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Volumn 117, Issue 2, 2004, Pages 265-277

Homeostatic expansion of T cells during immune insufficiency generates autoimmunity

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INTERLEUKIN 21;

EID: 1942453326     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(04)00335-6     Document Type: Article
Times cited : (585)

References (66)
  • 1
    • 0030067103 scopus 로고    scopus 로고
    • Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression
    • Akbar A.N., Borthwick N.J., Wickremasinghe R.G., Panayoitidis P., Pilling D., Bofill M., Krajewski S., Reed J.C., Salmon M. Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal. selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression Eur. J. Immunol. 26:1996;294-299.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 294-299
    • Akbar, A.N.1    Borthwick, N.J.2    Wickremasinghe, R.G.3    Panayoitidis, P.4    Pilling, D.5    Bofill, M.6    Krajewski, S.7    Reed, J.C.8    Salmon, M.9
  • 3
    • 0035400054 scopus 로고    scopus 로고
    • Cutting edge: The common gamma-chain is an indispensable subunit of the IL-21 receptor complex
    • Asao H., Okuyama C., Kumaki S., Ishii N., Tsuchiya S., Foster D., Sugamura K. Cutting edge. the common gamma-chain is an indispensable subunit of the IL-21 receptor complex J. Immunol. 167:2001;1-5.
    • (2001) J. Immunol. , vol.167 , pp. 1-5
    • Asao, H.1    Okuyama, C.2    Kumaki, S.3    Ishii, N.4    Tsuchiya, S.5    Foster, D.6    Sugamura, K.7
  • 4
    • 0032731705 scopus 로고    scopus 로고
    • Remission of juvenile rheumatoid arthritis after infection with parvovirus B19
    • Bateman H.E., Kirou K.A., Paget S.A., Crow M.K., Yee A.M. Remission of juvenile rheumatoid arthritis after infection with parvovirus B19. J. Rheumatol. 26:1999;2482-2484.
    • (1999) J. Rheumatol. , vol.26 , pp. 2482-2484
    • Bateman, H.E.1    Kirou, K.A.2    Paget, S.A.3    Crow, M.K.4    Yee, A.M.5
  • 5
    • 0037438490 scopus 로고    scopus 로고
    • Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: Attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses
    • Bennett F., Luxenberg D., Ling V., Wang I.M., Marquette K., Lowe D., Khan N., Veldman G., Jacobs K.A., Valge-Archer V.E.et al. Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation. attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses J. Immunol. 170:2003;711-718.
    • (2003) J. Immunol. , vol.170 , pp. 711-718
    • Bennett, F.1    Luxenberg, D.2    Ling, V.3    Wang, I.M.4    Marquette, K.5    Lowe, D.6    Khan, N.7    Veldman, G.8    Jacobs, K.A.9    Valge-Archer, V.E.10
  • 7
    • 0024327235 scopus 로고
    • Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning
    • Dardenne M., Lepault F., Bendelac A., Bach J.F. Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning. Eur. J. Immunol. 19:1989;889-895.
    • (1989) Eur. J. Immunol. , vol.19 , pp. 889-895
    • Dardenne, M.1    Lepault, F.2    Bendelac, A.3    Bach, J.F.4
  • 10
    • 0033180491 scopus 로고    scopus 로고
    • The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
    • Ernst B., Lee D.S., Chang J.M., Sprent J., Surh C.D. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity. 11:1999;173-181.
    • (1999) Immunity , vol.11 , pp. 173-181
    • Ernst, B.1    Lee, D.S.2    Chang, J.M.3    Sprent, J.4    Surh, C.D.5
  • 11
    • 0026235856 scopus 로고
    • Subsets of CD4+ T cells and their roles in the induction and prevention of autoimmunity
    • Fowell D., McKnight A.J., Powrie F., Dyke R., Mason D. Subsets of CD4+ T cells and their roles in the induction and prevention of autoimmunity. Immunol. Rev. 123:1991;37-64.
