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Volumn 89, Issue 10, 2008, Pages 2359-2376

The multifunctional NS1 protein of influenza A viruses

Author keywords

[No Author keywords available]

Indexed keywords

2'5' OLIGOADENYLATE SYNTHETASE; ALPHA INTERFERON; ANTIVIRUS AGENT; BETA INTERFERON; DOUBLE STRANDED RNA; INFLUENZA VACCINE; INTERFERON; LIVE VACCINE; NONSTRUCTURAL PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE R; RNA; SYNTHETASE; UNCLASSIFIED DRUG; INS1 PROTEIN, INFLUENZA VIRUS; PROTEIN; VIRUS PROTEIN;

EID: 54449099369     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.2008/004606-0     Document Type: Review
Times cited : (885)

References (150)
  • 1
    • 0026089363 scopus 로고
    • Regulation of the extent of splicing of influenza virus NS1 mRNA: Role of the rates of splicing and of the nucleocytoplasmic transport of NS1 mRNA
    • Alonso-Caplen, F. V. & Krug, R. M. (1991). Regulation of the extent of splicing of influenza virus NS1 mRNA: role of the rates of splicing and of the nucleocytoplasmic transport of NS1 mRNA. Mol Cell Biol 11, 1092-1098.
    • (1991) Mol Cell Biol , vol.11 , pp. 1092-1098
    • Alonso-Caplen, F.V.1    Krug, R.M.2
  • 2
    • 0026537278 scopus 로고
    • Nucleocytoplasmic transport: The influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA
    • Alonso-Caplen, F. V., Nemeroff, M. E., Qiu, Y. & Krug, R. M. (1992). Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA. Genes Dev 6, 255-267.
    • (1992) Genes Dev , vol.6 , pp. 255-267
    • Alonso-Caplen, F.V.1    Nemeroff, M.E.2    Qiu, Y.3    Krug, R.M.4
  • 3
    • 0033838456 scopus 로고    scopus 로고
    • Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus
    • Aragon, T., de la Luna, S., Novoa, I., Carrasco, L., Ortin, J. & Nieto, A. (2000). Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus. Mol Cell Biol 20, 6259-6268.
    • (2000) Mol Cell Biol , vol.20 , pp. 6259-6268
    • Aragon, T.1    de la Luna, S.2    Novoa, I.3    Carrasco, L.4    Ortin, J.5    Nieto, A.6
  • 4
    • 0020035742 scopus 로고
    • Pneumonia and influenza deaths during epidemics: Implications for prevention
    • Barker, W. H. & Mullooly, J. P. (1982). Pneumonia and influenza deaths during epidemics: implications for prevention. Arch Intern Med 142, 85-89.
    • (1982) Arch Intern Med , vol.142 , pp. 85-89
    • Barker, W.H.1    Mullooly, J.P.2
  • 5
    • 35448980010 scopus 로고    scopus 로고
    • Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus
    • Baskin, C. R., Bielefeldt-Ohmann, H., Garcia-Sastre, A., Tumpey, T. M., Van Hoeven, N., Carter, V. S., Thomas, M. J., Proll, S., Solorzano, A. & other authors (2007). Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus. J Virol 81, 11817-11827.
    • (2007) J Virol , vol.81 , pp. 11817-11827
    • Baskin, C.R.1    Bielefeldt-Ohmann, H.2    Garcia-Sastre, A.3    Tumpey, T.M.4    Van Hoeven, N.5    Carter, V.S.6    Thomas, M.J.7    Proll, S.8    Solorzano, A.9
  • 6
    • 0035956970 scopus 로고    scopus 로고
    • Basler, C. F., Reid, A. H., Dybing, J. K., Janczewski, T. A., Fanning, T. G., Zheng, H., Salvatore, M., Perdue, M. L., Swayne, D. E. & other authors (2001). Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes. Proc Natl Acad Sci U S A 98, 2746-2751.
    • Basler, C. F., Reid, A. H., Dybing, J. K., Janczewski, T. A., Fanning, T. G., Zheng, H., Salvatore, M., Perdue, M. L., Swayne, D. E. & other authors (2001). Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes. Proc Natl Acad Sci U S A 98, 2746-2751.
  • 9
    • 33744925682 scopus 로고    scopus 로고
    • X-ray structure of influenza virus NS1 effector domain
    • Bornholdt, Z. A. & Prasad, B. V. (2006). X-ray structure of influenza virus NS1 effector domain. Nat Struct Mol Biol 13, 559-560.
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 559-560
    • Bornholdt, Z.A.1    Prasad, B.V.2
  • 10
    • 1842832222 scopus 로고    scopus 로고
    • The influenza A virus NS1 protein binds small interfering RNAs and suppresses RNA silencing in plants
    • Bucher, E., Hemmes, H., de Haan, P., Goldbach, R. & Prins, M. (2004). The influenza A virus NS1 protein binds small interfering RNAs and suppresses RNA silencing in plants. J Gen Virol 85, 983-991.
    • (2004) J Gen Virol , vol.85 , pp. 983-991
    • Bucher, E.1    Hemmes, H.2    de Haan, P.3    Goldbach, R.4    Prins, M.5
  • 11
    • 0346121589 scopus 로고    scopus 로고
    • PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes
    • Burgui, I., Aragon, T., Ortin, J. & Nieto, A. (2003). PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes. J Gen Virol 84, 3263-3274.
    • (2003) J Gen Virol , vol.84 , pp. 3263-3274
    • Burgui, I.1    Aragon, T.2    Ortin, J.3    Nieto, A.4
  • 12
    • 44449140060 scopus 로고    scopus 로고
    • Protection against influenza A virus by memory CD8 T cells requires reactivation by bone marrow-derived dendritic cells
    • Castiglioni, P., Hall, D. S., Jacovetty, E. L., Ingulli, E. & Zanetti, M. (2008). Protection against influenza A virus by memory CD8 T cells requires reactivation by bone marrow-derived dendritic cells. J Immunol 180, 4956-4964.
    • (2008) J Immunol , vol.180 , pp. 4956-4964
    • Castiglioni, P.1    Hall, D.S.2    Jacovetty, E.L.3    Ingulli, E.4    Zanetti, M.5
  • 13
    • 33846849603 scopus 로고    scopus 로고
    • Amelioration of influenza virus pathogenesis in chickens attributed to the enhanced interferon-inducing capacity of a virus with a truncated NS1 gene
    • Cauthen, A. N., Swayne, D. E., Sekellick, M. J., Marcus, P. I. & Suarez, D. L. (2007). Amelioration of influenza virus pathogenesis in chickens attributed to the enhanced interferon-inducing capacity of a virus with a truncated NS1 gene. J Virol 81, 1838-1847.
    • (2007) J Virol , vol.81 , pp. 1838-1847
    • Cauthen, A.N.1    Swayne, D.E.2    Sekellick, M.J.3    Marcus, P.I.4    Suarez, D.L.5
  • 14
    • 0033560753 scopus 로고    scopus 로고
    • Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3′-end processing machinery
    • Chen, Z., Li, Y. & Krug, R. M. (1999). Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3′-end processing machinery. EMBO J 18, 2273-2283.
    • (1999) EMBO J , vol.18 , pp. 2273-2283
    • Chen, Z.1    Li, Y.2    Krug, R.M.3
  • 15
    • 0037038866 scopus 로고    scopus 로고
    • Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: A mechanism for the unusual severity of human disease?
    • Cheung, C. Y., Poon, L. L., Lau, A. S., Luk, W., Lau, Y. L., Shortridge, K. F., Gordon, S., Guan, Y. & Peiris, J. S. (2002). Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet 360, 1831-1837.
