IFNβ induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein

Cellular Microbiology

Volumn 9, Issue 4, 2007, Pages 930-938

  Opitz, Bastian ^a   Rejaibi, Amira ^a   Dauber, Bianca ^b   Eckhard, Jamina ^b   Vinzing, Maya ^a   Schmeck, Bernd ^a   Hippenstiel, Stefan ^a   Suttorp, Norbert ^a   Wolff, Thorsten ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b ROBERT KOCH INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BETA INTERFERON; COMPLEMENTARY DNA; INTERFERON BETA PROMOTER STIMULATOR 1; INTERFERON REGULATED FACTOR 3; MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN 5; NONSTRUCTURAL PROTEIN 1; RETINOIC ACID INDUCIBLE PROTEIN 1; RNA HELICASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR; VIRUS PROTEIN; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; IFIH1 PROTEIN, HUMAN; INTERFERON REGULATORY FACTOR 3; SIGNAL TRANSDUCING ADAPTOR PROTEIN; VISA PROTEIN, HUMAN;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA TRANSFECTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INFLUENZA VIRUS A; INTERFERON INDUCTION; INTERFERON PRODUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE; CELL LINE; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; TUMOR CELL LINE; VIROLOGY;

INFLUENZA A VIRUS; IPS; ORTHOMYXOVIRIDAE; RNA VIRUSES;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE; CELL LINE, TUMOR; DEAD-BOX RNA HELICASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; HUMANS; IMMUNOBLOTTING; INFLUENZA A VIRUS; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; MUTATION; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; VIRAL NONSTRUCTURAL PROTEINS;

EID: 33947171000     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2006.00841.x     Document Type: Article

References (39)