    • (1991) Immunol. Rev. , vol.123 , pp. 37-64
    • Fowell, D.1    McKnight, A.J.2    Powrie, F.3    Dyke, R.4    Mason, D.5
  • 12
    • 0029659052 scopus 로고    scopus 로고
    • Organ-specific autoimmunity induced by lymphopenia
    • Gleeson P.A., Toh B.H., van Driel I.R. Organ-specific autoimmunity induced by lymphopenia. Immunol. Rev. 149:1996;97-125.
    • (1996) Immunol. Rev. , vol.149 , pp. 97-125
    • Gleeson, P.A.1    Toh, B.H.2    Van Driel, I.R.3
  • 13
    • 0034655122 scopus 로고    scopus 로고
    • Cutting edge: Increased expression of Bcl-2 in antigen-specific memory CD8+ T cells
    • Grayson J.M., Zajac A.J., Altman J.D., Ahmed R. Cutting edge. increased expression of Bcl-2 in antigen-specific memory CD8+ T cells J. Immunol. 164:2000;3950-3954.
    • (2000) J. Immunol. , vol.164 , pp. 3950-3954
    • Grayson, J.M.1    Zajac, A.J.2    Altman, J.D.3    Ahmed, R.4
  • 14
    • 0036196305 scopus 로고    scopus 로고
    • Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: Highly potent regulators of diabetes that require TRANCE-RANK signals
    • Green E.A., Choi Y., Flavell R.A. Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells. highly potent regulators of diabetes that require TRANCE-RANK signals Immunity. 16:2002;183-191.
    • (2002) Immunity , vol.16 , pp. 183-191
    • Green, E.A.1    Choi, Y.2    Flavell, R.A.3
  • 15
    • 0013860971 scopus 로고
    • Ignaz Semmelweis, Oliver Wendell Holmes and puerperal infection
    • Greenhill J.P. Ignaz Semmelweis, Oliver Wendell Holmes and puerperal infection. Int. Surg. 45:1966;28-31.
    • (1966) Int. Surg. , vol.45 , pp. 28-31
    • Greenhill, J.P.1
  • 17
    • 0031856780 scopus 로고    scopus 로고
    • Programming for responsiveness to environmental antigens that trigger allergic respiratory disease in adulthood is initiated during the perinatal period
    • Holt P.G. Programming for responsiveness to environmental antigens that trigger allergic respiratory disease in adulthood is initiated during the perinatal period. Environ. Health Perspect. 106:1998;795-800.
    • (1998) Environ. Health Perspect. , vol.106 , pp. 795-800
    • Holt, P.G.1
  • 19
    • 0028824371 scopus 로고
    • Abnormal lymphocyte subsets in Kuwaiti patients with type-1 insulin-dependent diabetes mellitus and their first-degree relatives
    • Kaaba S.A., Al-Harbi S.A. Abnormal lymphocyte subsets in Kuwaiti patients with type-1 insulin-dependent diabetes mellitus and their first-degree relatives. Immunol. Lett. 47:1995;209-213.
    • (1995) Immunol. Lett. , vol.47 , pp. 209-213
    • Kaaba, S.A.1    Al-Harbi, S.A.2
  • 20
    • 0020683479 scopus 로고
    • Immunologic aspects of the nonobese diabetic (NOD) mouse. Abnormalities of cellular immunity
    • Kataoka S., Satoh J., Fujiya H., Toyota T., Suzuki R., Itoh K., Kumagai K. Immunologic aspects of the nonobese diabetic (NOD) mouse. Abnormalities of cellular immunity. Diabetes. 32:1983;247-253.
    • (1983) Diabetes , vol.32 , pp. 247-253
    • Kataoka, S.1    Satoh, J.2    Fujiya, H.3    Toyota, T.4    Suzuki, R.5    Itoh, K.6    Kumagai, K.7
  • 22
    • 0035122538 scopus 로고    scopus 로고
    • Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses
    • King C., Mueller Hoenger R., Malo Cleary M., Murali-Krishna K., Ahmed R., King E., Sarvetnick N. Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses. Nat. Med. 7:2001;206-214.
