In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation

Clinical Immunology

Volumn 115, Issue 1 SPEC. ISS., 2005, Pages 3-9

  Earle, K E ^a   Tang, Q ^a   Zhou, X ^a   Liu, W ^a   Zhu, S ^a   Bonyhadi, M L ^b   Bluestone, J A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CYCLACEL LTD   (United Kingdom)

Author keywords

Autoimmunity; CD4+CD25+; Human; Regulatory T cells; Suppression; Treg

Indexed keywords

ALLOANTIGEN; ANTIBODY; CD28 ANTIBODY; CD3 ANTIBODY; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR6; CYTOKINE; HLA DR ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; L SELECTIN; LIGAND; LYMPHOCYTE ANTIGEN; LYMPHOCYTE SURFACE MARKER; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; BLOOD CELL; CELL ACTIVITY; CELL CULTURE; CELL ISOLATION; CELL STIMULATION; CELL SURFACE; COCULTURE; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE RELEASE; EFFECTOR CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 18144396195     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clim.2005.02.017     Document Type: Conference Paper

References (37)

1. S. Sakaguchi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J. Immunol. 155 3 1995 1151 1164
2. J.A. Bluestone, and A.K. Abbas Natural versus adaptive regulatory T cells Nat. Rev., Immunol. 3 3 2003 253 257
3. S. Sakaguchi Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance Immunol. Rev. 182 2001 18 32
4. L. Chatenoud, B. Salomon, and J.A. Bluestone Suppressor T cells-They're back and critical for regulation of autoimmunity! Immunol. Rev. 182 2001 149 163
5. L.A. Schubert Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation J. Biol. Chem. 276 40 2001 37672 37679
6. R. Khattri An essential role for Scurfin in CD4+CD25+ T regulatory cells Nat. Immunol. 4 4 2003 337 342
7. S. Gregori Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development J. Immunol. 171 8 2003 4040 4047
8. Q. Tang In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes J. Exp. Med. 199 11 2004 1455 1465
9. E. Suri-Payer, and H. Cantor Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells J. Autoimmun. 16 2 2001 115 123
10. C. Asseman, S. Fowler, and F. Powrie Control of experimental inflammatory bowel disease by regulatory T cells Am. J. Respir. Crit. Care Med. 162 4 Pt. 2 2000 S185 S189
11. H. Liu CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4 J. Immunol. 171 10 2003 5012 5017
12. M.A. Alyanakian Diversity of regulatory CD4+ T cells controlling distinct organ-specific autoimmune diseases Proc. Natl. Acad. Sci. U. S. A. 100 26 2003 15806 15811
13. J.L. Cohen CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease J. Exp. Med. 196 3 2002 401 406
14. M. Edinger CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation Nat. Med. 9 9 2003 1144 1150
15. A. Kukreja Multiple immuno-regulatory defects in type-1 diabetes J. Clin. Invest. 109 1 2002 131 140
16. V. Viglietta Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis J. Exp. Med. 199 7 2004 971 979
17. M.A. Kriegel Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II J. Exp. Med. 199 9 2004 1285 1291
18. E. Gambineri, T.R. Torgerson, and H.D. Ochs Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis Curr. Opin. Rheumatol. 15 4 2003 430 435
19. A. Tommasini X-chromosome inactivation analysis in a female carrier of FOXP3 mutation Clin. Exp. Immunol. 130 1 2002 127 130
20. J.D. Fontenot, M.A. Gavin, and A.Y. Rudensky Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nat. Immunol. 4 4 2003 330 336
21. C. Baecher-Allan CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo Novartis Found Symp. 252 2003 67 88 (discussion 88-91, 106-14)
22. C. Baecher-Allan, V. Viglietta, and D.A. Hafler Inhibition of human CD4(+)CD25(+high) regulatory T cell function J. Immunol. 169 11 2002 6210 6217
23. C. Baecher-Allan CD4 + CD25high regulatory cells in human peripheral blood J. Immunol. 167 3 2001 1245 1253
24. H. Yagi Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells Int. Immunol. 16 11 2004 1643 1656
25. M.R. Walker Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells J. Clin. Invest. 112 9 2003 1437 1443
26. M. Belghith TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes Nat. Med. 9 9 2003 1202 1208
27. E. Chiffoleau, P.T. Walsh, and L. Turka Apoptosis and transplantation tolerance Immunol. Rev. 193 2003 124 145
28. P. Hoffmann Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells Blood 104 3 2004 895 903
29. M.K. Levings, R. Sangregorio, and M.G. Roncarolo Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function J. Exp. Med. 193 11 2001 1295 1302
30. W.R. Godfrey In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures Blood 104 2 2004 453 461
31. R.E. Kohler A role for macrophage inflammatory protein-3 alpha/CC chemokine ligand 20 in immune priming during T cell-mediated inflammation of the central nervous system J. Immunol. 170 12 2003 6298 6306
32. J. Shirane Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis Curr. Eye Res. 28 5 2004 297 306
33. A. Kaser Increased expression of CCL20 in human inflammatory bowel disease J. Clin. Immunol. 24 1 2004 74 85
34. A. Ivetic The cytoplasmic tail of l-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not Ezrin J. Biol. Chem. 277 3 2002 2321 2329
35. L. Biancone Role of l-selectin in the vascular homing of peripheral blood-derived endothelial progenitor cells J. Immunol. 173 8 2004 5268 5274
36. C.T. Huang Role of LAG-3 in regulatory T cells Immunity 21 4 2004 503 513
37. A. Trenado Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia J. Clin. Invest. 112 11 2003 1688 1696