    • (2002) Lancet , vol.360 , pp. 1831-1837
    • Cheung, C.Y.1    Poon, L.L.2    Lau, A.S.3    Luk, W.4    Lau, Y.L.5    Shortridge, K.F.6    Gordon, S.7    Guan, Y.8    Peiris, J.S.9
  • 17
    • 1242307789 scopus 로고    scopus 로고
    • Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: Evidence for a novel RNA-binding mode
    • Chien, C. Y., Xu, Y., Xiao, R., Aramini, J. M., Sahasrabudhe, P. V., Krug, R. M. & Montelione, G. T. (2004). Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: evidence for a novel RNA-binding mode. Biochemistry 43, 1950-1962.
    • (2004) Biochemistry , vol.43 , pp. 1950-1962
    • Chien, C.Y.1    Xu, Y.2    Xiao, R.3    Aramini, J.M.4    Sahasrabudhe, P.V.5    Krug, R.M.6    Montelione, G.T.7
  • 18
    • 0028923921 scopus 로고
    • Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs
    • de la Luna, S., Fortes, P., Beloso, A. & Ortin, J. (1995). Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs. J Virol 69, 2427-2433.
    • (1995) J Virol , vol.69 , pp. 2427-2433
    • de la Luna, S.1    Fortes, P.2    Beloso, A.3    Ortin, J.4
  • 19
    • 1842843155 scopus 로고    scopus 로고
    • Human influenza virus NS1 protein enhances viral pathogenicity and acts as an RNA silencing suppressor in plants
    • Delgadillo, M. O., Saenz, P., Salvador, B., Garcia, J. A. & Simon-Mateo, C. (2004). Human influenza virus NS1 protein enhances viral pathogenicity and acts as an RNA silencing suppressor in plants. J Gen Virol 85, 993-999.
    • (2004) J Gen Virol , vol.85 , pp. 993-999
    • Delgadillo, M.O.1    Saenz, P.2    Salvador, B.3    Garcia, J.A.4    Simon-Mateo, C.5
  • 20
    • 41149143074 scopus 로고    scopus 로고
    • Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase
    • Dittmann, J., Stertz, S., Grimm, D., Steel, J., Garcia-Sastre, A., Haller, O. & Kochs,G. (2008). Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase. J Virol 82, 3624-3631.
    • (2008) J Virol , vol.82 , pp. 3624-3631
    • Dittmann, J.1    Stertz, S.2    Grimm, D.3    Steel, J.4    Garcia-Sastre, A.5    Haller, O.6    Kochs, G.7
  • 21
    • 0345167006 scopus 로고    scopus 로고
    • A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice
    • Donelan, N. R., Basler, C. F. & Garcia-Sastre, A. (2003). A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice. J Virol 77, 13257-13266.
    • (2003) J Virol , vol.77 , pp. 13257-13266
    • Donelan, N.R.1    Basler, C.F.2    Garcia-Sastre, A.3
  • 24
    • 33745753573 scopus 로고    scopus 로고
    • Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence
    • Ehrhardt, C., Marjuki, H., Wolff, T., Nurnberg, B., Planz, O., Pleschka, S. & Ludwig, S. (2006). Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence. Cell Microbiol 8, 1336-1348.
    • (2006) Cell Microbiol , vol.8 , pp. 1336-1348
    • Ehrhardt, C.1    Marjuki, H.2    Wolff, T.3    Nurnberg, B.4    Planz, O.5    Pleschka, S.6    Ludwig, S.7
  • 25
    • 33947381763 scopus 로고    scopus 로고
    • Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses
    • Ehrhardt, C., Wolff, T., Pleschka, S., Planz, O., Beermann, W., Bode, J. G., Schmolke, M. & Ludwig, S. (2007). Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses. J Virol 81, 3058-3067.
    • (2007) J Virol , vol.81 , pp. 3058-3067
    • Ehrhardt, C.1    Wolff, T.2    Pleschka, S.3    Planz, O.4    Beermann, W.5    Bode, J.G.6    Schmolke, M.7    Ludwig, S.8
  • 26
    • 0034110653 scopus 로고    scopus 로고
    • Characterization of influenza virus NS1 protein by using a novel helper-virus-free reverse genetic system
    • Enami, M. & Enami, K. (2000). Characterization of influenza virus NS1 protein by using a novel helper-virus-free reverse genetic system. J Virol 74, 5556-5561.
    • (2000) J Virol , vol.74 , pp. 5556-5561
    • Enami, M.1    Enami, K.2
  • 27
    • 0028055149 scopus 로고
    • Influenza virus NS1 protein stimulates translation of the M1 protein
    • Enami, K., Sato, T. A., Nakada, S. & Enami, M. (1994). Influenza virus NS1 protein stimulates translation of the M1 protein. J Virol 68, 1432-1437.
    • (1994) J Virol , vol.68 , pp. 1432-1437
    • Enami, K.1    Sato, T.A.2    Nakada, S.3    Enami, M.4
  • 28
    • 0033152610 scopus 로고    scopus 로고
    • Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro
    • Falcon, A. M., Fortes, P., Marion, R. M., Beloso, A. & Ortin, J. (1999). Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. Nucleic Acids Res 27, 2241-2247.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2241-2247
    • Falcon, A.M.1    Fortes, P.2    Marion, R.M.3    Beloso, A.4    Ortin, J.5
  • 29
    • 1842536901 scopus 로고    scopus 로고
    • Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein
    • Falcon, A. M., Marion, R. M., Zurcher, T., Gomez, P., Portela, A., Nieto, A. & Ortin, J. (2004). Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein. J Virol 78, 3880-3888.
    • (2004) J Virol , vol.78 , pp. 3880-3888
    • Falcon, A.M.1    Marion, R.M.2    Zurcher, T.3    Gomez, P.4    Portela, A.5    Nieto, A.6    Ortin, J.7
  • 30
    • 26244458739 scopus 로고    scopus 로고
    • Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins
    • Falcon, A. M., Fernandez-Sesma, A., Nakaya, Y., Moran, T. M., Ortin, J. & Garcia-Sastre, A. (2005). Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins. J Gen Virol 86, 2817-2821.
    • (2005) J Gen Virol , vol.86 , pp. 2817-2821
    • Falcon, A.M.1    Fernandez-Sesma, A.2    Nakaya, Y.3    Moran, T.M.4    Ortin, J.5    Garcia-Sastre, A.6
  • 31
    • 0027252545 scopus 로고
    • Modification of eukaryotic initiation factor 4F during infection by influenza virus
    • Feigenblum, D. & Schneider, R. J. (1993). Modification of eukaryotic initiation factor 4F during infection by influenza virus. J Virol 67, 3027-3035.
    • (1993) J Virol , vol.67 , pp. 3027-3035
    • Feigenblum, D.1    Schneider, R.J.2
  • 32
    • 8644243888 scopus 로고    scopus 로고
    • Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes
    • Ferko, B., Stasakova, J., Romanova, J., Kittel, C., Sereinig, S., Katinger, H. & Egorov, A. (2004). Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes. J Virol 78, 13037-13045.
    • (2004) J Virol , vol.78 , pp. 13037-13045
    • Ferko, B.1    Stasakova, J.2    Romanova, J.3    Kittel, C.4    Sereinig, S.5    Katinger, H.6    Egorov, A.7
  • 35
    • 0028008470 scopus 로고
    • Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport
    • Fortes, P., Beloso, A. & Ortin, J. (1994). Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport. EMBO J 13, 704-712.
    • (1994) EMBO J , vol.13 , pp. 704-712
    • Fortes, P.1    Beloso, A.2    Ortin, J.3
  • 36
    • 0028907920 scopus 로고
    • Influenza virus NS1 protein alters the subnuclear localization of cellular splicing components
    • Fortes, P., Lamond, A. I. & Ortin, J. (1995). Influenza virus NS1 protein alters the subnuclear localization of cellular splicing components. J Gen Virol 76, 1001-1007.
    • (1995) J Gen Virol , vol.76 , pp. 1001-1007
    • Fortes, P.1    Lamond, A.I.2    Ortin, J.3
  • 37
    • 0037629646 scopus 로고    scopus 로고
    • PI3K and negative regulation of TLR signaling
    • Fukao, T. & Koyasu, S. (2003). PI3K and negative regulation of TLR signaling. Trends Immunol 24, 358-363.
