CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells

Journal of Immunology

Volumn 160, Issue 3, 1998, Pages 1212-1218

  Suri Payer, Elisabeth ^a   Amar, Anna Z ^a   Thornton, Angela M ^a   Shevach, Ethan M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PURIFICATION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; IMMUNOMODULATION; IMMUNOREGULATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; STRAIN DIFFERENCE; THYMECTOMY;

ANIMALS; ANTIGENS, CD4; AUTOANTIGENS; AUTOIMMUNE DISEASES; CELL DIFFERENTIATION; GASTRITIS; H(+)-K(+)-EXCHANGING ATPASE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, NUDE; MICE, SCID; MICE, TRANSGENIC; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 0031939403     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Kojima, A., and R. T. Prehn. 1981. Genetic susceptibility to post-thymectomy autoimmune diseases in mice. Immunogenetics 14:15.
2. Kojima, A., O. Taguchi, and Y. Nishizuka. 1980. Experimental production of possible autoimmune gastritis followed by macrocytic anemia in athymic nude mice. Lab. Invest. 42:387.
3. Tung, K. S. K., S. Smith, C. Teuscher, C. Cook, and R. E. Anderson. 1987. Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Am. J. Pathol. 126:293.
4. Taguchi, O., and Y. Nishizuka. 1987. Self tolerance and localized autoimmunity: mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance. J. Exp. Med. 165:146.
5. Suri-Payer, E., P. J. Kehn, A. W. Cheever, and E. M. Shevach. 1996. Pathogenesis of post-thymectomy autoimmune gastritis: identification of anti-H/K adenosine triphosphatase-reactive T cells. J. Immunol. 157:1799.
6. Gleeson, P. A., and B.-H. Toh. 1991. Molecular targets in pernicious anaemia. Immunol. Today 12:233.
7. Martinelli, T. M., I. R. Van Driel, F. Alderaccio, P. A. Gleeson, and B.-H. Toh. 1996. Analysis of mononuclear cell infiltrate and cytokine production in murine autoimmune gastritis. Gastroenterology 110:1791.
8. Fukuma, K., S. Sakaguchi, K. Kuribayashi, W.-L. Chen, R. Morishita, K. Sekita, H. Uchino, and T. Masuda. 1988. Immunologic and clinical studies on murine experimental autoimmune gastritis induced by neonatal thymectomy. Gastroenterology 94:274.
9. Jones, C. M., J. M. Callaghan, P. A. Gleeson, Y. Mori, T. Masuda, and B.-H. Toh. 1991. The parietal cell autoantigens recognized in neonatal thymectomy-induced murine gastritis are the α and β subunits of the gastric proton pump. Gastroenterology 101:287.
10. +-adenosine triphosphatase of parietal cells discerned by a murine gastritogenic T-cell clone. Gastroenterology 107:1408.
11. Alderuccio, F., B.-H. Toh, S.-S. Tan, P. A. Gleeson, and I. R. van Driel. 1993. An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus. J. Exp. Med. 178:419.
12. Gleeson, P. A., B.-H. Toh, and I. R. Van Driel. 1996. Organ-specific autoimmunity induced by lymphopenia. Immunol. Rev. 149:97.
13. Sakaguchi, S., and N. Sakaguchi. 1990. Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease. J. Exp. Med. 172:537.
14. Bonomo, A., P. J. Kehn, E. Payer, L. Rizzo, A. W. Cheever, and E. M. Shevach. 1995. Pathogenesis of post-thymectomy autoimmunity: role of syngeneic MLR-reactive T cells. J. Immunol. 154:6602.
15. Smith, H., Y.-H. Lou, P. Lacy, and K. S. K. Tung. 1992. Tolerance mechanism in experimental ovarian and gastric autoimmune diseases. J. Immunol. 149:2212.
16. Sakaguchi, S., and N. Sakaguchi. 1990. Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. J. Immunol. 142:471.
17. Sakaguchi, N., K. Miyai, and S. Sakaguchi. 1994. Ionizing radiation and autoimmunity: induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells. J. Immunol. 152:2586.
18. Ansahr Ahmed, S., and W. J. Penhale. 1981. Pathological changes in inbred strains of mice following early thymectomy and irradiation. Experientia 37:1341.
19. Barrett, S. P., B.-H. Toh, F. Alderuccio, I. R. van Driel, and P. A. Gleeson. 1995. Organ-specific autoimmunity induced by adult thymectomy and cyclophosphamide-induced lymphopenia. Eur. J. Immunol. 25:238.
20. Saoudi, A., B. Seddon, V. Heath, D. Fowell, and D. Mason. 1996. The physiological role of regulatory T cells in the prevention of autoimmunity: the function of the thymus in the generation of the regulatory T cell subset. Immunol. Rev. 149:795.
21. + T cells. Immunity 1:553.
22. Bonomo, A., P. J. Kehn, and E. M. Shevach. 1996. Post-thymectomy autoimmunity: abnormal T cell homeostasis. Immunol. Today 16:61.
23. Sakaguchi, S., K. Fukuma, K. Kuribayashi, and T. Masuda. 1985. Organ-specific autoimmune disease induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J. Exp. Med. 161:72.
24. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
25. lo thymocytes in vivo. Science 250: 1720.
26. Klaassen, C. H. W., T. J. F. Van Uem, M. P. De Moel, G. L. J. De Caluwé, H. G. P. Swarts, and J. J. H. H. M. De Pont. 1993. Functional expression of gastric H,K-ATPase using the baculovirus expression system. FEBS Lett. 329: 277.
27. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387.
28. Quin, H.-Y., M. W. J. Sadelain, C. Hitchon, J. Lauzon, and B. Singh. 1993. Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J. Immunol. 150:2072.
29. Miller, J. F. A. P., and W. R. Heath. 1993. Self-ignorance in the peripheral T-cell pool. Immunol. Rev. 133:131.
30. Ohashi, P. S., S. Oehen, K. Buerki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R. M. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305.
31. Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.
32. Garza, K. M., and K. S. K. Tung. 1995. Frequency of molecular mimicry among T cell peptides as the basis for autoimmune disease and autoantibody induction. J. Immunol. 155:5444.
33. Smith, H., Y. Sakamoto, K. Kasai, and K. S. K. Tung. 1991. Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy. J. Immunol. 147:2928.
34. Sakaguchi, S., T. Takahashi, and Y. Nishizuka. 1982. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J. Exp. Med. 156:1577.
35. Murakami, K., H. Maruyama, A. Nishio, K. Kuribayashi, M. Inaba, K. Inaba, M. Hosono, K. Shinagawa, M. Sakai, and T. Masuda. 1993. Effects of intrathymic injection of organ-specific autoantigens, parietal cells, at the neonatal stage on autoreactive effector and suppressor T cell precursors. Eur. J. Immunol. 23:809.
36. Kumar, V., and E. Sercarz. 1993. T cell regulatory circuitry: antigen-specific and TCR-idiopeptide-specific T cell interactions in EAE. Int. Rev. Immunol. 9:287.
37. + memory T cells in virus-infected hosts. J. Exp. Med. 183:1367.
38. Lafaille, J. J., K. Nagashima, M. Katsuki, and S. Tonegawa. 1994. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell 78:399.
39. Nishio, A., T. Katakai, H. Hosono, M. Inaba, M. Sakai, M. Okuma, S. Kasakura, and T. Masuda. 1995. Breakdown of self-tolerance by intrathymic injection of a T-cell line inducing autoimmune gastritis in mice. Immunology 85:270.
40. Lohse, A. W., F. Mor, N. Karin, and I. R. Cohen. 1989. Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells. Science 244:820.