 ; 166: 7282-7289.
    • (2001) J Immunol , vol.166 , pp. 7282-7289
    • Yamagiwa, S.1    Gray, J.D.2    Hashimoto, S.3    Horwitz, D.A.4
  • 19
    • 0037108485 scopus 로고    scopus 로고
    • Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25-precursors
    • Zheng SG, Gray JD, Ohtsuka K, Yamagiwa S, Horwitz DA. Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25-precursors. J Immunol 2002; 169: 4183-4189.
    • (2002) J Immunol , vol.169 , pp. 4183-4189
    • Zheng, S.G.1    Gray, J.D.2    Ohtsuka, K.3    Yamagiwa, S.4    Horwitz, D.A.5
  • 20
    • 0038044861 scopus 로고    scopus 로고
    • IL-10 and TGF-beta induce alloreactive CD4+CD25-T cells to acquire regulatory cell function
    • Chen ZM, O'Shaughnessy MJ, Gramaglia I et al. IL-10 and TGF-beta induce alloreactive CD4+CD25-T cells to acquire regulatory cell function. Blood 2003; 101: 5076-5083.
    • (2003) Blood , vol.101 , pp. 5076-5083
    • Chen, Z.M.1    O'Shaughnessy, M.J.2    Gramaglia, I.3
  • 21
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow ME, Jeffery EW, Hjerrild KA et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001; 27: 68-73.
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3
  • 22
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin RS, Ramsdell F, Peake J et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet 2001; 27: 18-20.
    • (2001) Nat Genet , vol.27 , pp. 18-20
    • Wildin, R.S.1    Ramsdell, F.2    Peake, J.3
  • 23
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 24
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 25
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003; 4: 337-342.
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 26
    • 0026712313 scopus 로고
    • The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice
    • Seder RA, Paul WE, Davis MM, Fazekas de St. Groth B. The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med 1992; 176: 1091-1098.
    • (1992) J Exp Med , vol.176 , pp. 1091-1098
    • Seder, R.A.1    Paul, W.E.2    Davis, M.M.3    Fazekas De St. Groth, B.4
  • 27
    • 0141446327 scopus 로고    scopus 로고
    • Adenovirus transduction induces expression of multiple chemokines and chemokine receptors in murine beta cells and pancreatic islets
    • Zhang N, Schroppel B, Chen D et al. Adenovirus transduction induces expression of multiple chemokines and chemokine receptors in murine beta cells and pancreatic islets. Am J Transplant 2003; 3: 1230-1241.
    • (2003) Am J Transplant , vol.3 , pp. 1230-1241
    • Zhang, N.1    Schroppel, B.2    Chen, D.3
  • 29
    • 0030248827 scopus 로고    scopus 로고
    • Different temporal and spatial distribution of TGF-beta 1 and TGF-beta 2 in rabbit vascular tissue: Potential role in normal vessel growth and maturation
    • Lopez-Candales A, Scott MJ, Wickline SA. Different temporal and spatial distribution of TGF-beta 1 and TGF-beta 2 in rabbit vascular tissue: potential role in normal vessel growth and maturation. Cytokine 1996; 8: 675-685.
    • (1996) Cytokine , vol.8 , pp. 675-685
    • Lopez-Candales, A.1    Scott, M.J.2    Wickline, S.A.3
  • 30
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4 (+) CD25 (+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4 (+) CD25 (+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001; 194: 629-644.
    • (2001) J Exp Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 31
    • 0025222517 scopus 로고
    • The transforming growth factor-beta family
    • Massague J. The transforming growth factor-beta family. Annu Rev Cell Biol 1990; 6: 597-641.
    • (1990) Annu Rev Cell Biol , vol.6 , pp. 597-641
    • Massague, J.1
  • 32
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 2003; 3: 807-820.
    • (2003) Nat Rev Cancer , vol.3 , pp. 807-820
    • Siegel, P.M.1    Massague, J.2
  • 33
    • 0030788803 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 abrogates Fas-induced growth suppression and apoptosis of murine bone marrow progenitor cells
    • Dybedal I, Guan F, Borge OJ et al. Transforming growth factor-beta1 abrogates Fas-induced growth suppression and apoptosis of murine bone marrow progenitor cells. Blood 1997; 90: 3395-3403.
    • (1997) Blood , vol.90 , pp. 3395-3403
    • Dybedal, I.1    Guan, F.2    Borge, O.J.3
  • 34
    • 0035854790 scopus 로고    scopus 로고
    • Bcl-xL blocks transforming growth factor-beta 1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells
    • Chipuk JE, Bhat M, Hsing AY, Ma J, Danielpour D. Bcl-xL blocks transforming growth factor-beta 1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells. J Biol Chem 2001; 276: 26614-26621.
    • (2001) J Biol Chem , vol.276 , pp. 26614-26621
    • Chipuk, J.E.1    Bhat, M.2    Hsing, A.Y.3    Ma, J.4    Danielpour, D.5
  • 35
    • 0037013930 scopus 로고    scopus 로고
    • Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation
    • Gorelik L, Constant S, Flavell RA. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J Exp Med 2002; 195: 1499-1505.