    • (2003) Trends Immunol , vol.24 , pp. 358-363
    • Fukao, T.1    Koyasu, S.2
  • 38
    • 34547870537 scopus 로고    scopus 로고
    • Mutation analysis of a recombinant NS replicon shows that influenza virus NS1 protein blocks the splicing and nucleo-cytoplasmic transport of its own viral mRNA
    • Garaigorta, U. & Ortin, J. (2007). Mutation analysis of a recombinant NS replicon shows that influenza virus NS1 protein blocks the splicing and nucleo-cytoplasmic transport of its own viral mRNA. Nucleic Acids Res 35, 4573-4582.
    • (2007) Nucleic Acids Res , vol.35 , pp. 4573-4582
    • Garaigorta, U.1    Ortin, J.2
  • 39
    • 29744444887 scopus 로고    scopus 로고
    • Genetic analysis of influenza virus NS1 gene: A temperature-sensitive mutant shows defective formation of virus particles
    • Garaigorta, U., Falcon, A. M. & Ortin, J. (2005). Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles. J Virol 79, 15246-15257.
    • (2005) J Virol , vol.79 , pp. 15246-15257
    • Garaigorta, U.1    Falcon, A.M.2    Ortin, J.3
  • 42
    • 0027518202 scopus 로고
    • Translational control by influenza virus. Selective translation is mediated by sequences within the viral mRNA 5′-untranslated region
    • Garfinkel, M. S. & Katze, M. G. (1993). Translational control by influenza virus. Selective translation is mediated by sequences within the viral mRNA 5′-untranslated region. J Biol Chem 268, 22223-22226.
    • (1993) J Biol Chem , vol.268 , pp. 22223-22226
    • Garfinkel, M.S.1    Katze, M.G.2
  • 43
    • 0036678864 scopus 로고    scopus 로고
    • Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza
    • Geiss, G. K., Salvatore, M., Tumpey, T. M., Carter, V. S., Wang, X., Basler, C. F., Taubenberger, J. K., Bumgarner, R. E., Palese, P. & other authors (2002). Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proc Natl Acad Sci U S A 99, 10736-10741.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10736-10741
    • Geiss, G.K.1    Salvatore, M.2    Tumpey, T.M.3    Carter, V.S.4    Wang, X.5    Basler, C.F.6    Taubenberger, J.K.7    Bumgarner, R.E.8    Palese, P.9
  • 45
    • 0023690369 scopus 로고
    • Two nuclear location signals in the influenza virus NS1 nonstructural protein
    • Greenspan, D., Palese, P. & Krystal, M. (1988). Two nuclear location signals in the influenza virus NS1 nonstructural protein. J Virol 62, 3020-3026.
    • (1988) J Virol , vol.62 , pp. 3020-3026
    • Greenspan, D.1    Palese, P.2    Krystal, M.3
  • 48
    • 33749004778 scopus 로고    scopus 로고
    • Influenza A virus NS1 protein binds p85β and activates phosphatidylinositol-3-kinase signaling
    • Hale, B. G., Jackson, D., Chen, Y. H., Lamb, R. A. & Randall, R. E. (2006). Influenza A virus NS1 protein binds p85β and activates phosphatidylinositol-3-kinase signaling. Proc Natl Acad Sci U S A 103, 14194-14199.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14194-14199
    • Hale, B.G.1    Jackson, D.2    Chen, Y.H.3    Lamb, R.A.4    Randall, R.E.5
  • 49
    • 47749143963 scopus 로고    scopus 로고
    • Structure of an avian influenza A virus NS1 protein effector domain
    • Hale, B. G., Barclay, W. S., Randall, R. E. & Russell, R. J. (2008a). Structure of an avian influenza A virus NS1 protein effector domain. Virology 378, 1-5.
    • (2008) Virology , vol.378 , pp. 1-5
    • Hale, B.G.1    Barclay, W.S.2    Randall, R.E.3    Russell, R.J.4
  • 50
    • 38349136199 scopus 로고    scopus 로고
    • Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation
    • Hale, B. G., Batty, I. H., Downes, C. P. & Randall, R. E. (2008b). Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation. J Biol Chem 283, 1372-1380.
    • (2008) J Biol Chem , vol.283 , pp. 1372-1380
    • Hale, B.G.1    Batty, I.H.2    Downes, C.P.3    Randall, R.E.4
  • 51
    • 0027102716 scopus 로고
    • Binding of influenza A virus NS1 protein to dsRNA in vitro
    • Hatada, E. & Fukuda, R. (1992). Binding of influenza A virus NS1 protein to dsRNA in vitro. J Gen Virol 73, 3325-3329.
    • (1992) J Gen Virol , vol.73 , pp. 3325-3329
    • Hatada, E.1    Fukuda, R.2
  • 52
    • 0025340196 scopus 로고
    • Analysis of influenza A virus temperature-sensitive mutants with mutations in RNA segment 8
    • Hatada, E., Hasegawa, M., Shimizu, K., Hatanaka, M. & Fukuda, R. (1990). Analysis of influenza A virus temperature-sensitive mutants with mutations in RNA segment 8. J Gen Virol 71, 1283-1292.
    • (1990) J Gen Virol , vol.71 , pp. 1283-1292
    • Hatada, E.1    Hasegawa, M.2    Shimizu, K.3    Hatanaka, M.4    Fukuda, R.5
  • 53
    • 0030982614 scopus 로고    scopus 로고
    • Binding of the influenza virus NS1 protein to model genome RNAs
    • Hatada, E., Saito, S., Okishio, N. & Fukuda, R. (1997). Binding of the influenza virus NS1 protein to model genome RNAs. J Gen Virol 78, 1059-1063.
    • (1997) J Gen Virol , vol.78 , pp. 1059-1063
    • Hatada, E.1    Saito, S.2    Okishio, N.3    Fukuda, R.4
  • 54
    • 0032980412 scopus 로고    scopus 로고
    • Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells
    • Hatada, E., Saito, S. & Fukuda, R. (1999). Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells. J Virol 73, 2425-2433.
    • (1999) J Virol , vol.73 , pp. 2425-2433
    • Hatada, E.1    Saito, S.2    Fukuda, R.3
  • 56
    • 33645037542 scopus 로고    scopus 로고
    • Variation in the ability of human influenza A viruses to induce and inhibit the IFN-β pathway
    • Hayman, A., Comely, S., Lackenby, A., Murphy, S., McCauley, J., Goodbourn, S. & Barclay, W. (2006). Variation in the ability of human influenza A viruses to induce and inhibit the IFN-β pathway. Virology 347, 52-64.
    • (2006) Virology , vol.347 , pp. 52-64
    • Hayman, A.1    Comely, S.2    Lackenby, A.3    Murphy, S.4    McCauley, J.5    Goodbourn, S.6    Barclay, W.7
  • 57
    • 33847214535 scopus 로고    scopus 로고
    • NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response
    • Hayman, A., Comely, S., Lackenby, A., Hartgroves, L. C., Goodbourn, S., McCauley, J. W. & Barclay, W. S. (2007). NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response. J Virol 81, 2318-2327.
    • (2007) J Virol , vol.81 , pp. 2318-2327
    • Hayman, A.1    Comely, S.2    Lackenby, A.3    Hartgroves, L.C.4    Goodbourn, S.5    McCauley, J.W.6    Barclay, W.S.7
  • 58
    • 41949094828 scopus 로고    scopus 로고
    • Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling
    • Heikkinen, L. S., Kazlauskas, A., Melen, K., Wagner, R., Ziegler, T., Julkunen, I. & Saksela, K. (2008). Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling. J Biol Chem 283, 5719-5727.