    • (2001) Nat. Med. , vol.7 , pp. 206-214
    • King, C.1    Mueller Hoenger, R.2    Malo Cleary, M.3    Murali-Krishna, K.4    Ahmed, R.5    King, E.6    Sarvetnick, N.7
  • 23
    • 0035175577 scopus 로고    scopus 로고
    • A defect in central tolerance in NOD mice
    • Kishimoto H., Sprent J. A defect in central tolerance in NOD mice. Nat. Immunol. 2:2001;1025-1031.
    • (2001) Nat. Immunol. , vol.2 , pp. 1025-1031
    • Kishimoto, H.1    Sprent, J.2
  • 26
    • 0026548979 scopus 로고
    • Epidemiology of the rheumatic diseases
    • Kwoh C.K. Epidemiology of the rheumatic diseases. Curr. Opin. Rheumatol. 4:1992;138-144.
    • (1992) Curr. Opin. Rheumatol. , vol.4 , pp. 138-144
    • Kwoh, C.K.1
  • 27
    • 0034529395 scopus 로고    scopus 로고
    • Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire
    • La Gruta N.L., Driel I.R., Gleeson P.A. Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire. Eur. J. Immunol. 30:2000;3380-3386.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 3380-3386
    • La Gruta, N.L.1    Driel, I.R.2    Gleeson, P.A.3
  • 28
    • 0029414791 scopus 로고
    • Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development
    • Leonard W.J., Shores E.W., Love P.E. Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development. Immunol. Rev. 148:1995;97-114.
    • (1995) Immunol. Rev. , vol.148 , pp. 97-114
    • Leonard, W.J.1    Shores, E.W.2    Love, P.E.3
  • 31
    • 0038136722 scopus 로고    scopus 로고
    • Like all that lives': Biology, medicine and bacteria in the age of Pasteur and Koch
    • Mendelsohn J.A. Like all that lives'. biology, medicine and bacteria in the age of Pasteur and Koch Hist. Philos. Life Sci. 24:2002;3-36.
    • (2002) Hist. Philos. Life Sci. , vol.24 , pp. 3-36
    • Mendelsohn, J.A.1
  • 33
    • 0030476922 scopus 로고    scopus 로고
    • The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry
    • O'Reilly L.A., Huang D.C., Strasser A. The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J. 15:1996;6979-6990.
    • (1996) EMBO J. , vol.15 , pp. 6979-6990
    • O'Reilly, L.A.1    Huang, D.C.2    Strasser, A.3
  • 35
    • 0036852893 scopus 로고    scopus 로고
    • Interleukin-21 and the IL-21 receptor: Novel effectors of NK and T cell responses
    • Parrish-Novak J., Foster D.C., Holly R.D., Clegg C.H. Interleukin-21 and the IL-21 receptor. novel effectors of NK and T cell responses J. Leukoc. Biol. 72:2002;856-863.
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 856-863
    • Parrish-Novak, J.1    Foster, D.C.2    Holly, R.D.3    Clegg, C.H.4
  • 36
    • 0038107478 scopus 로고    scopus 로고
    • Attrition of virus-specific memory CD8+ T cells during reconstitution of lymphopenic environments
    • Peacock C.D., Kim S.K., Welsh R.M. Attrition of virus-specific memory CD8+ T cells during reconstitution of lymphopenic environments. J. Immunol. 171:2003;655-663.
    • (2003) J. Immunol. , vol.171 , pp. 655-663
    • Peacock, C.D.1    Kim, S.K.2    Welsh, R.M.3
  • 38
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • Powrie F., Leach M.W., Mauze S., Caddle L.B., Coffman R.L. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 5:1993;1461-1471.
    • (1993) Int. Immunol. , vol.5 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Caddle, L.B.4    Coffman, R.L.5
  • 39
    • 0028354067 scopus 로고
    • Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?
    • Rabinovitch A. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes. 43:1994;613-621.
