-
1
-
-
0028965644
-
Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
-
Ulevitch R.J., Tobias P.S. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol. 13:1995;437-449.
-
(1995)
Annu. Rev. Immunol.
, vol.13
, pp. 437-449
-
-
Ulevitch, R.J.1
Tobias, P.S.2
-
2
-
-
0035524488
-
Toll-like receptors and innate immunity
-
Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1:2001;135-145.
-
(2001)
Nat. Rev. Immunol.
, vol.1
, pp. 135-145
-
-
Medzhitov, R.1
-
3
-
-
0012929728
-
Toll-like receptors
-
Takeda K., et al. Toll-like receptors. Annu. Rev. Immunol. 21:2003;335-376.
-
(2003)
Annu. Rev. Immunol.
, vol.21
, pp. 335-376
-
-
Takeda, K.1
-
4
-
-
0028970060
-
Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
-
Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:1995;251-276.
-
(1995)
Annu. Rev. Immunol.
, vol.13
, pp. 251-276
-
-
Trinchieri, G.1
-
7
-
-
0029090285
-
Molecular mechanism in tolerance to lipopolysaccharide
-
Zeigler-Heitbrock H.W. Molecular mechanism in tolerance to lipopolysaccharide. J. Inflamm. 45:1995;13-26.
-
(1995)
J. Inflamm.
, vol.45
, pp. 13-26
-
-
Zeigler-Heitbrock, H.W.1
-
8
-
-
20244384395
-
Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface Toll-like receptor 4 expression
-
Nomura F., et al. Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface Toll-like receptor 4 expression. J. Immunol. 164:2000;3476-3479.
-
(2000)
J. Immunol.
, vol.164
, pp. 3476-3479
-
-
Nomura, F.1
-
9
-
-
0028229050
-
Tolerance to lipopolysaccharide involves mobilization of nuclear factor κB with predominance of p50 homodimers
-
Zeigler-Heitbrock H.W., et al. Tolerance to lipopolysaccharide involves mobilization of nuclear factor κB with predominance of p50 homodimers. J. Biol. Chem. 269:1994;17001-17004.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 17001-17004
-
-
Zeigler-Heitbrock, H.W.1
-
10
-
-
0037178785
-
IRAK-M is a negative regulator of Toll-like receptor signaling
-
Kobayashi K., et al. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 110:2002;191-202.
-
(2002)
Cell
, vol.110
, pp. 191-202
-
-
Kobayashi, K.1
-
11
-
-
0036850946
-
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
-
Kinjyo I., et al. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity. 17:2002;583-591.
-
(2002)
Immunity
, vol.17
, pp. 583-591
-
-
Kinjyo, I.1
-
12
-
-
18744371050
-
SOCS-1 participates in negative regulation of LPS responses
-
Nakagawa R., et al. SOCS-1 participates in negative regulation of LPS responses. Immunity. 17:2002;677-687.
-
(2002)
Immunity
, vol.17
, pp. 677-687
-
-
Nakagawa, R.1
-
13
-
-
0036707521
-
PI3K-mediated negative feedback regulation of IL-12 production in DCs
-
Fukao T., et al. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat. Immunol. 3:2002;875-881.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 875-881
-
-
Fukao, T.1
-
14
-
-
0037199972
-
The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
-
Guha M., Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277:2002;32124-32132.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32124-32132
-
-
Guha, M.1
Mackman, N.2
-
15
-
-
0036195935
-
Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice
-
Fukao T., et al. Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Nat. Immunol. 3:2002;295-304.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 295-304
-
-
Fukao, T.1
-
16
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
-
Hirsch E., et al. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation. Science. 287:2000;1049-1053.
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
-
17
-
-
0034635264
-
Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
-
Sasaki T., et al. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration. Science. 287:2000;1040-1046.
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
-
18
-
-
0034635221
-
Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction
-
Li Z., et al. Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction. Science. 287:2000;1046-1049.
-
(2000)
Science
, vol.287
, pp. 1046-1049
-
-
Li, Z.1
-
19
-
-
0037047590
-
Impaired B and T cell antigen receptor signaling in p110δ PI3-kinase mutant mice
-
Okkenhaug K., et al. Impaired B and T cell antigen receptor signaling in p110δ PI3-kinase mutant mice. Science. 297:2002;1031-1034.