    • (2008) J Biol Chem , vol.283 , pp. 5719-5727
    • Heikkinen, L.S.1    Kazlauskas, A.2    Melen, K.3    Wagner, R.4    Ziegler, T.5    Julkunen, I.6    Saksela, K.7
  • 59
    • 33646497012 scopus 로고    scopus 로고
    • Influenza virus NS1 protein protects against lymphohematopoietic pathogenesis in an in vivo mouse model
    • Hyland, L., Webby, R., Sandbulte, M. R., Clarke, B. & Hou, S. (2006). Influenza virus NS1 protein protects against lymphohematopoietic pathogenesis in an in vivo mouse model. Virology 349, 156-163.
    • (2006) Virology , vol.349 , pp. 156-163
    • Hyland, L.1    Webby, R.2    Sandbulte, M.R.3    Clarke, B.4    Hou, S.5
  • 60
    • 0018648729 scopus 로고
    • The smallest genome RNA segment of influenza virus contains two genes that may overlap
    • Inglis, S. C., Barrett, T., Brown, C. M. & Almond, J. W. (1979). The smallest genome RNA segment of influenza virus contains two genes that may overlap. Proc Natl Acad Sci U S A 76, 3790-3794.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 3790-3794
    • Inglis, S.C.1    Barrett, T.2    Brown, C.M.3    Almond, J.W.4
  • 61
    • 41949123710 scopus 로고    scopus 로고
    • A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity
    • Jackson, D., Hossain, M. J., Hickman, D., Perez, D. R. & Lamb, R. A. (2008). A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc Natl Acad Sci U S A 105, 4381-4386.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 4381-4386
    • Jackson, D.1    Hossain, M.J.2    Hickman, D.3    Perez, D.R.4    Lamb, R.A.5
  • 62
    • 38349180176 scopus 로고    scopus 로고
    • A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice
    • Jiao, P., Tian, G., Li, Y., Deng, G., Jiang, Y., Liu, C., Liu, W., Bu, Z., Kawaoka, Y. & Chen, H. (2008). A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. J Virol 82, 1146-1154.
    • (2008) J Virol , vol.82 , pp. 1146-1154
    • Jiao, P.1    Tian, G.2    Li, Y.3    Deng, G.4    Jiang, Y.5    Liu, C.6    Liu, W.7    Bu, Z.8    Kawaoka, Y.9    Chen, H.10
  • 63
    • 34250810666 scopus 로고    scopus 로고
    • Multiple anti-interferon actions of the influenza A virus NS1 protein
    • Kochs, G., Garcia-Sastre, A. & Martinez-Sobrido, L. (2007a). Multiple anti-interferon actions of the influenza A virus NS1 protein. J Virol 81, 7011-7021.
    • (2007) J Virol , vol.81 , pp. 7011-7021
    • Kochs, G.1    Garcia-Sastre, A.2    Martinez-Sobrido, L.3
  • 65
    • 33747366052 scopus 로고    scopus 로고
    • Influenza A virus NS1 protein does not suppress RNA interference in mammalian cells
    • Kok, K. H. & Jin, D. Y. (2006). Influenza A virus NS1 protein does not suppress RNA interference in mammalian cells. J Gen Virol 87, 2639-2644.
    • (2006) J Gen Virol , vol.87 , pp. 2639-2644
    • Kok, K.H.1    Jin, D.Y.2
  • 66
    • 0015792298 scopus 로고
    • Cytoplasmic and nuclear virus-specific proteins in influenza virus-infected MDCK cells
    • Krug, R. M. & Etkind, P. R. (1973). Cytoplasmic and nuclear virus-specific proteins in influenza virus-infected MDCK cells. Virology 56, 334-348.
    • (1973) Virology , vol.56 , pp. 334-348
    • Krug, R.M.1    Etkind, P.R.2
  • 67
    • 0033124625 scopus 로고    scopus 로고
    • Influenza virus overcomes apoptosis by rapid multiplication
    • Kurokawa, M., Koyama, A. H., Yasuoka, S. & Adachi, A. (1999). Influenza virus overcomes apoptosis by rapid multiplication. Int J Mol Med 3, 527-530.
    • (1999) Int J Mol Med , vol.3 , pp. 527-530
    • Kurokawa, M.1    Koyama, A.H.2    Yasuoka, S.3    Adachi, A.4
  • 68
    • 40149111112 scopus 로고    scopus 로고
    • Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells
    • Lam, W. Y., Tang, J. W., Yeung, A. C., Chiu, L. C., Sung, J. J. & Chan, P. K. (2008). Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells. J Virol 82, 2741-2751.
    • (2008) J Virol , vol.82 , pp. 2741-2751
    • Lam, W.Y.1    Tang, J.W.2    Yeung, A.C.3    Chiu, L.C.4    Sung, J.J.5    Chan, P.K.6
  • 69
    • 0018715086 scopus 로고
    • Segment 8 of the influenza virus genome is unique in coding for two polypeptides
    • Lamb, R. A. & Choppin, P. W. (1979). Segment 8 of the influenza virus genome is unique in coding for two polypeptides. Proc Natl Acad Sci U S A 76, 4908-4912.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 4908-4912
    • Lamb, R.A.1    Choppin, P.W.2
  • 70
    • 0018973537 scopus 로고
    • Sequence of interrupted and uninterrupted mRNAs and cloned DNA coding for the two overlapping nonstructural proteins of influenza virus
    • Lamb, R. A. & Lai, C. J. (1980). Sequence of interrupted and uninterrupted mRNAs and cloned DNA coding for the two overlapping nonstructural proteins of influenza virus. Cell 21, 475-485.
    • (1980) Cell , vol.21 , pp. 475-485
    • Lamb, R.A.1    Lai, C.J.2
  • 71
    • 0004787450 scopus 로고
    • Mapping of the two overlapping genes for polypeptides NS1 and NS2 on RNA segment 8 of influenza virus genome
    • Lamb, R. A., Choppin, P. W., Chanock, R. M. & Lai, C. J. (1980). Mapping of the two overlapping genes for polypeptides NS1 and NS2 on RNA segment 8 of influenza virus genome. Proc Natl Acad Sci U S A 77, 1857-1861.
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 1857-1861
    • Lamb, R.A.1    Choppin, P.W.2    Chanock, R.M.3    Lai, C.J.4
  • 72
    • 0032574845 scopus 로고    scopus 로고
    • Regulation of a nuclear export signal by an adjacent inhibitory sequence: The effector domain of the influenza virus NS1 protein
    • Li, Y., Yamakita, Y. & Krug, R. M. (1998). Regulation of a nuclear export signal by an adjacent inhibitory sequence: the effector domain of the influenza virus NS1 protein. Proc Natl Acad Sci U S A 95, 4864-4869.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 4864-4869
    • Li, Y.1    Yamakita, Y.2    Krug, R.M.3
  • 73
    • 0034743629 scopus 로고    scopus 로고
    • The 3′-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo
    • Li, Y., Chen, Z. Y., Wang, W., Baker, C. C. & Krug, R. M. (2001). The 3′-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo. RNA 7, 920-931.
    • (2001) RNA , vol.7 , pp. 920-931
    • Li, Y.1    Chen, Z.Y.2    Wang, W.3    Baker, C.C.4    Krug, R.M.5
  • 75
    • 33646517711 scopus 로고    scopus 로고
    • Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA
    • Li, S., Min, J. Y., Krug, R. M. & Sen, G. C. (2006a). Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA. Virology 349, 13-21.
    • (2006) Virology , vol.349 , pp. 13-21
    • Li, S.1    Min, J.Y.2    Krug, R.M.3    Sen, G.C.4
  • 76
    • 33750719489 scopus 로고    scopus 로고
    • The NS1 gene contributes to the virulence of H5N1 avian influenza viruses
    • Li, Z., Jiang, Y., Jiao, P., Wang, A., Zhao, F., Tian, G., Wang, X., Yu, K., Bu, Z. & Chen, H. (2006b). The NS1 gene contributes to the virulence of H5N1 avian influenza viruses. J Virol 80, 11115-11123.
