IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes

Journal of Immunology

Volumn 178, Issue 2, 2007, Pages 732-739

  Peluso, Ilaria ^a   Fantini, Massimo Claudio ^a   Fina, Daniele ^a   Caruso, Roberta ^a   Boirivant, Monica ^b   MacDonald, Thomas T ^c   Pallone, Francesco ^a   Monteleone, Giovanni ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 7; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL GROWTH; CELL SURVIVAL; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFLAMMATORY DISEASE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 33846196712     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.2.732     Document Type: Article

References (27)

1. Leonard, W. J., and R. Spolski. 2005. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat. Rev. Immunol. 5: 688-698.
2. Collins, M., M. J. Whitters, and D. A. Young. 2003. IL-21 and IL-21 receptor: a new cytokine pathway modulates innate and adaptive immunity. Immunol. Res. 28: 131-140.
3. Monteleone, G., I. Monteleone, D. Fina, P. Vavassori, G. Del Vecchio Blanco, R. Caruso, R. Tersigni, L. Alessandroni, L. Biancone, G. C. Naccari, et al. 2005. Interleukin-21 enhances T-helper cell type I signaling and interferon-γ production in Crohn's disease. Gastroenterology 128: 687-694.
4. Distler, J. H., A. Jungel, O. Kowal-Bielecka, B. A. Michel, R. E. Gay, H. Sprott, M. Matucci Cerinic, M. Chilla, K. Reich, J. R. Kalden, et al. 2005. Expression of ihterleukin-21 receptor in epidermis from patients with systemic sclerosis. Arthritis Rheum. 52: 856-864.
5. Pelletier, M., A. Bouchard, and D. Girard. 2004. In vivo and in vitro roles of IL-21 in inflammation. J. Immunol. 173: 7521-7530.
6. Parrish-Novak, J., D. C. Foster, R. D. Holly, and C. H. Clegg. 2002. Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J. Leukocyte Biol. 72: 856-863.
7. + regulatory T cell depletion augments immunotherapy of micrometastases by an IL-21-secreting cellular vaccine. J. Immunol. 176: 1750-1758.
8. Ziegler, S. F. 2006. FOXP3: of mice and men. Annu. Rev. Immunol. 24: 209-226.
9. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
10. Dejaco, C., C. Duftner, B. Grubeck-Loebenstein, and M. Schirmer. 2006. Imbalance of regulatory T cells in human autoimmune diseases. Immunology 117: 289-300.
11. Kretschmer, K., I. Apostolou, D. Hawiger, K. Khazaie, M. C. Nussenzweig, and H. von Boehmer. 2005. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6: 1219-1227.
12. - T cell activation in the presence of T regulatory cells. J. Immunol. 175: 641-645.
13. + T regulatory cell activities in lung cancer. Cancer Res. 65: 5211-5220.
14. + regulatory cell activation and function by dendritic cells. Int. Immunol. 16: 1769-1780.
15. + regulatory T cell activity. J. Immunol. 175: 7274-1280.
16. - T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172: 5149-5153.
17. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
18. + immunoregulatory cells. J. Immunol. 167: 1137-1140.
19. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162: 5317-5326.
20. + regulatory T cells in inflamed sinovia. J. Exp. Med. 201: 1793-1803.
21. + suppressor T cells. Immunol. Rev. 182: 58-67.
22. + T cells. J. Immunol. 173: 5008-5020.
23. + precursors. J. Immunol. 175: 6107-6116.
24. Jungel, A., J. H. Distler, M. Kurowska-Stolarska, C. A. Seemayer, R. Seibl, A. Forster, B. A. Michel, R. E. Gay, F. Emmrich, S. Gay, and O. Distler. 2004. Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum. 50: 1468-1476.
25. Vollmer, T. L., R. Liu, M. Price, S. Rhodes, A. La Cava, and F. D. Shi. 2005. Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J. Immunol. 174: 2696-2701.
26. King, C., A. Ilic, K. Koelsch, and N. Sarvetnick. 2004. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 117: 265-277.
27. Rouse, B. T., and S. Suvas. 2004. Regulatory cells and infectious agents: détentes cordial and contraire. J. Immunol. 173: 2211-2215.