-
(2002)
Science
, vol.297
, pp. 1031-1034
-
-
Okkenhaug, K.1
-
20
-
-
0037119630
-
A crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in B cell development and activation
-
Clayton E., et al. A crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med. 196:2002;753-763.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 753-763
-
-
Clayton, E.1
-
21
-
-
0030985901
-
Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-ζ in bacterial lipopolysaccharide-treated human monocytes
-
Herrera-Velit P., et al. Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-ζ in bacterial lipopolysaccharide-treated human monocytes. J. Biol. Chem. 272:1997;16445-16452.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16445-16452
-
-
Herrera-Velit, P.1
-
22
-
-
0034577944
-
Toll-like receptor 2-mediated NF-κB activation requires a Rac1-dependent pathway
-
Arbibe L., et al. Toll-like receptor 2-mediated NF-κB activation requires a Rac1-dependent pathway. Nat. Immunol. 1:2000;533-540.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 533-540
-
-
Arbibe, L.1
-
23
-
-
0035451664
-
A novel function of phosphorothioate oligodeoxynucleotides as chemoattractants for primary macrophages
-
Baek K.H., et al. A novel function of phosphorothioate oligodeoxynucleotides as chemoattractants for primary macrophages. J. Immunol. 167:2001;2847-2854.
-
(2001)
J. Immunol.
, vol.167
, pp. 2847-2854
-
-
Baek, K.H.1
-
24
-
-
0027979446
-
Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C γ 2
-
Ren C.L., et al. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C γ 2. J. Exp. Med. 179:1994;673-680.
-
(1994)
J. Exp. Med.
, vol.179
, pp. 673-680
-
-
Ren, C.L.1
-
25
-
-
0033393957
-
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
-
Wong B.R., et al. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol. Cell. 4:1999;1041-1049.
-
(1999)
Mol. Cell
, vol.4
, pp. 1041-1049
-
-
Wong, B.R.1
-
26
-
-
0037322295
-
Toll signaling: The TIReless quest for specificity
-
Imler J.L., Hoffmann J.A. Toll signaling: the TIReless quest for specificity. Nat. Immunol. 4:2003;105-106.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 105-106
-
-
Imler, J.L.1
Hoffmann, J.A.2
-
27
-
-
0033669743
-
TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide
-
Lee J., et al. TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide. J. Leukoc. Biol. 68:2000;909-915.
-
(2000)
J. Leukoc. Biol.
, vol.68
, pp. 909-915
-
-
Lee, J.1
-
28
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang C., et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature. 412:2001;346-351.
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
-
29
-
-
0037352702
-
Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages
-
Ojaniemi M., et al. Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur. J. Immunol. 33:2003;597-605.
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 597-605
-
-
Ojaniemi, M.1
-
30
-
-
0033118982
-
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
-
Lu H.T., et al. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18:1999;1845-1857.
-
(1999)
EMBO J.
, vol.18
, pp. 1845-1857
-
-
Lu, H.T.1
-
31
-
-
0035133227
-
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
-
Kim A.H., et al. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol. Cell. Biol. 21:2001;893-901.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 893-901
-
-
Kim, A.H.1
-
32
-
-
0035839556
-
Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells
-
Gratton J.P., et al. Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J. Biol. Chem. 276:2001;30359-30365.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30359-30365
-
-
Gratton, J.P.1
-
33
-
-
0030992837
-
Signaling through the lipid products of phosphoinositide-3-OH kinase
-
Toker A., Cantley L.C. Signaling through the lipid products of phosphoinositide-3-OH kinase. Nature. 387:1997;673-676.
-
(1997)
Nature
, vol.387
, pp. 673-676
-
-
Toker, A.1
Cantley, L.C.2
-
34
-
-
0033038491
-
Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit
-
Sizemore N., et al. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol. Cell. Biol. 19:1999;4798-4805.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 4798-4805
-
-
Sizemore, N.1
-
35
-
-
0031943618
-
The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
-
Gately M.K., et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16:1998;495-521.