    • (2006) J Virol , vol.80 , pp. 11115-11123
    • Li, Z.1    Jiang, Y.2    Jiao, P.3    Wang, A.4    Zhao, F.5    Tian, G.6    Wang, X.7    Yu, K.8    Bu, Z.9    Chen, H.10
  • 77
    • 53149131362 scopus 로고    scopus 로고
    • Mechanism of influenza A virus NS1 protein interaction with the p85β, but not the p85α, subunit of PI3K and upregulation of PI3K activity
    • in press, doi:10.1074/jbc.M802737200
    • Li, Y., Anderson, D. H., Liu, Q. & Zhou, Y. (2008). Mechanism of influenza A virus NS1 protein interaction with the p85β, but not the p85α, subunit of PI3K and upregulation of PI3K activity. J Biol Chem (in press). doi:10.1074/jbc.M802737200.
    • (2008) J Biol Chem
    • Li, Y.1    Anderson, D.H.2    Liu, Q.3    Zhou, Y.4
  • 79
    • 0030710459 scopus 로고    scopus 로고
    • Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein
    • Liu, J., Lynch, P. A., Chien, C. Y., Montelione, G. T., Krug, R. M. & Berman, H. M. (1997). Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. Nat Struct Biol 4, 896-899.
    • (1997) Nat Struct Biol , vol.4 , pp. 896-899
    • Liu, J.1    Lynch, P.A.2    Chien, C.Y.3    Montelione, G.T.4    Krug, R.M.5    Berman, H.M.6
  • 80
    • 43049090761 scopus 로고    scopus 로고
    • Virulence of H5N1 avian influenza virus enhanced by a 15-nucleotide deletion in the viral nonstructural gene
    • Long, J. X., Peng, D. X., Liu, Y. L., Wu, Y. T. & Liu, X. F. (2008). Virulence of H5N1 avian influenza virus enhanced by a 15-nucleotide deletion in the viral nonstructural gene. Virus Genes 36, 471-478.
    • (2008) Virus Genes , vol.36 , pp. 471-478
    • Long, J.X.1    Peng, D.X.2    Liu, Y.L.3    Wu, Y.T.4    Liu, X.F.5
  • 81
    • 0028040760 scopus 로고
    • The influenza virus NS1 protein: A novel inhibitor of pre-mRNA splicing
    • Lu, Y., Qian, X. Y. & Krug, R. M. (1994). The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing. Genes Dev 8, 1817-1828.
    • (1994) Genes Dev , vol.8 , pp. 1817-1828
    • Lu, Y.1    Qian, X.Y.2    Krug, R.M.3
  • 82
    • 0028847292 scopus 로고
    • Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor
    • Lu, Y., Wambach, M., Katze, M. G. & Krug, R. M. (1995). Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor. Virology 214, 222-228.
    • (1995) Virology , vol.214 , pp. 222-228
    • Lu, Y.1    Wambach, M.2    Katze, M.G.3    Krug, R.M.4
  • 83
    • 0025914886 scopus 로고
    • Phylogenetic relationship of the nonstructural (NS) genes of influenza A viruses
    • Ludwig, S., Schultz, U., Mandler, J., Fitch, W. M. & Scholtissek, C. (1991). Phylogenetic relationship of the nonstructural (NS) genes of influenza A viruses. Virology 183, 566-577.
    • (1991) Virology , vol.183 , pp. 566-577
    • Ludwig, S.1    Schultz, U.2    Mandler, J.3    Fitch, W.M.4    Scholtissek, C.5
  • 85
    • 0030694071 scopus 로고    scopus 로고
    • The N-terminal half of the influenza virus NS1 protein is sufficient for nuclear retention of mRNA and enhancement of viral mRNA translation
    • Marion, R. M., Aragon, T., Beloso, A., Nieto, A. & Ortin, J. (1997a). The N-terminal half of the influenza virus NS1 protein is sufficient for nuclear retention of mRNA and enhancement of viral mRNA translation. Nucleic Acids Res 25, 4271-4277.
    • (1997) Nucleic Acids Res , vol.25 , pp. 4271-4277
    • Marion, R.M.1    Aragon, T.2    Beloso, A.3    Nieto, A.4    Ortin, J.5
  • 86
    • 0030830205 scopus 로고    scopus 로고
    • Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo
    • Marion, R. M., Zurcher, T., de la Luna, S. & Ortin, J. (1997b). Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo. J Gen Virol 78, 2447-2451.
    • (1997) J Gen Virol , vol.78 , pp. 2447-2451
    • Marion, R.M.1    Zurcher, T.2    de la Luna, S.3    Ortin, J.4
  • 87
    • 35048818922 scopus 로고    scopus 로고
    • Dicer is involved in protection against influenza A virus infection
    • Matskevich, A. A. & Moelling, K. (2007). Dicer is involved in protection against influenza A virus infection. J Gen Virol 88, 2627-2635.
    • (2007) J Gen Virol , vol.88 , pp. 2627-2635
    • Matskevich, A.A.1    Moelling, K.2
  • 88
    • 34249785982 scopus 로고    scopus 로고
    • Nuclear and nucleolar targeting of influenza A virus NS1 protein: Striking differences between different virus subtypes
    • Melen, K., Kinnunen, L., Fagerlund, R., Ikonen, N., Twu, K. Y., Krug, R. M. & Julkunen, I. (2007). Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes. J Virol 81, 5995-6006.
    • (2007) J Virol , vol.81 , pp. 5995-6006
    • Melen, K.1    Kinnunen, L.2    Fagerlund, R.3    Ikonen, N.4    Twu, K.Y.5    Krug, R.M.6    Julkunen, I.7
  • 89
    • 33846061693 scopus 로고    scopus 로고
    • Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus
    • Mibayashi, M., Martinez-Sobrido, L., Loo, Y. M., Cardenas, W. B., Gale, M., Jr & Garcia-Sastre, A. (2007). Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. J Virol 81, 514-524.
    • (2007) J Virol , vol.81 , pp. 514-524
    • Mibayashi, M.1    Martinez-Sobrido, L.2    Loo, Y.M.3    Cardenas, W.B.4    Gale Jr, M.5    Garcia-Sastre, A.6
  • 90
    • 33646478272 scopus 로고    scopus 로고
    • The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2′-5′ oligo (A) synthetase/RNase L pathway
    • Min, J. Y. & Krug, R. M. (2006). The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: inhibiting the 2′-5′ oligo (A) synthetase/RNase L pathway. Proc Natl Acad Sci U S A 103, 7100-7105.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7100-7105
    • Min, J.Y.1    Krug, R.M.2
  • 91
    • 34247566514 scopus 로고    scopus 로고
    • A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis
    • Min, J. Y., Li, S., Sen, G. C. & Krug, R. M. (2007). A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis. Virology 363, 236-243.
    • (2007) Virology , vol.363 , pp. 236-243
    • Min, J.Y.1    Li, S.2    Sen, G.C.3    Krug, R.M.4
  • 92
    • 34548569397 scopus 로고    scopus 로고
    • Influenza A virus non-structural protein 1 (NS1) interacts with cellular multifunctional protein nucleolin during infection
    • Murayama, R., Harada, Y., Shibata, T., Kuroda, K., Hayakawa, S., Shimizu, K. & Tanaka, T. (2007). Influenza A virus non-structural protein 1 (NS1) interacts with cellular multifunctional protein nucleolin during infection. Biochem Biophys Res Commun 362, 880-885.
    • (2007) Biochem Biophys Res Commun , vol.362 , pp. 880-885
    • Murayama, R.1    Harada, Y.2    Shibata, T.3    Kuroda, K.4    Hayakawa, S.5    Shimizu, K.6    Tanaka, T.7
  • 94
    • 0028820529 scopus 로고
    • The influenza virus NS1 protein forms multimers in vitro and in vivo
    • Nemeroff, M. E., Qian, X. Y. & Krug, R. M. (1995). The influenza virus NS1 protein forms multimers in vitro and in vivo. Virology 212, 422-428.
