Inhibition of human CD4+CD25+high regulatory T cell function

Journal of Immunology

Volumn 169, Issue 11, 2002, Pages 6210-6217

  Baecher Allan, Clare ^a   Viglietta, Vissia ^a   Hafler, David A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR; T LYMPHOCYTE RECEPTOR; CYTOKINE; INTERLEUKIN 10; NERVE GROWTH FACTOR RECEPTOR; TNFRSF18 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RECEPTOR;

ANTIGEN DETECTION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; INFLAMMATION; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; T LYMPHOCYTE ACTIVATION; BIOLOGICAL MODEL; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; COCULTURE; DRUG ANTAGONISM; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; METABOLISM; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; COCULTURE TECHNIQUES; CYTOKINES; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MODELS, IMMUNOLOGICAL; RECEPTORS, INTERLEUKIN-2; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036883944     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.11.6210     Document Type: Article

References (22)

1. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
2. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301.
3. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
4. + T cells with regulatory properties from human blood. J. Exp. Med. 193:1303.
5. + T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193:1285.
6. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193:1295.
7. + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J. Exp. Med. 193:1311.
8. high regulatory cells in human peripheral blood. J. Immunol. 167:1245.
9. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311.
10. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194:629.
11. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3:135.
12. Kruisbeek, A. M., M. L. Davis, L. A. Matis, and D. L. Longo. 1984. Self-recognition specificity expressed by T cells from nude mice: absence of detectable Ia-restricted T cells in nude mice that do exhibit self-K/D-restricted T cell responses. J. Exp. Med. 160:839.
13. Mason, D. 2001. Some quantitative aspects of T-cell repertoire selection: the requirement for regulatory T cells. Immunol. Rev. 182:80.
14. + regulatory T cells. J. Exp. Med. 194:847.
15. Duda, P. W., M. C. Schmied, S. L. Cook, J. I. Krieger, and D. A. Hafler. 2000. Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. J Clin. Invest. 105:967.
16. Duda, P. W., J. I. Krieger, M. C. Schmied, C. Balentine, and D. A. Hafler. 2000. Human and murine CD4 T cell reactivity to a complex antigen: recognition of the synthetic random polypeptide glatiramer acetate. J. Immunol. 165:7300.
17. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431.
18. + T helper cells. J. Exp. Med. 196:255.
19. + regulatory, contact-dependent T cells induce interleukin I-producing, contact-independent type 1-like regulatory T cells. J. Exp. Med. 196:247.
20. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:5317.
21. + thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur. J. Immunol. 31:1247.
22. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor βI production and responsiveness. J. Exp. Med. 196:237.