-
(1998)
Annu. Rev. Immunol.
, vol.16
, pp. 495-521
-
-
Gately, M.K.1
-
36
-
-
0031446317
-
+ T-cell subsets in autoimmunity
-
+ T-cell subsets in autoimmunity. Curr. Opin. Immunol. 9:1997;872-883.
-
(1997)
Curr. Opin. Immunol.
, vol.9
, pp. 872-883
-
-
O'Garra, A.1
-
37
-
-
0034121654
-
Dendritic cells in cancer immunotherapy
-
Fong L., Engleman E.G. Dendritic cells in cancer immunotherapy. Annu. Rev. Immunol. 18:2000;245-273.
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 245-273
-
-
Fong, L.1
Engleman, E.G.2
-
38
-
-
0036284984
-
The role of Th1/Th2 polarization in mucosal immunity
-
Neurath M.F., et al. The role of Th1/Th2 polarization in mucosal immunity. Nat. Med. 8:2002;567-573.
-
(2002)
Nat. Med.
, vol.8
, pp. 567-573
-
-
Neurath, M.F.1
-
39
-
-
0033856462
-
PI3-kinase inhibition: A target for drug development?
-
Stein R.C., Waterfield M.D. PI3-kinase inhibition: a target for drug development? Mol. Med. Today. 6:2000;347-357.
-
(2000)
Mol. Med. Today
, vol.6
, pp. 347-357
-
-
Stein, R.C.1
Waterfield, M.D.2
-
40
-
-
0035813157
-
Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells
-
Re F., Strominger J.L. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J. Biol. Chem. 276:2001;37692-37699.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37692-37699
-
-
Re, F.1
Strominger, J.L.2
-
41
-
-
0034780463
-
Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages
-
Jones B.W., et al. Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages. Ann. Rheum. Dis. 60:2001;6-12.
-
(2001)
Ann. Rheum. Dis.
, vol.60
, pp. 6-12
-
-
Jones, B.W.1
-
42
-
-
0037031924
-
Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA
-
Monick M.M., et al. Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. J. Biol. Chem. 277:2002;32992-33000.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32992-33000
-
-
Monick, M.M.1
-
43
-
-
0033563141
-
Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages
-
Diaz-Guerra M.J., et al. Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages. J. Immunol. 162:1999;6184-6190.
-
(1999)
J. Immunol.
, vol.162
, pp. 6184-6190
-
-
Diaz-Guerra, M.J.1
-
44
-
-
0031587403
-
Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages
-
Park Y.C., et al. Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages. Biochem. Biophys. Res. Commun. 240:1997;692-696.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.240
, pp. 692-696
-
-
Park, Y.C.1
-
45
-
-
0029978925
-
Inhibition of phosphatidylinositol-3′-kinase prevents induction of endotoxin tolerance in vitro
-
Bowling W.M., et al. Inhibition of phosphatidylinositol-3′-kinase prevents induction of endotoxin tolerance in vitro. J. Surg. Res. 63:1996;287-292.
-
(1996)
J. Surg. Res.
, vol.63
, pp. 287-292
-
-
Bowling, W.M.1
-
46
-
-
0037099629
-
Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation
-
Ishii K.J., et al. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J. Exp. Med. 196:2002;269-274.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 269-274
-
-
Ishii, K.J.1
-
47
-
-
0036134876
-
CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3′-OH kinase pathway
-
Park Y., et al. CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3′-OH kinase pathway. J. Immunol. 168:2002;5-8.
-
(2002)
J. Immunol.
, vol.168
, pp. 5-8
-
-
Park, Y.1
-
48
-
-
0035451664
-
A novel function of phosphorothioate oligodeoxynucleotides as chemoattractants for primary macrophages
-
Baek K.H., et al. A novel function of phosphorothioate oligodeoxynucleotides as chemoattractants for primary macrophages. J. Immunol. 167:2001;2847-2854.
-
(2001)
J. Immunol.
, vol.167
, pp. 2847-2854
-
-
Baek, K.H.1
|