    • (1995) Virology , vol.212 , pp. 422-428
    • Nemeroff, M.E.1    Qian, X.Y.2    Krug, R.M.3
  • 95
    • 0032086357 scopus 로고    scopus 로고
    • Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3′ end formation of cellular pre-mRNAs
    • Nemeroff, M. E., Barabino, S. M., Li, Y., Keller, W. & Krug, R. M. (1998). Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3′ end formation of cellular pre-mRNAs. Mol Cell 1, 991-1000.
    • (1998) Mol Cell , vol.1 , pp. 991-1000
    • Nemeroff, M.E.1    Barabino, S.M.2    Li, Y.3    Keller, W.4    Krug, R.M.5
  • 96
    • 34548149666 scopus 로고    scopus 로고
    • The RNA binding domain of influenza A virus NS1 protein affects secretion of tumor necrosis factor alpha, interleukin-6, and interferon in primary murine tracheal epithelial cells
    • Newby, C. M., Sabin, L. & Pekosz, A. (2007). The RNA binding domain of influenza A virus NS1 protein affects secretion of tumor necrosis factor alpha, interleukin-6, and interferon in primary murine tracheal epithelial cells. J Virol 81, 9469-9480.
    • (2007) J Virol , vol.81 , pp. 9469-9480
    • Newby, C.M.1    Sabin, L.2    Pekosz, A.3
  • 97
    • 0037444193 scopus 로고    scopus 로고
    • Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS
    • Noah, D. L., Twu, K. Y. & Krug, R. M. (2003). Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS. Virology 307, 386-395.
    • (2003) Virology , vol.307 , pp. 386-395
    • Noah, D.L.1    Twu, K.Y.2    Krug, R.M.3
  • 100
    • 34447299235 scopus 로고    scopus 로고
    • Orthomyxoviridae: The viruses and their replication
    • 5th edn, pp, Edited by D. M. Knipe & P. M. Howley. Philadelphia: Lippincott Williams & Wilkins
    • Palese, P. & Shaw, M. L. (2007). Orthomyxoviridae: the viruses and their replication. In Fields Virology, 5th edn, pp. 1647-1689. Edited by D. M. Knipe & P. M. Howley. Philadelphia: Lippincott Williams & Wilkins.
    • (2007) Fields Virology , pp. 1647-1689
    • Palese, P.1    Shaw, M.L.2
  • 101
    • 0028880783 scopus 로고
    • Translational control by influenza virus. Identification of cis-acting sequences and trans-acting factors which may regulate selective viral mRNA translation
    • Park, Y. W. & Katze, M. G. (1995). Translational control by influenza virus. Identification of cis-acting sequences and trans-acting factors which may regulate selective viral mRNA translation. J Biol Chem 270, 28433-28439.
    • (1995) J Biol Chem , vol.270 , pp. 28433-28439
    • Park, Y.W.1    Katze, M.G.2
  • 102
    • 0020326232 scopus 로고
    • Polymorphism of the NS1 proteins of type A influenza virus
    • Petri, T., Patterson, S. & Dimmock, N. J. (1982). Polymorphism of the NS1 proteins of type A influenza virus. J Gen Virol 61, 217-231.
    • (1982) J Gen Virol , vol.61 , pp. 217-231
    • Petri, T.1    Patterson, S.2    Dimmock, N.J.3
  • 103
    • 33750984771 scopus 로고    scopus 로고
    • Pichlmair, A., Schulz, O., Tan, C. P., Naslund, T. I., Liljestrom, P., Weber, F. & Reis e Sousa, C. (2006). RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 314, 997-1001.
    • Pichlmair, A., Schulz, O., Tan, C. P., Naslund, T. I., Liljestrom, P., Weber, F. & Reis e Sousa, C. (2006). RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 314, 997-1001.
  • 104
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type-I- and type-II-interferon-mediated signalling
    • Platanias, L. C. (2005). Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 5, 375-386.
    • (2005) Nat Rev Immunol , vol.5 , pp. 375-386
    • Platanias, L.C.1
  • 105
    • 0019424258 scopus 로고
    • The structure and synthesis of influenza virus phosphoproteins
    • Privalsky, M. L. & Penhoet, E. E. (1981). The structure and synthesis of influenza virus phosphoproteins. J Biol Chem 256, 5368-5376.
    • (1981) J Biol Chem , vol.256 , pp. 5368-5376
    • Privalsky, M.L.1    Penhoet, E.E.2
  • 106
    • 0029400032 scopus 로고
    • An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure
    • Qian, X. Y., Chien, C. Y., Lu, Y., Montelione, G. T. & Krug, R. M. (1995). An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure. RNA 1, 948-956.
    • (1995) RNA , vol.1 , pp. 948-956
    • Qian, X.Y.1    Chien, C.Y.2    Lu, Y.3    Montelione, G.T.4    Krug, R.M.5
  • 107
    • 0028274131 scopus 로고
    • The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A)
    • Qiu, Y. & Krug, R. M. (1994). The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A). J Virol 68, 2425-2432.
    • (1994) J Virol , vol.68 , pp. 2425-2432
    • Qiu, Y.1    Krug, R.M.2
  • 108
    • 0029295578 scopus 로고
    • The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing
    • Qiu, Y., Nemeroff, M. & Krug, R. M. (1995). The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing. RNA 1, 304-316.
    • (1995) RNA , vol.1 , pp. 304-316
    • Qiu, Y.1    Nemeroff, M.2    Krug, R.M.3
  • 110
    • 36348940608 scopus 로고    scopus 로고
    • Interferons and viruses: An interplay between induction, signalling, antiviral responses and virus countermeasures
    • Randall, R. E. & Goodbourn, S. (2008). Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 89, 1-47.
    • (2008) J Gen Virol , vol.89 , pp. 1-47
    • Randall, R.E.1    Goodbourn, S.2
  • 111
    • 33750719677 scopus 로고    scopus 로고
    • Richt, J. A., Lekcharoensuk, P., Lager, K. M., Vincent, A. L., Loiacono, C. M., Janke, B. H., Wu, W. H., Yoon, K. J., Webby, R. J. & other authors (2006). Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine. J Virol 80, 11009-11018.
    • Richt, J. A., Lekcharoensuk, P., Lager, K. M., Vincent, A. L., Loiacono, C. M., Janke, B. H., Wu, W. H., Yoon, K. J., Webby, R. J. & other authors (2006). Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine. J Virol 80, 11009-11018.
  • 113
    • 0036147256 scopus 로고    scopus 로고
    • Effects of influenza A virus NS1 protein on protein expression: The NS1 protein enhances translation and is not required for shutoff of host protein synthesis
    • Salvatore, M., Basler, C. F., Parisien, J. P., Horvath, C. M., Bourmakina, S., Zheng, H., Muster, T., Palese, P. & Garcia-Sastre, A. (2002). Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis. J Virol 76, 1206-1212.
    • (2002) J Virol , vol.76 , pp. 1206-1212
    • Salvatore, M.1    Basler, C.F.2    Parisien, J.P.3    Horvath, C.M.4    Bourmakina, S.5    Zheng, H.6    Muster, T.7    Palese, P.8    Garcia-Sastre, A.9
  • 114
    • 0038205593 scopus 로고    scopus 로고
    • Localization of influenza virus proteins to nuclear dot 10 structures in influenza virus-infected cells
    • Sato, Y., Yoshioka, K., Suzuki, C., Awashima, S., Hosaka, Y., Yewdell, J. & Kuroda, K. (2003). Localization of influenza virus proteins to nuclear dot 10 structures in influenza virus-infected cells. Virology 310, 29-40.
