CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion

Journal of Immunology

Volumn 173, Issue 5, 2004, Pages 2942-2951

  Sarween, Nadia ^a   Chodos, Anna ^b   Raykundalia, Chandra ^a   Khan, Mahmood ^a   Abbas, Abul K ^b   Walker, Lucy S K ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIABETES MELLITUS; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

EID: 4344657757     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.5.2942     Document Type: Article

References (69)

1. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387.
2. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160:1212.
3. Seddon, B., and D. Mason. 1999. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J. Exp. Med. 189:877.
4. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303.
5. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431.
6. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
7. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164:183.
8. + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J. Immunol. 169:2461.
9. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
10. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295.
11. + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 169:4712.
12. Andre, I., A. Gonzalez, B. Wang, J. Katz, C. Benoist, and D. Mathis. 1996. Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc. Natl. Acad. Sci. USA 93:2260.
13. Allison, J., L. Malcolm, N. Chosich, and J. F. Miller. 1992. Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin-2 in islet β cells. Eur. J. Immunol. 22:1115.
14. Higuchi, Y., P. Herrera, P. Muniesa, J. Huarte, D. Belin, P. Ohashi, P. Aichele, L. Orci, and J. D. Vassalli. 1992. Expression of a tumor necrosis factor a transgene in murine pancreatic β cells results in severe and permanent insulitis without evolution towards diabetes. J. Exp. Med. 176:1719.
15. Picarella, D. E., A. Kratz, C. B. Li, N. H. Ruddle, and R. A. Flavell. 1992. Insulitis in transgenic mice expressing tumor necrosis factor β (lymphotoxin) in the pancreas. Proc. Natl. Acad. Sci. USA 89:10036.
16. Holz, A., K. Brett, and M. B. Oldstone. 2001. Constitutive β cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes. J. Clin. Invest. 108:1749.
17. Katz, J., B. Wang, K. Haskins, C. Benoist, and D. Mathis. 1993. Following a diabetogenic cell from genesis through pathogenesis. Cell 74:1089.
18. Akkaraju, S., W. Y. Ho, D. Leong, K. Canaan, M. M. Davis, and C. C. Goodnow. 1997. A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity 7:255.
19. Sarukhan, A., A. Lanoue, A. Franzke, N. Brousse, J. Buer, and H. von Boehmer. 1998. Changes in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model. EMBO J. 17:71.
20. Debray-Sachs, M., C. Carnaud, C. Boitard, H. Cohen, I. Gresser, P. Bedossa, and J. F. Bach. 1991. Prevention of diabetes in NOD mice treated with antibody to murine IFNγ. J. Autoimmun. 4:237.
21. Campbell, I. L., T. W. Kay, L. Oxbrow, and L. C. Harrison. 1991. Essential role for interferon-γ and interluekin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 87:739.
22. Prud'homme, G. J., and Y. Chang. 1999. Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-γ receptor/IgG1 fusion protein. Gene Ther. 5:771.
23. von Herrath, M. G., and M. B. Oldstone. 1997. Interferon-γ is essential for destruction of β cells and development of insulin-dependent diabetes mellitus. J. Exp. Med. 185:531.
24. Savinov, A. Y., F. S. Wong, and A. V. Chervonsky. 2001. IFN-γ affects homing of diabetogenic T cells. J. Immunol. 16:6637.
25. Wang, B., I. Andre, A. Gonzalez, J. D. Katz, M. Aguet, C. Benoist, and D. Mathis. 1997. Interferon-γ impacts at multiple points during the progression of autoimmune diabetes. Proc. Natl. Acad. Sci. USA 94:13844.
26. Frigerio, S., T. Junt, B. Lu, C. Gerard, U. Zumsteg, G. A. Hollander, and L. Piali. 2002. β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat. Med. 8:1414.
27. + regulatory T cells in vivo. J. Exp. Med. 198:249.
28. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:5317.
29. Kawai, T., M. Seki, K. Hiromatsu, J. W. Eastcott, G. F. Watts, M. Sugai, D. J. Smith, S. A. Porcelli, and M. A. Taubman. 1999. Selective diapedesis of Th1 cells induced by endothelial cell RANTES. J. Immunol. 163:3269.
30. Bonecchi, R., G. Bianchi, P. P. Bordignon, D. D'Ambrosio, R. Lang, A. Borsatti, S. Sozzani, P. Allavena, P. A. Gray, A., Mantovani, et al. 1998. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 187:875.
31. + T lymphocytes primed by myeloid or plasmacytoid dendritic cells. Eur. J. Immunol. 33:474.
32. Nakajima, C., T. Mukai, N. Yamaguchi, Y. Morimoto, W.-R. Park, M. Iwasaki, P. Gao, S. Ono, H. Fujiwara, and T. Hamaoka. 2002. Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: dependence on the release from persistent TCR-triggering and requirement for IFN-γ stimulation. Eur. J. Immunol. 32:1792.
33. + T cells. J. Exp. Med. 183:2669.
34. + T suppressor cell clones produce transforming growth factor β, but not interleukin 10, and are distinct from type 1 T regulatory cells. J. Exp. Med. 196:1335.
35. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995.
36. + regulatory T cells control Leishmania major persistence and immunity. Nature 420:502.
37. + T regulatory cells suppress Helicobacter hepaticus-induced colitis. J. Exp. Med. 196:505.
