The 3′-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAS in vivo

RNA

Volumn 7, Issue 6, 2001, Pages 920-931

  Wormsley, Steven ^a   Samarsky, Dmitry A ^b   Fournier, Maurille J ^c   Baserga, Susan J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

3 end processing; CPSF; Influenza virus NS1A protein; PABII; Pre mRNA splicing

Indexed keywords

CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; MESSENGER RNA; MESSENGER RNA PRECURSOR; VIRUS PROTEIN; RNA BINDING PROTEIN; RNA PRECURSOR;

ARTICLE; INFLUENZA VIRUS; INTRON; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RNA PROCESSING; RNA SPLICING; TRANS SPLICING; AMINO ACID SEQUENCE; CELL LINE; HUMAN; METABOLISM; MOLECULAR GENETICS;

INFLUENZA VIRUS;

AMINO ACID SEQUENCE; CELL LINE; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; RNA PRECURSORS; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEINS;

EID: 0034743629     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838201010226     Document Type: Article

References (40)

1. Regulation of the extent of splicing of influenza virus NS1 mRNA: Role of the rate of splicing and of the nucleocytoplasmic transport of NS1 mRNA
2. The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins
3. Coupling RNA polymerase II transcription with pre-mRNA processing
4. Exon recognition in vertebrate splicing
5. Infleunza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3′ end processing machinery
6. Mechanism and regulation of mRNA polyadenylation
7. Transcription factor TFIID recruits CPSF for formation of 3′ end mRNA
8. A functional interaction between the carboxy-terminal domain of RNA polymerase II and pre-mRNA splicing
9. Terminal exon definition occurs cotranscriptionally and promotes termination of RNA polymerase II
10. Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport
11. Involvement of the carboxy terminus of vertebrate poly(A) polymerase in U1A autoregulation and in the coupling of splicing and polyadenylation
12. RNA polymerase II is an essential mRNA polyadenylation factor
13. RNA polymerase II and the integration of nuclear events
14. Phosphorylated RNA polymerase II stimulates pre-mRNA splicing
15. Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit
16. Cleavage and polyadenylation factor (CPF) specificity interacts with the pre-mRNA 3′ processing signal AAUAAA
17. Expression and replication of the influenza virus genome
18. Mapping of the two overlapping genes for polypeptides NS1 and NS2 on RNA segment 8 of influenza virus genome
19. Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: Collnear and interrupted mRNAs code for overlapping proteins
20. The influenza virus NS1 protein: A novel inhibitor of pre-mRNA splicing
21. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription
22. mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription
23. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo
24. Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus
25. Influenza virus NS1 protein interacts with the 30kD subunit of cleavage and specificity factor and inhibits 3′ end formation of cellular pre-mRNAs
26. The influenza virus NS1 protein forms multimers in vitro and in vivo
27. Upstream introns influence the efficiency of final intron removal and RNA 3′-end formation
28. Lack of an effect of the efficiency of RNA 3′-end formation on the efficiency of removal of either the final or the penultimate intron in intact cells
29. Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns
30. In vitro polyadenylation is stimulated by the presence of an upstream intron
31. Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template
32. Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA
33. The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A)
34. The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing
35. Polyadenylation sites for influenza virus mRNA
36. Reciprocal effects of splicing and polyadenylation on human immunodeficiency virus type 1 pre-mRNA processing
37. The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3′-end processing and splicing
38. The mechanism of 3′ cleavage and polyadenylation of eukaryotic pre-mRNA
39. The RNA-binding and effector domains are conserved to different extends among influenza A and B viruses
40. RNA-binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids