Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens

Journal of General Virology

Volumn 88, Issue 5, 2007, Pages 1403-1409

  Kochs, Georg ^a   Koerner, Iris ^a   Thiel, Lena ^b   Kothlow, Sonja ^c   Kaspers, Bernd ^c   Ruggli, Nicolas ^d   Summerfield, Artur ^d   Pavlovic, Jovan ^e   Stech, Jürgen ^b,f   Staeheli, Peter ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (Switzerland)

^e UNIVERSITY OF ZURICH   (Switzerland)

^f FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; NONSTRUCTURAL PROTEIN 1; NONSTRUCTURAL PROTEIN 3; PROTEIN KINASE R; PROTEIN MX1; UNCLASSIFIED DRUG; VIRULENCE FACTOR; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIVISION; CELL LINE; CHICKEN; CONTROLLED STUDY; HUMAN; IMMUNE RESPONSE; INFLUENZA VIRUS A; INTERFERON PRODUCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; UPPER RESPIRATORY TRACT; VIROGENESIS; VIRUS MUTATION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CHICKENS; DOGS; HUMANS; INFLUENZA A VIRUS, H7N7 SUBTYPE; INFLUENZA IN BIRDS; INFLUENZA, HUMAN; INTERFERON-BETA; INTERFERONS; LUNG; MICE; ORTHOMYXOVIRIDAE INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VERO CELLS; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE;

AVES; GALLUS GALLUS; INFLUENZA A VIRUS; MAMMALIA; MUS;

EID: 34248187720     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.82764-0     Document Type: Article

References (36)