1. Andrejeva, J., Childs, K.S., Young, D.F., Carlos, T.S., Stock, N., Goodbourn, S., and Randall, R.E. (2004) The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci USA 101: 17264-17269.
2. Barchet, W., Krug, A., Cella, M., Newby, C., Fischer, J.A., Dzionek, A., et al. (2005) Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways. Eur J Immunol 35: 236-242.
3. Barnes, B., Lubyova, B., and Pitha, P.M. (2002) On the role of IRF in host defense. J Interferon Cytokine Res 22: 59-71.
4. Bergmann, M., Garcia-Sastre, A., Carnero, E., Pehamberger, H., Wolff, K., Palese, P., and Muster, T. (2000) Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication. J Virol 74: 6203-6206.
5. Diebold, S.S., Montoya, M., Unger, H., Alexopoulou, L., Roy, P., Haswell, L.E., et al. (2003) Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature 424: 324-328.
6. Diebold, S.S., Kaisho, T., Hemmi, H., Akira, S., and Reis e Sousa, C. (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303: 1529-1531.
7. Edelmann, K.H., Richardson-Burns, S., Alexopoulou, L., Tyler, K.L., Flavell, R.A., and Oldstone, M.B. (2004) Does Toll-like receptor 3 play a biological role in virus infections? Virology 322: 231-238.
8. Fitzgerald, K.A., McWhirter, S.M., Faia, K.L., Rowe, D.C., Latz, E., Golenbock, D.T., et al. (2003) IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4: 491-496.
9. Garcia-Sastre, A. (2004) Identification and characterization of viral antagonists of type I interferon in negative-strand RNA viruses. Curr Top Microbiol Immunol 283: 249-280.
10. Guillot, L., Le Goffic, R., Bloch, S., Escriou, N., Akira, S., Chignard, M., and Si-Tahar, M. (2005) Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem 280: 5571-5580.
11. Hayman, A., Comely, S., Lackenby, A., Murphy, S., McCauley, J., Goodbourn, S., and Barclay, W. (2006) Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway. Virology 347: 52-64.
12. Hemmi, H., Takeuchi, O., Sato, S., Yamamoto, M., Kaisho, T., Sanjo, H., et al. (2004) The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med 199: 1641-1650.
13. Hiscott, J., Lin, R., Nakhaei, P., and Paz, S. (2006) MasterCARD: A priceless link to innate immunity. Trends Mol Med 12: 53-56.
14. Honda, K., Yanai, H., Takaoka, A., and Taniguchi, T. (2005) Regulation of the type I IFN induction: A current view. Int Immunol 17: 1367-1378.
15. Horimoto, T., and Kawaoka, Y. (2005) Influenza: Lessons from past pandemics, warnings from current incidents. Nat Rev Microbiol 3: 591-600.
16. Juang, Y.T., Lowther, W., Kellum, M., Au, W.C., Lin, R., Hiscott, J., and Pitha, P.M. (1998) Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3. Proc Natl Acad Sci USA 95: 9837-9842.
17. Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., et al. (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441: 101-105.
18. Kawai, T., and Akira, S. (2005) Pathogen recognition with Toll-like receptors. Curr Opin Immunol 17: 338-344.
19. Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., et al. (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6: 981-988.
20. Levy, D.E., and Darnell, J.E., Jr (2002) Stats: Transcriptional control and biological impact. Nat Rev Mol Cell Biol 3: 651-662.
21. Lopez, C.B., Moltedo, B., Alexopoulou, L., Bonifaz, L., Flavell, R.A., and Moran, T.M. (2004) TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses. J Immunol 173: 6882-6889.
22. Lopez, C.B., Yount, J.S., and Moran, T.M. (2006) Toll-like receptor-independent triggering of dendritic cell maturation by viruses. J Virol 80: 3128-3134.
23. Ludwig, S., Wang, X., Ehrhardt, C., Zheng, H., Donelan, N., Planz, O., et al. (2002) The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors. J Virol 76: 11166-11171.
24. Ludwig, S., Pleschka, S., Planz, O., and Wolff, T. (2006) Ringing the alarm bells: Signalling and apoptosis in influenza virus infected cells. Cell Microbiol 8: 375-386.
25. Lund, J.M., Alexopoulou, L., Sato, A., Karow, M., Adams, N.C., Gale, N.W., et al. (2004) Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci USA 101: 5598-5603.
26. Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., and Tschopp, J. (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 1167-1172.
27. Niwa, H., Yamamura, K., and Miyazaki, J. (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108: 193-199.
28. Noah, D.L., Twu, K.Y., and Krug, R.M. (2003) Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS. Virology 307: 386-395.
29. Opitz, B., Puschel, A., Schmeck, B., Hocke, A.C., Rosseau, S., Hammerschmidt, S., etal. (2004) Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J Biol Chem 279: 36426-36432.
30. Philpott, D.J., and Girardin, S.E. (2004) The role of Toll-like receptors and Nod proteins in bacterial infection. Mol Immunol 41: 1099-1108.
31. Seth, R.B., Sun, L., Ea, C.K., and Chen, Z.J. (2005) Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122: 669-682.
32. Talon, J., Horvath, C.M., Polley, R., Basler, C.F., Muster, T., Palese, P., and Garcia-Sastre, A. (2000) Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J Virol 74: 7989-7996.
33. Unterstab, G., Ludwig, S., Anton, A., Planz, O., Dauber, B., Krappmann, D., et al. (2005) Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1. Proc Natl Acad Sci USA 102: 13640-13645.
34. Veckman, V., Osterlund, P., Fagerlund, R., Melen, K., Matikainen, S., and Julkunen, I. (2006) TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells. Virology 345: 96-104.
35. Wolff, T., O'Neill, R.E., and Palese, P. (1996) Interaction cloning of NS1-I, a human protein that binds to the nonstructural NS1 proteins of influenza A and B viruses. J Virol 70: 5363-5372.
36. Wolff, T., Pfleger, R., Wehner, T., Reinhardt, J., and Richt, J.A. (2000) A short leucine-rich sequence in the Borna disease virus p10 protein mediates association with the viral phospho- and nucleoproteins. J Gen Virol 81: 939-947.
37. Xu, L.G., Wang, Y.Y., Han, K.J., Li, L.Y., Zhai, Z., and Shu, H.B. (2005) VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell 19: 727-740.
38. Yewdell, J., and Garcia-Sastre, A. (2002) Influenza virus still surprises. Curr Opin Microbiol 5: 414-418.
39. Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., et al. (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 5: 730-737.