Influenza virus NS1 protein induces apoptosis in cultured cells

Journal of Virology

Volumn 75, Issue 17, 2001, Pages 7875-7881

  Schultz Cherry, S ^a   Dybdahl Sissoko, N ^a   Neumann, G ^a   Kawaoka, Y ^a   Hinshaw, V S ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; DIMERIZATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLUENZA VIRUS; INFLUENZA VIRUS A; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; VIRUS MUTATION;

ANIMALS; APOPTOSIS; CELL LINE; DOGS; HELA CELLS; HUMANS; KIDNEY; MUTATION; ORTHOMYXOVIRIDAE; PLASMIDS; REASSORTANT VIRUSES; TRANSFECTION; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0034872412     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.17.7875-7881.2001     Document Type: Article

References (73)

1. Dendritic cells acquire antigen from apoptotic cells and induce class I- restricted CTLs
2. Nucleocytoplasmic transport: The influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA
3. A novel RNA-binding motif in influenza A virus non-structural protein 1
4. Potential roles of apoptosis in viral pathogenesis
5. Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells
6. Programmed cell death (apoptosis) in human monocytes infected by influenza A virus
7. Rescue of influenza A virus from recombinant DNA
8. Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport
9. Virus clearance through apoptosis-dependent phagocytosis of influenza A virus-infected cells by macrophages
10. Co-expression of Fas and Fas-ligand on the surface of influenza virus-infected cells
11. The role of interferon in influenza virus tissue tropism
12. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems
13. Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): Mechanism of action
14. Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells
15. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
16. Binding of influenza A virus NS1 protein to dsRNA in vitro
17. Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells
18. Apoptosis: A mechanism of cell killing by influenza A and B viruses
19. Programmed cell death in animal development
20. Influence of host species on the evolution of the nonstructural (NS) gene of influenza A viruses
21. Apoptosis. Its significance in cancer and cancer therapy
22. Orthomyxoviridae
23. TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes
24. Characterization of influenza virus-induced death of J774.1 macrophages
25. The influenza virus NS1 protein: A novel inhibitor of pre-mRNA splicing
26. Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor
27. A fatal relationship-influenza virus interactions with the host cell
28. Apoptosis, oncosis, and necrosis. An overview of cell death
29. In vivo induction of apoptosis by influenza virus
30. Role of neuraminidase in influenza virus-induced apoptosis
31. Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3′ end formation of cellular pre-mRNAs
32. The influenza virus NS1 protein forms multimers in vitro and in vivo
33. Genetic engineering of influenza and other negative-strand RNA viruses containing segmented genomes
34. Generation of influenza A viruses entirely from cloned cDNAs
35. Infectious influenza A and B virus variants with long carboxyl terminal deletions in the NS1 polypeptides
36. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen
37. Bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation
38. The influenza virus NEP (NS2 protein) mediates the nuclear export of viral xibonucleoproteins
39. Differential induction of cytotoxicity and apoptosis by influenza virus strains of differing virulence
40. Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA
41. New approach for inhibiting Rev function and HIV-1 production using the influenza virus NS1 protein
42. An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure
43. The influenza virus NS1 protein is a poly(A)binding protein that inhibits nuclear export of mRNAs containing poly(A)
44. The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing
45. E1A 12S in the absence of E1B or other cooperating oncogenes enables cells to overcome apoptosis
46. Apoptosis in viral infections
47. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system
48. Viruses and apoptosis
49. Influenza virus neuraminidase activates latent transforming growth factor beta
50. Induction of apoptosis by influenza virus
51. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
52. Viruses and apoptosis
53. The choice of alternative 5′ splice sites in influenza virus M1 mRNA is regulated by the viral polymerase complex
54. Induction of apoptosis by influenza virus infection
55. Mechanism of the induction of apoptosis by influenza virus infection
56. Activation of the apoptotic Fas antigen-encoding gene upon influenza virus infection involving spontaneously produced beta-interferon
57. Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells
58. Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection
59. Recruitment of apoptotic cysteine proteases (caspases) in influenza virus-induced cell death
60. Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein
61. Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase
62. Regulation of apoptosis by viral gene products
63. Apoptosis in the pathogenesis and treatment of disease
64. Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans
65. Destruction of lymphocytes by a virulent avian influenza A virus
66. Virulent avian influenza A viruses: Their effect on avian lymphocytes and macrophages in vivo and in vitro
67. Transcription stimulation of the Fas-encoding gene by nuclear factor for interleukin-6 expression upon influenza virus infection
68. The RNA-binding and effector domains of the viral NS1 protein are conserved to different extents among influenza A and B viruses
69. U6atac snRNA, the highly divergent counterpart of U6 snRNA, is the specific target that mediates inhibition of AT-AC splicing by the influenza virus NS1 protein
70. RNA binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids
71. Interaction cloning of NS1-1 a human protein that binds to the nonstructural NS1 proteins of influenza A and B viruses
72. NS1-binding protein (NS1-BP): A novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells
73. Viruses and apoptosis