1. Bergmann, M., Garcia-Sastre, A., Carnero, E., Pehamberger, H., Wolff, K., Palese, P. & Muster, T. (2000). Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication. J Virol 74, 6203-6206.
2. Cauthen, A. N., Swayne, D. E., Sekellick, M. J., Marcus, P. I. & Suarez, D. L. (2007). Amelioration of influenza virus pathogenesis in chickens attributed to the enhanced interferon-inducing capacity of a virus with a truncated NS1 gene. J Virol 81, 1838-1847.
3. Chen, Z., Li, Y. & Krug, R. M. (1999). Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3′-end processing machinery. EMBO J 18, 2273-2283.
4. Dauber, B., Heins, G. & Wolff, T. (2004). The influenza B virus nonstructural NS1 protein is essential for efficient viral growth and antagonizes beta interferon induction. J Virol 78, 1865-1872.
5. Donelan, N. R., Basler, C. F. & Garcia-Sastre, A. (2003). A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice. J Virol 77, 13257-13266.
6. Falcon, A. M., Marion, R. M., Zurcher, T., Gomez, P., Portela, A., Nieto, A. & Ortin, J. (2004). Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein. J Virol 78, 3880-3888.
7. Fortes, P., Beloso, A. & Ortin, J. (1994). Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport. EMBO J 13, 704-712.
8. Gabriel, G., Dauber, B., Wolff, T., Planz, O., Klenk, H. D. & Stech, J. (2005). The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc Natl Acad Sci U S A 102, 18590-18595.
9. Garaigorta, U., Falcon, A. M. & Ortin, J. (2005). Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles. J Virol 79, 15246-15257.
10. Garcia-Sastre, A., Egorov, A., Matassov, D., Brandt, S., Levy, D. E., Durbin, J. E., Palese, P. & Muster, T. (1998). Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252, 324-330.
11. Hale, B. G., Jackson, D., Chen, Y. H., Lamb, R. A. & Randall, R. E. (2006). Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling. Proc Natl Acad Sci U S A 103, 14194-14199.
12. Haller, O., Arnheiter, H., Gresser, I. & Lindenmann, J. (1979). Genetically determined, interferon-dependent resistance to influenza virus in mice. J Exp Med 149, 601-612.
13. Haller, O., Kochs, G. & Weber, F. (2006). The interferon response circuit: induction and suppression by pathogenic viruses. Virology 344, 119-130.
14. Hayman, A., Comely, S., Lackenby, A., Murphy, S., McCauley, J., Goodbourn, S. & Barclay, W. (2006). Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway. Virology 347, 52-64.
15. Jorns, C., Holzinger, D., Thimme, R., Spangenberg, H. C., Weidmann, M., Rasenack, J., Blum, H. E., Haller, O. & Kochs, G. (2006). Rapid and simple detection of IFN-neutralizing antibodies in chronic hepatitis C non-responsive to IFN-alpha. J Med Virol 78, 74-82.
16. Krug, R. M., Yuan, W., Noah, D. L. & Latham, A. G. (2003). Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein. Virology 309, 181-189.
17. Li, S., Min, J. Y., Krug, R. M. & San, G. C. (2006). Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA. Virology 349, 13-21.
18. Mibayashi, M., Martinez-Sobrido, L., Loo, Y. M., Cardenas, W. B., Gale, M., Jr & Garcia-Sastre, A. (2007). Inhibition of retinoic acid-inducible gene 1-mediated induction of beta interferon by the NS1 protein of influenza A virus. J Virol 81, 514-524.
19. Noah, D. L., Twu, K. Y. & Krug, R. M. (2003). Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS. Virology 307, 386-395.
20. Petro, T. M. (2005). Disparate expression of IL-12 by SJL/J and B10.S macrophages during Theiler's virus infection is associated with activity of TLR7 and mitogen-activated protein kinases. Microbes Infect 7, 224-232.
21. Pichlmair, A., Schulz, O., Tan, C. P., Naslund, T. I., Liljestrom, P., Weber, F. & Reis e Sousa, C. (2006). RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 314, 997-1001.
22. Quinlivan, M., Zamarin, D., Garcia-Sastre, A., Cullinane, A., Chambers, T. & Palese, P. (2005). Attenuation of equine influenza viruses through truncations of the NS1 protein. J Virol 79, 8431-8439.
23. Reed, L. J. & Muench, H. (1938). A simple method of estimating fifty percent endpoints. Am J Hyg 27, 493-497.
24. Scheiblauer, H., Kendal, A. P. & Rott, R. (1995). Pathogenicity of influenza A/Seal/Mass/1/80 virus mutants for mammalian species. Arch Virol 140, 341-348.
25. Schwarz, H., Harlin, O., Ohnemus, A., Kaspers, B. & Staeheli, P. (2004). Synthesis of IFN-beta by virus-infected chicken embryo cells demonstrated with specific antisera and a new bioassay. J Interferon Cytokine Res 24, 179-184.
26. Seo, S. H., Hoffmann, E. & Webster, R. G. (2002). Lethal H5N1 influenza viruses escape host anti-viral cytokine responses. Nat Med 8, 950-954.
27. Solorzano, A., Webby, R. J., Lager, K. M., Janke, B. H., Garcia-Sastre, A. & Richt, J. A. (2005). Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. J Virol 79, 7535-7543.
28. Spackman, E., Senne, D. A., Myers, T. J., Bulaga, L. L., Garber, L. P., Perdue, M. L., Lohman, K., Daum, L. T. & Suarez, D. L. (2002). Development of a real-time reverse transcriptase PCR assay for type A influenza virus and the avian H5 and H7 hemagglutinin subtypes. J Clin Microbiol 40, 3256-3260.
29. Staeheli, P., Dreiding, P., Haller, O. & Lindenmann, J. (1985). Polyclonal and monoclonal antibodies to the interferon-inducible protein Mx of influenza virus-resistant mice. J Biol Chem 260, 1821-1825.
30. Staeheli, P., Haller, O., Boll, W., Lindenmann, J. & Weissmann, C. (1986). Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell 44, 147-158.
31. Staeheli, P., Grob, R., Meier, E., Sutcliffe, J. G. & Haller, O. (1988). Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation. Mol Cell Biol 8, 4518-4523.
32. Talon, J., Horvath, C. M., Polley, R., Basler, C. F., Muster, T., Palese, P. & Garcia-Sastre, A. (2000). Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J Virol 74, 7989-7996.
33. Wang, X., Basler, C. F., Williams, B. R., Silverman, R. H., Palese, P. & Garcia-Sastre, A. (2002). Functional replacement of the carboxy-terminal two-thirds of the influenza A virus NS1 protein with short heterologous dimerization domains. J Virol 76, 12951-12962.
34. Webster, R. G., Hinshaw, V. S., Bean, W. J., Van Wyke, K. L., Geraci, J. R., St Aubin, D. J. & Petursson, G. (1981). Characterization of an influenza A virus from seals. Virology 113, 712-724.
35. Yang, Y. L., Reis, L. F., Pavlovic, J., Aguzzi, A., Schafer, R., Kumar, A., Williams, B. R., Aguet, M. & Weissmann, C. (1995). Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J 14, 6095-6106.
36. Zhirnov, O. P., Konakova, T. E., Wolff, T. & Klenk, H. D. (2002). NS1 protein of influenza A virus down-regulates apoptosis. J Virol 76, 1617-1625.