Biophysical Characterization of the Complex between Double-Stranded RNA and the N-Terminal Domain of the NS1 Protein from Influenza A Virus: Evidence for a Novel RNA-Binding Mode

Biochemistry

Volumn 43, Issue 7, 2004, Pages 1950-1962

  Chien, Chen Ya ^a   Xu, Yujia ^b   Xiao, Rong ^a   Aramini, James M ^a   Sahasrabudhe, Parag V ^a   Krug, Robert M ^c   Montelione, Gaetano T ^a,b,d  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CONFORMATIONS; DNA; FILTRATION; NUCLEAR MAGNETIC RESONANCE; PROTEINS; RNA; SEDIMENTATION; STOICHIOMETRY; VIRUSES; X RAY CRYSTALLOGRAPHY;

CIRCULAR DICHROISM; DISSOCIATION CONSTANTS;

BIOCHEMISTRY;

DIMER; DNA HYBRID; DOUBLE STRANDED DNA; DOUBLE STRANDED RNA; EPITOPE; PROTEIN NS1; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOPHYSICS; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; ELECTRICITY; GEL FILTRATION; INFLUENZA VIRUS A; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SEDIMENTATION; STOICHIOMETRY;

CARBON ISOTOPES; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; DNA, VIRAL; EPITOPE MAPPING; INFLUENZA A VIRUS; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID HETERODUPLEXES; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTONS; RNA, DOUBLE-STRANDED; RNA, VIRAL; RNA-BINDING PROTEINS; THERMODYNAMICS; ULTRACENTRIFUGATION; VIRAL NONSTRUCTURAL PROTEINS;

EUKARYOTA; INFLUENZA A VIRUS; INFLUENZA VIRUS; PROKARYOTA; RNA VIRUSES;

EID: 1242307789     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi030176o     Document Type: Article

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