38. + T helper cells. J. Exp. Med. 196:255.
39. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196:237.
40. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:756.
41. Phillips, J. M., N. M. Parish, M. Drage, and A. Cooke. 2001. Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes. J. Immunol. 167:6087.
42. Mauri, C., D. Gray, N. Mushtaq, and M. Londei. 2003. Prevention of arthritis by interleukin 10-producing B cells. J. Exp. Med. 197.
43. + T cells in autoimmune diabetes. Nat. Immunol. 2:1117.
44. + regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells. J. Exp. Med. 196:247.
45. + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J. Exp. Med. 188:1883.
46. + regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J. Immunol. 168:5979.
47. Prlic, M., B. R. Blazar, A. Khoruts, T. Zell, and S. C. Jameson. 2001. Homeostatic expansion occurs independently of costimulatory signals. J. Immunol. 167:55664.
48. Rabinovitch, A., W. L. Suarez-Pinzon, O. Sorensen, R. C. Bleackley, and R. F. Power. 1995. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol. 154:4874.
49. Sarvetnick, N., D. Liggitt, S. L. Pitts, S. E. Hansen, and T. A. Stewart. 1988. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-γ. Cell 52:773.
50. Kanagawa, O., G. Xu, A. Tevaarwerk, and B. A. Vaupel. 2000. Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-γ receptor loci. J. Immunol. 164:3919.
51. Serreze, D. V., C. M. Post, H. D. Chapman, E. A. Johnson, B. Lu, and P. B. Rothman. 2000. Interferon-γ receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice. Diabetes 49:2007.
52. Hultgren, B., X. Huang, N. Dybdal, and T. A. Stewart. 1996. Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice. Diabetes 45:812.
53. Nicoletti, F., P. Zaccone, R. Di Marco, M. Di Mauro, G. Magro, S. Grasso, L. Mughini, P. Meroni, and G. Garotta. 1996. The effects of a nonimmunogenic form of murine soluble interferon-γ receptor on the development of autoimmune diabetes in the NOD mouse. Endocrinology 137:5567.
54. + regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo. J. Exp. Med. 198:259.
55. Serreze, D. V., H. D. Chapman, C. M. Post, E. A. Johnson, W. L. Suarez-Pinzon, and A. Rabinovitch. 2001. Th1 to Th2 cytokine shifts in nonobese diabetic mice: sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation. J. Immunol. 166:1352.
56. Trembleau, S., P. Giuseppe, S. Gregori, N. Giarratana, and L. Adorini. 2003. IL-12 administration accelerates autoimmune diabetes in both wild-type and IFNγ-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFNγ. J. Immunol. 170:5491.
57. Piali, L., C. Weber, G. LaRosa, C. R. Mackay, T. A. Springer, I. Clark-Lewis, and B. Moster. 1998. The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig. Eur. J. Immunol. 28:961.
58. Homey, B., M. C. Dieu-Nosjean, A. Wiesenborn, C. Massacrier, J. J. Pin, E. Oldham, D. Catron, M. E. Buchanan, A. Muller, R. DeWaal Malefyt, et al. 2000. Up-regulation of macrophage inflammatory protein-3α/CCL20 and CC chemokine receptor 6 in psoriasis. J. Immunol. 164:6621.
59. Lee, K. H., K. Y. Chung, and Y. J. Koh. 1995. Memory T lymphocytes adherence to interferon γ-activated human dermal microvascular endothelial cells via Eselectin. J. Dermatol. Sci. 10:166.
60. Kulidjian, A. A., A. C. Issekutz, and T. B. Issekutz. 2002. Differential role of E-selectin and P-selectin in T lymphocyte migration to cutaneous inflammatory reactions induced by cytokines. Int. Immunol. 14:751.
61. Reinhardt, R. L., D. C. Bullard, C. T. Weaver, and M. K. Jenkins. 2003. Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. J. Exp. Med. 197:743.
62. Hill, N. J., K. van Gunst, and N. Sarvetnick. 2003. Th1 and Th2 pancreatic inflammation differentially affects homing of islet-reactive CD4 cells in nonobese diabetic mice. J. Immunol. 170:1649.
63. + T cells. J. Exp. Med. 197:643.
64. Greening, J. E., T. I. Tree, K. T. Kotowicz, A. G. Van Halteren, B. O. Roep, N. J. Klein, and M. Peakman. 2003. Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T cells. Diabetes 52:717.
65. Christen, U., D. B. McGavern, A. S. Luster, M. G. von Herrath, and M. B. A. Oldstone. 2003. Among CXCR3 chemokines, IFN-γ-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-γ (CXCL9) imprints a pattern for the subsequent development of autoimmune disease. J. Immunol. 171:6838.
66. Aust, G., D. Sittig, M. Steinert, P. Lamesch, and T. Lohmann. 2002. Graves' disease is associated with an altered CXCR3 and CCR5 expression in thyroid-derived compared to peripheral blood lymphocytes. Clin. Exp. Immunol. 127:479.
67. Sorensen, T. L., C. Trebst, P. Kivisakk, K. L. Klaege, A. Majmudar, R. Ravid, H. Lassmann, D. B. Olsen, R. M. Strieter, R. M. Ransohoff, et al. 2002. Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. J. Neuroimmunol. 127:59.
68. Mahad, D. J., J. Lawry, S. J. Howell, and M. N. Woodroofe. 2003. Longitudinal study of chemokine receptor expression on peripheral lymphocytes in multiple sclerosis: CXCR3 upregulation is associated with relapse. Mult. Scler. 9:189.
69. Xie, J. H., N. Nomura, M. Lu, S. L. Chen, G. E. Koch, Y. Weng, R. Rosa, J. Di Salvo, J. Mudgett, L. B. Peterson, et al. 2003. Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation. J. Leukocyte Biol. 73:771.