Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice

Diabetes

Volumn 55, Issue 7, 2006, Pages 2098-2105

  Alard, Pascale ^a   Manirarora, Jean N ^a   Parnell, Sarah A ^a   Hudkins, Jason L ^a   Clark, Sherry L ^a   Kosiewicz, Michele M ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

APC, antigen presenting cell; CTLA 4, cytotoxic T lymphocyte associated antigen 4; Foxp3, Forkhead box P3; GAPDH, glyceraldehyde 3 phosphate dehydrogenase; GITR, glucocorticoid induced tumor necrosis factor receptor; PE, phycoethrin

Indexed keywords

ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCOCORTICOID; TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 2 RECEPTOR; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; CD25+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOID TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; ANIMAL; C57BL MOUSE; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; IMPAIRED GLUCOSE TOLERANCE; ISOLATION AND PURIFICATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; NONOBESE DIABETIC MOUSE; POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; FEMALE; FLOW CYTOMETRY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; POLYMERASE CHAIN REACTION; PREDIABETIC STATE; RECEPTORS, INTERLEUKIN-2; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 33747030655     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-0810     Document Type: Article

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