    • (2002) J Exp Med , vol.195 , pp. 1499-1505
    • Gorelik, L.1    Constant, S.2    Flavell, R.A.3
  • 36
    • 0033623339 scopus 로고    scopus 로고
    • TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression
    • Heath VL, Murphy EE, Grain C, Tomlinson MG, O'Garra A. TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression. Eur J Immunol 2000; 30: 2639-2649.
    • (2000) Eur J Immunol , vol.30 , pp. 2639-2649
    • Heath, V.L.1    Murphy, E.E.2    Grain, C.3    Tomlinson, M.G.4    O'Garra, A.5
  • 37
    • 0037243827 scopus 로고    scopus 로고
    • CD4+CD25+ T (R) cells suppress innate immune pathology through cytokine-dependent mechanisms
    • Maloy KJ, Salaun L, Cahill R, Dougan G, Saunders NJ, Powrie F. CD4+CD25+ T (R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 2003; 197: 111-119.
    • (2003) J Exp Med , vol.197 , pp. 111-119
    • Maloy, K.J.1    Salaun, L.2    Cahill, R.3    Dougan, G.4    Saunders, N.J.5    Powrie, F.6
  • 38
    • 0038326625 scopus 로고    scopus 로고
    • Superantigen-induced regulatory T cells display different suppressive functions in the presence or absence of natural CD4+CD25+ regulatory T cells in vivo
    • Grundstrom S, Cederbom L, Sundstedt A, Scheipers P, Ivars F. Superantigen-induced regulatory T cells display different suppressive functions in the presence or absence of natural CD4+CD25+ regulatory T cells in vivo. J Immunol 2003; 170: 5008-5017.
    • (2003) J Immunol , vol.170 , pp. 5008-5017
    • Grundstrom, S.1    Cederbom, L.2    Sundstedt, A.3    Scheipers, P.4    Ivars, F.5
  • 39
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003; 197: 403-411.
    • (2003) J Exp Med , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6
  • 40
    • 0036884607 scopus 로고    scopus 로고
    • B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans
    • Montagnoli C, Bacci A, Bozza S et al. B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J Immunol 2002; 169: 6298-6308.
    • (2002) J Immunol , vol.169 , pp. 6298-6308
    • Montagnoli, C.1    Bacci, A.2    Bozza, S.3
  • 41
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-{beta} induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-{beta} induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 42
    • 0037383757 scopus 로고    scopus 로고
    • Twenty-first century Foxp3
    • O'Garra A, Vieira P. Twenty-first century Foxp3. Nat Immunol 2003; 4: 304-306.
    • (2003) Nat Immunol , vol.4 , pp. 304-306
    • O'Garra, A.1    Vieira, P.2
  • 43
    • 0242407713 scopus 로고    scopus 로고
    • Control of immune homeostasis by naturally arising regulatory CD4+ T cells
    • Gavin M, Rudensky A. Control of immune homeostasis by naturally arising regulatory CD4+ T cells. Curr Opin Immunol 2003; 15: 690-696.
    • (2003) Curr Opin Immunol , vol.15 , pp. 690-696
    • Gavin, M.1    Rudensky, A.2
  • 44
    • 0028180315 scopus 로고
    • The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms
    • Kingsley DM. The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 1994; 8: 133-146.
    • (1994) Genes Dev , vol.8 , pp. 133-146
    • Kingsley, D.M.1
  • 45
    • 0023851917 scopus 로고
    • Transforming growth factor-beta 2: cDNA cloning and sequence analysis
    • Madisen L, Webb NR, Rose TM et al. Transforming growth factor-beta 2: cDNA cloning and sequence analysis. DNA 1988; 7: 1-8.
    • (1988) DNA , vol.7 , pp. 1-8
    • Madisen, L.1    Webb, N.R.2    Rose, T.M.3
  • 46
    • 0023665170 scopus 로고
    • Membrane binding characteristics of two forms of transforming growth factor-beta
    • Segarini PR, Roberts AB, Rosen DM, Seyedin SM. Membrane binding characteristics of two forms of transforming growth factor-beta. J Biol Chem 1987; 262: 14655-14662.
    • (1987) J Biol Chem , vol.262 , pp. 14655-14662
    • Segarini, P.R.1    Roberts, A.B.2    Rosen, D.M.3    Seyedin, S.M.4
  • 47
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B, Lenschow DJ, Rhee L et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000; 12: 431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3
  • 48
    • 0035425004 scopus 로고    scopus 로고
    • B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis
    • Liu Z, Geboes K, Hellings P et al. B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis. J Immunol 2001; 167: 1830-1838.
    • (2001) J Immunol , vol.167 , pp. 1830-1838
    • Liu, Z.1    Geboes, K.2    Hellings, P.3
  • 49
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi T, Tagami T, Yamazaki S et al. Immunologic self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000; 192: 303-310.
    • (2000) J Exp Med , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3
  • 50
    • 0031647622 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
    • Takahashi T, Kuniyasu Y, Toda M et al. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998; 10: 1969-1980.
    • (1998) Int Immunol , vol.10 , pp. 1969-1980
    • Takahashi, T.1    Kuniyasu, Y.2    Toda, M.3
  • 51
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998; 188: 287-296.
    • (1998) J Exp Med , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2


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