    • (2003) Virology , vol.310 , pp. 29-40
    • Sato, Y.1    Yoshioka, K.2    Suzuki, C.3    Awashima, S.4    Hosaka, Y.5    Yewdell, J.6    Kuroda, K.7
  • 117
    • 0036734038 scopus 로고    scopus 로고
    • Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
    • Seo, S. H., Hoffmann, E. & Webster, R. G. (2002). Lethal H5N1 influenza viruses escape host anti-viral cytokine responses. Nat Med 8, 950-954.
    • (2002) Nat Med , vol.8 , pp. 950-954
    • Seo, S.H.1    Hoffmann, E.2    Webster, R.G.3
  • 118
    • 0033557045 scopus 로고    scopus 로고
    • Influenza virus inhibits cleavage of the HSP70 pre-mRNAs at the polyadenylation site
    • Shimizu, K., Iguchi, A., Gomyou, R. & Ono, Y. (1999). Influenza virus inhibits cleavage of the HSP70 pre-mRNAs at the polyadenylation site. Virology 254, 213-219.
    • (1999) Virology , vol.254 , pp. 213-219
    • Shimizu, K.1    Iguchi, A.2    Gomyou, R.3    Ono, Y.4
  • 119
    • 33846160497 scopus 로고    scopus 로고
    • Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K
    • Shin, Y.-K., Liu, Q., Tikoo, S. K., Babiuk, L. A. & Zhou, Y. (2007a). Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K. J Gen Virol 88, 13-18.
    • (2007) J Gen Virol , vol.88 , pp. 13-18
    • Shin, Y.-K.1    Liu, Q.2    Tikoo, S.K.3    Babiuk, L.A.4    Zhou, Y.5
  • 120
    • 36349018937 scopus 로고    scopus 로고
    • SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signalling pathway activation
    • Shin, Y. K., Li, Y., Liu, Q., Anderson, D. H., Babiuk, L. A. & Zhou, Y. (2007b). SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signalling pathway activation. J Virol 81, 12730-12739.
    • (2007) J Virol , vol.81 , pp. 12730-12739
    • Shin, Y.K.1    Li, Y.2    Liu, Q.3    Anderson, D.H.4    Babiuk, L.A.5    Zhou, Y.6
  • 121
    • 36348987303 scopus 로고    scopus 로고
    • Viral encounters with 2′,5′-oligoadenylate synthetase and RNase L during the interferon antiviral response
    • Silverman, R. H. (2007). Viral encounters with 2′,5′-oligoadenylate synthetase and RNase L during the interferon antiviral response. J Virol 81, 12720-12729.
    • (2007) J Virol , vol.81 , pp. 12720-12729
    • Silverman, R.H.1
  • 123
    • 19944419799 scopus 로고    scopus 로고
    • Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs
    • Solorzano, A., Webby, R. J., Lager, K.M., Janke, B. H., Garcia-Sastre, A. & Richt, J. A. (2005). Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. J Virol 79, 7535-7543.
    • (2005) J Virol , vol.79 , pp. 7535-7543
    • Solorzano, A.1    Webby, R.J.2    Lager, K.M.3    Janke, B.H.4    Garcia-Sastre, A.5    Richt, J.A.6
  • 124
    • 11444262203 scopus 로고    scopus 로고
    • Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1β and 18
    • Stasakova, J., Ferko, B., Kittel, C., Sereinig, S., Romanova, J., Katinger, H. & Egorov, A. (2005). Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1β and 18. J Gen Virol 86, 185-195.
    • (2005) J Gen Virol , vol.86 , pp. 185-195
    • Stasakova, J.1    Ferko, B.2    Kittel, C.3    Sereinig, S.4    Romanova, J.5    Katinger, H.6    Egorov, A.7
  • 125
    • 0344015773 scopus 로고    scopus 로고
    • Multiple alignment comparison of the non-structural genes of influenza A viruses
    • Suarez, D. L. & Perdue, M. L. (1998). Multiple alignment comparison of the non-structural genes of influenza A viruses. Virus Res 54, 59-69.
    • (1998) Virus Res , vol.54 , pp. 59-69
    • Suarez, D.L.1    Perdue, M.L.2
  • 126
    • 14444284599 scopus 로고    scopus 로고
    • Subbarao, K., Klimov, A., Katz, J., Regnery, H., Lim, W., Hall, H., Perdue, M., Swayne, D., Bender, C. & other authors (1998). Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279, 393-396.
    • Subbarao, K., Klimov, A., Katz, J., Regnery, H., Lim, W., Hall, H., Perdue, M., Swayne, D., Bender, C. & other authors (1998). Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279, 393-396.
  • 127
    • 0029842883 scopus 로고    scopus 로고
    • Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection
    • Takizawa, T., Ohashi, K. & Nakanishi, Y. (1996). Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection. J Virol 70, 8128-8132.
    • (1996) J Virol , vol.70 , pp. 8128-8132
    • Takizawa, T.1    Ohashi, K.2    Nakanishi, Y.3
  • 128
    • 0033870894 scopus 로고    scopus 로고
    • Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein
    • Talon, J., Horvath, C. M., Polley, R., Basler, C. F., Muster, T., Palese, P. & Garcia-Sastre, A. (2000a). Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J Virol 74, 7989-7996.
    • (2000) J Virol , vol.74 , pp. 7989-7996
    • Talon, J.1    Horvath, C.M.2    Polley, R.3    Basler, C.F.4    Muster, T.5    Palese, P.6    Garcia-Sastre, A.7
  • 130
    • 0031670374 scopus 로고    scopus 로고
    • Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase
    • Tan, S. L. & Katze, M. G. (1998). Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase. J Interferon Cytokine Res 18, 757-766.
    • (1998) J Interferon Cytokine Res , vol.18 , pp. 757-766
    • Tan, S.L.1    Katze, M.G.2
  • 131
    • 0035140519 scopus 로고    scopus 로고
    • To, K. F., Chan, P. K., Chan, K. F., Lee, W. K., Lam, W. Y., Wong, K. F., Tang, N. L., Tsang, D. N., Sung, R. Y. & other authors (2001). Pathology of fatal human infection associated with avian influenza A H5N1 virus. J Med Virol 63, 242-246.
    • To, K. F., Chan, P. K., Chan, K. F., Lee, W. K., Lam, W. Y., Wong, K. F., Tang, N. L., Tsang, D. N., Sung, R. Y. & other authors (2001). Pathology of fatal human infection associated with avian influenza A H5N1 virus. J Med Virol 63, 242-246.
  • 132
    • 0024337975 scopus 로고
    • The B allele of the NS gene of avian influenza viruses, but not the A allele, attenuates a human influenza A virus for squirrel monkeys
    • Treanor, J. J., Snyder, M. H., London, W. T. & Murphy, B. R. (1989). The B allele of the NS gene of avian influenza viruses, but not the A allele, attenuates a human influenza A virus for squirrel monkeys. Virology 171, 1-9.
    • (1989) Virology , vol.171 , pp. 1-9
    • Treanor, J.J.1    Snyder, M.H.2    London, W.T.3    Murphy, B.R.4
  • 133
    • 33645792617 scopus 로고    scopus 로고
    • The CPSF30 binding site on the NS1A protein of influenza A virus s a potential antiviral target
    • Twu, K. Y., Noah, D. L., Rao, P., Kuo, R. L. & Krug, R. M. (2006). The CPSF30 binding site on the NS1A protein of influenza A virus s a potential antiviral target. J Virol 80, 3957-3965.
    • (2006) J Virol , vol.80 , pp. 3957-3965
    • Twu, K.Y.1    Noah, D.L.2    Rao, P.3    Kuo, R.L.4    Krug, R.M.5
  • 134
    • 34547110101 scopus 로고    scopus 로고
    • The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells
    • Twu, K. Y., Kuo, R. L., Marklund, J. & Krug, R. M. (2007). The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells. J Virol 81, 8112-8121.