    • (1994) Diabetes , vol.43 , pp. 613-621
    • Rabinovitch, A.1
  • 40
    • 0037384047 scopus 로고    scopus 로고
    • Overexpression of bcl-2 in T cells affects insulitis in the nonobese diabetic mouse
    • Rietz C., Screpanti V., Brenden N., Bohme J., Fernandez C. Overexpression of bcl-2 in T cells affects insulitis in the nonobese diabetic mouse. Scand. J. Immunol. 57:2003;342-349.
    • (2003) Scand. J. Immunol. , vol.57 , pp. 342-349
    • Rietz, C.1    Screpanti, V.2    Brenden, N.3    Bohme, J.4    Fernandez, C.5
  • 41
    • 0020629371 scopus 로고
    • Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs
    • Rocha B., Freitas A.A., Coutinho A.A. Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs. J. Immunol. 131:1983;2158-2164.
    • (1983) J. Immunol. , vol.131 , pp. 2158-2164
    • Rocha, B.1    Freitas, A.A.2    Coutinho, A.A.3
  • 42
    • 0025293535 scopus 로고
    • Prevention of type I diabetes in NOD mice by adjuvant immunotherapy
    • Sadelain M.W., Qin H.Y., Lauzon J., Singh B. Prevention of type I diabetes in NOD mice by adjuvant immunotherapy. Diabetes. 39:1990;583-589.
    • (1990) Diabetes , vol.39 , pp. 583-589
    • Sadelain, M.W.1    Qin, H.Y.2    Lauzon, J.3    Singh, B.4
  • 43
    • 0028128975 scopus 로고
    • Neonatal injections of cyclosporin enhance autoimmune diabetes in non-obese diabetic mice
    • Sai P., Senecat O., Martignat L., Gouin E. Neonatal injections of cyclosporin enhance autoimmune diabetes in non-obese diabetic mice. Clin. Exp. Immunol. 97:1994;138-145.
    • (1994) Clin. Exp. Immunol. , vol.97 , pp. 138-145
    • Sai, P.1    Senecat, O.2    Martignat, L.3    Gouin, E.4
  • 44
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B., Lenschow D.J., Rhee L., Ashourian N., Singh B., Sharpe A., Bluestone J.A. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 12:2000;431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3    Ashourian, N.4    Singh, B.5    Sharpe, A.6    Bluestone, J.A.7
  • 50
    • 0033529506 scopus 로고    scopus 로고
    • Erythropoietin can induce the expression of bcl-x(L) through Stat5 in erythropoietin-dependent progenitor cell lines
    • Silva M., Benito A., Sanz C., Prosper F., Ekhterae D., Nunez G., Fernandez-Luna J.L. Erythropoietin can induce the expression of bcl-x(L) through Stat5 in erythropoietin-dependent progenitor cell lines. J. Biol. Chem. 274:1999;22165-22169.
    • (1999) J. Biol. Chem. , vol.274 , pp. 22165-22169
    • Silva, M.1    Benito, A.2    Sanz, C.3    Prosper, F.4    Ekhterae, D.5    Nunez, G.6    Fernandez-Luna, J.L.7
  • 51
    • 0029948374 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells
    • Sitnicka E., Ruscetti F.W., Priestley G.V., Wolf N.S., Bartelmez S.H. Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells. Blood. 88:1996;82-88.
    • (1996) Blood , vol.88 , pp. 82-88
    • Sitnicka, E.1    Ruscetti, F.W.2    Priestley, G.V.3    Wolf, N.S.4    Bartelmez, S.H.5
  • 52
    • 0030114840 scopus 로고    scopus 로고
    • The association between immunodeficiency and the development of autoimmune disease
    • Sleasman J.W. The association between immunodeficiency and the development of autoimmune disease. Adv. Dent. Res. 10:1996;57-61.
    • (1996) Adv. Dent. Res. , vol.10 , pp. 57-61
    • Sleasman, J.W.1
  • 53
    • 0345097318 scopus 로고    scopus 로고
    • Transgenic bcl-2 is not sufficient to rescue all hematolymphoid defects in STAT5A/5B-deficient mice
    • Snow J.W., Abraham N., Ma M.C., Bronson S.K., Goldsmith M.A. Transgenic bcl-2 is not sufficient to rescue all hematolymphoid defects in STAT5A/5B-deficient mice. Exp. Hematol. 31:2003;1253-1258.
    • (2003) Exp. Hematol. , vol.31 , pp. 1253-1258
    • Snow, J.W.1    Abraham, N.2    Ma, M.C.3    Bronson, S.K.4    Goldsmith, M.A.5
  • 54
    • 0037460105 scopus 로고    scopus 로고
    • Cytokines and T cell homeostasis
    • Sprent J., Surh C.D. Cytokines and T cell homeostasis. Immunol. Lett. 85:2003;145-149.
    • (2003) Immunol. Lett. , vol.85 , pp. 145-149
    • Sprent, J.1    Surh, C.D.2
  • 55
    • 0034698825 scopus 로고    scopus 로고
    • Homeostatic T cell proliferation: How far can T cells be activated to self-ligands?
    • Surh C.D., Sprent J. Homeostatic T cell proliferation. how far can T cells be activated to self-ligands? J. Exp. Med. 192:2000;F9-F14.
    • (2000) J. Exp. Med. , vol.192
    • Surh, C.D.1    Sprent, J.2
  • 56
    • 0036721772 scopus 로고    scopus 로고
    • The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7
    • Szanya V., Ermann J., Taylor C., Holness C., Fathman C.G. The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J. Immunol. 169:2002;2461-2465.
    • (2002) J. Immunol. , vol.169 , pp. 2461-2465
    • Szanya, V.1    Ermann, J.2    Taylor, C.3    Holness, C.4    Fathman, C.G.5
  • 59
    • 0034812119 scopus 로고    scopus 로고
    • Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models
    • Todd J.A., Wicker L.S. Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models. Immunity. 15:2001;387-395.
    • (2001) Immunity , vol.15 , pp. 387-395
    • Todd, J.A.1    Wicker, L.S.2
  • 60
    • 0028267677 scopus 로고
    • Turnover of naive- and memory-phenotype T cells
    • Tough D.F., Sprent J. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1994;1127-1135.
    • (1994) J. Exp. Med. , vol.179 , pp. 1127-1135
    • Tough, D.F.1    Sprent, J.2
  • 61
    • 0014804261 scopus 로고
    • Transfer of autoimmune thyroiditis of the rat with lymph node cells
    • Twarog F.J., Rose N.R. Transfer of autoimmune thyroiditis of the rat with lymph node cells. J. Immunol. 104:1970;1467-1475.
    • (1970) J. Immunol. , vol.104 , pp. 1467-1475
    • Twarog, F.J.1    Rose, N.R.2
  • 63
    • 0026658962 scopus 로고
    • Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. the NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes
    • Wicker L.S., Appel M.C., Dotta F., Pressey A., Miller B.J., DeLarato N.H., Fischer P.A., Boltz R.C. Jr., Peterson L.B. Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes. J. Exp. Med. 176:1992;67-77.
    • (1992) J. Exp. Med. , vol.176 , pp. 67-77
    • Wicker, L.S.1    Appel, M.C.2    Dotta, F.3    Pressey, A.4    Miller, B.J.5    Delarato, N.H.6    Fischer, P.A.7    Boltz, R.C.Jr.8    Peterson, L.B.9
  • 64
    • 0027948090 scopus 로고
    • Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes
    • Wicker L.S., Todd J.A., Prins J.B., Podolin P.L., Renjilian R.J., Peterson L.B. Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes. J. Exp. Med. 180:1994;1705-1713.
    • (1994) J. Exp. Med. , vol.180 , pp. 1705-1713
    • Wicker, L.S.1    Todd, J.A.2    Prins, J.B.3    Podolin, P.L.4    Renjilian, R.J.5    Peterson, L.B.6
  • 66
    • 0037427517 scopus 로고    scopus 로고
    • Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain
    • Zhang J.L., Foster D., Sebald W. Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain. Biochem. Biophys. Res. Commun. 300:2003;291-296.
    • (2003) Biochem. Biophys. Res. Commun. , vol.300 , pp. 291-296
    • Zhang, J.L.1    Foster, D.2    Sebald, W.3


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