    • (2007) J Virol , vol.81 , pp. 8112-8121
    • Twu, K.Y.1    Kuo, R.L.2    Marklund, J.3    Krug, R.M.4
  • 135
    • 35548976678 scopus 로고    scopus 로고
    • Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine
    • Vincent, A. L., Ma, W., Lager, K. M., Janke, B. H., Webby, R. J., Garcia-Sastre, A. & Richt, J. A. (2007). Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine. Vaccine 25, 7999-8009.
    • (2007) Vaccine , vol.25 , pp. 7999-8009
    • Vincent, A.L.1    Ma, W.2    Lager, K.M.3    Janke, B.H.4    Webby, R.J.5    Garcia-Sastre, A.6    Richt, J.A.7
  • 136
    • 0031985445 scopus 로고    scopus 로고
    • U6atac snRNA, the highly divergent counterpart of U6 snRNA, is the specific target that mediates inhibition of AT-AC splicing by the influenza virus NS1 protein
    • Wang, W. & Krug, R. M. (1998). U6atac snRNA, the highly divergent counterpart of U6 snRNA, is the specific target that mediates inhibition of AT-AC splicing by the influenza virus NS1 protein. RNA 4, 55-64.
    • (1998) RNA , vol.4 , pp. 55-64
    • Wang, W.1    Krug, R.M.2
  • 137
    • 0032995665 scopus 로고    scopus 로고
    • RNA binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids
    • Wang, W., Riedel, K., Lynch, P., Chien, C. Y., Montelione, G. T. & Krug, R. M. (1999). RNA binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids. RNA 5, 195-205.
    • (1999) RNA , vol.5 , pp. 195-205
    • Wang, W.1    Riedel, K.2    Lynch, P.3    Chien, C.Y.4    Montelione, G.T.5    Krug, R.M.6
  • 138
    • 0034466776 scopus 로고    scopus 로고
    • Influenza A virus NS1 protein prevents activation of NF-κB and induction of alpha/beta interferon
    • Wang, X., Li, M., Zheng, H., Muster, T., Palese, P., Beg, A. A. & Garcia-Sastre, A. (2000). Influenza A virus NS1 protein prevents activation of NF-κB and induction of alpha/beta interferon. J Virol 74, 11566-11573.
    • (2000) J Virol , vol.74 , pp. 11566-11573
    • Wang, X.1    Li, M.2    Zheng, H.3    Muster, T.4    Palese, P.5    Beg, A.A.6    Garcia-Sastre, A.7
  • 139
    • 0036891842 scopus 로고    scopus 로고
    • Functional replacement of the carboxyterminal two-thirds of the influenza A virus NS1 protein with short heterologous dimerization domains
    • Wang, X., Basler, C. F., Williams, B. R., Silverman, R. H., Palese, P. & Garcia-Sastre, A. (2002). Functional replacement of the carboxyterminal two-thirds of the influenza A virus NS1 protein with short heterologous dimerization domains. J Virol 76, 12951-12962.
    • (2002) J Virol , vol.76 , pp. 12951-12962
    • Wang, X.1    Basler, C.F.2    Williams, B.R.3    Silverman, R.H.4    Palese, P.5    Garcia-Sastre, A.6
  • 140
    • 33646453915 scopus 로고    scopus 로고
    • Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
    • Weber, F., Wagner, V., Rasmussen, S. B., Hartmann, R. & Paludan, S. R. (2006). Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J Virol 80, 5059-5064.
    • (2006) J Virol , vol.80 , pp. 5059-5064
    • Weber, F.1    Wagner, V.2    Rasmussen, S.B.3    Hartmann, R.4    Paludan, S.R.5
  • 142
    • 0029942023 scopus 로고    scopus 로고
    • Interaction cloning of NS1-I, a human protein that binds to the nonstructural NS1 proteins of influenza A and B viruses
    • Wolff, T., O'Neill, R. E. & Palese, P. (1996). Interaction cloning of NS1-I, a human protein that binds to the nonstructural NS1 proteins of influenza A and B viruses. J Virol 70, 5363-5372.
    • (1996) J Virol , vol.70 , pp. 5363-5372
    • Wolff, T.1    O'Neill, R.E.2    Palese, P.3
  • 143
    • 0031847217 scopus 로고    scopus 로고
    • NS1-Binding protein (NS1-BP): A novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells
    • Wolff, T., O'Neill, R. E. & Palese, P. (1998). NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells. J Virol 72, 7170-7180.
    • (1998) J Virol , vol.72 , pp. 7170-7180
    • Wolff, T.1    O'Neill, R.E.2    Palese, P.3
  • 144
    • 0018869605 scopus 로고
    • Influenza virus-specific RNA and protein syntheses in cells infected with temperature-sensitive mutants defective in the genome segment encoding nonstructural proteins
    • Wolstenholme, A. J., Barrett, T., Nichol, S. T. & Mahy, B. W. (1980). Influenza virus-specific RNA and protein syntheses in cells infected with temperature-sensitive mutants defective in the genome segment encoding nonstructural proteins. J Virol 35, 1-7.
    • (1980) J Virol , vol.35 , pp. 1-7
    • Wolstenholme, A.J.1    Barrett, T.2    Nichol, S.T.3    Mahy, B.W.4
  • 145
    • 34547136235 scopus 로고    scopus 로고
    • Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses
    • Yin, C., Khan, J. A., Swapna, G. V., Ertekin, A., Krug, R. M., Tong, L. & Montelione, G. T. (2007). Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses. J Biol Chem 282, 20584-20592.
    • (2007) J Biol Chem , vol.282 , pp. 20584-20592
    • Yin, C.1    Khan, J.A.2    Swapna, G.V.3    Ertekin, A.4    Krug, R.M.5    Tong, L.6    Montelione, G.T.7
  • 147
    • 34250828457 scopus 로고    scopus 로고
    • Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling
    • Zhirnov, O. P. & Klenk, H. D. (2007). Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling. Apoptosis 12, 1419-1432.
    • (2007) Apoptosis , vol.12 , pp. 1419-1432
    • Zhirnov, O.P.1    Klenk, H.D.2
  • 148
    • 0036148072 scopus 로고    scopus 로고
    • NS1 protein of influenza A virus down-regulates apoptosis
    • Zhirnov, O. P., Konakova, T. E., Wolff, T. & Klenk, H. D. (2002). NS1 protein of influenza A virus down-regulates apoptosis. J Virol 76, 1617-1625.
    • (2002) J Virol , vol.76 , pp. 1617-1625
    • Zhirnov, O.P.1    Konakova, T.E.2    Wolff, T.3    Klenk, H.D.4
  • 149
    • 37349127838 scopus 로고    scopus 로고
    • A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens
    • Zhu, Q., Yang, H., Chen, W., Cao, W., Zhong, G., Jiao, P., Deng, G., Yu, K., Yang, C. & other authors (2008). A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens. J Virol 82, 220-228.
    • (2008) J Virol , vol.82 , pp. 220-228
    • Zhu, Q.1    Yang, H.2    Chen, W.3    Cao, W.4    Zhong, G.5    Jiao, P.6    Deng, G.7    Yu, K.8    Yang, C.9
  • 150
    • 39049146010 scopus 로고    scopus 로고
    • Genetic characterization of the NS gene indicates co-circulation of two sub-lineages of highly pathogenic avian influenza virus of H5N1 subtype in Northern Europe in 2006
    • Zohari, S., Gyarmati, P., Thoren, P., Czifra, G., Brojer, C., Belak, S. & Berg, M. (2008). Genetic characterization of the NS gene indicates co-circulation of two sub-lineages of highly pathogenic avian influenza virus of H5N1 subtype in Northern Europe in 2006. Virus Genes 36, 117-125.
    • (2008) Virus Genes , vol.36 , pp. 117-125
    • Zohari, S.1    Gyarmati, P.2    Thoren, P.3    Czifra, G.4    Brojer, C.5    Belak, S.6    Berg, M.7


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